[go: up one dir, main page]

WO2012033792A3 - Treatment of diseases - Google Patents

Treatment of diseases Download PDF

Info

Publication number
WO2012033792A3
WO2012033792A3 PCT/US2011/050618 US2011050618W WO2012033792A3 WO 2012033792 A3 WO2012033792 A3 WO 2012033792A3 US 2011050618 W US2011050618 W US 2011050618W WO 2012033792 A3 WO2012033792 A3 WO 2012033792A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
treating
diketopiperazine
reducing
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/050618
Other languages
French (fr)
Other versions
WO2012033792A2 (en
Inventor
David Bar-Or
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DMI Acquisition Corp
Original Assignee
DMI Acquisition Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DMI Acquisition Corp filed Critical DMI Acquisition Corp
Priority to JP2013528258A priority Critical patent/JP2013537195A/en
Priority to EP11824041.5A priority patent/EP2613786A4/en
Priority to CA2810844A priority patent/CA2810844C/en
Publication of WO2012033792A2 publication Critical patent/WO2012033792A2/en
Publication of WO2012033792A3 publication Critical patent/WO2012033792A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides (i) a method of treating metabolic syndrome in an animal, (ii) a method of suppressing the appetite of an animal (Hi) a method of treating obesity in an animal, (iv) a method of reducing the weight of an animal in need thereof, (v) a method of reducing a blood lipid level in an animal in need thereof, (vi) a method of treating nonalcoholic steatohepatitis in an animal, and (vii) a method of inhibiting adipogenesis. The methods comprise administering an effective amount of an active ingredient, wherein the active ingredient comprises a diketopiperazine, a prodrug of a diketopiperazine or a pharmaceutically-acceptable salt of either of them to the animal.
PCT/US2011/050618 2010-09-07 2011-09-07 Treatment of diseases Ceased WO2012033792A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2013528258A JP2013537195A (en) 2010-09-07 2011-09-07 Disease treatment
EP11824041.5A EP2613786A4 (en) 2010-09-07 2011-09-07 TREATMENT OF DISEASES
CA2810844A CA2810844C (en) 2010-09-07 2011-09-07 Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38042610P 2010-09-07 2010-09-07
US61/380,426 2010-09-07
US201161512151P 2011-07-27 2011-07-27
US61/512,151 2011-07-27

Publications (2)

Publication Number Publication Date
WO2012033792A2 WO2012033792A2 (en) 2012-03-15
WO2012033792A3 true WO2012033792A3 (en) 2012-06-07

Family

ID=45811135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/050618 Ceased WO2012033792A2 (en) 2010-09-07 2011-09-07 Treatment of diseases

Country Status (5)

Country Link
US (2) US8507496B2 (en)
EP (1) EP2613786A4 (en)
JP (1) JP2013537195A (en)
CA (1) CA2810844C (en)
WO (1) WO2012033792A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1311269E (en) 2000-08-04 2012-05-10 Dmi Biosciences Inc Method of using diketopiperazines and composition containing them
CN103191409A (en) 2003-05-15 2013-07-10 Dmi生物科学公司 Treatment of T-cell mediated diseases
JP5856843B2 (en) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド Pharmaceutical composition using diketopiperazine
JP2013537195A (en) 2010-09-07 2013-09-30 ディエムアイ アクイジション コーポレイション Disease treatment
WO2012033789A2 (en) * 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
EP3721884A1 (en) * 2011-10-10 2020-10-14 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine)
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
CA2846394A1 (en) 2011-10-28 2013-05-02 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
MX2015010937A (en) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same.
WO2015075406A1 (en) 2013-11-19 2015-05-28 Lipopeptide Ab New treatment of chronic ulcers
RU2020136589A (en) 2014-08-18 2020-12-24 Ампио Фармасьютикалз, Инк. TREATMENT OF DEGENERATIVE JOINT DISEASES
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES
JP6671367B2 (en) * 2015-07-17 2020-03-25 サントリーホールディングス株式会社 Anti-obesity composition containing cyclic dipeptide
WO2017014149A1 (en) * 2015-07-17 2017-01-26 サントリーホールディングス株式会社 Anti-obesity composition
WO2017083774A1 (en) 2015-11-11 2017-05-18 Onefocus Vision, Inc. Accommodating lens with cavity
KR102012554B1 (en) 2016-07-13 2019-08-23 주식회사 노브메타파마 Cytoprotective composition for protection of cell containing Cyclo His-Pro as Active Ingredient
WO2018012901A1 (en) * 2016-07-13 2018-01-18 주식회사 노브메타파마 Composition for cell protection containing cyclo histidine-proline as active ingredient
WO2018089699A1 (en) * 2016-11-11 2018-05-17 Onefocus Vision, Inc. Accommodating cavity lens shaped with photocleavable insert
KR102133151B1 (en) * 2019-03-28 2020-07-13 주식회사 노브메타파마 Composition comprising chp (cyclo-his pro) for preventing, improving or treating of peritoneal fibrosis
US12053467B2 (en) 2020-12-18 2024-08-06 NovMeta Pharma Co., Ltd. Method of treating fibrosis
JP2023098225A (en) * 2021-12-28 2023-07-10 ブラザー工業株式会社 Computer program for terminal, terminal and method performed by terminal
CN119837994A (en) * 2025-01-16 2025-04-18 广州中医药大学(广州中医药研究院) Application of cyclic dipeptide in improving or treating diseases related to dyslipidemia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5418218A (en) * 1992-07-10 1995-05-23 The University Of Maryland At Baltimore Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent
US20030225103A1 (en) * 2000-08-04 2003-12-04 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
US20050119177A1 (en) * 2003-05-15 2005-06-02 David Bar-Or Treatment of T-cell mediated diseases

Family Cites Families (190)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941790A (en) 1967-07-03 1976-03-02 National Research Development Corporation Bis diketopiperazines
US4006261A (en) 1973-09-28 1977-02-01 Firmenich S.A. Flavoring with mixtures of theobromine and cyclic dipeptides
US3928330A (en) 1973-12-19 1975-12-23 Ciba Geigy Corp Substituted piperazinedione carboxylic acids and metal salts thereof
GB1459488A (en) 1974-03-19 1976-12-22 Wyeth John & Brother Ltd Piperazinedione derivatives
US3989284A (en) 1975-04-23 1976-11-02 Hydril Company Tubular connection
US4088649A (en) 1975-07-02 1978-05-09 Firmenich S.A. Process for preparing a diketo-piperazine
US4205057A (en) 1978-01-17 1980-05-27 Government Of The United States Cerebrospinal fluid protein fragments
JPS6236331Y2 (en) 1979-05-16 1987-09-16
DE2940654A1 (en) 1979-10-06 1981-04-16 Bayer Ag, 5090 Leverkusen DIMERES KETEN OF 1,2 ,, - TRIAZOL-3-CARBONIC ACID
US4289759A (en) 1980-06-23 1981-09-15 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
US4331595A (en) 1980-06-23 1982-05-25 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
JPS5836225U (en) 1981-08-31 1983-03-09 株式会社東芝 metal flat pallet
JPS5973574U (en) 1982-11-10 1984-05-18 三菱自動車工業株式会社 Electromagnetic fuel injection device
US4694061A (en) 1983-10-12 1987-09-15 Ciba-Geigy Corporation Radiation-sensitive polycondensates, processes for their preparation coated material and its use
US4727018A (en) 1984-05-18 1988-02-23 Eichner Ronald D Immunoregulation of transplantable tissue
US4806538A (en) 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
JPH0245309Y2 (en) 1984-12-21 1990-11-30
CS254868B1 (en) 1985-06-11 1988-02-15 Jiri Vanzura Process for producing cyclic dipeptides
US4661500A (en) 1985-08-29 1987-04-28 Roman Rozencwaig Method of medical treatment with serotonin antagonists
US4771056A (en) 1985-08-29 1988-09-13 Roman Rozencwaig Method of medical treatment with serotonin antagonists
US5047401A (en) 1985-09-09 1991-09-10 Board Of Regents, The University Of Texas System Use of dipeptide alkyl esters to treat GVHD
US4694081A (en) 1985-09-23 1987-09-15 Monsanto Company Process to prepare 2,5-diketopiperazines
PT83613B (en) 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
JPS63290868A (en) 1987-05-22 1988-11-28 Fujisawa Pharmaceut Co Ltd Diketopiperazine derivative and salts thereof
US5512544A (en) 1987-09-13 1996-04-30 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising an anticytokine
US5407926A (en) 1987-12-29 1995-04-18 Alcon Laboratories, Inc. Ophthalmic composition
US4992552A (en) 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids
US5144073A (en) 1988-08-31 1992-09-01 Hubbs John C Process for preparation of dipeptides
US5238938A (en) 1989-02-10 1993-08-24 Otsuka Pharmaceutical Co., Ltd. Indole derivatives
DE3906952A1 (en) 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3- (C (DOWN ARROW)) (DOWN ARROW) (DOWN ARROW) 6 (DOWN ARROW) -C (DOWN ARROW) 1 (DOWN ARROW) (DOWN ARROW) 8 (DOWN ARROW)) ALKANSULFINYL AND 2 SULPHONE -METHOXYMETHYL-PROPYL) - (2-TRIMETHYLAMMONIO-ETHYL) PHOSPHATES, METHOD FOR PRODUCING THE MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5902790A (en) 1995-10-03 1999-05-11 Cytran, Inc. Pharmaceutical angiostatic dipeptide compositions and method of use thereof
DE68922102T2 (en) 1989-10-13 1995-10-19 Phobos Nv Process for the continuous production of high molecular weight polyester resins.
CA2060515A1 (en) 1990-03-15 1991-09-16 John B. Hill Process for manufacturing aspartame from a diketopiperazine and novel intermediates and derivatives therefor
US6180616B1 (en) 1990-05-10 2001-01-30 Atsuo F. Fukunaga Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
CA2095539A1 (en) 1990-11-14 1992-05-15 Robert D. Cook Diagnosis and treatment of multiple sclerosis
US5776892A (en) 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
JPH04234374A (en) 1990-12-27 1992-08-24 Ajinomoto Co Inc Production of diketopiperazine derivative
US5543503A (en) 1991-03-29 1996-08-06 Genentech Inc. Antibodies to human IL-8 type A receptor
US5538993A (en) 1991-09-12 1996-07-23 Yissum Research Development Company Certain tetrahydrocannabinol-7-oic acid derivatives
AU2905092A (en) 1991-10-28 1993-06-07 Cytoven Pharmaceutical dipeptide compositions and methods of use thereof
JPH05244982A (en) 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd Humanized b-b10
JPH05163148A (en) 1991-12-18 1993-06-29 Kanebo Ltd Anti-neoplastic agent
GB9200210D0 (en) 1992-01-07 1992-02-26 British Bio Technology Compounds
US5352461A (en) 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
JP3176478B2 (en) 1992-05-29 2001-06-18 いすゞ自動車株式会社 Drowsy driving prevention device
US5648486A (en) 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
US5434151A (en) 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5358938A (en) 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5463083A (en) 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
GB9217331D0 (en) 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
EP0656004A1 (en) 1992-08-20 1995-06-07 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
WO1994014846A1 (en) 1992-12-18 1994-07-07 Molecular Rx, Inc. Assay and treatment for demyelinating diseases such as multiple sclerosis
ES2068742B1 (en) 1993-02-11 1995-11-16 Uriach & Cia Sa J NEW DERIVATIVES OF PIRIDINIO.
WO1994020063A2 (en) 1993-03-04 1994-09-15 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US6107050A (en) 1993-05-03 2000-08-22 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic test for alzheimers disease
KR960703597A (en) 1993-07-23 1996-08-31 데이비드 엘 토메이 METHODS OF TREATING APOPTOSIS AND ASSOCIATED CONDITIONS
GB9324872D0 (en) 1993-12-03 1994-01-19 Univ Pasteur Pharmaceutical compounds
IL112627A0 (en) 1994-02-14 1995-05-26 Xenova Ltd Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
JP2921731B2 (en) 1994-03-10 1999-07-19 日清製油株式会社 Gelling agents for organic solvents or fats and oils
FR2717484A1 (en) 1994-03-16 1995-09-22 Pf Medicament New pseudo-bis-peptide cpds.
WO1995026734A1 (en) 1994-04-04 1995-10-12 Freeman William R Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
GB9410387D0 (en) 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds
US5550132A (en) 1994-06-22 1996-08-27 University Of North Carolina Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines
WO1996000391A1 (en) 1994-06-23 1996-01-04 Affymax Technologies N.V. Methods for the synthesis of diketopiperazines
US5990112A (en) 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
US5817751A (en) 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
US5792776A (en) 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
KR100276570B1 (en) 1994-06-27 2001-02-01 사이토메드 인코포레이티드 Compounds and methods for thr treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
CA2196215C (en) 1994-07-29 2000-08-15 Shigeyuki Tasaka 1,4-dihydropyridine compound and pharmaceutical composition containing the same
HU225493B1 (en) 1994-10-05 2007-01-29 Amarin Neuroscience Ltd Use of antidepressants, mao inhibitors and serotonine reuptake inhibitors for the treatment of multiple sclerosis (ms) and other demyelinating conditions
CZ282794A3 (en) 1994-11-16 1996-04-17 Galena Pentapeptidic precursors of biologically active cyclic dipeptides
CA2206053A1 (en) 1994-12-01 1996-06-06 Toyama Chemical Co., Ltd. Novel 2,3-diketopiperazine derivatives or their salts
JP3634891B2 (en) 1995-04-06 2005-03-30 株式会社海洋バイオテクノロジー研究所 Chitinase inhibitor
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JPH11508583A (en) 1995-07-06 1999-07-27 ゼネカ・リミテッド Peptide-based fibronectin inhibitors
US6060452A (en) 1996-03-13 2000-05-09 Cytran, Inc. Analogs of L-Glu-L-Trp having pharmacological activity
US6541224B2 (en) 1996-03-14 2003-04-01 Human Genome Sciences, Inc. Tumor necrosis factor delta polypeptides
CN1215404A (en) 1996-04-03 1999-04-28 佩普里瑟奇公司 Non-dendritic backbone piptide carrier
US5919785A (en) 1996-04-03 1999-07-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036888A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6262119B1 (en) 1996-04-12 2001-07-17 Peptide Technology Limited Methods of treating immunopathologies using polyunsaturated fatty acids
US5932579A (en) 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
US5985581A (en) 1996-07-25 1999-11-16 The Mclean Hospital Corporation Use of presenilin-1 for diagnosis of alzheimers disease
AU4720397A (en) 1996-09-09 1998-03-26 Microbial Screening Technologies Pty. Limited Terpenylated diketopiperazines, (drimentines)
NZ335544A (en) 1996-10-04 2001-08-31 Neuronz Ltd Use of GPE (tripeptide or dipeptide) in form of Gly-Pro-Glu or Gly-Pro or Pro-Glu as a neuromodulator
RU2125728C1 (en) 1996-10-10 1999-01-27 Пермская государственная медицинская академия Method of immunodiagnostics of multiple sclerosis
EP0835660A1 (en) 1996-10-14 1998-04-15 Gaston Edmond Filomena Merckx Products containing methylcobalamin for the treatment of multiple sclerosis or other demyelinating conditions
US6441172B1 (en) 1996-11-07 2002-08-27 Torrey Pines Institute For Molecular Studies Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
US5932112A (en) 1996-11-27 1999-08-03 Browning Transport Management, Inc. Method and apparatus for killing microorganisms in ship ballast water
RU2112242C1 (en) 1996-12-09 1998-05-27 Пермская государственная медицинская академия Method for diagnosing the cases of multiple sclerosis
JPH10226615A (en) 1997-02-18 1998-08-25 Pola Chem Ind Inc Composition containing aspartic acid-phenylalanine cyclic dipeptide derivative
JPH10245315A (en) 1997-03-05 1998-09-14 Pola Chem Ind Inc Composition containing cyclodipeptide derivative
US6306909B1 (en) 1997-03-12 2001-10-23 Queen's University At Kingston Anti-epileptogenic agents
WO1998040748A1 (en) 1997-03-14 1998-09-17 Neuromark Diagnosing neurologic disorders
US6265535B1 (en) 1997-05-30 2001-07-24 The Trustees Of The University Of Pennsylvania Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses
RU2128840C1 (en) 1997-06-16 1999-04-10 Пермская государственная медицинская академия Method for diagnosing the cases of multiple sclerosis
US6222029B1 (en) 1997-08-01 2001-04-24 Genset 5′ ESTs for secreted proteins expressed in brain
US5834032A (en) 1997-08-11 1998-11-10 Song; Moon K. Compositions and methods for treating diabetes
US7202279B1 (en) 1998-02-11 2007-04-10 Georgetown University Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
EP0939124A3 (en) 1998-02-24 2001-03-21 Smithkline Beecham Plc MGBP1 sequences
AU3370099A (en) 1998-03-31 1999-10-18 Mayo Foundation For Medical Education And Research Use of platelet activating factor (paf) inhibitors to inhibit il-5 induced eosinophil activation or degranulation
AU3467099A (en) 1998-04-03 1999-10-25 Cytran Ltd. Methods for production of therapeutic cytokines
EP1067951A2 (en) 1998-04-03 2001-01-17 Cytran Ltd. Use of l-glu-l-trp in the treatment of hiv infection
AU767241B2 (en) 1998-09-14 2003-11-06 Qiang Xu Immunosuppressive agents
US6461875B1 (en) 1998-10-02 2002-10-08 Ischemia Technologies, Inc. Test for rapid evaluation of ischemic states and kit
US6475743B1 (en) 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US6492179B1 (en) 1998-10-02 2002-12-10 Ischemia Techologies, Inc. Test for rapid evaluation of ischemic states and kit
EP1117686B1 (en) 1998-10-02 2008-07-16 Ischemia Technologies, Inc. Methods and materials for detection and measurement of free radical damage
WO2000020840A1 (en) 1998-10-02 2000-04-13 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
DE19847690A1 (en) 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Diagnosing sepsis and severe infections, useful for assessing severity and progress of treatment, by measuring content of peptide prohormone or their derived fragments
US6358957B1 (en) 1998-11-12 2002-03-19 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
US7026322B2 (en) 1998-11-12 2006-04-11 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
EP1166781A4 (en) 1999-01-20 2002-08-21 Kyowa Hakko Kogyo Kk PROTEASOME INHIBITORS
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
AU3760400A (en) 1999-03-19 2000-10-09 Vanderbilt University Methods and reagents for the diagnosis and treatment of multiple sclerosis
US6090780A (en) 1999-04-07 2000-07-18 Chandon Prasad Histidyl-proline diketopiperazine and method of use
US6689765B2 (en) 1999-05-04 2004-02-10 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
JP2000327575A (en) 1999-05-26 2000-11-28 Teika Seiyaku Kk Remedy for inflammatiory disease containing diketopiperazine derivative and new diketopiperazine derivative
DE19937721A1 (en) 1999-08-10 2001-02-15 Max Planck Gesellschaft New diketopiperazines
EP1225879A2 (en) 1999-10-22 2002-07-31 Orbon Corporation Ophthalmic formulation of dopamine antagonists
JP2003517468A (en) 1999-11-12 2003-05-27 ワイス Branched adamantyl and noradamatyl aryl- and aralkylpiperazines having serotonin 5-HT1A activity
US6677473B1 (en) 1999-11-19 2004-01-13 Corvas International Inc Plasminogen activator inhibitor antagonists
US20050096323A1 (en) 1999-11-30 2005-05-05 Novoscience Pharma Inc. Diketopiperazine derivatives to inhibit thrombin
AU785285B2 (en) 2000-03-10 2006-12-21 Sun Pharma Global Fze Methods and compositions for treating and preventing posterior segment ophthalmic disorders
DE10019879A1 (en) 2000-04-20 2001-10-25 Degussa Production of known and new 2,5-diketopiperazine derivatives useful for the synthesis of bioactive compounds, e.g. cyclo(Lys-Lys)
US7288545B2 (en) 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
JP5101781B2 (en) 2000-05-09 2012-12-19 アンギオアールエックス コーポレイション Piperazinedione compounds
DE10026998A1 (en) 2000-05-31 2001-12-13 Fresenius Kabi De Gmbh Process for the preparation of a cosmetic composition comprising human serum albumin obtained from transgenic non-human mammals
JP2004533402A (en) 2000-06-08 2004-11-04 リリー アイコス リミテッド ライアビリティ カンパニー Tetracyclic diketopiperazine compounds as PDEV inhibitors
EP1311277A4 (en) 2000-07-18 2004-08-25 Joslin Diabetes Center Inc FIBROSIS MODULATION METHOD
CZ20002680A3 (en) 2000-07-21 2002-03-13 Ev®En Ing. Csc. Kasafírek Cyclic alkylthiopeptides
CZ20002681A3 (en) 2000-07-21 2002-03-13 Ev®En Ing. Csc. Kasafírek Cyclic tyrosine dipeptides
WO2002012201A1 (en) 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
US20070208087A1 (en) 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
US6815214B2 (en) 2000-12-29 2004-11-09 Celltech R & D, Inc. Pharmaceutical uses and synthesis of diketopiperazines
GB2372740A (en) 2001-01-17 2002-09-04 Xenova Ltd Diketopiperazines
WO2002059604A2 (en) 2001-01-26 2002-08-01 Oxford Glycosciences (Uk) Ltd Diagnosis and treatment of multiple sclerosis
CA2443487A1 (en) 2001-04-13 2002-10-24 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
CA2446380A1 (en) 2001-05-08 2002-11-14 Yale University Proteomimetic compounds and methods
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
WO2003032809A2 (en) 2001-10-15 2003-04-24 The Medstar Research Institute Modulation of akt-dependent response to prevent restenosis
EP2325193A3 (en) 2001-11-02 2012-05-02 Insert Therapeutics, Inc. Methods and compositions for therapeutic use of RNA interference
US20040063654A1 (en) 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
GB0128108D0 (en) 2001-11-23 2002-01-16 Astrazeneca Ab Therapeutic use
WO2003056026A1 (en) 2001-12-27 2003-07-10 Ajinomoto Co., Inc. Process for production of glutamic acid derivatives
AU2002358163A1 (en) 2002-01-18 2003-07-30 Unilever Plc Cosmetic compositions comprising a cyclodipeptide compound
WO2003086282A2 (en) 2002-04-05 2003-10-23 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
US20040038865A1 (en) 2002-08-01 2004-02-26 Mannkind Corporation Cell transport compositions and uses thereof
US20080260838A1 (en) 2003-08-01 2008-10-23 Mannkind Corporation Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
ES2295695T3 (en) 2002-08-02 2008-04-16 Nereus Pharmaceuticals, Inc. DEHYDROPHENYLHYSINAS AND ITS ANALOGS AND THE SYNTHESIS OF DEHYDROPHENYLHYTHINES AND THEIR ANALOGS.
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
KR20050042146A (en) 2002-08-06 2005-05-04 아플라겐 게엠베하 Binding molecules
DE10238144A1 (en) 2002-08-15 2004-02-26 Basf Ag Use of aryl-substituted 3,6-dialkylidene-2,5-piperazinedione derivatives as photostable UV filters in cosmetic or pharmaceutical compositions for protecting human skin or hair against solar radiation
WO2004022569A1 (en) 2002-09-03 2004-03-18 Georgetown University Akt inhibitors, pharmaceutical compositions, and uses thereof
WO2004030522A2 (en) 2002-10-02 2004-04-15 Dmi Biosciences, Inc. Diagnosis and monitoring of diseases
US7196169B2 (en) 2002-10-11 2007-03-27 Queen's University At Kingston Isolated post-translationally modified mammalian proteins for monitoring and diagnosing muscle damage
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
EP1572669A2 (en) 2002-11-22 2005-09-14 Novo Nordisk A/S 2,5-diketopiperazines for the treatment of obesity
EP1972344A1 (en) 2002-12-20 2008-09-24 Chakshu Research, Inc. Ophthalmic formulation for the prevention and treatment of ocular conditions
PT1651620E (en) 2003-07-30 2012-02-10 Xenon Pharmaceuticals Inc Piperazine derivatives and their use as therapeutic agents
WO2005023815A2 (en) 2003-09-03 2005-03-17 Neuren Pharmaceuticals Limited Neuroprotective bicyclic compounds and methods for their use
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
DK1791542T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte for pharmaceutical delivery
EP1850843A4 (en) 2005-02-14 2012-02-15 Merck Sharp & Dohme ACTIVITY INHIBITORS OF AKT
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
MX2008013216A (en) 2006-04-14 2008-10-27 Mannkind Corp Glucagon-like peptide 1(glp-1) pharmaceutical formulations.
US20080017576A1 (en) 2006-06-15 2008-01-24 Rensselaer Polytechnic Institute Global model for optimizing crossflow microfiltration and ultrafiltration processes
AR061240A1 (en) 2006-06-20 2008-08-13 Lilly Co Eli COMPOUNDS OF 4-ISOQUINOLIN-PHENOL, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE AS ANTINEOPLASIC AND / OR ANTIVIRAL AGENTS.
AU2007272954A1 (en) * 2006-07-11 2008-01-17 Harkness Pharmaceuticals, Inc. Methods of treating obesity using satiety factors
CN101743007B (en) 2007-07-12 2015-04-08 南佛罗里达大学 AKT/PKB inhibitors with antitumor activity
WO2009032651A1 (en) 2007-08-31 2009-03-12 Smithkline Beecham Corporation Inhibitors of akt activity
NZ583576A (en) 2007-09-25 2012-06-29 Abbott Lab Octahydropentalene compounds as chemokine receptor antagonists
WO2009114725A2 (en) 2008-03-12 2009-09-17 Children's Hospital Medical Center Mobilization of hematopoietic stem cells
JP5856843B2 (en) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド Pharmaceutical composition using diketopiperazine
TWI528982B (en) 2009-03-04 2016-04-11 曼凱公司 An improved dry powder drug delivery system
JP2013537195A (en) 2010-09-07 2013-09-30 ディエムアイ アクイジション コーポレイション Disease treatment
WO2012033789A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
EP3721884A1 (en) 2011-10-10 2020-10-14 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine)
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
CA2846394A1 (en) 2011-10-28 2013-05-02 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
JP3176478U (en) 2012-04-11 2012-06-21 ネイス株式会社 Exercise air trampoline
MX2015010937A (en) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5418218A (en) * 1992-07-10 1995-05-23 The University Of Maryland At Baltimore Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent
US20030225103A1 (en) * 2000-08-04 2003-12-04 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
US20050119177A1 (en) * 2003-05-15 2005-06-02 David Bar-Or Treatment of T-cell mediated diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
EVANS ET AL.: "Metabolic effects of platelet-activating factor in rats in vivo: stimulation of hepatic glycogenolysis and lipogenesis", BIOCHEM JOURNAL, vol. 269, no. 1, 1 July 1990 (1990-07-01), pages 269 - 272 *
GOUNTOPOULOU ET AL.: "TNF is a potent inducer op platelet-activating factor synthesis in adipocytes but not in preadipocytes: Differential regulation by P13K.", CYTOKINE, vol. 41, no. 2, 3 January 2008 (2008-01-03), pages 174 - 184, XP022458537, DOI: doi:10.1016/j.cyto.2007.11.008 *
HANSAI ET AL.: "Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity", J. CLIN ENDOCRINOL METAB, vol. 89, no. 10, 1 October 2004 (2004-10-01), pages 4963 - 4971 *
IYER ET AL.: "Inflammatory lipid mediators in adipocyte function and obesity", NATURE REVIEWS ENDOCRINOLOGY, 1 February 2010 (2010-02-01), pages 71 - 82, XP055212341, DOI: doi:10.1038/nrendo.2009.264 *
See also references of EP2613786A4 *
YANG ET AL.: "Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis", GUT, vol. 53, no. 6, 1 January 2004 (2004-01-01), pages 877 - 883 *

Also Published As

Publication number Publication date
CA2810844A1 (en) 2012-03-15
US8507496B2 (en) 2013-08-13
US20130303463A1 (en) 2013-11-14
CA2810844C (en) 2017-03-21
EP2613786A4 (en) 2013-10-23
JP2013537195A (en) 2013-09-30
US9034878B2 (en) 2015-05-19
EP2613786A2 (en) 2013-07-17
US20120172294A1 (en) 2012-07-05
WO2012033792A2 (en) 2012-03-15

Similar Documents

Publication Publication Date Title
WO2012033792A3 (en) Treatment of diseases
WO2011014255A8 (en) Treatment of crohn's disease with laquinimod
WO2012002760A3 (en) Method for treating and diagnosing cancer by using cell-derived microvesicles
HK1198869A1 (en) Combination treatments for hepatitis c
WO2011107755A3 (en) Immediate/delayed drug delivery
WO2013100567A8 (en) Phenyl carbamate compounds for use in alleviating or treating pain and neuropathic pain
MY156316A (en) Methods of treating non-alcoholic steatohepatitis (nash) using cysteamine products
WO2011107750A3 (en) Delayed prolonged drug delivery
WO2011107749A3 (en) Pulsatile drug release
MX337614B (en) Treatment of lupus nephritis using laquinimod.
HK1201065A1 (en) Novel quinoxaline inhibitors of pi3k
WO2012149549A3 (en) Bacillus bacteria for use in treating and preventing infection in aquatic animals
WO2012072713A3 (en) Lysine demethylase inhibitors such as cyclylcyclopropanamine derivatives for use in the treatment of diseases and disorders associated with flaviviridae
WO2013103919A3 (en) Compositions and methods for treating metabolic disorders
WO2011127333A3 (en) Compounds for treating disease, for administering, and for pharmaceutical compositions
HK1198279A1 (en) Treatment of multiple sclerosis with combination of laquinimod and glatiramer acetate
WO2010080756A3 (en) Harmine derivatives for reducing body weight
HK1198278A1 (en) Treatment of multiple sclerosis with combination of laquinimod and interferon-beta
WO2012071369A3 (en) A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease
RU2012145116A (en) PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF NON-ALCOHOLIC FAT HEPATOSIS AND METHOD FOR PREVENTING OR TREATMENT OF NON-ALCOHOLIC FATTY HEPATOSIS USING IT
WO2011044523A3 (en) Compositions and methods for treating obesity
WO2008070010A3 (en) Hydroxylamine derivatives for the treatment of stroke
WO2011136573A3 (en) Yeast hydrolysate having obesity treatment effects and antioxidant activity
WO2007133796A3 (en) Methods and compositions for treatment of sleep apnea comprising administration of an endothelin antagonist
WO2012106058A3 (en) Animal treatments

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11824041

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2013528258

Country of ref document: JP

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2810844

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2011824041

Country of ref document: EP