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WO2012038745A1 - Dispositif d'injection - Google Patents

Dispositif d'injection Download PDF

Info

Publication number
WO2012038745A1
WO2012038745A1 PCT/GB2011/051778 GB2011051778W WO2012038745A1 WO 2012038745 A1 WO2012038745 A1 WO 2012038745A1 GB 2011051778 W GB2011051778 W GB 2011051778W WO 2012038745 A1 WO2012038745 A1 WO 2012038745A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
chamber
injection device
housing
volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2011/051778
Other languages
English (en)
Inventor
Ian Charles Cleathero
Lyndon Wild
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical House Ltd
Original Assignee
Medical House Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical House Ltd filed Critical Medical House Ltd
Publication of WO2012038745A1 publication Critical patent/WO2012038745A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula

Definitions

  • This invention relates to injection devices and more specifically to autoinjector devices for the administration of liquid medication, for example, insulin or growth hormone.
  • An autoinjector is an automatic injection device designed to facilitate automated delivery of a dose of medicament to a patient through a hypodermic needle, the injection usually being administered by the patient themselves.
  • An autoinjector works, for example, by delivering an injection automatically upon actuation by the patient pressing a button, moving a lever or part of a housing etc. This is in contrast to a conventional manual syringe where the patient himself needs to directly depress a plunger into a barrel containing medicament in order to effect the injection.
  • autoinjector and "injection device” are used interchangeably in the following description.
  • EP-A-1998831 the end of the needle insertion stage occurs when the syringe holder 100 strikes an internal boss within the front housing 200. This may cause impact loading on the syringe and increases the risk of syringe breakage. Although the impact is attenuated to some extent by the device's return spring, this is limited by the need for the return spring to provide a lower load when compressed than the main spring energy source when extended, and the loading from the return spring is entirely dependent on position and not speed.
  • Figure 1 is a cross sectional view of the front part of an injection device embodying one aspect of the present invention
  • Figure 2 is cross sectional view of the front housing showing detail of the pockets
  • Figures 3-5 are cross sectional views showing the tabs almost, partially and fully inserted into the pockets.
  • reference to a "forward” direction means the direction which is towards the patient when the injection device is in use.
  • the “forward” or “front” end of the injection device is the end nearest the patient's skin when the device is in use.
  • reference to a “rearward” direction means the direction which is away from the patient and the “rearward” end of the device is the end furthest from the patient's skin when the injection device is in use.
  • the mechanism described below provides damping at the end of the insertion phase by compressing air in pockets and restricting the exhaust of the compressed air.
  • a resistance is provided and, as the rate of exhaust is restricted, the damping force provided will increase as the speed of insertion increases meaning that the speed of the insertion can be effectively controlled.
  • the front housing 200 of the injection device is provided with four pockets 210 on the interior surface of upstanding boss 220.
  • the pockets are open in a rearward axial direction.
  • the pockets are preferably equally spaced, but need not be so.
  • the middle pocket210b, as illustrated, is shown complete and the left and right-most pockets 210a, 210c are shown in section.
  • the syringe support means 100 (the “syringe holder") is provided with four tabs 1 10 projecting axially forward therefrom.
  • the middle tab 1 10b as illustrated, is shown complete and the left and right-most tabs 1 10a, 1 10c are shown in section.
  • Figure 3 also shows the return spring 12, the syringe needle 10 and the front part of the syringe cone.
  • the syringe support means 100 carries the syringe and needle forwards in the direction indicated by the arrow, under force provided by the main spring energy source (not illustrated).
  • the tabs 1 10 approach the pockets 210.
  • the tabs 1 10 enter the pockets 210, thereby displacing the air present in the pockets. Both the size of the outlet and the volume of the chamber are decreased by the presence of the tab in the pocket.
  • the tabs 1 10 are configured to be a close fit to the internal dimensions of the pockets 210. Therefore the rate at which the displaced air can escape is restricted and so at least some of the remaining air is compressed. This compression provides resistance to further forward movement of the syringe support means 100, damping its movement and avoiding an undesirable sudden impact between the syringe support means 100 and the front housing 200.
  • the needle insertion stage ends when the flange 104 of the syringe support means 100 contacts the internal boss 220 of the front housing 200. In this position, as illustrated in Figure 5, the tabs 1 10 are preferably fully engaged in the pockets 210.
  • the air chamber could be defined between the front housing and another forward moving component or part of the syringe support means.
  • the air chamber could be defined between the syringe barrel per se and a part of the front housing, or between the front housing and the injection site.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention porte sur un dispositif d'injection comprenant : un boîtier dans lequel peut être montée une seringue comprenant une aiguille à son extrémité avant; et une source d'énergie en communication avec ladite seringue pour fournir une force avant apte à déplacer ladite seringue axialement vers l'avant de telle sorte que ladite aiguille peut pénétrer dans un site d'injection; caractérisé en ce que le dispositif d'injection comprend en outre une chambre délimitée par une partie avant du boîtier de celui-ci et contenant un gaz compressible, la chambre ayant une sortie pour ledit gaz et des moyens pour réduire le volume de la chambre. Le volume de la chambre est dépendant de la position axiale de la seringue et, au fur et à mesure que la seringue se déplace axialement vers l'avant, le volume de la chambre diminue et ledit gaz est comprimé à l'intérieur de la chambre et évacué de celle-ci à une vitesse régulée par la dimension de ladite sortie.
PCT/GB2011/051778 2010-09-21 2011-09-21 Dispositif d'injection Ceased WO2012038745A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1015805.3 2010-09-21
GB1015805.3A GB2483860B (en) 2010-09-21 2010-09-21 Injection device

Publications (1)

Publication Number Publication Date
WO2012038745A1 true WO2012038745A1 (fr) 2012-03-29

Family

ID=43065574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/051778 Ceased WO2012038745A1 (fr) 2010-09-21 2011-09-21 Dispositif d'injection

Country Status (2)

Country Link
GB (1) GB2483860B (fr)
WO (1) WO2012038745A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5779677A (en) * 1994-01-17 1998-07-14 Laboratoire Aguettant Automatic drug injector
WO2005070481A1 (fr) * 2004-01-23 2005-08-04 The Medical House Plc Dispositif d'injection
WO2007100899A2 (fr) * 2006-02-28 2007-09-07 Sciele Pharma, Inc. Amortisseur de chocs pour injecteur automatique
EP1998831A1 (fr) 2006-01-23 2008-12-10 The Medical House Plc Injecteur automatique ameliore supportant la seringue a l'avant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7798993B2 (en) * 1998-07-29 2010-09-21 Becton, Dickinson And Company Single use syringe
SE9803662D0 (sv) * 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab Autoinjector
US8551054B2 (en) * 2008-05-20 2013-10-08 Shl Group Ab Device for a medicament delivery device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5779677A (en) * 1994-01-17 1998-07-14 Laboratoire Aguettant Automatic drug injector
WO2005070481A1 (fr) * 2004-01-23 2005-08-04 The Medical House Plc Dispositif d'injection
EP1715903B1 (fr) 2004-01-23 2007-10-24 The Medical House Plc Dispositif d'injection
EP1998831A1 (fr) 2006-01-23 2008-12-10 The Medical House Plc Injecteur automatique ameliore supportant la seringue a l'avant
US20100152655A1 (en) * 2006-01-23 2010-06-17 The Medical House Plc Improved autoinjector supporting the syringe at the front
WO2007100899A2 (fr) * 2006-02-28 2007-09-07 Sciele Pharma, Inc. Amortisseur de chocs pour injecteur automatique

Also Published As

Publication number Publication date
GB2483860B (en) 2015-08-05
GB2483860A (en) 2012-03-28
GB201015805D0 (en) 2010-10-27

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