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WO2012142192A3 - Appareil et procédé pour réaliser des émulsions uniformes - Google Patents

Appareil et procédé pour réaliser des émulsions uniformes Download PDF

Info

Publication number
WO2012142192A3
WO2012142192A3 PCT/US2012/033165 US2012033165W WO2012142192A3 WO 2012142192 A3 WO2012142192 A3 WO 2012142192A3 US 2012033165 W US2012033165 W US 2012033165W WO 2012142192 A3 WO2012142192 A3 WO 2012142192A3
Authority
WO
WIPO (PCT)
Prior art keywords
making uniform
uniform emulsions
emulsions
droplets
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/033165
Other languages
English (en)
Other versions
WO2012142192A2 (fr
Inventor
Mark A. Gray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2012142192A2 publication Critical patent/WO2012142192A2/fr
Publication of WO2012142192A3 publication Critical patent/WO2012142192A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C11/00—Component parts, details or accessories not specifically provided for in groups B05C1/00 - B05C9/00
    • B05C11/10—Storage, supply or control of liquid or other fluent material; Recovery of excess liquid or other fluent material
    • B05C11/1002—Means for controlling supply, i.e. flow or pressure, of liquid or other fluent material to the applying apparatus, e.g. valves
    • B05C11/1034—Means for controlling supply, i.e. flow or pressure, of liquid or other fluent material to the applying apparatus, e.g. valves specially designed for conducting intermittent application of small quantities, e.g. drops, of coating material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B01F23/451—Mixing liquids with liquids; Emulsifying using flow mixing by injecting one liquid into another
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71755—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding components in a pulsating or intermittent manner
    • B01F35/717551—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding components in a pulsating or intermittent manner using electrical pulses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention porte sur un appareil et un procédé pour la production commandée d'un nombre connu de petites gouttelettes ayant une distribution de taille étroite. La présente invention porte également sur un procédé pour la fusion de gouttelettes à l'aide d'un appareil qui commande la formation de gouttelettes.
PCT/US2012/033165 2011-04-11 2012-04-11 Appareil et procédé pour réaliser des émulsions uniformes Ceased WO2012142192A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161474076P 2011-04-11 2011-04-11
US61/474,076 2011-04-11

Publications (2)

Publication Number Publication Date
WO2012142192A2 WO2012142192A2 (fr) 2012-10-18
WO2012142192A3 true WO2012142192A3 (fr) 2013-03-14

Family

ID=47009951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/033165 Ceased WO2012142192A2 (fr) 2011-04-11 2012-04-11 Appareil et procédé pour réaliser des émulsions uniformes

Country Status (1)

Country Link
WO (1) WO2012142192A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140193857A1 (en) 2012-09-12 2014-07-10 Cypho, Inc. Centrifuge tube droplet generator
US11118218B2 (en) 2012-09-12 2021-09-14 Cypho, Inc. Common port emulsion generation system
EP2925447B1 (fr) * 2012-11-30 2020-04-08 The Broad Institute, Inc. Système dynamique de rendement élevé pour délivrer des réactifs
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
JP7146743B2 (ja) 2016-09-23 2022-10-04 アルヴェオ テクノロジーズ インコーポレイテッド 分析種を検出するための方法および組成物
WO2020132010A1 (fr) * 2018-12-20 2020-06-25 Alveo Technologies, Inc. Procédés et compositions de détection de produits d'amplification
CA3124120A1 (fr) 2018-12-20 2020-06-25 Alveo Technologies, Inc. Systeme de test de diagnostic base sur l'impedance portatif pour la detection d'analytes
JP7443845B2 (ja) * 2020-03-16 2024-03-06 セイコーエプソン株式会社 液体噴射装置
US12023637B2 (en) 2020-03-23 2024-07-02 Mark A. Gray Capillary tube droplet generation systems and methods
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080171078A1 (en) * 2007-01-12 2008-07-17 Mark Gray Uniformly sized liposomes
US20080171077A1 (en) * 2007-01-12 2008-07-17 Mark Gray Method and apparatus for making uniformly sized particles
US20100285975A1 (en) * 2007-07-24 2010-11-11 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080171078A1 (en) * 2007-01-12 2008-07-17 Mark Gray Uniformly sized liposomes
US20080171077A1 (en) * 2007-01-12 2008-07-17 Mark Gray Method and apparatus for making uniformly sized particles
US20100285975A1 (en) * 2007-07-24 2010-11-11 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RYAN TEWHEY ET AL.: "Microdroplet-based PCR amplification for large scale targeted sequencing", NAT BIOTECHNOL., vol. 27, no. 11, November 2009 (2009-11-01), pages 1025 - 1031, XP055103848, DOI: doi:10.1038/nbt.1583 *

Also Published As

Publication number Publication date
WO2012142192A2 (fr) 2012-10-18

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