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WO2012142067A3 - Formulations, salts, and solid forms of substituted cyclohexylmethanamines, processes for preparation, and uses thereof - Google Patents

Formulations, salts, and solid forms of substituted cyclohexylmethanamines, processes for preparation, and uses thereof Download PDF

Info

Publication number
WO2012142067A3
WO2012142067A3 PCT/US2012/032977 US2012032977W WO2012142067A3 WO 2012142067 A3 WO2012142067 A3 WO 2012142067A3 US 2012032977 W US2012032977 W US 2012032977W WO 2012142067 A3 WO2012142067 A3 WO 2012142067A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
cyclohexylmethanamines
formulations
salts
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/032977
Other languages
French (fr)
Other versions
WO2012142067A2 (en
Inventor
John Dankwardt
Susan S. D'souza
Steve FABIAN
Michael FILIOS
Sharon M. Laughlin
Michael Joseph SIZENSKY
John Snoonian
Charles VANDENBOSSCHE
Harold Scott Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sunovion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunovion Pharmaceuticals Inc filed Critical Sunovion Pharmaceuticals Inc
Publication of WO2012142067A2 publication Critical patent/WO2012142067A2/en
Publication of WO2012142067A3 publication Critical patent/WO2012142067A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Provided herein are pharmaceutical compositions and single unit dosage forms comprising a substituted cyclohexylmethanamine, or a pharmaceutically acceptable salt or solid form thereof. Also provided are methods of making the substituted cyclohexylmethanamine, or a pharmaceutically acceptable salt or solid form thereof, methods of making a pharmaceutical composition comprising the substituted cyclohexylmethanamine, or a pharmaceutically acceptable salt or solid form thereof, and method of their use for treating, managing, or preventing various disorders, such as a CNS disease.
PCT/US2012/032977 2011-04-13 2012-04-11 Formulations, salts, and solid forms of substituted cyclohexylmethanamines, processes for preparation, and uses thereof Ceased WO2012142067A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161475098P 2011-04-13 2011-04-13
US61/475,098 2011-04-13

Publications (2)

Publication Number Publication Date
WO2012142067A2 WO2012142067A2 (en) 2012-10-18
WO2012142067A3 true WO2012142067A3 (en) 2012-12-06

Family

ID=47009926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/032977 Ceased WO2012142067A2 (en) 2011-04-13 2012-04-11 Formulations, salts, and solid forms of substituted cyclohexylmethanamines, processes for preparation, and uses thereof

Country Status (1)

Country Link
WO (1) WO2012142067A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010075064A1 (en) * 2008-12-16 2010-07-01 Sepracor Inc. Triple reuptake inhibitors and methods of their use
US20100190861A1 (en) * 2006-01-06 2010-07-29 Liming Shao Cycloalkylamines as monoamine reuptake inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100190861A1 (en) * 2006-01-06 2010-07-29 Liming Shao Cycloalkylamines as monoamine reuptake inhibitors
WO2010075064A1 (en) * 2008-12-16 2010-07-01 Sepracor Inc. Triple reuptake inhibitors and methods of their use

Also Published As

Publication number Publication date
WO2012142067A2 (en) 2012-10-18

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