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WO2012036884A3 - Bioproduction of aromatic chemicals from lignin-derived compounds - Google Patents

Bioproduction of aromatic chemicals from lignin-derived compounds Download PDF

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Publication number
WO2012036884A3
WO2012036884A3 PCT/US2011/049619 US2011049619W WO2012036884A3 WO 2012036884 A3 WO2012036884 A3 WO 2012036884A3 US 2011049619 W US2011049619 W US 2011049619W WO 2012036884 A3 WO2012036884 A3 WO 2012036884A3
Authority
WO
WIPO (PCT)
Prior art keywords
lignin
enzymes
derived compounds
bioproduction
bioconversion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/049619
Other languages
French (fr)
Other versions
WO2012036884A2 (en
Inventor
Ranjini Chatterjee
Kenneth Zahn
Kenneth Mitchell
Gary Y. Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aligna Technologies Inc
Original Assignee
Aligna Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aligna Technologies Inc filed Critical Aligna Technologies Inc
Priority to CA2811403A priority Critical patent/CA2811403A1/en
Priority to JP2013529175A priority patent/JP2014506115A/en
Priority to AU2011302522A priority patent/AU2011302522A1/en
Priority to EP11825655.1A priority patent/EP2616481A4/en
Priority to CN201180044555.0A priority patent/CN103797026A/en
Publication of WO2012036884A2 publication Critical patent/WO2012036884A2/en
Publication of WO2012036884A3 publication Critical patent/WO2012036884A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01018—Glutathione transferase (2.5.1.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as enzymes in the bioconversion of the lignin fractions to the aromatic chemical products; (iii) polynucleotides that can be used to transform the host cells to express the selection of polypeptides as enzymes in the bioconversion of the lignin fractions; and (iv) the transformants that express the enzymes.
PCT/US2011/049619 2010-09-15 2011-08-29 Bioproduction of aromatic chemicals from lignin-derived compounds Ceased WO2012036884A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2811403A CA2811403A1 (en) 2010-09-15 2011-08-29 Bioproduction of aromatic chemicals from lignin-derived compounds
JP2013529175A JP2014506115A (en) 2010-09-15 2011-08-29 Bioproduction of aromatic chemicals from lignin-derived compounds
AU2011302522A AU2011302522A1 (en) 2010-09-15 2011-08-29 Bioproduction of aromatic chemicals from lignin-derived compounds
EP11825655.1A EP2616481A4 (en) 2010-09-15 2011-08-29 Bioproduction of aromatic chemicals from lignin-derived compounds
CN201180044555.0A CN103797026A (en) 2010-09-15 2011-08-29 Bioproduction of aromatic chemicals from lignin-derived compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40340010P 2010-09-15 2010-09-15
US61/403,400 2010-09-15
US45570910P 2010-10-25 2010-10-25
US61/455,709 2010-10-25

Publications (2)

Publication Number Publication Date
WO2012036884A2 WO2012036884A2 (en) 2012-03-22
WO2012036884A3 true WO2012036884A3 (en) 2012-08-02

Family

ID=45832163

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/049619 Ceased WO2012036884A2 (en) 2010-09-15 2011-08-29 Bioproduction of aromatic chemicals from lignin-derived compounds

Country Status (6)

Country Link
EP (1) EP2616481A4 (en)
JP (1) JP2014506115A (en)
CN (1) CN103797026A (en)
AU (1) AU2011302522A1 (en)
CA (1) CA2811403A1 (en)
WO (1) WO2012036884A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9775347B2 (en) 2013-06-14 2017-10-03 Washington State University Methods to convert lignin to phenolic and carboxylate compounds
WO2015005307A1 (en) 2013-07-09 2015-01-15 東レ株式会社 Method for producing saccharide solution
CA3059588A1 (en) 2017-04-17 2018-10-25 Board Of Trustees Of Michigan State University Methods for lignin depolymerization using thiols
WO2018204424A1 (en) * 2017-05-01 2018-11-08 National Technology & Engineering Solutions Of Sandia, Llc Novel compositions and methods for synthesizing deep eutectic solvents from lignin derived phenolic compounds
CN109423456B (en) * 2017-08-30 2022-08-19 中国石油化工股份有限公司 Azotobacter chroococcum as well as identification method and application thereof
KR101831966B1 (en) 2017-10-27 2018-02-23 경상대학교산학협력단 Method for producing humified lignin conversion product
GB202011259D0 (en) * 2020-07-21 2020-09-02 Givaudan Sa Method for the production of musk fragrance ingredient
CN117285663A (en) * 2023-10-17 2023-12-26 中国石油大学(华东) Method for mildly and stepwise separating lignocellulose biomass components

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US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4943529A (en) 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
DD266710A3 (en) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Process for the biotechnical production of alkaline phosphatase
AU3145184A (en) 1983-08-16 1985-02-21 Zymogenetics Inc. High expression of foreign genes in schizosaccharomyces pombe
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4946783A (en) 1987-01-30 1990-08-07 President And Fellows Of Harvard College Periplasmic protease mutants of Escherichia coli
US5010182A (en) 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
GB8724885D0 (en) 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
EP0397687B1 (en) 1987-12-21 1994-05-11 The University Of Toledo Agrobacterium mediated transformation of germinating plant seeds
AU4005289A (en) 1988-08-25 1990-03-01 Smithkline Beecham Corporation Recombinant saccharomyces
DE394538T1 (en) 1989-04-28 1991-04-11 Rhein Biotech Ges. Fuer Biotechnologische Prozesse Und Produkte Mbh, 4000 Duesseldorf YEAR CELLS OF THE SCHWANNIOMYCES GENERATION.
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
FR2649120B1 (en) 1989-06-30 1994-01-28 Cayla NOVEL STRAIN AND ITS MUTANTS OF FILAMENTOUS MUSHROOMS, PROCESS FOR PRODUCING RECOMBINANT PROTEINS USING SAID STRAIN, AND STRAINS AND PROTEINS OBTAINED BY SAID METHOD
JP2002034557A (en) * 2000-07-18 2002-02-05 Rengo Co Ltd Cleavage enzyme for aryl glycerol-β-aryl ether type bond which is a main unit bond of lignin, method for producing the same, and microorganism producing the same

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI 10 February 2006 (2006-02-10), accession no. BD26841.1 *
MASAI ET AL.: "A bacterial enzyme degrading the model lignin compound beta-etherase is a member of the glutathione-S-transferase superfamily", FEBS LETTERS, vol. 323, no. 1,2, May 1993 (1993-05-01), pages 135 - 140 *
OTSUKA ET AL.: "Detection and characterization of a novel extracellular fungal enzyme that catalyzes the specific and hydrolytic cleavage of lignin guaiacylglycerol beta-aryl ether linkages", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 270, 2003, pages 2353 - 2362 *
SATO ET AL.: "Identification of three alcohol dehydrogenase genes involved in the stereospecific catabolism of arylglycerol-beta-aryl ether by Sphingobium sp. strain SYK-6", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 75, no. 16, 19 June 2009 (2009-06-19), pages 5195 - 5201 *
See also references of EP2616481A4 *

Also Published As

Publication number Publication date
CN103797026A (en) 2014-05-14
EP2616481A4 (en) 2014-04-02
EP2616481A2 (en) 2013-07-24
CA2811403A1 (en) 2012-03-22
JP2014506115A (en) 2014-03-13
WO2012036884A2 (en) 2012-03-22
AU2011302522A1 (en) 2013-05-02

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