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WO2012159672A1 - Appareil d'analyse de liquides - Google Patents

Appareil d'analyse de liquides Download PDF

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Publication number
WO2012159672A1
WO2012159672A1 PCT/EP2011/058544 EP2011058544W WO2012159672A1 WO 2012159672 A1 WO2012159672 A1 WO 2012159672A1 EP 2011058544 W EP2011058544 W EP 2011058544W WO 2012159672 A1 WO2012159672 A1 WO 2012159672A1
Authority
WO
WIPO (PCT)
Prior art keywords
pumping
magnetic element
diaphragm
pump
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/058544
Other languages
German (de)
English (en)
Inventor
Rolf Uthemann
Michael Kussmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hach Lange GmbH
Original Assignee
Hach Lange GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hach Lange GmbH filed Critical Hach Lange GmbH
Priority to PCT/EP2011/058544 priority Critical patent/WO2012159672A1/fr
Publication of WO2012159672A1 publication Critical patent/WO2012159672A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
    • F04B17/04—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors using solenoids
    • F04B17/042—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors using solenoids the solenoid motor being separated from the fluid flow
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/10—Valves; Arrangement of valves
    • F04B53/1077—Flow resistance valves, e.g. without moving parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K33/00—Motors with reciprocating, oscillating or vibrating magnet, armature or coil system
    • H02K33/16—Motors with reciprocating, oscillating or vibrating magnet, armature or coil system with polarised armatures moving in alternate directions by reversal or energisation of a single coil system
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K49/00—Dynamo-electric clutches; Dynamo-electric brakes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"

Definitions

  • the invention relates to a two-part Fiüsstechniks analyzer, consisting of a base unit and a replaceable separate Fluidikmodu! consists, in which at least the largest part of the liquid fluidics is arranged.
  • the analyzer has a two-part microfluidic liquid membrane pump for transporting the liquid in the fluidic module.
  • Such fluid analysis devices can be designed both as laboratory anafyse devices for carrying out individual measurements and as process analyzers for the quasi-continuous determination of an anhydrite in a liquid, for example in water.
  • the fluidic module comprises most of the fluidic fluid or fluid fluidics, including the pumping mimics required for fluid transport.
  • the two-part diaphragm pump is divided into the pump drive and the pump mimic, the pump drive being arranged on or in the base unit and the pump mimic being arranged on or in the fluidic module.
  • the problem here is a characterizationsunfurfe and precise coupling of the base unit side pump drive with the fluidikmodul moment pumping mimic.
  • the object of the invention is in contrast to provide a two-part Fiüsstechniks- analyzer with a precise and reliable two-part microfluidic liquid membrane pump. This object is achieved according to the invention with the features of claim 1.
  • the Anaiyse réelle invention has a diaphragm pump on or in the Fluidikmodu! a pumping chamber, a pumping membrane, and a ferromagnetic displacing means operatively connected to the pumping membrane.
  • the displacer moves the eiastic pumping membrane between a suction position and an ejection position, and pushes the pumping membrane into the pumping chamber on the way to the ejection position so that the pumping chamber is emptied.
  • the pump parts of the fluidic module form the pumping mimic.
  • the base unit has a magnetic element, which is arranged on the side facing away from the pumping chamber of the pumping membrane.
  • the magnetic element is thus arranged on the rear side of the pumping membrane and not, viewed from the pumping membrane, arranged beyond the pumping chamber.
  • the magnetic element generates a variable magnetic field through which the ferromagnetic displacement means and the pumping membrane moved by the displacer means are moved between a suction position and an ejection position to produce a pumping motion of the pumping membrane.
  • the variable magnetic field can be generated in various ways, for example, by a switchable stationary electromagnet or by a permanent magnet is moved mechanically.
  • the pump drive and the pump mimics of the two-part diaphragm pump are coupled to transmit the pumping movement of the pump drive to the displacement means only magnetic and non-contact with each other.
  • the base unit and the fluidic module can, at least in relation to the diaphragm pump, be designed to be completely free of openings. This ensures high reliability and accuracy of the split diaphragm pump.
  • the displacer may be formed as a ferromagnetic rigid solid body. The displacer forms a plunger which has approximately the shape of the pumping chamber and can push the pumping membrane into the pumping chamber.
  • the displacer means is a liquid ferrofluid in a ferrofluid space of the fluidic module, which is arranged on the side of the pump diaphragm remote from the pumping chamber.
  • the pumping membrane separates the pumping chamber from the ferrofluid space.
  • the volume of the ferrofluid space must be at least as large as the volume of the pumping chamber so that all the ferrofluid in the suction position of the pumping membrane can be pushed into the ferrofluid space.
  • the magnetic element is formed permanent magnetic and arranged to be movable perpendicular to the diaphragm ground plane. In its movement, the permanent magnet magnetic element takes with the Verdrängermittei and moves the Verdrängermittei in this way between its suction position and its ejection position.
  • the magnetic element is preferably made of rare earths, such as neodymium. Such magnetic elements can generate a relatively strong static magnetic field for a long time.
  • the permanent magnet magnetic element is driven by a separate drive arrangement.
  • the drive assembly may consist of an electric motor drive, which moves the permanent magnetic magnetic element via a corresponding mechanism between its end positions.
  • the drive arrangement a Have electromagnet which moves the magnetic element directly or indirectly between its two end positions.
  • a biasing element which biases the Magneteiement, the displacer and / or the pumping membrane in the ejection position.
  • the pumping membrane closes an inlet opening and / or an outlet opening of the pumping chamber.
  • the pumping membrane closes the inlet opening or the outlet opening in the deenergized state of the pump drive, so that a liquid flow in the area of the membrane pump is prevented.
  • a backflow is avoided in this way when the analyzer is switched off. Therefore, the diaphragm pump may preferably be designed completely valve-free,
  • FIG. 1 is a schematic representation of a fluid analyzer consisting of a base unit and a separate exchangeable fluidic module,
  • FIG. 2 shows a two-part microfluidic fluid diaphragm pump of the analyzer of FIG. 1, and FIG.
  • FIG. 3 shows a second embodiment of a two-part fluidic microfluidic diaphragm pump
  • FIG. 1 schematically shows a liquid analyzer 10, which in the present case is a process analyzer designed as a submersible probe for water analysis.
  • the analyzer photometrically determines an analyte in the water.
  • the analyzer 10 is formed in two parts, and consists of a base unit 12 and a separate replaceable fluidic module 14, the has the entire liquid Fiuidik the analyzer.
  • the base module 14 has a carrier liquid tank 26 from which the carrier liquid flows to a dialysis membrane 24, where the assay diffuses through an ion-selective dialysis membrane 24 into the passing carrier liquid.
  • the dialysate flows to a peristaltic pump 19, which is formed by the three diaphragm pumps 20, 21, 22, which are each designed identically to one another.
  • the reagent is fed to the dialysate, which can be precisely metered, for example, by a second peristaltic pump.
  • the peristaltic pump 19 pumps the dialysate with the reagent to a measuring section 27, in which the dialysate is measured photometrically. Subsequently, the dialysate is pumped into a waste tank 30.
  • the base module 14 contains only wear-free modules, while the Fluidikmodui has the wear assemblies, in particular all liquid-conducting assemblies and parts.
  • FIG. 1 The structure of a first embodiment of a two-part microfluidic liquid membrane pump 20 is shown in FIG. This is a diaphragm pump in which a ferromagnetic displacement means 40 is formed as a liquid ferrofluid.
  • the fluidic module 14 is essentially formed by three plastic plates 60, 62, 64, an elastic membrane 54 and a ferrofluid space container 66.
  • the three plates 60, 62, 64 are glued or welded together.
  • a pumping chamber 34 is formed, which is recessed into the middle plate 62 as a concave depression.
  • At the bottom of the chamber are an inlet opening 56 and a Outlet opening 58 is provided, through which the liquid to be pumped flows into the pumping chamber 34 and can flow out of this again.
  • an elastic pumping diaphragm 54 is arranged, which is shown in Figure 2 in the ejection position by the reference numeral 54 and by the reference numeral 54 'in the suction position.
  • the proximal plate 64 has an opening 68 through which the ferrofluid 40 may flow into and out of the cavity located at the back of the pumping membrane 54 to thereby bias the pumping membrane 54 to its ejection position ,
  • the ferrofluid space container 66 encloses a ferrofluid space 39 whose volume is a multiple of the volume of the pumping chamber 34.
  • the ferrofluid space 39 is filled with a liquid ferrofluid 40, wherein in the ferrofluid space 39 at least one volume of air is present which has at least the volume of the pumping chamber 34.
  • the top of the ferrofluid space 39 is closed by a gas-permeable but liquid-tight membrane body 77, for example by a so-called frit, so that the ferrofluid volume in the ferrofluid space 39 can change.
  • the ferrofluid 40 is ferromagnetic, i. it is attracted by an external magnetic field.
  • the ferrofluid 40 in the ferrofluidic space 39 has a magnetic center of gravity 41, 41 'that travels depending on whether or not the pumping chamber 34 is filled with the ferrofluid on the back of the pumping membrane 54.
  • the ferrofluid 40' in the ferrofluid space 39 occupies a larger volume, so that the magnetic center of gravity 41 'of the ferrofluid in the ferrofluid space 39 also moves upwards.
  • a magnetic element 50 On the base unit 12 is as a magnetic element 50 is a ring-shaped permanent magnet made of rare earth, for example, neodymium, arranged, which is axially displaceable.
  • the magnetic center of gravity 51, 51 'of the magnetic element can also be displaced in this way.
  • the two end position magnetic centers 41, 41 'of ferrofluid 40, 40' in ferrofluid space 39 are arranged within the interval defined by the two end position magnetic centers 51, 51 'of magnetic element 50, 50'.
  • the Magneteiement 50 is fixed to a non-ferromagnetic Haitering 70, at the other longitudinal end of an annular permanent magnet 46,46 'is arranged, which can be actively actuated by an electromagnet 48 in the form of a ring coil in both directions.
  • the electromagnet 48 and the permanent magnet 46 form a drive arrangement 44.
  • the annular permanent magnet 46 which is axially magnetized, is displaced between its two end positions.
  • the ferromagnetic fluid displacement means 40, 40 'in the ferrofluid space 39 between its suction volume and its pumping volume is also changed via the magnetic element 50.
  • a biasing element 72 is provided in the form of a compression spring which biases the magnetic element 50 into its pumping position, so that when the analyzer 10 is switched off electrically, the pumping membrane 54 is likewise in its pumping position and closes both the inlet opening 54 and the outlet opening 58. Reflux is therefore excluded even when the analyzer 10 is switched off. As a result, the diaphragm pump 20 can be formed completely valve-free.
  • FIG. 3 shows a second exemplary embodiment of a two-part microfluidic liquid-membrane pump 80.
  • the Displacer 81 is presently designed as a ferromagnetic rigid solid body, and has a mushroom-shaped displacement body, which has approximately the complementary outer shape to the bottom of the pumping chamber 34.
  • an electromagnet is provided in the present case, which acts directly on the ferromagnetic displacement means 81.
  • a biasing member 72 'formed as a compression coil spring biases the displacer 81 into the pumping position.

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Power Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Reciprocating Pumps (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un appareil d'analyse de liquides (10) présentant un appareil de base (12) et un module fluidique (14) échangeable séparé, ainsi qu'une pompe à membrane à fluide (20, 21, 22 ; 80) microfluidique en deux parties. L'appareil d'analyse de liquides (10) comporte une chambre de pompe (34) et une membrane de pompe (54) munie d'un moyen de déplacement (40) ferromagnétique relié de manière à coopérer avec la membrane de pompe (54). La chambre de pompe (34), la membrane de pompe (54) et le moyen de déplacement (40) sont agencés sur le module fluidique (14). Un élément magnétique (50) produisant un champ magnétique variable est agencé sur le côté de la membrane de pompe (54) opposé à la chambre de pompe (34). Le moyen de déplacement (40) et la membrane de pompe (54) déplacée par ce dernier sont déplacés par le champ magnétique entre une position d'aspiration et une position d'éjection pour produire un mouvement de pompage de la membrane de pompe (54), l'élément magnétique (50) étant agencé sur l'appareil de base (12).
PCT/EP2011/058544 2011-05-25 2011-05-25 Appareil d'analyse de liquides Ceased WO2012159672A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2011/058544 WO2012159672A1 (fr) 2011-05-25 2011-05-25 Appareil d'analyse de liquides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2011/058544 WO2012159672A1 (fr) 2011-05-25 2011-05-25 Appareil d'analyse de liquides

Publications (1)

Publication Number Publication Date
WO2012159672A1 true WO2012159672A1 (fr) 2012-11-29

Family

ID=44262774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/058544 Ceased WO2012159672A1 (fr) 2011-05-25 2011-05-25 Appareil d'analyse de liquides

Country Status (1)

Country Link
WO (1) WO2012159672A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103954736A (zh) * 2014-05-12 2014-07-30 大连海事大学 水下实时微流控芯片生化检测装置及其检测方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6116863A (en) * 1997-05-30 2000-09-12 University Of Cincinnati Electromagnetically driven microactuated device and method of making the same
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
WO2002057744A2 (fr) * 2001-01-22 2002-07-25 Microgen Systems, Inc. Biodetecteur automatise obtenu par microfabrication
US20050069424A1 (en) * 2003-09-26 2005-03-31 Ming-Chang Lu Micro pump using ferrofluid or magneto-rheological fluid
WO2005031163A1 (fr) * 2003-09-25 2005-04-07 Cytonome, Inc. Integration de composants microfluidiques dans un systeme microfluidique
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
WO2007114912A2 (fr) * 2006-03-30 2007-10-11 Wayne State University Micro-pompe à diaphragme et clapet anti-retour

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6116863A (en) * 1997-05-30 2000-09-12 University Of Cincinnati Electromagnetically driven microactuated device and method of making the same
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
WO2002057744A2 (fr) * 2001-01-22 2002-07-25 Microgen Systems, Inc. Biodetecteur automatise obtenu par microfabrication
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
WO2005031163A1 (fr) * 2003-09-25 2005-04-07 Cytonome, Inc. Integration de composants microfluidiques dans un systeme microfluidique
US20050069424A1 (en) * 2003-09-26 2005-03-31 Ming-Chang Lu Micro pump using ferrofluid or magneto-rheological fluid
WO2007114912A2 (fr) * 2006-03-30 2007-10-11 Wayne State University Micro-pompe à diaphragme et clapet anti-retour

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103954736A (zh) * 2014-05-12 2014-07-30 大连海事大学 水下实时微流控芯片生化检测装置及其检测方法
CN103954736B (zh) * 2014-05-12 2016-03-02 大连海事大学 水下实时微流控芯片生化检测装置

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