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WO2012159173A1 - Dose measuring means for a medicine - Google Patents

Dose measuring means for a medicine Download PDF

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Publication number
WO2012159173A1
WO2012159173A1 PCT/BE2011/000038 BE2011000038W WO2012159173A1 WO 2012159173 A1 WO2012159173 A1 WO 2012159173A1 BE 2011000038 W BE2011000038 W BE 2011000038W WO 2012159173 A1 WO2012159173 A1 WO 2012159173A1
Authority
WO
WIPO (PCT)
Prior art keywords
dose
measuring means
medicine
foil
dispenser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BE2011/000038
Other languages
French (fr)
Inventor
Jonathan AMRAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2012159173A1 publication Critical patent/WO2012159173A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Definitions

  • Dose-measuring means for a medicine Dose-measuring means for a medicine.
  • the present invention relates to a dose-measuring means for a medicine.
  • the invention is intended for the oral administration of medicines with an appropriate dosage.
  • oral administration forms for medicines consist of pills that contain a determined and dosed quantity of a medicine.
  • capsules consisting of two composing parts manufactured in soluble gelatin, in which a dosed quantity of medicine is provided.
  • These capsules can also consist of one piece, as for instance in cod liver oil capsules or garlic capsules, whereby it is important not to release the content in the mouth, because of the unpleasant taste of the content.
  • a disadvantage of hard pills is that the dose in most cases cannot easily be subdivided.
  • Hard pills are often provided with a groove along which the pill can be broken into two parts but this division is not always accurate en also does not allow to dose smaller fractions of the pill very well.
  • hard pills are hard to take and for this reason they are most often produced in rounded shapes and are taken together with a fluid and swallowed.
  • the present invention is aimed at providing a solution for the aforementioned and other disadvantages, while it provides a dose-measuring means that consists of an extra thin foil that is soluble in the mouth and that contains or carries a determined dose of a medicine.
  • An advantage tied to this dose-measuring means is that the dose can easily be subdivided in smaller but accurate doses that can be taken on multiple times of the day, and this without the need for a fluid.
  • the soluble foil comprises a matrix of gelatin.
  • An advantage of a matrix of gelatin is that it can be produced in an extra thin shape and that it can melt very quickly under the influence of saliva and of the temperature in the mouth.
  • Another advantage of a matrix of gelatin is that it is by itself colorless, but can be stained as desired with a dye that for instance is a marker for the dose of the medicine hat is contained therein or is applied to it.
  • the dose-measuring means is provided in a dispenser as a pile of foils.
  • An advantage of such an embodiment is that the dispenser can easily be taken along in a discrete way, and that the desired dosage can be taken out of the dispenser at the desired point in time, by removing the foils from the dispenser one by one by means of a stroking movement with a fingertip.
  • the desired dosage can be recognized by the color in which the foil with medicine is produced, so as to prevent mistakes.
  • the foil can take a shape adapted to the dimensions of a fingertip in order to enable it to be easily taken up by a finger.
  • an aromatic substance is provided in or on the foil.
  • An advantage of such an aromatic substance is that an eventually unpleasant taste of the medicine can be masked.
  • Another advantage of such an aromatic substance is that the taking of a medicine can be paired with a pleasant taste in the mouth which facilitates the administration to children for instance.
  • figure 1 represents schematically and in perspective a dose-measuring means according to the invention
  • figure 2 represents schematically and in perspective a dispenser for the dose-measuring means according to figure 1;
  • figure 3 represents the dispenser of figure 2 but in a closed state.
  • the in figure 1 represented dose-measuring means 1 comprises mainly a carrier in the shape of an extra thin foil 2 onto which or wherein an accurate dose of a medicine is provided and that dissolves or becomes fluid upon contact with saliva and/or with the heat of the cavity of a mouth.
  • foil that allows to be dissolved in the mouth very quickly and this within a time span of less than one minute.
  • Such foils are preferably less than 100 micrometer thick, even better less than 20 micrometer thick.
  • the thickness of the foil can be dependent on the desired dissolution time that on itself can be a function of the medicine to be administered.
  • the soluble foil comprises preferably a matrix of gelatin that is solid at room temperature and that dissolves by intake in the mouth by the temperature and/or the presence of saliva.
  • the soluble foil can also comprise a soluble material differing from gelatin.
  • the medicine is for example a powder that is provided in an appropriate way on the surface of the foil or is a medicine that is incorporated into the matrix of gelatin itself, e.g. by mixing the medicine in a liquid or powdery state in the liquid gelatin before this is solidified in order to fix the dose-measuring means.
  • the dose-measuring means can be provided with a dye, also incorporated into the matrix of gelatin and/or in the medicine added and serves for instance to identify the present medicine or the dosage thereof whereby for instance a different color indicates a different dosage.
  • an aromatic substance can be incorporated into the matrix of gelatin or in the medicine that masks the taste of the medicine and preferably conveys a pleasant taste to the medicine, which facilitates the intake of the medicine by children.
  • the foil can be provided at its surface with a friction enhancing means or with an adhesive of vegetal or animal origin that enhances the movement of the surface by a fingertip.
  • the medicine is administered by taking the dosage-measuring means in the mouth, whereby the foil is dissolved and whereby the medicine present on or in the foil is released.
  • the patient can for instance smoothly recognize the desired or imposed dosage by choosing the color, so that it becomes easy for a physician to impose a spread of the dose over a certain time-span by providing the patient with a color scheme in function of time.
  • another dosage can also be discerned for instance by another shape of the foil or by an imprint that for instance shows the time at which the dose-measuring means must be taken.
  • the shape of the dose-measuring means is by no means limited to a circular shape.
  • the dose-measuring means can be packed in an individual packaging or in a dispenser of which an example is represented in figure 2.
  • This dispenser 4 is formed by a holder, composed of a bottom 6 and an upright wall 7, and a cover 5 with a part 8 that can be opened and that hinges around a hinge 9 which in the example shown is a film hinge that is manufactured out of the same material as the material of the dispenser 4.
  • the part 8 of the cover that can be opened hinges between an open position, as shown in figure 2, and a closed position, as shown in figure 3, whereby the cover in this position can be locked by means of a fastener 10.
  • the bottom 6 of the dispenser 4 rises upwards to the side of the part 8 of the cover that can be opened, in such a way that the standing rim is reduced towards the part 8 of the cover that can be opened and at the end merges with the bottom 6.
  • the standing rims are provided with two sideward supports 11,12 for the part 8 of the cover that can be opened.
  • the dispenser 4 is preferably executed such that in a closed state shown in figure 3 it is air- and/or moisture- tight so as to enhance the can life of the dosed material 1.
  • the dispenser 4 can be manufactured from a somewhat flexible plastic that allows to compress the dispenser 4 and after closure to release it, such that after the release a lower pressure is created which also can enhance the can life of the dosed material.
  • the functioning of the dispenser 4 according to the invention is very simple and as follows.
  • ⁇ pile of extra thin dose-measuring means 1 is packed in a dispenser 4, whereby the foils 2 optionally have a color that is a mark for the dose per foil 2 of the medicine 3 that is provided in or on the foils.
  • the patient opens the hinge-able part of the cover 8 after unlocking it when he wishes to take a dose via the mouth, and strokes with a fingertip over the upper foil 2 of the pile thereby releasing the foil from the dispenser 4, whereby it can help if the dose-measuring means 1 is provided with a surface with a friction enhancing agent or with a vegetal or animal adhesive that enhances the movement of the surface by a fingertip. Thanks to the bottom 6 that extends to the rim at the side of the hinge-able part of the cover 8, the dose-measuring means 1 can easily and smoothly be shoved out of the dispenser 4 and be brought into the mouth, in order to administer the medicine 3 as discussed above.
  • the patient can repeat this act until he has taken up the desired dose, after which he can close the dispenser and store it for further use.
  • the dispenser 4 is adapted to the size of a fingertip and is small as a consequence, preferably smaller than 30 x 30 mm x 5 mm and easy to store and can be used in a discrete way.
  • the patient can easily recognize the dosage by the color of the foil 2 which is different for every dosage.
  • dose-measuring means can be held, whereby the patient can recognize the different dosages for instance by the color or the shape of the dose- measuring means.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

Dose-measuring means (1) that comprises an extra thin foil (2) that is soluble in the mouth and that contains or carries a defined dose of a medicine (3).

Description

Dose-measuring means for a medicine.
The present invention relates to a dose-measuring means for a medicine.
More in particular, the invention is intended for the oral administration of medicines with an appropriate dosage.
Traditionally oral administration forms for medicines consist of pills that contain a determined and dosed quantity of a medicine.
As a rule these pills are hard, sometimes also in the shape of effervescent tablets that have to be dissolved in water.
One also knows capsules consisting of two composing parts manufactured in soluble gelatin, in which a dosed quantity of medicine is provided.
These capsules can also consist of one piece, as for instance in cod liver oil capsules or garlic capsules, whereby it is important not to release the content in the mouth, because of the unpleasant taste of the content.
One also knows pills in the shape of oral sucking tablets or melting tablets, that can melt in the mouth and whereby no fluid needs to be taken in and that slowly release an active ingredient. Such oral administration forms show a number of disadvantages .
A disadvantage of hard pills is that the dose in most cases cannot easily be subdivided.
Hard pills are often provided with a groove along which the pill can be broken into two parts but this division is not always accurate en also does not allow to dose smaller fractions of the pill very well.
Another disadvantage of hard pills is that they are hard to take and for this reason they are most often produced in rounded shapes and are taken together with a fluid and swallowed.
Especially for large pills one will need in most cases a glass of water or a beverage to be able to take in the dose .
Another disadvantage of hard pills is that the packaging of them is not always suited to take along small dosages in a discrete way.
The present invention is aimed at providing a solution for the aforementioned and other disadvantages, while it provides a dose-measuring means that consists of an extra thin foil that is soluble in the mouth and that contains or carries a determined dose of a medicine. An advantage tied to this dose-measuring means is that the dose can easily be subdivided in smaller but accurate doses that can be taken on multiple times of the day, and this without the need for a fluid.
Preferably, the soluble foil comprises a matrix of gelatin.
An advantage of a matrix of gelatin is that it can be produced in an extra thin shape and that it can melt very quickly under the influence of saliva and of the temperature in the mouth.
Another advantage of a matrix of gelatin is that it is by itself colorless, but can be stained as desired with a dye that for instance is a marker for the dose of the medicine hat is contained therein or is applied to it.
Preferably the dose-measuring means is provided in a dispenser as a pile of foils.
An advantage of such an embodiment is that the dispenser can easily be taken along in a discrete way, and that the desired dosage can be taken out of the dispenser at the desired point in time, by removing the foils from the dispenser one by one by means of a stroking movement with a fingertip.
Another advantage is that the desired dosage can be recognized by the color in which the foil with medicine is produced, so as to prevent mistakes. Another advantage is that the foil can take a shape adapted to the dimensions of a fingertip in order to enable it to be easily taken up by a finger.
Preferably an aromatic substance is provided in or on the foil.
An advantage of such an aromatic substance is that an eventually unpleasant taste of the medicine can be masked.
Another advantage of such an aromatic substance is that the taking of a medicine can be paired with a pleasant taste in the mouth which facilitates the administration to children for instance.
With the intention of better showing the characteristics of the invention, hereafter, as an example without any limitative character, a preferred form of embodiment is described of the invention, with reference to the accompanying drawings, wherein: figure 1 represents schematically and in perspective a dose-measuring means according to the invention;
figure 2 represents schematically and in perspective a dispenser for the dose-measuring means according to figure 1;
figure 3 represents the dispenser of figure 2 but in a closed state.
The in figure 1 represented dose-measuring means 1 according to the invention comprises mainly a carrier in the shape of an extra thin foil 2 onto which or wherein an accurate dose of a medicine is provided and that dissolves or becomes fluid upon contact with saliva and/or with the heat of the cavity of a mouth.
By an extra thin foil is understood a foil that allows to be dissolved in the mouth very quickly and this within a time span of less than one minute. Such foils are preferably less than 100 micrometer thick, even better less than 20 micrometer thick.
The thickness of the foil can be dependent on the desired dissolution time that on itself can be a function of the medicine to be administered.
The soluble foil comprises preferably a matrix of gelatin that is solid at room temperature and that dissolves by intake in the mouth by the temperature and/or the presence of saliva.
The soluble foil can also comprise a soluble material differing from gelatin.
The medicine is for example a powder that is provided in an appropriate way on the surface of the foil or is a medicine that is incorporated into the matrix of gelatin itself, e.g. by mixing the medicine in a liquid or powdery state in the liquid gelatin before this is solidified in order to fix the dose-measuring means. In addition the dose-measuring means can be provided with a dye, also incorporated into the matrix of gelatin and/or in the medicine added and serves for instance to identify the present medicine or the dosage thereof whereby for instance a different color indicates a different dosage.
In addition an aromatic substance can be incorporated into the matrix of gelatin or in the medicine that masks the taste of the medicine and preferably conveys a pleasant taste to the medicine, which facilitates the intake of the medicine by children.
Optionally the foil can be provided at its surface with a friction enhancing means or with an adhesive of vegetal or animal origin that enhances the movement of the surface by a fingertip.
The use of the dosage-means according to the invention is very simple and as follows.
The medicine is administered by taking the dosage-measuring means in the mouth, whereby the foil is dissolved and whereby the medicine present on or in the foil is released.
The solution of the foil happens very quickly in the circumstances of the cavity of the mouth, while it remains solid at room temperature and in dry conditions.
The patient can for instance smoothly recognize the desired or imposed dosage by choosing the color, so that it becomes easy for a physician to impose a spread of the dose over a certain time-span by providing the patient with a color scheme in function of time.
Optionally another dosage can also be discerned for instance by another shape of the foil or by an imprint that for instance shows the time at which the dose-measuring means must be taken. The shape of the dose-measuring means is by no means limited to a circular shape.
The dose-measuring means can be packed in an individual packaging or in a dispenser of which an example is represented in figure 2.
This dispenser 4 is formed by a holder, composed of a bottom 6 and an upright wall 7, and a cover 5 with a part 8 that can be opened and that hinges around a hinge 9 which in the example shown is a film hinge that is manufactured out of the same material as the material of the dispenser 4.
The part 8 of the cover that can be opened hinges between an open position, as shown in figure 2, and a closed position, as shown in figure 3, whereby the cover in this position can be locked by means of a fastener 10.
The bottom 6 of the dispenser 4 rises upwards to the side of the part 8 of the cover that can be opened, in such a way that the standing rim is reduced towards the part 8 of the cover that can be opened and at the end merges with the bottom 6. The standing rims are provided with two sideward supports 11,12 for the part 8 of the cover that can be opened.
The dispenser 4 is preferably executed such that in a closed state shown in figure 3 it is air- and/or moisture- tight so as to enhance the can life of the dosed material 1.
The dispenser 4 can be manufactured from a somewhat flexible plastic that allows to compress the dispenser 4 and after closure to release it, such that after the release a lower pressure is created which also can enhance the can life of the dosed material.
The functioning of the dispenser 4 according to the invention is very simple and as follows.
Ά pile of extra thin dose-measuring means 1 is packed in a dispenser 4, whereby the foils 2 optionally have a color that is a mark for the dose per foil 2 of the medicine 3 that is provided in or on the foils.
The patient opens the hinge-able part of the cover 8 after unlocking it when he wishes to take a dose via the mouth, and strokes with a fingertip over the upper foil 2 of the pile thereby releasing the foil from the dispenser 4, whereby it can help if the dose-measuring means 1 is provided with a surface with a friction enhancing agent or with a vegetal or animal adhesive that enhances the movement of the surface by a fingertip. Thanks to the bottom 6 that extends to the rim at the side of the hinge-able part of the cover 8, the dose-measuring means 1 can easily and smoothly be shoved out of the dispenser 4 and be brought into the mouth, in order to administer the medicine 3 as discussed above.
The patient can repeat this act until he has taken up the desired dose, after which he can close the dispenser and store it for further use.
The dispenser 4 is adapted to the size of a fingertip and is small as a consequence, preferably smaller than 30 x 30 mm x 5 mm and easy to store and can be used in a discrete way.
The patient can easily recognize the dosage by the color of the foil 2 which is different for every dosage.
Besides in one dispenser several dose-measuring means can be held, whereby the patient can recognize the different dosages for instance by the color or the shape of the dose- measuring means.
The present invention is in no way limited to the form of embodiment described by way of an example and represented in the figures, however, such a dose-measuring means according to the invention can be realized in various forms without leaving the scope of the invention.

Claims

Claims .
1. - Dose-measuring means (1) that consists of an extra thin foil (2) that is soluble in the mouth and that contains or carries a determined dose of a medicine (3) .
2. - Dose-measuring means (1) according to claim 1, characterized in that the soluble foil (2) comprises a matrix of gelatin.
3. - Dose-measuring means (1) according to claim 1 or 2, characterized in that the foil (2) is a carrier onto which a medicine (3) is provided.
4. - Dose-measuring means (1) according to claim 1 or 2, characterized in that the medicine (3) is taken up in the foil (2) itself.
5. - Dose-measuring means (1) according to claim 1 or 2, characterized in that the foil (2) has a color.
6. - Dose-measuring means (1) according to claim 5, characterized in that the color marks a defined dosage of the medicine (3) on or in the foil.
7. - Dose-measuring means (1) according to one of the preceding claims, characterized in that a pile of foils (2) is provided in a dispenser (4) .
8.- Dose-measuring means (1) according to claim 7, characterized in that the foils (2) can be released from the dispenser (4) one by one by means of a stroking movement with a fingertip.
9.- Dose-measuring means (1) according to claim 8, characterized in that a foil (2) that lies on a finger, can be introduced into the mouth where the foil (2) with the medicine (3) melts and the medicine (3) is spread in the cavity of the mouth.
10. - Dose-measuring means (1) according to one of the preceding claims, characterized in that an aromatic substance is provided on or in the foil, that masks the eventually unpleasant taste of the medicine.
11. - Dose-measuring means (1) according to one of the preceding claims, characterized in that several piles of foil (2) of different dosages are held in one dispenser.
PCT/BE2011/000038 2011-05-20 2011-06-29 Dose measuring means for a medicine Ceased WO2012159173A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE2011/0308 2011-05-20
BE2011/0308A BE1020178A3 (en) 2011-05-20 2011-05-20 DOSING AGENT FOR A MEDICINAL PRODUCT.

Publications (1)

Publication Number Publication Date
WO2012159173A1 true WO2012159173A1 (en) 2012-11-29

Family

ID=44508530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2011/000038 Ceased WO2012159173A1 (en) 2011-05-20 2011-06-29 Dose measuring means for a medicine

Country Status (2)

Country Link
BE (1) BE1020178A3 (en)
WO (1) WO2012159173A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040115137A1 (en) * 2002-12-17 2004-06-17 Verrall Andrew P. Water-soluble film for oral administration
US20080063779A1 (en) * 2002-10-30 2008-03-13 Reg Macquarrie Edible dissolving gelatin strips
US20080152695A1 (en) * 2006-06-14 2008-06-26 Clark Richard T Oral/buccal transmucosal delivery methods for electrolyte compositions including xylitol
US20090196907A1 (en) * 2008-01-31 2009-08-06 Bunick Frank J Edible film-strips for immediate release of active ingredients
US20100240724A1 (en) * 2007-10-03 2010-09-23 C.L. Pharm Edible Film

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080063779A1 (en) * 2002-10-30 2008-03-13 Reg Macquarrie Edible dissolving gelatin strips
US20040115137A1 (en) * 2002-12-17 2004-06-17 Verrall Andrew P. Water-soluble film for oral administration
US20080152695A1 (en) * 2006-06-14 2008-06-26 Clark Richard T Oral/buccal transmucosal delivery methods for electrolyte compositions including xylitol
US20100240724A1 (en) * 2007-10-03 2010-09-23 C.L. Pharm Edible Film
US20090196907A1 (en) * 2008-01-31 2009-08-06 Bunick Frank J Edible film-strips for immediate release of active ingredients

Also Published As

Publication number Publication date
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