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WO2012028242A1 - Dispositif de transmission d'énergie électrique sans contact pour des composants de bioréacteurs - Google Patents

Dispositif de transmission d'énergie électrique sans contact pour des composants de bioréacteurs Download PDF

Info

Publication number
WO2012028242A1
WO2012028242A1 PCT/EP2011/003941 EP2011003941W WO2012028242A1 WO 2012028242 A1 WO2012028242 A1 WO 2012028242A1 EP 2011003941 W EP2011003941 W EP 2011003941W WO 2012028242 A1 WO2012028242 A1 WO 2012028242A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrical energy
component
bioreactor
transmission
contact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/003941
Other languages
German (de)
English (en)
Inventor
Daniel SÜß
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim Biotech GmbH
Original Assignee
Sartorius Stedim Biotech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sartorius Stedim Biotech GmbH filed Critical Sartorius Stedim Biotech GmbH
Publication of WO2012028242A1 publication Critical patent/WO2012028242A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/32005—Type of drive
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F38/00—Adaptations of transformers or inductances for specific applications or functions
    • H01F38/14—Inductive couplings

Definitions

  • the invention relates to a device which contactlessly supplies energy-requiring components of a bioreactor with energy.
  • a device is used in particular in disposable, mixing and bioreactors in the pharmaceutical, chemical, biotechnology or food industry.
  • Maintaining sterility is an important feature for safe production or research for the disposable, mixing and bioreactors used by the pharmaceutical, chemical, biotechnology or food industries.
  • a device for non-contact transmission of electrical energy which has a feeding part with an induction coil, the electrical energy is supplied, and a plurality of powered parts, each with one arranged in a magnetic field generated by the induction coil induced coil ,
  • the powered parts differ in the load part, wherein each of the powered parts having different load parts has an electric power matching section corresponding to the single feeding part to supply electric power in response to the electric power supply Receive load part of the feeding part.
  • the individual feeding part is used, whereby only the fed parts take into account the load difference.
  • a bioreactor comprising a container, a shaft housing for passing a shaft through a wall, a stirrer connected to the shaft in the interior of the container, a drive arranged outside the container, connectable to the shaft, wherein the shaft is mounted in the shaft housing via at least one ball bearing and sealed by at least one seal with respect to the shaft housing, characterized in that the seal as a
  • Radial shaft sealing ring with two arranged in the longitudinal direction of the shaft successively, is formed on the shaft dry running sealing lips, that the radial shaft seal to the interior of the container towards a closed end face, which merges in the radial direction in a trained as a protective lip sealing lip, and that the radial shaft seal to the outside lying drive has a sealing lip, which is pressed by a spring ring sealing against the shaft surface.
  • the disadvantage here is that an opening in the bioreactor for the agitator shaft must be present through the lying outside the bioreactor drive motor for the agitator shaft. Thus, sterility is not completely ensured by, for example, design errors or faulty seals.
  • a bioreactor in which the drive does not affect the sterility of the container interior of the disposable container. This is achieved by a mixing system consisting of a disposable container with flexible walls and a mixing device inside of the bioreactor has an encapsulated drive and a mixer shaft. It is disadvantageous that the drive motor is present in the interior of the bioreactor, since it can, for example, to thermal or similar influences, such as when the engine heats up and thus influences the medium in the bioreactor. Damage to the engine is also conceivable if high temperatures or humidities prevail within the bioreactor.
  • the invention is therefore based on the object to provide a device with which energy-requiring bioreactor components are supplied with the maintenance of sterility safe and reliable with electrical energy.
  • the object is achieved by a device according to claim 1.
  • the device according to the invention transfers contactless electrical energy for one or more bioreactor components.
  • energy is inductively supplied to a receiver component.
  • the transmitter component is placed outside the bioreactor. A stationary placement is possible. Due to the inductive energy transfer to the receiver component, it is possible without cabling to supply bioreactor components with energy. This is particularly advantageous when high humidity or sour ambient air prevail.
  • the transmitter and receiver components are preferably axially opposite and are arranged at a defined distance from each other. This distance is particularly preferably between 0 mm and 5 mm.
  • the Transmission is independent of the axial angular position of the components with each other. Ideally, transmitted signals behave as if there were a direct electrical connection from the source to the load.
  • the at least one component is arranged within the bioreactor.
  • the receiver component which supplies the at least one component with electrical energy is preferably also inside the bioreactor.
  • the bioreactor is made of flexible plastic.
  • Such disposable bioreactors must be inexpensive to implement.
  • the transmitter component may be stationary and reusable. Thus, only the receiver component needs to be discarded after use.
  • implementation of wireless inductive power supply through a flexible plastic wall is easy to implement. The efficiency can thus be kept high and it comes to low losses.
  • the at least one component is a sensor device, a drive for a mixer shaft, a valve system, a port system, a gassing device or another component which requires energy.
  • the component has the receiver component, which, for example, can be integrated directly into the component.
  • the mixer shaft is set in rotation. But it is For example, a linear up and down movement conceivable.
  • the receptor component can be sterilized by radiation while retaining its functionality.
  • radiation for example, the usual for disposable bioreactors gamma radiation is applicable.
  • sterilization by means of ionizing radiation, UV-C, beta or electron radiation can be realized.
  • the transmission component is an induction coil and the receiver component is an induced coil.
  • Induction coil is supplied with electricity and generates a magnetic field.
  • the receiver component has at least one accumulator which stores the electrical energy supplied by the transmission component and delivers it to a motor for starting or operating the bioreactor component (s).
  • Bioreactor within the bioreactor already be powered, and it is not necessary that the recipient of the bioreactor acquires a transmission component.

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Power Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne un dispositif de transmission d'énergie électrique sans contact pour des composants de bioréacteurs. Les bioréacteurs connus présentent souvent des ouvertures afin de garantir une alimentation en énergie au moyen de câbles ou d'entraîner un arbre d'agitateur. De telles ouvertures ne sont ni sûres ni fiables du point de vue de la stérilité. Le dispositif de transmission d'énergie électrique sans contact selon l'invention est équipé d'un composant de transmission et d'un composant de réception. Le composant de transmission transmet de l'énergie électrique sur une base inductive à au moins un composant d'un bioréacteur. Le dispositif selon l'invention convient en particulier pour des bioréacteurs dans l'industrie pharmaceutique, chimique, biotechnologique ou agro-alimentaire.
PCT/EP2011/003941 2010-09-02 2011-08-05 Dispositif de transmission d'énergie électrique sans contact pour des composants de bioréacteurs Ceased WO2012028242A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010036193A DE102010036193A1 (de) 2010-09-02 2010-09-02 Vorrichtung zur kontaktlosen Übertragung elektrischer Energie für Bioreaktorbauteile
DE102010036193.3 2010-09-02

Publications (1)

Publication Number Publication Date
WO2012028242A1 true WO2012028242A1 (fr) 2012-03-08

Family

ID=44651606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/003941 Ceased WO2012028242A1 (fr) 2010-09-02 2011-08-05 Dispositif de transmission d'énergie électrique sans contact pour des composants de bioréacteurs

Country Status (2)

Country Link
DE (1) DE102010036193A1 (fr)
WO (1) WO2012028242A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109997942A (zh) * 2019-05-06 2019-07-12 北京红螺食品有限公司 一种果脯加工用消毒灭菌设备

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726840A1 (de) 1996-06-25 1998-01-02 Matsushita Electric Works Ltd Vorrichtung zur berührungslosen Übertragung elektrischer Energie
WO2005118771A2 (fr) * 2004-06-04 2005-12-15 Xcellerex, Inc. Systemes de bioreacteurs jetables et procedes associes
DE102006022651B3 (de) * 2006-05-12 2007-10-18 Sartorius Biotech Gmbh Behälter mit flexiblen Wänden
EP2020433A2 (fr) * 2007-07-30 2009-02-04 Xcellerex, Inc. Système de bioréacteur à perfusion continue
DE102008025507A1 (de) 2008-05-28 2009-12-03 Sartorius Stedim Biotech Gmbh Mischsystem
DE102008010427B4 (de) 2008-02-21 2010-05-12 Sartorius Stedim Biotech Gmbh Bioreaktor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726840A1 (de) 1996-06-25 1998-01-02 Matsushita Electric Works Ltd Vorrichtung zur berührungslosen Übertragung elektrischer Energie
WO2005118771A2 (fr) * 2004-06-04 2005-12-15 Xcellerex, Inc. Systemes de bioreacteurs jetables et procedes associes
DE102006022651B3 (de) * 2006-05-12 2007-10-18 Sartorius Biotech Gmbh Behälter mit flexiblen Wänden
EP2020433A2 (fr) * 2007-07-30 2009-02-04 Xcellerex, Inc. Système de bioréacteur à perfusion continue
DE102008010427B4 (de) 2008-02-21 2010-05-12 Sartorius Stedim Biotech Gmbh Bioreaktor
DE102008025507A1 (de) 2008-05-28 2009-12-03 Sartorius Stedim Biotech Gmbh Mischsystem

Also Published As

Publication number Publication date
DE102010036193A1 (de) 2012-03-08

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