WO2012168216A2 - Cosmetic or dermatological emulsion preparations which are free from fatty alcohols - Google Patents

Abstract

The invention relates to cosmetic or dermatological emulsion preparations containing polyglyceryl-10-stearate and no fatty alcohols.

Description

 Fatty alcohol-free cosmetic or dermatological emulsion preparations

The invention includes cosmetic or dermatological emulsion preparations containing polyglyceryl-10-stearate which are free of fatty alcohols.

Emulsions, in particular W / O, O / W, O / W / O or W / O / W emulsions, are often used as cosmetic or medical preparations. Emulsions are generally understood to mean heterogeneous systems which consist of two liquids which are immiscible or only slightly miscible with one another, which are usually referred to as phases. In an emulsion, one of the two liquids (W / O) is dispersed in the form of very fine droplets in the other liquid. The liquids (pure or as solutions) are present in an emulsion in a more or less fine distribution, which is generally limited stability.

If the two liquids are water and oil and oil droplets are finely distributed in water, then it is an oil-in-water emulsion (O / W emulsion, eg milk). The basic character, for example electrical conductivity, sensor technology, dyeability of the continuous phase, an O / W emulsion is characterized by the water. A water-in-oil emulsion (W / O emulsion, eg butter) is the reverse principle, with the basic character being determined by the oil.

The prior art knows several important factors that have a positive influence on the stability and rheology of emulsions.

Emulsions for their formation and stabilization generally require one or more emulsifiers, thickeners and / or bodying agents to be stable over a cosmetically acceptable period of time, generally 1 year after opening a cosmetic preparation.

 This often requires large amounts of emulsifiers. This in turn can be at

Consumers to misperceptions to intolerance and in extreme cases, even to phenomena such as Mallorca acne or similar. to lead.

It is therefore desirable to provide emulsion formulations which comprise the smallest possible amounts of emulsifiers and are nevertheless sufficiently stable in formulated. To stabilize or thicken emulsions, fatty alcohols such as myristyl alcohol, behenyl alcohol, stearyl alcohol, palmityl alcohol, etc. are often used. The generic term fatty alcohols stands for monohydric primary alcohols with 8 to 22

Carbon atoms and branched or unbranched chains. They are obtained by a reduction of the triglycerides, fatty acids or fatty acid methyl esters and form elementary raw materials for the production of various chemical secondary products. What the

Regarding chain length, an even number of carbon atoms is a hallmark of the

natural origin.

 Chain components of 16 and 18 C atoms are suitable as classical components for cosmetic or dermatological creams and ointments. Depending on their molecular weight, they are high-boiling oily liquids, waxy masses or solid products, e.g. Octanol (caprylic alcohol), octenol, octadienol, decanol (capric alcohol), decenol, decadienol, dodecanol (lauryl alcohol), dodecenol, dodecadienol, tetradecanol (myristyl alcohol), hexadecanol (cetyl alcohol), octadecanol (stearyl alcohol or isostearyl alcohol),

Octadecenol (oleyl alcohol or erucyl alcohol), octadecene diol (ricinoleic alcohol),

Octadecadienol (linoleyl alcohol), octadecatrienol (linolenyl alcohol), eicosanol

(Arachidyl alcohol), eicosenol (gadoleyl alcohol), docosanol (behenyl alcohol) or docosenol (erucyl alcohol or brassidyl alcohol). Particular embodiments are offered as mixtures of saturated primary alcohols having 14-20 carbon atoms, especially cetylstearyl alcohol.

 However, fatty alcohols cause a characteristic, waxy, dull and rich skin feeling. Depending on the product, target group and / or product concept, this property is not always wanted.

It is therefore desirable to provide emulsion preparation without fatty alcohols, which, however, nevertheless represent the widest possible range of variations and above all stable emulsions.

Furthermore, cosmetic or dermatological preparations must meet some aesthetic criteria in order to obtain sufficient consumer acceptance.

The person skilled in the art emulsifiers from the food industry are known as glyceryl stearate citrate (Imwitor®) or polyglyceryl-10-stearate.

However, in search of suitable emulsifiers which meet the desired requirements of cosmetics or dermatology, these emulsifiers appear to be

excluded. Glyceryl stearate citrate must be used in cosmetic preparations in such a high amount or in combination with co-emulsifiers to obtain stable emulsions, so that the desire for reduced emulsifier content with glyceryl stearate citrate is not met.

 Polyglyceryl-10-stearate (PG-10 stearate, CAS No .: 79777-30-3) is a hydrophilic emulsifier and has an HLB of 12.

 Polyglyceryl-10 stearates are commercially available as blends, for example, as Polyaldo 10-1-S (Lonza), Nikkol Decaglyn 1 -S (Nikko Chemicals Co., Ltd.) or Salacos PGMSV (The Nisshin OilliO Group, Ltd.).

Polyglyceryl-10-stearate is known from ice cream manufacture and has a brown color. Also due to this aesthetically problematic circumstance, the application in cosmetic emulsions seemed to ban itself.

Heliogel®, which in addition to Sodium Acrylates Copolymer, Hydrogenated Polyisobutenes, Phospholipids, Helianthus Annuus (Sunflower) Seed Oil also contains polyglyceryl-10 stearates, is available for purchase.

In cosmetic preparations, PG-10 stearate is merely part of a

Called aftershave glands. In this preparation, 6 wt.% PG-10 stearate are described in addition to other emulsifiers such as lecithin and PEG 150 distearate (WO 2003082182).

JP 2005162664 discloses PG-10 stearate in hair dye preparation comprising peroxides. A cosmetic topical application therefore excludes.

US 5925615 discloses PG-10 stearate in shampoo formulations comprising

Polyethylene glycols and parabens.

 DE 19547679 A1 describes a hair care emulsions with PG-10-stearate and

Preservatives.

 DE 19724587 A1 describes a hair rinse with PG-10-stearate and also polyethylene glycols and parabens.

 WO 0027197 A1 discloses preparations comprising besides PG-10-stearate one or more UV filters, lecithins, polyethylene glycols and parabens.

 DE 102008028821 A1 and DE 102008028822 A1 disclose stick preparations with PG-10 stearate.

DE 10213955 A1 discloses PG-10 stearate in an aftershave lotion wherein the content of PG-10 stearate is 6% or more. US 20060018853 describes peel-off preparation with PG-10-stearate with

Decaglyceryl triisostearate and lecithin.

It has surprisingly been found that polyglyceryl-10-stearate can be used as an emulsifier in cosmetic or dermatological preparations without showing the disadvantages of the coloring effect and the instability.

 Furthermore, it has surprisingly been found that formulations with polyglyceryl-10-stearate can be formulated without fatty alcohols and have sufficient stability without exhibiting the abovementioned problems of the fatty alcohols.

The invention is a cosmetic or dermatological emulsion preparation comprising polyglyceryl-10-stearate, preferably less than 6% by weight, in particular in the range from 0.1 to 2.8% by weight, based on the total mass of the preparation, and comprising no fatty alcohols, in particular none of the chain length between C12-20 and most preferably C16-18.

O / W emulsion preparations 1 and 3 consisting of

 1 3

 Panthenol 1, 5 0

 Propylene Glycol - 10

 Benzethonium chloride 1, 0 0.25

 Lauroylethylarginate 1, 0 1, 5

 medical white oil 0 6

 Isopropyl palmitate 1 0

 Caprylic / Capric Triglyceride 0 3

 Cetyl alcohol 0 3

 linear silicone oil 0 3

 cyclic silicone oil 0 3

 Shea butter 0 0.5

 Dicaprylyl carbonate 2 0

 Glyceryl stearate 0 1, 2

 Tapioca starch 1 0

 Glycerol 5 10

 Citric acid 0.0050 0

 Sodium hydroxide 45% 0.35 0.01

 Polyglyceryl-10 Stearate 0.7 1, 8

Polyacrylic acid, Na salt 0.5 0.02 (Carbopol 981)

 Trisodium EDTA 0 1

 Perfume 0, 10 0.35

 Water ad 100 ad 100 and O / W emulsion formulations 46 and 48 consisting of

sind erfindungsgemäß ausgenommen, wobei die Zahlenwerte Gewichtsanteile bezogen auf die Gesamtmasse der Zubereitungen darstellen.

are excluded according to the invention, wherein the numerical values represent parts by weight based on the total mass of the preparations.

The preparations according to the invention are advantageously based on an emulsion, preferably an O / W emulsion, or hydrodispersion. The preparations thus prepared, preferably emulsions, have a low emulsifier content of less than 6% and thus satisfy the desire for well-tolerated, mild products, without compromising stability is impaired. Less than 6% by weight or less than 3% by weight of PG-10 stearate does not mean 0% by weight. The minimum proportion of PG-10 stearate is preferably 0.1% by weight.

Surprisingly, those with less than 6 wt.% Polyglyceryl-10-stearate

prepared preparations stable for a period of at least 3 years

Room temperature and at least 6 months at 40 ° C storage.

Furthermore, it was surprisingly found that polyglyceryl-10-stearate, also used as the only emulsifier, leads to stable emulsions. A waiver of additional emulsifiers is thus possible and comes so the desire for reduced

Emulsifier contents after.

Fatty alcohol-free means that the proportion of fatty alcohols, in particular C12-20, less than 1%, based on the total mass of the preparation, more preferably below 0.25%, and especially below 0, 1%.

 It is surprisingly found that solely by the inventive choice of PG-10 stearate emulsifier in the preparations and waiving fatty alcohols a broader

Variability can be achieved in terms of the adjusted skin feel of the preparation.

 It has been shown in sensory evaluations of variations with different PG-10 stearate contents that a broad sensory diversity can be achieved (see Figure 2 and the following table).

Number of subjects = 9

 Test product Designation C D

 Dimensional stability 6.5 7, 1

 Coveredness 5, 1 7,0

 Strength 1, 7 3.9

 Thread pulling 0.5 1, 7

 Toughness 0.7 2.4

 Spreadability 8.4 5.8

 Salary 5 circles 2, 1 4.9

 Moisture 5 circles 7.5 4.4

 Slipperiness 5 circles 3, 1 1, 9

 Oily 20 circles 1, 8 4.0

 Waxy 20 circles 0.6 2.8

 Greasy 20 circles 0.5 3.9

 Moisture 20 circles 4.9 2, 1

White 0, 1 1, 3 It is often fatty alcohols that are responsible for the skin feel of a cosmetic or dermatological formulation.

Furthermore, it was surprisingly found that PG-10 stearate can be added to the emulsion formation both in the water and in the fat phase. In both cases, the same product is obtained. The differences in consistency are not significant and not relevant to a consumer.

 Figure 1 shows these consistency studies. The consistency was determined using a consistency determination device according to Fligge (according to DE 29 09 087).

On the X-axis, on the one hand, the value of the consistency of the formulas A and B to be compared is plotted after one day (left) and after 30 days (right). Formula A differs from formula B in that the PG-10 Stearate emulsifier was added to the water phase in case A and to the fat phase in case B. All further steps were identical for both formulations.

 The consistency value is plotted on the y axis. It can be seen that both formulas even have the same consistency numerically after one day, ie they are identical in terms of consistency. After 30 days there is a numerical difference, but the consumer can not understand it.

 The studies confirm the extraordinary properties of PG-10 stearate. Since it is not relevant in which phase you give the emulsifier, you have in the

Phase distribution in production greater flexibility.

 A process for the preparation of cosmetic or dermatological emulsion preparations with polyglyceryl-10-stearate as emulsifier, preferably single emulsifier, allows the addition both in the water and / or in the oil phase of the emulsion.

PG-10-containing preparations can thus be produced more easily and give the person skilled an outstanding flexibility with regard to viscosity, sensor technology, application form and tolerance to a wide variety of ingredients and production.

Limiting the use of PG-10 stearate in cosmetics to the lowest possible levels may have been obvious to a cosmetic professional due to the brown color of the PG-10 stearate, but due to the low levels it would then have to emanate from a reduced emulsifying effect. However, surprisingly, this did not materialize when using less than 6% by weight PG-10 stearate, in particular in the range from 0.1 to 2.8% by weight, based on the total amount of the preparation.

 In several long-term stability studies showed the PG-10 stearate containing

Preparations no instabilities, phase separation, coalescence, Ostwald ripening or Change in droplet size with time or creaming. The formulations as disclosed in the examples were optically stable for at least 6 months at room temperature and at 40 ° C. That is, no phase separation or phase separation was observed.

 Additional emulsifiers may be added to the preparations according to the invention. However, this is not required or mandatory in all cases according to the invention.

If additional emulsifiers are added, these are preferably to be selected from the group of emulsifiers which are solid, pasty or liquid at 25 ° C and not ethoxylated. Particularly preferred additional emulsifiers are to be selected from the group 1, 2 Propandiolfettsäureester, acetoglycerides, acetylated mono- / diglycerides, alkali or

Ammonium soaps, ammonium phosphatides, sorbitan monoisostearate, C10-C22 fatty acids, cetearyl sulfate, cetearyl glucosides, cetyl phosphate, cetylstearyl alcohol in combination with sodium cetyl stearyl sulphate, citroglyceride esters, citric acid monoglycerides,

Diacetyltartaric acid monoglycerides, diisostearoyl polyglyceryl-3 diisostearate (Isolan PDI), egg lecithin, emulsifier YN (trade name), acetic acid monoglycerides, mixed propylene glycol glycerol esters, glyceryl laurate, glyceryl myristate, glyceryl oleate in combination with propylene glycol, glyceryl stearate, glyceryl stearate SE, glyceryl stearate citrate, glycol distearate, isostearyl diglyceryl succinate , Isostearylglyceryl ether, potassium cetyl phosphate,

Lactoglycerides, lactylated mono- / diglycerides, lecithin, methyl glucose sesquistearate,

Lactic acid monoglycerides, mono- and diglycerides of fatty acids esterified with acetic acid and tartaric acid, monoglyceride acetate, monoglyceride citrate, monoglyceride diacetyl tartrate, monoglyceride lactate, monoglyceride tartrate, Na, K and Ca salts of stearoyl-2-lactyl lactic acid, Na, K and Ca; stearoyl-2-lactoyl-lactate, Na, K and Ca stearoyl-2-lactyllactate, Na, K and Ca stearoyl lactic acid, Na salt of lauryl sulfuric acid,

Sodium cetyl phosphate, sodium cetyl stearyl sulfate, sodium dodecyl sulfate and / or

Dodecyl hydrogen sulfate, polyglycerol-3-diisostearate (LameformTGl), polyglycerol ester of interesterified ricinoleic acid, polyglycerol fatty acid ester, polyglycerol polycrinoleate, polyglyceryl dimerate isostearate, polyglyceryl polyricinoleate (Admul WOL 1403),

Polyglyceryl-1 dipolyhydroxystearate (Dehymuls PGPH), polyglyceryl-2-laurate, polyglyceryl-2-sesquiisostearate, polyglyceryl-3 beeswax (Cera Bellina), polyglyceryl-3 cetyl ether

(Chimexane NL), polyglyceryl-3 distearate (Cremophor GS 32), polyglyceryl-3 methylglucose distearate (Tego Care 450), polyglyceryl-3-oleate, polyglyceryl-3-methylglycose distearate, polyglyceryl-4-caprate (polyglycerol caprate T2010190), polyglyceryl-4

Diisostearate / polyhydroxystearate / sebacate (Isolan GPS), polyglyceryl-4 isostearate (Isolan GI 34), polyoxyethylene stearic acid ester, polyoxylstearate mono- / diglyceride, propylene glycol stearate SE, propylene glycol fatty acid ester, propylene glycol mono- / di-fatty acid ester, rapeseed lecithin, sucrose glycerides , Sucrose esters of fatty acids, soy lecithin, sorbates bsp. Sorbitan monolaurate (sorbate 20), sorbitan di-citrate, sorbitan butucate,

Sorbitan dihydroxystearate, sorbitan diisostearate, sorbitan adipate, sorbitan dioleate,

Sorbitan dicinoleate, sorbitan ditartrate, sorbitan monocitrate, sorbitan monoerucate,

Sorbitan monohydroxystearate, sorbitan monomaleate, sorbitan monoricinoleate,

Sorbitan monostearate (sorbate 60), sorbitan monotartrate, sorbitan sesquiterate,

Sorbitan sesquierucate, sorbitan sesquihydroxystearate, sorbitan sesquiisostearate,

Sorbitan sesquimlate, sorbitan sesquioleate, sorbitan squiricinoleate, sorbitan sesquitartrate, sorbitan tricitrate, sorbitan trierucate, sorbitan trihydroxystearate, sorbitan triisostearate,

Sorbitan monooleate, sorbitan trimaleate, sorbitan trioleate, sorbitan triricinoleate, sorbitan tristearate (sorbate 65), sorbitan tritartrate, stearic acid and its salts, sucrose, triethyl citrate, tartaric acid glycerides, tartaric acid glycerides and / or sugar fatty acid esters, particularly preferred is glyceryl stearate.

The preparations according to the invention preferably comprise no further additional emulsifier except PG-10 stearate. The proportion of additional emulsifiers should therefore preferably be less than 0.01% by weight, based on the total mass of the preparation, in order to be considered to be present according to the invention-without additional emulsifier.

Lecithins is the classic name for a group of chemical compounds called phosphatidylcholines. These are phospholipids, which are composed of fatty acids, glycerol, phosphoric acid and choline. Lecithins are

Components of the cell membrane of animal and plant organisms. They are accompanying substances in fats and oils. They allow the emulsification of fats and water and are therefore important natural surfactants (emulsifiers) for food and feed. Lecithins are widely accepted in the EU as a food additive (E 322) for foodstuffs with a maximum limit on infant formula only. In medicine and cosmetics, they are also used as an active ingredient, in dietetics as a dietary supplement. In addition to their structure-forming properties, lecithins are ascribed numerous functional tasks. They are actively involved in both anabolic lipid metabolism and catabolic lipid metabolism.

Lecithins are therefore excluded according to the invention.

The preparations according to the invention also contain no parabens,

Formalgehydabspalter, organohalogens, benzoic acid and its salts, formates and tea tree oil and advantageously also no benzyl alcohol and / or phenoxyethanol. These substances are all common preservatives, but they also show

Disadvantages. So, DMDM Hydantoin is a formaldehyde releaser. As is generally known, formaldehyde is a toxic substance and its use in cosmetics is not uncontroversial. Benzyl alcohol has a characteristic odor which must be masked in a formulation with perfume. Unfortunately, perfume ingredients are often suspected of irritating or sensitizing. Therefore it is desirable to keep the perfume concentration as low as possible. Phenoxyethanol is repeatedly suspected Type IV

Trigger contact allergies and is thus increasingly rejected by consumers.

Organic halides are relatively highly reactive substances and interact with the cell membrane and are thus strongly rejected by consumers.

Tea tree oil is not approved as a drug and is considered a risk substance for the

Occurrence of contact dermatitis scored.

The cosmetic or dermatological preparations according to the invention may further contain cosmetic adjuvants and other active ingredients, such as are commonly used in such preparations, for. Preservatives, preservatives, bactericides, anti-foaming agents, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances, fats, oils, waxes or other common ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, Electrolytes, organic solvents or silicone derivatives, self-tanning, buffers, pH regulators, herbal

Extracts, surfactants, propellants, powders, sebum-absorbing substances, UV filters, active ingredients such as anti-age, anti-cellulite, anti-acne, anti-rosacea, anti-eczema, antioxidants, moisturizers, chelating agents, antitraspirants, bleaches and dyes, etc .; if the additive meets the required properties with regard to the absence of fatty alcohols,

microbiological stability and skin friendliness not hindered.

In preparing the formulations of the present invention, another unexpected advantage is seen in the use of polyglyceryl-10-stearate.

In emulsion production, usually one water and one fat phase must be heated, mixed and then re-cooled. This means at least two times the addition of heat energy. Energetically, this is unfavorable and just as problematic in possibly thermally labile active ingredients.

Surprisingly, this two-fold warming is through the use of

Polyglyceryl-10-stearate as emulsifier not necessary. Emulsion preparations with PG-10 stearate can be prepared in the cold-cold process. Normally, the fat phase is melted to 80-100 ° C and heats the water phase parallel to 80-100 ° C on. These two hot phases are combined and stirred. Subsequently, it is homogenized. In production, this often has to be cooled.

This process is called hot / hot process. Cold / cold method is thus analogous, you have a water phase at room temperature and a fat phase at room temperature, which gives together and homogenized, which is energetically a big advantage.

The preparations according to the invention are therefore preferred for the incorporation of thermally labile active substances, such as natural oils, active substances, vitamins, perfume or individual perfume ingredients.

 Thermally labile substances are those which, when heated above 50 ° C., change in color, smell or in physical parameters or even degrade completely or partially.

The following examples illustrate the preparations according to the invention. The

given proportions are by weight, in each case based on the total mass of the preparation.

Examples

Silicone in water emulsion

 1 2 3 4 5

 Bis-PEG / PPG-16/16 PEG / PPG16 / 16 1, 0 2.0 8.0 5.0

Dimethicone, Caprylic / Caprictriglyceride

 Bis-PEG / PPG-14/14 dimethicone, 3.0

Cyclomethicone

 Polyglyceryl-10 stearate 2.0 4.0 4.0 3.0 5.0 cyclic silicone oil (cyclomethicone) 12.5 15 25.0 10.0 7.5 linear silicone oil (dimethicone) 5.0 15.0 5, 0 12.0 15.0

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Glycerin 5.0 7.5 10.0 3.0 1, 0

 Carbomer 0.05 0, 1 0.05 0, 1 0.1

 Panthenol 0,5 1, 0 0,75 0,25 0,1

 Perfume q, s, q, s, q, s, q, s, q, s,

Stearyl dimethicone 0.5 - 0.7 - - Methylisothiazolinone - 0.10 - 0.06 -

Piroctonolamine - - 0.25 0.15 -

Lauroylethylarginate - - - 0.15 1.75

Water ad 100 ad 100 ad 100 ad 100 ad 100

O / W emulsion

 6 7 8 9 10

Polyglyceryl-10 stearate 1.0 1.5 1.75 5.0 6.25

Ethylhexyl methoxycinnamate 5.0 3.0 2.0 2.0 5.0

Ethylhexylglycerol 1 - 0.5 l -

Aluminum Chlorohydrate - 1 0.02 1 -

Ethanol - - 3.0 1 -

Ammonium acryloyldimethyltaurate / VP 0.5 0.75 0.5 2.0 0.25 Copolymer

 Carbomer 0.3 0.1 0.2 0.05 0.1

Caprylic / Capric Triglyceride - - 1.0 - 0.5

Glycerystearate 0.5-2.0-1.0

Myristyl myristate - 1.5 1.0 2.5 -

Perfume q, s, q, s, q, s, q, s, q, s,

Sea salt - - 0,01 0,5 -

Benzethonium chloride 2.0 0.35 0.15 0.05

Dehydroacetic acid - 0.3 - - -

Ethylhexylglycerol - 0.5 - - -

Glycerol 5 10 7.5 15 7.5

Tocopherol acetate 0.5 0.25 0.5 0.1 -

Titanium dioxide - 2.5 1.2 0.15 -

Water ad 100 ad 100 ad 100 ad 100 ad 100

O / W emulsion

 11 12 13 14 15

Polyglyceryl-10 Stearate 1 1.0 2.5 2 1.5 Cetearyl glucoside - 8 - - -

Cyclomethicone 12.5 15 28.0 25.0 17.5

Glyceryl stearate - 1, 0 0.5 0.25 0.5

Dimethicone 5.0 13.0 5.0 12.0 15.0

Glycerin 5 10 15 3 7.5

Carbomer 0.05 0, 1 0.05 0, 1 0.3

Acrylates / C 10-30 Alkyl Acrylates 0.2 - 0.5 Crosspolymer

 Methylisothiazolinone 0.06 0.10 0.08-0.04

Panthenol 0,5 1, 0 0,75 0,25 0, 1

Dehydroacetic acid - - - 0.5 -

Piroctone Olamine - - - 0, 1 -

Perfume q, s, q, s, q, s, q, s, q, s, modified starch 0,5 - - 0, 15 -

Water ad 100 ad 100 ad 100 ad 100 ad 100

Claims

claims 1 . Cosmetic or dermatological emulsion preparation comprising less than 6  % Polyglyceryl-10-stearate, based on the total mass of the preparation, characterized in that the preparation contains no fatty alcohols and no lecithins and is free of parabens, formaldehyde releasers, organic halides, benzoic acid and its salts, formates and tea tree oil and O / W emulsion preparations 1 and 3 consisting of

and O / W emulsion formulations 46 and 48 consisting of  46 48 Panthenol 1, 5 0 Propylene Glycol - 10  Benzethonium chloride 2.0 -  Piroctonolamine - 0.25  medical white oil 0 3  Isopropyl palmitate 1 0  Caprylic / Capric Triglyceride 0 3  Cetyl alcohol 0 3  linear silicone oil 0 3  cyclic silicone oil 0 3  Shea butter 0 0.5  Dicaprylyl carbonate 2 0  Glyceryl Stearate 0 1, 2  Tapioca starch 1 0  Glycerol 5 10  Citric acid 0.0050 0  Sodium hydroxide 45% 0.35 0.01  Polyglyceryl-10 Stearate 0.7 1, 8  Polyacrylic acid, Na salt 0.5 0.02  Trisodium EDTA 0 1  Perfume 0, 10 0.35  Water ad 100 ad 100 are excluded, where the numerical values by weight based on the  Represent total mass of the preparations. 2. Preparation according to claim 1, comprising less than 3 wt.% Polyglyceryl-10-stearate, based on the total mass of the preparation. 3. A preparation according to claim 2, comprising 0, 1 to 2.8 wt.% Polyglyceryl-10-stearate, based on the total mass of the preparation. 4. Preparation according to one of the preceding claims, in addition to polyglyceryl-10 stearate no further emulsifiers. 5. A preparation according to claim 1, 2 or 3, comprising in addition to polyglyceryl-10-stearate one or more emulsifiers which are solid, pasty or liquid at 25 ° C and not ethoxylated. 6. Preparation according to claim 5, comprising as additional emulsifier glyceryl stearate. 7. Preparation according to one of the preceding claims as O / W emulsion. 8. Preparation according to one of claims 1 to 6 as a hydrodispersion. 9. Preparation according to one of the preceding claims comprising one or more thermally labile agents.