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WO2012170614A3 - Dna methylation markers in non-small cell lung cancer and methods of using the same - Google Patents

Dna methylation markers in non-small cell lung cancer and methods of using the same Download PDF

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Publication number
WO2012170614A3
WO2012170614A3 PCT/US2012/041228 US2012041228W WO2012170614A3 WO 2012170614 A3 WO2012170614 A3 WO 2012170614A3 US 2012041228 W US2012041228 W US 2012041228W WO 2012170614 A3 WO2012170614 A3 WO 2012170614A3
Authority
WO
WIPO (PCT)
Prior art keywords
lung cancer
small cell
cell lung
methods
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/041228
Other languages
French (fr)
Other versions
WO2012170614A2 (en
Inventor
Steven H. LIN
John Heymach
Jing Wang
John Minna
Luc Girard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of WO2012170614A2 publication Critical patent/WO2012170614A2/en
Publication of WO2012170614A3 publication Critical patent/WO2012170614A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided herein are unique sets of genes that are regulated by methylation in non-small cell lung cancer ("NSCLC") that are useful as a biomarker or in an assay for determining, diagnosing or subtyping lung cancer and/or the outcome of certain drug therapies.
PCT/US2012/041228 2011-06-07 2012-06-07 Dna methylation markers in non-small cell lung cancer and methods of using the same Ceased WO2012170614A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161494142P 2011-06-07 2011-06-07
US61/494,142 2011-06-07

Publications (2)

Publication Number Publication Date
WO2012170614A2 WO2012170614A2 (en) 2012-12-13
WO2012170614A3 true WO2012170614A3 (en) 2013-04-04

Family

ID=47296727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/041228 Ceased WO2012170614A2 (en) 2011-06-07 2012-06-07 Dna methylation markers in non-small cell lung cancer and methods of using the same

Country Status (1)

Country Link
WO (1) WO2012170614A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140227694A1 (en) * 2013-02-08 2014-08-14 Zymo Research Corporation Epigenetic markers of pluripotency
CN105849120A (en) * 2013-10-06 2016-08-10 美国卫生和人力服务部 Modified pseudomonas exotoxin A
CN108680745B (en) * 2018-01-03 2021-06-15 湖州市中心医院 Application of serum lipid biomarkers in early diagnosis of NSCLC
CN115772565B (en) * 2021-09-08 2023-09-05 广州市基准医疗有限责任公司 Methylation site for auxiliary detection of lung cancer somatic EGFR gene mutation and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080241842A1 (en) * 2005-07-09 2008-10-02 Lovelace Respiratory Research Institute Gene Methylation as a Biomarker in Sputum
WO2009023172A2 (en) * 2007-08-09 2009-02-19 The Johns Hopkins University Predictions of responsiveness to egfr inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080241842A1 (en) * 2005-07-09 2008-10-02 Lovelace Respiratory Research Institute Gene Methylation as a Biomarker in Sputum
WO2009023172A2 (en) * 2007-08-09 2009-02-19 The Johns Hopkins University Predictions of responsiveness to egfr inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GOTO, Y. ET AL.: "Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma", CANCER RES., vol. 69, no. 23, 1 December 2009 (2009-12-01), pages 9073 - 9082 *
GU, J. ET AL.: "Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer", CLIN. CANCER RES., vol. 12, no. 24, 15 December 2006 (2006-12-15), pages 7329 - 38 *
KIM, B. ET AL.: "Clinical validity of the lung cancer biomarkers identified by bioinformatics analysis of public expression data", CANCER RES., vol. 67, no. 15, 1 August 2007 (2007-08-01), pages 7431 - 7438 *

Also Published As

Publication number Publication date
WO2012170614A2 (en) 2012-12-13

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