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WO2012037615A1 - Agent antimicrobien amélioré et procédé permettant de conserver un contrôle microbien - Google Patents

Agent antimicrobien amélioré et procédé permettant de conserver un contrôle microbien Download PDF

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Publication number
WO2012037615A1
WO2012037615A1 PCT/AU2011/001229 AU2011001229W WO2012037615A1 WO 2012037615 A1 WO2012037615 A1 WO 2012037615A1 AU 2011001229 W AU2011001229 W AU 2011001229W WO 2012037615 A1 WO2012037615 A1 WO 2012037615A1
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial agent
antimicrobial
pathogens
composition
treated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2011/001229
Other languages
English (en)
Inventor
Alan Pemberton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GLOBAL FUTURE SOLUTIONS Pty Ltd
Original Assignee
GLOBAL FUTURE SOLUTIONS Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2010904266A external-priority patent/AU2010904266A0/en
Priority claimed from AU2010236068A external-priority patent/AU2010236068A1/en
Application filed by GLOBAL FUTURE SOLUTIONS Pty Ltd filed Critical GLOBAL FUTURE SOLUTIONS Pty Ltd
Publication of WO2012037615A1 publication Critical patent/WO2012037615A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/04—Polysiloxanes
    • C09D183/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/16—Antifouling paints; Underwater paints
    • C09D5/1606—Antifouling paints; Underwater paints characterised by the anti-fouling agent
    • C09D5/1612—Non-macromolecular compounds
    • C09D5/1625—Non-macromolecular compounds organic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/26—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen nitrogen-containing groups

Definitions

  • the invention relates to antimicrobial agents and methods for maintaining microbial control using such agents.
  • SanitisatiOQ and disinfection of articles, domestic and commercial apparatus and property is known to reduce the costs of absenteeism from workplaces as a result of bacterial and viral infections of staff, to lengthen the life of household consumables including food and domestic items which are susceptible to mould and fungus deterioration and to maintain the health of employees and a hygienic working environment.
  • Many antimicrobial treatments are known to have many advantages over chemical based disinfectants and antibacterial treatments which employ toxic chemicals to poison pathogens.
  • Bleed harmful toxins into the environment May be carcinogenic
  • RO/AU methods for their application suffer however from a low life span thereby reducing the effective usefulness of the agents.
  • Further deficiencies of prior art antimicrobial agents include the length of time required to enable the agent to bond to a surface to be treated, the degree to which such agent evaporates upon contact with surfaces and generally in respect to the s pathogenic kill rate. There is therefore a demand for an improved antimicrobial agent which has a long life and which can remain in place upon surfaces.
  • the improved antimicrobial agent should be effective to kill or deactivate a wide range of pathogens including Gram positive bacteria, Or m negative bacteria, viruses, protozoa 25 parasites, fungi, algae, mould, yeast, and spores.
  • the improved antimicrobial agent should be relatively easy to use and able to be used in a wide range of applications. There is a requirement for an improved antimicrobial agent that minimises or overcomes at least one of the disadvantages referred to above, or to provide the public with a useful or commercial choice. Other objects and advantages of the present invention will become apparent from the following description wherein, by way of illustration and example, a preferred embodiment of the present invention is disclosed.
  • silane base molecule anchored by covalent bonds for bonding the antimicrobial agent to a surface through cross-links and polymerisation with the molecules of the surface
  • the antimicrobial agent upon application to a surface the antimicrobial agent will dry quickly, will adhere to the surface rapidly and will be capable of remaining active upon a treated surface for an extended period of time.
  • the antimicrobial agent may be easily applied to any number of domestic, commercial or industrial uscs.Prcfcrably, surfaces to be treated using the antimicrobial may be treated by pump or mist spraying the antimicrobial agent in solution upon the surface, by dipping or soaking the item to be treated in a solution containing the antimicrobial agent.
  • the antimicrobial agent may be diluted with water or with other liquids according to the nature of the various applications, the surface to be treated, the length of time in which the antimicrobial agent is to remain upon the surface and depending upon the level of toxicity permitted in relation to the application.
  • the antimicrobial agent is capable of killing or deactivating pathogens which are resistant to bactericides or sanitisers as a result of mutagenesis.
  • the antimicrobial agent does not increase mutagenicity of pathogens.
  • composition comprising the antimicrobial agent of the invention and a carrier.
  • the present invention relates to antimicrobial technology to combat pathogens such as0 bacteria, fungi, mould, viruses and parasitic protozoa.
  • the antimicrobial agent of the invention is a natural, chemical free, water based product which can be used on almost any surface including fabrics, carpet, upholstery, drapes, linens, wood, plastics, stone, porcelain and metals.
  • the antimicrobial agent is also suitable for use as a hand sanitiser and for food related antimicrobial applications as it is non-toxic to humans and animals.
  • the antimicrobial agent inactivates and kills pathogens through the process of lysis, wherein contact of the pathogen's cellular wall with the antimicrobial film produces cellular wall disruption.
  • the contacting cellulnr wall is broken or ruptured and the pathogenic microbe is no longer able to control its internal hydrostatic pressure, resulting in implosion or explosion of0 the species, depending on ambient pressure. No transfer of chemical or chemical residues occurs during this process.
  • the antimicrobial film is not depleted and will continue to lyse pathogenic cells.
  • the basic active antimicrobial agent compound of the present invention is: Octadecyldimemyl(3-trihydroxysU chloride (“ODTA”)
  • ODTA Octadecyldimemyl(3-trihydroxysU chloride
  • ClODTA is classified as an organic functional trihydroxysilane as it contains a functional organic group (quaternary nitrogen) covalently bound to a silicon atom.
  • Organosilane denotes a minimum of one carbon-silicon bond.
  • Trihydroxy describes die number of hydroxy groups bound to the silicon atom.
  • the antimicrobial agent of the present invention is prepared as a trialkoxysilane.
  • Trialkoxysilancs undergo a wide variety of chemical reactions including transesterification, acetylation, halogenation, condensation and hydrolysis to name but a few. The most important of these reactions are hydrolysis (which is used to prepare the antimicrobial agent) and condensation, (which is required for the antimicrobial agent to bond to surfaces and form polymeric films).
  • Hydrolysis of ODTA to antimicrobial agent is performed as a trialkoxysilane.
  • Silanol containing antimicrobial agents undergo auto condensation reactions with other Silanol substituted antimicrobial agent molecules and with the surface of a substrate, eliminating water.
  • Drying after application produces a durable, non-leaching, bonded, antimicrobial surface.
  • organosilane quaternaries are known in the art, improvements to the manner in which such antimicrobial agents act are not only possible but highly desirable.
  • the inventor has produced an improved organosilane quaternary which is capable of rapidly and securely binding to the substrates of a wide range of surfaces including the skin of living organisms and remaining active for extended periods of time upon the surfaces.
  • the antimicrobial agent of die present invention will react with oxide and hydroxyl containing surfaces through a condensation reaction.
  • the bonds formed are covalent and are resistant to rehydration.
  • Coatings on siliceous materials (glass, sand) are removed by thermal means £>250°C) or concentrated chemical treatment (K.OH, NaOH, HF).
  • Durable coatings on metal are dependent on (he metal substrate.
  • Coatings incorporating the antimicrobial agent have been applied to textile fibres including cotton, cellulose acetate, polyester, nylon, wool, rayon, acrylon, etc.
  • Durable coatings are readily applied to various natural and plastic surfaces including cotton, cellulose, wool, nylon, PVC, polyester, rayon, etc. Evaporation of the application media promotes T-resin film formation on the substrate. Electrostatic or H-bonding interactions provide bonding. Uniform film formation occurs through even "wetting" of the plastic surface. Durable films arc achieved on nylon, fibreglass, epoxy, polyester, PVC substrates. Less durable films are obtained on PE and PP. Film formation on PTFE and other fluorirtated substrates have not been reported. Antimicrobial Chemistry
  • the antimicrobial agent of the present invention is a unique antimicrobial material. It forms a water stable solution at low concentrations. There are no additives in the antimicrobial agent of the invention added to promote stability. This solution has the antimicrobial properties of typical aqueous solutions of quaternary ammonium compounds. On application to surfaces, the material reacts to produce a bonded antimicrobial coating. On evaporation of the water solvent, a durable bonded coating is produced which has improved and sustained antimicrobial properties.
  • the antimicrobial agent when applied to a surface, transforms from a water soluble monomelic species to an insoluble, macromolecular antimicrobial film. This film is stable and durable. Pathogens Inactivated By The Antimicrobial
  • Pathogens which are killed or inactivated by the antimicrobial agent of the present invention include:
  • HIV-1 HIV-1 (AIDS)
  • antimicrobial agent may be used neat, it may also be incorporated in an antimicrobial agent together with a carrier.
  • Suitable carriers are known in the art, for example, water or aqueous carriers such as aqueous alcohol comprising water and an alcohol such as methanol, ethanol or propanol.
  • the composition further comprises other components such as other antimicrobial agents and antisceptics, surfactants, fragrances, colouring agents and the like, as known in the art.
  • antimicrobial agents include but are not limited to peroxides such as hydrogen peroxide and benzalkonium chlorides such as N-octyl-N-ben2 l-N,N- dimethylammonium chloride, N-decyl-N-benzyl-N,N-dimethylaromonium chloride, N- dodecyl-N-benzyl-N,N-dimethylammonium chloride, N-tctradecyl-N-benzyl-N,N- dimcthylamroonium chloride, N-hexadecyl-N-benzyl-N,N-dimethylarnmonium chloride and N-octadecyl-N'benzyl-N,N-dimethylammonium chloride.
  • Suitable antisceptics include bisbiguanidra and polybiguanides such as alexidine, chlorhexidine and polyhexamethylencbiguanide or salts or mixtures thereof
  • Suitable surfactants include ethoxylated alcohols such as poly(oxy-l,2-ethanediyl-alpha- (nonyl-phenyl)-omega-hydroxy ethoxylated alcohol.
  • compositions of the invention include but are not limited to hand sanitisers and disinfectants.
  • the antimicrobial agent of the invention can be diluted according to the requirements of the particular application.
  • the antimicrobial agent may be used as an improved hand sanitiscr which is gentle to the user's hands and protects the user from pathogens for periods of at least 24 hours.
  • the active antimicrobial agent is diluted as follows:
  • the antimicrobial agent When applied as a hand sanitiser, the antimicrobial agent forms a protective antimicrobial barrier on the skin.
  • the antimicrobial protection remains through a minimum of ten hand washings and may be effective for 24 hours or longer.
  • the solution gently moisturizes the skin as it protects and prevents drying, redness and chapping.
  • the hand sanitiser application offers long lasting protection against pathogenic organisms including viruses, fungi and bacteria including staphylococci, streptococci and E.coli and will kill all strains of Staphylococcus aureus including drug resistant MRSA.
  • the hand sanitiser application of the antimicrobial agent may be quickly and easily applied using a spray applicator. It is a colourless product which is invisible on application and will not stain skin or clothing.
  • An additional benefit of employing the antimicrobial agent as a hand sanitiser is its ability to kill viruses that are commonly found in the workplace or in domestic environments where people gather, for instance, swine flu.
  • sanitisers on the market are primarily ethyl or isopropyl alcohol formulations which are largely antibacterial in nature, they only provide protection for a few minutes due to evaporation of the alcohol.
  • the antimicrobial agent is also highly suitable for application as an hospital grade disinfectant as it provides a highly durable antipathogenic coating that inhibits the growth of bacteria fungi, and algae on a variety of surfaces and which lasts up to 28 days.
  • the active antimicrobial agent is diluted as follows: l S Hospital Grade Disinfectant ⁇ Composition I
  • Thc antimicrobial agent is non-toxic to humans, animals and the environment It is non- corrosive, will not stain any surface and is odourless. Moreover it has been found to be resistant to new superbugs which is particularly important in a hospital setting.
  • the antimicrobial agent is safe for food contact surfaces and may be effective protection against pathogens for at least 28 days.
  • Pood grade applications of the antimicrobial agent have also been shown to be very effective protection against pathogens. Pood based applications may require greater dilution according to permissible toxicity levels in order to retain a food grade rating.
  • the antimicrobial is suitable for a wide range of both household and commercial uses. Household uses may include:
  • antimicrobial agent Commercial uses of the antimicrobial agent may include:
  • the antimicrobial agent of the invention can be applied to both organic or inorganic substrates by brushing, dipping, padding, soaking, spraying, fogging or by using foam finishing techniques. After application the agent bonds with the substrate of the surface upon which it is applied and forms a protective film upon the surface.
  • Suitable commercial applications of the antimicrobial agent includes use in homes, offices, automobiles and institutions e.g., schools, hospitals, day care centres, banks, churches, correctional facilities, hotels, cruise and freight liners.
  • the active antimicrobial agent is effective against odour causing bacteria, bacteria which cause staining and discolouration, fungi (mould and mildew) and algae as a static agent and can be used as a final bacteriostatic finish on, for example, the following items to impart bacteriostatic/fungi static (mould and mildew) activity:
  • Building materials and components siding, insulation and non-food contact cabinetry, wallboard, wood and wood components: interior structural wood as defined as only wood needed for basic building structure as found in the dried in stage of construction, wood dried in contact with foundations, interior and exterior wall sill plates, wood studs, wood or celJulosic sheathing, floor joists and sub- flooring.
  • interior structural wood as defined as only wood needed for basic building structure as found in the dried in stage of construction, wood dried in contact with foundations, interior and exterior wall sill plates, wood studs, wood or celJulosic sheathing, floor joists and sub- flooring.
  • Fabrics made of acetates, acrylics, cotton, fibreglass, linen, Lycra, nylon, orlon, polyester, polyethylene, polyolcfins, polypropylene, rayon, silk, spandex, vinyl, and wool.
  • Fibreglass duct board for air handling systems at point of manufacture
  • Footwear boots, shoes and components
  • Hard Surfaces such as tubs, glazed tiles, vanity tops, shower curtains, shower stalls, sinks, washable walls, wall paper for non-food contact, floors, window sills, cabinets, garbage cans, appliances, refrigerators (exterior), fibreglass, formica, glazed tile, glazed porcelain, synthetic marble, synthetic quartz, synthetic granite, plastic, vinyl
  • Interior non food contact hard surfaces floors, walls, ceiling tiles, ceramic, tile, concrete, chrome, stainless steel, vinyl, porcelain, paper wall covering, wood and glass fixture, marble, aluminium, book covers, pictures and furniture;
  • the antimicrobial can be used in paints and coatings as an "in can" preservative for protection of paint film and coating film.
  • Types of paints and coatings include: latex indoor/outdoor paints and stains, wood stains, architectural paints, lacquer and maintenance coatings, films, laminates and finishes including alkyd, urethane, enamel, epoxy, siloxalinc, amino resins, textile coatings, extrusion coatings, architectural coatings and overlays, anticorrosion coatings, fire-resistant coatings, aliphatic coatings, vinylestcr and polyester coatings, gel coatings, amino resins, resins used as additive mixes for cement, epoxy laminating resins, and blends and copolymers thereof;
  • Polyurethane foam for packaging and cushioning in non-food contact applications Polyurethane foam used as a growth medium for non-food crops and plants Pre-moistened towelettes and tissue wipes (these do not impart pesticidal properties)
  • roofing materials - defined as shingles, roofing granules, tiles, membranes, underlay wood shakes, felt, stone and synthetic overcoats
  • Socks comprised of nylon, nylon orlon, cotton nylon, linen/Lycra, acrylic polypropylencAiylon Lycra, wool/silk/nylon/Lycra and wool/acrylic/nylon Lycra
  • upholstery made of acetates, acrylics, cotton, fibrcglass, nylon, polyester, polyethylene, polyolefins, polypropylene, rayon, spandex, vinyl, wool
  • Disposable wiping cloths that can be used for multiple purposes such as dusting or washing furniture, cars, walls, windows, floors, appliances, dishes, counter tops Women's hosiery
  • Conventional commercial applications of the antimicrobial agent include use in homes, offices, automobiles and institutions e.g., schools, hospitals, day-care centres, churches, correctional facilities, hotels, cruise and freight liners.
  • the antimicrobial agent is non-toxic to humans and animals, for the sake of occupational health and safety and overall precaution, the user should wear protective eyewear (goggles or face shield) and gloves when using the antimicrobial in large volumes. Areas and articles to be treated should be clean and dry before applying the antimicrobial to them. Children and pets should be removed from the treated area until it is completely dry.
  • the methods by which the antimicrobial may be applied include:
  • the antimicrobial agent may be applied without dilution and then let to stand until dry or let to stand for 3 minutes before and wiping dry with a cloth or sponge. If spotting occurs, wipe with moist cloth or sponge. Test for staining and colour-fastness of fabrics and carpets by treating and drying a small, concealed area prior to application. When treating coarser substrates, a higher volume of the antimicrobial agent may be required due to absorption. Dry carpet areas and surfaces before re-entry and normal use. A fan may be used to assist in drying carpels.
  • Dipping/Soaking Application Use appropriate sized wash basin or tub for dipping soaking the item to be treated. Enough of the antimicrobial agent should be used so as to completely submerge the item, The item should be completely submerged in solution for 3 minutes, then removed and dried. For larger items (e.g., bedspreads, curtains, draperies), place in washing machine on spin cycle to aid in the removal of excess liquid. Test for staining and colourfastness of fabrics and carpets by treating and drying a small, concealed area prior to application. Do not reuse solution after dipping soaking, The substrate can be dried at room temperatures or at temperatures to a maximum of 160* C (320°F), for example in a clothes dryer. Remove excess liquid before attempting to dry in clothes dryer. The antimicrobial agent can be reapplied every three months, if necessary, or when odour, staining and discolouration due to bacteria, mould stains, and mildew stains return.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention a trait à un agent antimicrobien amélioré qui est doté d'une molécule de base de silane fixée au moyen de liaisons covalentes permettant de lier l'agent antimicrobien à une surface au moyen de liaisons réticulées et d'une polymérisation avec les molécules de la surface, d'un atome d'azote à charge positive, situé au centre, permettant d'attirer les membranes cytoplasmiques à charge négative des agents pathogènes vers une surface active de l'agent antimicrobien, où au contact avec l'atome d'azote, la membrane cytoplasmique à charge négative des agents pathogènes est électrocutée et détruite, et d'une chaîne moléculaire longue fixée à l'atome d'azote qui perce la membrane cytoplasmique des agents pathogènes qui entrent en contact avec celle-ci, ce qui entraîne une lyse, ledit processus de lyse ne transférant aucun électron ou atome entre l'agent antimicrobien ou les agents pathogènes. Lorsqu'il est appliqué sur une surface, l'agent antimicrobien sèche rapidement, colle à la surface rapidement et reste actif sur une surface traitée pendant une longue durée. L'agent antimicrobien peut être facilement appliqué à un nombre infini d'utilisations domestiques, commerciales ou industrielles.
PCT/AU2011/001229 2010-09-22 2011-09-22 Agent antimicrobien amélioré et procédé permettant de conserver un contrôle microbien Ceased WO2012037615A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
AU2010904266 2010-09-22
AU2010904266A AU2010904266A0 (en) 2010-09-22 An improved antimicrobial agent and method of maintaining microbial control.
AU2010904394A AU2010904394A0 (en) 2010-09-30 An improved antimicrobial agent and method for maintaining microbial control
AU2010904394 2010-09-30
AU2010236068 2010-10-28
AU2010236068A AU2010236068A1 (en) 2009-10-28 2010-10-28 An improved antimicrobial agent
AU2010101184 2010-10-28
AU2010101184A AU2010101184A4 (en) 2009-10-28 2010-10-28 An improved antimicrobial agent

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WO2012037615A1 true WO2012037615A1 (fr) 2012-03-29

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Cited By (13)

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WO2014060755A1 (fr) * 2012-10-17 2014-04-24 Arcis Biotechnology Holdings Limited Préparations nettoyantes, aseptisantes et stérilisantes
WO2015139074A1 (fr) * 2014-03-17 2015-09-24 Air Sanz Holdings Pty Ltd Compositions antimicrobiennes d'assainissement d'air et leur utilisation
WO2015139085A1 (fr) * 2014-03-17 2015-09-24 Gfs Corporation Aus Pty Ltd Compositions de désinfectant antimicrobien et leur utilisation
WO2015189568A1 (fr) * 2014-06-12 2015-12-17 Fantex Limited Antimicrobien liquide comprenant un polymère soluble dans l'eau et un agent antimicrobien soluble dans l'eau
WO2016073634A1 (fr) 2014-11-04 2016-05-12 Daniel Moros Composition et procédé pour former une surface autodécontaminante
US10194664B2 (en) 2014-11-04 2019-02-05 Allied Bioscience, Inc. Methods of preparing self-decontaminating surfaces using reactive silanes, triethanolamine and titanium anatase sol
US10258046B2 (en) 2014-11-04 2019-04-16 Allied Bioscience, Inc. Antimicrobial coatings comprising quaternary silanes
US10980236B2 (en) 2014-11-04 2021-04-20 Allied Bioscience, Inc. Broad spectrum antimicrobial coatings comprising combinations of organosilanes
US10993441B2 (en) 2014-11-04 2021-05-04 Allied Bioscience, Inc. Antimicrobial coatings comprising organosilane homopolymers
WO2022093571A1 (fr) * 2020-11-02 2022-05-05 Microban Products Company Utilisation d'alcools éthoxylés pour empêcher une propagation de virus enveloppés
US11653995B2 (en) 2018-03-28 2023-05-23 Parasol Medical, Llc Antimicrobial treatment for a surgical headlamp system
EP4037483A4 (fr) * 2019-10-03 2023-10-18 Allied Bioscience, Inc Revêtements antimicrobiens à large spectre comprenant des combinaisons d'organosilanes
US11998650B2 (en) 2017-11-08 2024-06-04 Parasol Medical, Llc Method of limiting the spread of norovirus within a cruise ship

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