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WO2012028167A3 - Acridinium ester chemiluminescence upon reductive triggering - Google Patents

Acridinium ester chemiluminescence upon reductive triggering Download PDF

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Publication number
WO2012028167A3
WO2012028167A3 PCT/EP2010/057017 EP2010057017W WO2012028167A3 WO 2012028167 A3 WO2012028167 A3 WO 2012028167A3 EP 2010057017 W EP2010057017 W EP 2010057017W WO 2012028167 A3 WO2012028167 A3 WO 2012028167A3
Authority
WO
WIPO (PCT)
Prior art keywords
acridinium ester
reductive
triggering
mixtures
ester chemiluminescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/057017
Other languages
French (fr)
Other versions
WO2012028167A2 (en
Inventor
Bert Zomer
Henk Bloemen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INNOHYPHEN BV
Original Assignee
INNOHYPHEN BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INNOHYPHEN BV filed Critical INNOHYPHEN BV
Priority to PCT/EP2010/057017 priority Critical patent/WO2012028167A2/en
Publication of WO2012028167A2 publication Critical patent/WO2012028167A2/en
Publication of WO2012028167A3 publication Critical patent/WO2012028167A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21K—NON-ELECTRIC LIGHT SOURCES USING LUMINESCENCE; LIGHT SOURCES USING ELECTROCHEMILUMINESCENCE; LIGHT SOURCES USING CHARGES OF COMBUSTIBLE MATERIAL; LIGHT SOURCES USING SEMICONDUCTOR DEVICES AS LIGHT-GENERATING ELEMENTS; LIGHT SOURCES NOT OTHERWISE PROVIDED FOR
    • F21K2/00—Non-electric light sources using luminescence; Light sources using electrochemiluminescence
    • F21K2/06—Non-electric light sources using luminescence; Light sources using electrochemiluminescence using chemiluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Electromagnetism (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

Acridinium esters show strong chemiluminescence under reducing conditions. Reducing conditions involve reduced metal ions or reduced aromatic quinones. This chemistry can be used in the detection and quantification of acridinium ester, (mixtures) of oxidants or (mixtures) of reducing compounds.
PCT/EP2010/057017 2010-05-20 2010-05-20 Acridinium ester chemiluminescence upon reductive triggering Ceased WO2012028167A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2010/057017 WO2012028167A2 (en) 2010-05-20 2010-05-20 Acridinium ester chemiluminescence upon reductive triggering

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2010/057017 WO2012028167A2 (en) 2010-05-20 2010-05-20 Acridinium ester chemiluminescence upon reductive triggering

Publications (2)

Publication Number Publication Date
WO2012028167A2 WO2012028167A2 (en) 2012-03-08
WO2012028167A3 true WO2012028167A3 (en) 2012-05-18

Family

ID=45524469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/057017 Ceased WO2012028167A2 (en) 2010-05-20 2010-05-20 Acridinium ester chemiluminescence upon reductive triggering

Country Status (1)

Country Link
WO (1) WO2012028167A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102018015288A2 (en) 2017-08-08 2021-11-09 Euroimmun Medizinische Labordiagnostika Ag METHOD TO PROVE A BASOPHIL ACTIVATION
EP4010704A1 (en) 2019-08-06 2022-06-15 Euroimmun Medizinische Labordiagnostika AG An improved autoantibody detection assay

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522677A1 (en) * 1991-07-10 1993-01-13 TDK Corporation Method of measuring concentration of immunoreactant using electrochemiluminescence
US6045727A (en) * 1996-01-16 2000-04-04 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
US20090148879A1 (en) * 2007-12-10 2009-06-11 Mattingly Phillip G Stabilizing Compositions, Methods and Kits for Chemiluminescent Assays
WO2010045986A1 (en) * 2008-10-24 2010-04-29 Zomerbloemen Bv Method to measure total antioxidant capacity and total oxidative power

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515469A (en) 1965-01-22 1966-07-25
US6002007A (en) 1988-02-20 1999-12-14 Dade Behring Marburg Gmbh Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays
JP3207933B2 (en) 1992-09-09 2001-09-10 株式会社ヤトロン Light emission method of acridinium derivative and method of detecting target substance using the same
EP0761652A1 (en) 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof
WO1998002421A1 (en) 1996-07-16 1998-01-22 De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods
US6673560B1 (en) 1998-11-25 2004-01-06 Bayer Corporation Measurement of hydride using chemiluminescent acridinium compounds and applications thereof
US7309615B2 (en) 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
EP1994007A4 (en) 2006-02-07 2010-10-27 Siemens Healthcare Diagnostics SOLID PHASE SYNTHESIS OF ACRIDINIUM DERIVATIVES

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522677A1 (en) * 1991-07-10 1993-01-13 TDK Corporation Method of measuring concentration of immunoreactant using electrochemiluminescence
US6045727A (en) * 1996-01-16 2000-04-04 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
US20090148879A1 (en) * 2007-12-10 2009-06-11 Mattingly Phillip G Stabilizing Compositions, Methods and Kits for Chemiluminescent Assays
WO2010045986A1 (en) * 2008-10-24 2010-04-29 Zomerbloemen Bv Method to measure total antioxidant capacity and total oxidative power

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAOXIN LI ET AL: "Flow-Injection Simultaneous Chemiluminescence Determination of Ascorbic Acid and L-Cysteine with Partial Least Squares Calibration", MICROCHIMICA ACTA ; AN INTERNATIONAL JOURNAL ON MICRO AND TRACEANALYSIS, SPRINGER-VERLAG, VI, vol. 149, no. 3-4, 1 April 2005 (2005-04-01), pages 205 - 212, XP019377118, ISSN: 1436-5073, DOI: 10.1007/S00604-005-0325-8 *
BAOXIN LI ET AL: "Secondary chemiluminescence emission of the luminol-ferricyanide system induced by reducing agents", MICROCHIMICA ACTA ; AN INTERNATIONAL JOURNAL ON MICRO AND TRACEANALYSIS, SPRINGER-VERLAG, VI, vol. 162, no. 1-2, 22 October 2007 (2007-10-22), pages 189 - 198, XP019633447, ISSN: 1436-5073 *
WILLIAM J COOPER ET AL: "A chemiluminescence method for the analysis of H2O2 in natural waters", MARINE CHEMISTRY, vol. 70, no. 1-3, 1 May 2000 (2000-05-01), pages 191 - 200, XP055021986, ISSN: 0304-4203, DOI: 10.1016/S0304-4203(00)00025-6 *

Also Published As

Publication number Publication date
WO2012028167A2 (en) 2012-03-08

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