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WO2012023937A1 - Optique et lentilles intraoculaires pour inhiber la migration cellulaire et réduire la dysphotopsie de bord optique - Google Patents

Optique et lentilles intraoculaires pour inhiber la migration cellulaire et réduire la dysphotopsie de bord optique Download PDF

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Publication number
WO2012023937A1
WO2012023937A1 PCT/US2010/045923 US2010045923W WO2012023937A1 WO 2012023937 A1 WO2012023937 A1 WO 2012023937A1 US 2010045923 W US2010045923 W US 2010045923W WO 2012023937 A1 WO2012023937 A1 WO 2012023937A1
Authority
WO
WIPO (PCT)
Prior art keywords
optic
peripheral edge
edge surface
anterior
flat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/045923
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English (en)
Inventor
Valdemar Portney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/US2010/045923 priority Critical patent/WO2012023937A1/fr
Publication of WO2012023937A1 publication Critical patent/WO2012023937A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/16965—Lens includes ultraviolet absorber
    • A61F2002/1699—Additional features not otherwise provided for

Definitions

  • This invention relates to intraocular lenses (IOLs) and, more particularly, to IOL which inhibits cell migration from the eye onto an optical zone of the IOL and reduce optic edge dysphotopsia in the eye.
  • IOLs intraocular lenses
  • An intraocular lens is commonly used to replace the natural lens of a human eye for aphakia treatment. It is common practice to implant an IOL in a region of the eye known as the capsular bag. There are two problems with many IOLs following implantation in the capsular bag:
  • a common treatment for this condition is to use a laser to destroy the cells and a central region of the posterior capsular bag. Although this treatment is effective and is usually done when the vision diminishes to unacceptable level. There is also cost associated with the laser treatment. In addition, it also may result in the IOL positional shift in the capsular bag thus affecting IOL optical performance,
  • US Patent 6,162,249 describes the IOLs with optic peripheral edge having a substantially continuous curved configuration relative to the central optical axis in order to maintain square-edge IOL feature to have a sharp edge at the junction between peripheral edge surface and optical surface of the IOL and, as a result, to inhibit cell migration together with the reduction of edge glare or dysphotopsia.
  • peripheral edge shape thus limiting the edge shape to certain configurations which might not be optimal for reduction in edge dysphotopsia.
  • the common process to produce optic peripheral edge of the optic is to use milling where the endmill cuts out the lens shape from the button or cut the corresponding shape in the mold for the optic molding.
  • To produce the optic peripheral edge shape that is not parallel to the optical axis would require a specially shaped endmill and its precise location along the vertical axis parallel to the optical axis or additional fabrication process to polish out the optic periphery edge to a desirable configuration.
  • IOLs which inhibit growth of cells at the IOL placed in the capsular bag and further optimize the optic peripheral edge shape for dysphotopsia reduction and also to allow using conventional manufacturing processes.
  • IOLs have been discovered that combine ease of manufacturing with an unlimited configurations of the optic peripheral edge to diverge the reflected light over the wide area of the retina. Such IOLs are effective to inhibit cell migration due to the presence of sharp discontinuity between the optical peripheral edge surface and lens anterior or posterior surface.
  • the optic peripheral edge surface can maintain flat shape parallel to the optical axis of the optic and as such, easy to manufacture with a commonly available endmill and utilizing conventional manufacturing processes.
  • the IOLs in accordance with the present invention includes an optic having a central optical axis, an optic anterior surface, an opposing optic posterior surface and an optic peripheral edge between the optic surfaces.
  • the optic of the IOL is adapted for placement in the capsular bag of the eye and for focusing light toward the eye's retina.
  • the IOLs in accordance with the present invention further include at least one fixation member commonly called a haptic, and preferably two fixation members, connected to the optic for fixation the IOL in the eye.
  • the IOL may include a plate shape haptc or include the optic consisting of several lenses.
  • the optic peripheral edge of the present IOLs include an undulated or periodic segment of a substantially continuous configuration in the direction around the central optical axis of the optic, meaning in the plane perpendicular to the optical axis of the optic.
  • a preferable embodiment includes the entire optic peripheral edge having a substantially continuous curved configuration of variable curvature i.e., undulated or periodic in the plane perpendicular to the optical axis thus maintaining the cylinder shape of the optic peripheral edge substantially around the optic.
  • variable curvature of substantially continuous curved configuration includes radii with their optical centers either within the optic and outside the optic and also being substantially smaller the radius of the optic of equivalent dimension but circular shape of substantially constant radius.
  • the presence of the regions of smaller radii results in broad divergence of the reflected from the optic peripheral edge light over much larger retinal area than in the circular shape optic with substantially constant radius of the flat peripheral edge. Therefore, the present IOLs lead to reduced edge dysphotopsia in the eye relative to the dysphotopsia gained with a substantially identical IOL with optic shape of substantially constant radius and peripheral edge surface of flat peripheral edge.
  • optic peripheral edge of the disclosed IOL maintains discontinues sharp corner (corner edge) between the optic peripheral edge surface and optical surface, so called square-edged shape as the prior art square-edged IOL with the optic of a substantially constant radius.
  • the flat peripheral edge between anterior and posterior surfaces of the invented IOL may be tilted from preferable parallel to central optical axis configuration to up about 45 degrees to the central optical axis.
  • the preferable embodiment maintains discontinuous sharp corners between the optical peripheral edge and both anterior and posterior optical surfaces.
  • FIG. 1 is a partial cross-sectional view of an optic of a prior art IOL.
  • FIG. 2 is a partial cross-sectional view of another optic of a prior art IOL.
  • FIG. 3 is a plane view of one embodiment of IOL in accordance with the present invention superimposed over the equivalent IOL shape but with circular optic of substantially constant radius.
  • FIG. 4 is a cross-sectional view taken generally along line 4-4 of FIG. 3.
  • FIG. 5 is a plane of a segment taken from the IOL of FIG 3.
  • FIG. 1 illustrates a partial cross-sectional view of an optic 10 of a prior art IOL which has curved optic peripheral edge 30 along the central optical axis 50 as compared with a flat optic peripheral edge 40 (dashed line) that is parallel to the optical axis 50.
  • the optic peripheral edge maintains sharp corner edge 35 with anterior or posterior surface 20 similai' to the flat optic peripheral edge 40 to provide inhibition of cell growth.
  • Curved optic peripheral edge 30 provides a reduction in dysphotopsia as compared with flat circular peripheral edge 40 of the optic with substantially constant radius.
  • FIG. 2 illustrates a partial cross-sectional view of an optic 100 of another prior art IOL which has more complex curved optic peripheral edge 130 along the central optical axis 150 as compared with the flat optic peripheral edge 140 that is parallel to the optical axis 150.
  • the optic peripheral edge also maintains sharp corner edge 135 with anterior or posterior surface 110 similar to the flat optic peripheral edge 140 to provide inhibition of cell growth.
  • Curved optic peripheral edge 130 also provides a reduction in dysphotopsia as compared with flat circular peripheral edge 140 of the optic with substantially constant radius.
  • FIG. 3 illustrates a plane view of an embodiment of IOL 200 in accordance with the present invention.
  • the optic 205 incorporates an undulated or periodic peripheral edge 210 around the optic except at the location of the fixation members 230 and 240.
  • the optic 205 of optic diameter "d” is superimposed over the optic of constant radius that is half of "d” and with circular peripheral edge 220.
  • the optic 205 has central optical axis 260 which is also the optical axis of the optic with circular peripheral edge 220.
  • the optic may have an oval shape and the corresponding diameter is the average diameter of smallest and largest optic diameters.
  • the optic 205 is circular shape in plan, with an undulated or periodic peripheral edge 210 and bi-convex shape with the optical axis 260.
  • this configuration is clearly illustrative as other configurations and shapes may be employed.
  • the optic 205 may be constructed of any of the commonly utilized IOL materials used for rigid optics, such as polymethylmethacrylate (PMMA), or commonly employed materials used for deformable optics, such as silicone polymeric materials, acrylic polymeric materials, hydrogel-forming polymeric materials and the like.
  • PMMA polymethylmethacrylate
  • silicone polymeric materials such as silicone polymeric materials, acrylic polymeric materials, hydrogel-forming polymeric materials and the like.
  • Two fixation members 230 and 240 in this embodiment are generally C or J-shaped and are connected to the optic 205.
  • the segment 250 of the optic 205 that includes variable radii of the peripheral edge 210 and the central optical axis 260 is referenced to in order to explain the invented IOL in more details in the following figure.
  • FIG. 4 illustrates a cross-sectional view taken generally along line 4—4 of FIG. 3.
  • the preferred embodiment of peripheral edge 210 of the optic 205 is shown as flat and parallel to the optical axis 260 and include discontinuous sharp edges 215 and 225 between the peripheral edge surface and anterior and posterior surfaces 270 and 275.
  • the peripheral edge 220 of the optic of substantially constant radius of half diameter "d" shown on FIG. 3 is also included for the reference.
  • the inhibition of the cell and reduction of the edge glare per the invented IOL can be achieved with the peripheral edge being substantially flat with discontinuous sharp corner edge forming between the peripheral edge surface and only one of the anterior and posterior surfaces.
  • the substantially flat peripheral edge surface can be tilted to the optical axis by up to about 45 degrees.
  • FIG. 5 explains the invented IOL in more details on the example of the segment 250 of FIG. 3.
  • the peripheral edge 210 within the segment 250 of the optic 205 includes the regions "A" and "B” of substantially continuous curvatures which include radii and "Ro" somewhere within the corresponding regions "A” and “B” correspondent ⁇ .
  • the central optical axis 260 and the peripheral edge 220 of substantially constant radius with the same optical axis 260 are shown on the figure.
  • the radius has the center of radius 280 within the optic 205 and is substantially smaller the distance between peripheral edge 220 and optical axis 260.
  • the radius "Ro" has the center of radius 290 outside the optic 205 and is also substantially smaller the distance between peripheral edge 220 and optical axis 260.
  • the segment 250 of the preferred embodiment includes the regions "A" and "B" that are connected and repeated substantially over the whole peripheral edge 210 of the optic 205 in FIG. 3.
  • the regions can be located at substantially different parts of the optic peripheral edge and without a repetition.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une lentille intraoculaire implantable dans un œil comprenant une optique qui peut être placée dans le sac capsulaire de l'œil et diriger la lumière vers la rétine de l'œil. L'optique comprend un axe optique central, une surface antérieure, une surface postérieure opposée et une surface de bord périphérique optique entre lesdites surfaces. Le bord périphérique comprend des régions de conception sensiblement continue dont les rayons sont tels que leurs centres optiques se trouvent soit à l'intérieur soit à l'extérieur de l'optique, et sont sensiblement plus petits que le rayon de l'optique de dimension équivalente mais de forme circulaire d'un rayon sensiblement constant. La surface de bord périphérique présente une conception sensiblement plane dans la direction entre les surfaces. L'intersection de la surface de bord périphérique et de la surface antérieure et/ou de la surface postérieure forme un bord de coin pointu discontinu.
PCT/US2010/045923 2010-08-18 2010-08-18 Optique et lentilles intraoculaires pour inhiber la migration cellulaire et réduire la dysphotopsie de bord optique Ceased WO2012023937A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2010/045923 WO2012023937A1 (fr) 2010-08-18 2010-08-18 Optique et lentilles intraoculaires pour inhiber la migration cellulaire et réduire la dysphotopsie de bord optique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/045923 WO2012023937A1 (fr) 2010-08-18 2010-08-18 Optique et lentilles intraoculaires pour inhiber la migration cellulaire et réduire la dysphotopsie de bord optique

Publications (1)

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WO2012023937A1 true WO2012023937A1 (fr) 2012-02-23

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Family Applications (1)

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PCT/US2010/045923 Ceased WO2012023937A1 (fr) 2010-08-18 2010-08-18 Optique et lentilles intraoculaires pour inhiber la migration cellulaire et réduire la dysphotopsie de bord optique

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020128647A1 (fr) * 2018-12-21 2020-06-25 Alcon Inc. Bord à courbures multiples pour lentilles ophtalmiques
WO2025104362A1 (fr) 2023-11-14 2025-05-22 Voptica S.L. Lentille intraoculaire pour chirurgie de cataractes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264692B1 (en) * 1992-09-28 2001-07-24 Bausch & Lomb Surgical, Inc. Ophthalmic lens with reduced edge glare and method of making
US20080077239A1 (en) * 2006-09-21 2008-03-27 Advanced Medical Optics, Inc. Intraocular lenses for managing glare, adhesion, and cell migration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264692B1 (en) * 1992-09-28 2001-07-24 Bausch & Lomb Surgical, Inc. Ophthalmic lens with reduced edge glare and method of making
US20080077239A1 (en) * 2006-09-21 2008-03-27 Advanced Medical Optics, Inc. Intraocular lenses for managing glare, adhesion, and cell migration

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020128647A1 (fr) * 2018-12-21 2020-06-25 Alcon Inc. Bord à courbures multiples pour lentilles ophtalmiques
US11607308B2 (en) 2018-12-21 2023-03-21 Alcon Inc. Multi-curvature edge for ophthalmic lenses
WO2025104362A1 (fr) 2023-11-14 2025-05-22 Voptica S.L. Lentille intraoculaire pour chirurgie de cataractes

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