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WO2012022467A3 - Nouveaux dérivés de benzoquinone et utilisation de ces dérivés en tant que modulateurs de la fonction mitochondriale - Google Patents

Nouveaux dérivés de benzoquinone et utilisation de ces dérivés en tant que modulateurs de la fonction mitochondriale Download PDF

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Publication number
WO2012022467A3
WO2012022467A3 PCT/EP2011/004122 EP2011004122W WO2012022467A3 WO 2012022467 A3 WO2012022467 A3 WO 2012022467A3 EP 2011004122 W EP2011004122 W EP 2011004122W WO 2012022467 A3 WO2012022467 A3 WO 2012022467A3
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Prior art keywords
modulators
mitochondrial function
benzoquinone derivatives
novel benzoquinone
novel
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PCT/EP2011/004122
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English (en)
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WO2012022467A2 (fr
Inventor
Achim Feurer
Barbara Hoffmann-Enger
Holger Deppe
Michael Soeberdt
Nuri Gueven
Roman Haefeli
Fabrice Heitz
Michael Erb
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Santhera Pharmaceuticals Schweiz GmbH
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Santhera Pharmaceuticals Schweiz GmbH
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Priority to EP11746182.2A priority Critical patent/EP2606022A2/fr
Publication of WO2012022467A2 publication Critical patent/WO2012022467A2/fr
Publication of WO2012022467A3 publication Critical patent/WO2012022467A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/28—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of non-condensed quinone rings
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne de nouveaux dérivés de benzoquinone. Ces composés sont efficaces en tant que modulateurs de la fonction mitochondriale et sont utiles dans le traitement d'états pathologiques caractérisés par une fonction mitochondriale altérée.
PCT/EP2011/004122 2010-08-16 2011-08-16 Nouveaux dérivés de benzoquinone et utilisation de ces dérivés en tant que modulateurs de la fonction mitochondriale Ceased WO2012022467A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11746182.2A EP2606022A2 (fr) 2010-08-16 2011-08-16 Nouveaux dérivés de benzoquinone et utilisation de ces dérivés en tant que modulateurs de la fonction mitochondriale

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US37396210P 2010-08-16 2010-08-16
EP10008541.4 2010-08-16
US61/373,962 2010-08-16
EP10008541 2010-08-16
US201061424958P 2010-12-20 2010-12-20
US61/424,958 2010-12-20
EP10015843.5 2010-12-20
EP10015843 2010-12-20

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WO2012022467A3 true WO2012022467A3 (fr) 2012-06-28

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WO2012167122A1 (fr) 2011-06-03 2012-12-06 Indiana University Research And Technology Corporation Composés, compositions et méthodes de traitement de troubles de dommage oxydant de l'adn
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
AU2013329171A1 (en) * 2012-10-10 2015-04-30 Arizona Board Of Regents, On Behalf Of Arizona State University Multifunctional radical quenchers
JP6405312B2 (ja) * 2012-10-23 2018-10-17 ニコックス サイエンス アイルランド 眼科用のキノン系一酸化窒素供与化合物
EP2970158B1 (fr) 2013-03-15 2019-02-20 BioElectron Technology Corporation Dérivés de quinone à groupe alkyle-hétéroaryle substitué de traitement de troubles de stress oxydatif
JP6461150B2 (ja) 2013-07-31 2019-01-30 ノバルティス アーゲー １，４−二置換ピリダジン誘導体およびｓｍｎ欠損に関連する状態を処置するためのその使用
US20170182117A1 (en) * 2014-05-28 2017-06-29 Stealth Biotherapeutics Corp Therapeutic compositions including therapeutic small molecules and uses thereof
CN104387253A (zh) * 2014-11-03 2015-03-04 南昌大学 α–生育醌在治疗糖尿病或肥胖症药物中的应用
US10472340B2 (en) 2015-02-17 2019-11-12 Arizona Board Of Regents On Behalf Of Arizona State University Substituted phenothiazines as mitochondrial agents
EP3719006B1 (fr) 2015-02-17 2022-04-06 Arizona Board of Regents on behalf of Arizona State University Compositions pharmaceutiques comprenant dérivés du 2-amino-pyrimidin-5-ol deutérés et non-deutérés pour le traitemnt de maladies mitochondriales (par ex. obésité)
TW201720437A (zh) * 2015-10-29 2017-06-16 Tohoku Techno Arch Co Ltd 肌萎縮性疾病治療劑
AU2016369616B2 (en) * 2015-12-17 2021-03-25 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
US11390605B2 (en) 2016-08-25 2022-07-19 Arizona Board Of Regents On Behalf Of Arizona State University Substituted pyrimidine compounds as multifunctional radical quenchers and their uses
KR20210093957A (ko) 2018-12-18 2021-07-28 스텔스 바이오테라퓨틱스 코포레이션 미토콘드리아-표적화 펩타이드
CA3156499A1 (fr) * 2019-10-04 2021-04-08 Stealth Biotherapeutics Inc. Analogues chinone, hydrochinone et naphtochinone de vatiquinone pour le traitement de maladies a troubles mitochondriaux
WO2021202986A1 (fr) 2020-04-03 2021-10-07 Stealth Biotherapeutics Corp Compositions et méthodes pour la prévention et/ou le traitement d'une maladie mitochondriale, notamment l'ataxie de friedreich
CN116172993A (zh) * 2023-04-27 2023-05-30 潍坊医学院附属医院 艾地苯醌在制备预防和/或治疗脑缺血再灌注损伤的药物中的应用

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