[go: up one dir, main page]

WO2012038975A3 - Processes for the preparation of asenapine and intermediates thereof - Google Patents

Processes for the preparation of asenapine and intermediates thereof Download PDF

Info

Publication number
WO2012038975A3
WO2012038975A3 PCT/IN2011/000648 IN2011000648W WO2012038975A3 WO 2012038975 A3 WO2012038975 A3 WO 2012038975A3 IN 2011000648 W IN2011000648 W IN 2011000648W WO 2012038975 A3 WO2012038975 A3 WO 2012038975A3
Authority
WO
WIPO (PCT)
Prior art keywords
asenapine
preparation
intermediates
processes
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2011/000648
Other languages
French (fr)
Other versions
WO2012038975A2 (en
Inventor
Manne Satyanarayana Reddy
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Elevathingal Nicholas Madhu
Komati Satyanarayana
Peri Seetha Rama Sarma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of WO2012038975A2 publication Critical patent/WO2012038975A2/en
Publication of WO2012038975A3 publication Critical patent/WO2012038975A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Improved processes for preparation of asenapine by using specific intermediates and reaction conditions are provided. The intermediates for preparation of asenapine and the pharmaceutical composition comprising asenapine are also provided.
PCT/IN2011/000648 2010-09-22 2011-09-21 Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof Ceased WO2012038975A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN2766/CHE/2010 2010-09-22
IN2766CH2010 2010-09-22
IN3313/CHE/2010 2010-11-08
IN3313CH2010 2010-11-08
IN1719CH2011 2011-05-20
IN1719/CHE/2011 2011-05-20

Publications (2)

Publication Number Publication Date
WO2012038975A2 WO2012038975A2 (en) 2012-03-29
WO2012038975A3 true WO2012038975A3 (en) 2012-05-18

Family

ID=45874221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000648 Ceased WO2012038975A2 (en) 2010-09-22 2011-09-21 Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof

Country Status (1)

Country Link
WO (1) WO2012038975A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6014656B2 (en) 2011-05-18 2016-10-25 ラビラトリオス レスビ エス エレ Compound polymorphs
WO2012156676A1 (en) * 2011-05-18 2012-11-22 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
WO2013035109A1 (en) * 2011-09-08 2013-03-14 Mylan Laboratories Ltd Improved process for the preparation of asenapine maleate
CN102746209A (en) * 2012-06-20 2012-10-24 盛世泰科生物医药技术(苏州)有限公司 A synthetic method for 3-(2-(4-chlorophenoxy)phenyl )-1-methyl-2,4-dione
CN103893139B (en) * 2012-12-28 2018-06-08 石药集团中奇制药技术（石家庄）有限公司 A kind of asenapine composition and preparation method thereof
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
CN103342707B (en) * 2013-06-28 2015-09-02 甘肃皓天化学科技有限公司 For the preparation of the preparation method of A Sainaping intermediate
CN104098580B (en) * 2014-07-22 2016-04-13 成都百裕科技制药有限公司 A kind of preparation method of asenapine key intermediate
EP3338768B1 (en) 2016-12-20 2019-10-30 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
CA3047354A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
ES2881783T3 (en) 2017-06-26 2021-11-30 Lts Lohmann Therapie Systeme Ag Transdermal therapeutic system containing asenapine and silicone acrylic polymer
EP3810099A1 (en) 2018-06-20 2021-04-28 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
JP7502199B2 (en) 2018-06-20 2024-06-18 エルテーエス ローマン テラピー－ジステーメ アーゲー Transdermal therapeutic system containing asenapine
CN112830931A (en) 2019-08-13 2021-05-25 浙江奥翔药业股份有限公司 Method for preparing asenapine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023600A1 (en) * 1994-03-02 1995-09-08 Akzo Nobel N.V. Sublingual or buccal pharmaceutical composition
WO2006106136A1 (en) * 2005-04-07 2006-10-12 N.V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
WO2007046554A1 (en) * 2005-10-21 2007-04-26 Sumitomo Chemical Company, Limited Process for production of dibenzoxepinopyrrole compound, intermediate for production of the compound, and process for production of the intermediate
WO2008078482A1 (en) * 2006-12-22 2008-07-03 Sumitomo Chemical Company, Limited Process for producing intermediate of asenapine synthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023600A1 (en) * 1994-03-02 1995-09-08 Akzo Nobel N.V. Sublingual or buccal pharmaceutical composition
WO2006106136A1 (en) * 2005-04-07 2006-10-12 N.V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
CN1861604A (en) * 2005-04-07 2006-11-15 奥格诺爱尔兰有限公司 Crystal form of asenapine maleate
WO2007046554A1 (en) * 2005-10-21 2007-04-26 Sumitomo Chemical Company, Limited Process for production of dibenzoxepinopyrrole compound, intermediate for production of the compound, and process for production of the intermediate
WO2008078482A1 (en) * 2006-12-22 2008-07-03 Sumitomo Chemical Company, Limited Process for producing intermediate of asenapine synthesis

Also Published As

Publication number Publication date
WO2012038975A2 (en) 2012-03-29

Similar Documents

Publication Publication Date Title
WO2012038975A3 (en) Processes for the preparation of asenapine and intermediates thereof
WO2010122578A3 (en) Process for preparation of sitagliptin and its intermediates
HK1210782A1 (en) Lfa-1 inhibitor and polymorph thereof
WO2012025944A3 (en) Sitagliptin, salts and polymorphs thereof
WO2011138281A3 (en) Process for the preparation of dithiine tetracarboxydiimides
WO2013098833A3 (en) Processes and intermediates for preparing rivaroxaban
WO2011091131A3 (en) Eslicarbazepine acetate and its polymorphs
HUE037511T2 (en) Process for the preparation of tuluenediamine by hydrogenation of dinitrotoluene
WO2013121436A3 (en) A process for preparation of rivaroxaban and intermediates thereof
IL222649A0 (en) Saxagliptin intermediates, saxagliptin polymorphs, and processes for preparation thereof
WO2012103810A1 (en) Certain chemical entities, compositions, and methods
WO2014057498A3 (en) Process for the preparation of cobicistat intermediates
WO2012137227A3 (en) Solid forms of antiretroviral compounds and anti-oxidative acids, processes for preparation and pharmaceutical compositions thereof
WO2011139886A3 (en) Preparation of febuxostat
EP2528923A4 (en) Process for the preparation of darunavir and darunavir intermediates
WO2013128379A3 (en) Crystalline polymorphic forms of linagliptin
IN2013MN00733A (en)
HUP1000637A2 (en) Process for the preparation of pharmaceutical intermediates with high purity
WO2012021707A3 (en) Premature-termination-codons readthrough compounds
WO2012061012A3 (en) 4-amino-2h-pyran-2-one analogs as anticancer agents
WO2012051126A3 (en) Anti-inflammatory macrolides
WO2011045774A3 (en) Extended release pharmaceutical compositions of paliperidone and processes of preparation thereof
WO2010059916A3 (en) Preparation of docetaxel
WO2013030654A8 (en) Processes for the preparation of (r)-2-acetamido-n-benzyl-3-methoxypropionamide and intermediates thereof
WO2011063072A3 (en) Process for the preparation of substituted phenylalanines

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11826516

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11826516

Country of ref document: EP

Kind code of ref document: A2