WO2012022341A1 - Composition and use thereof for reducing body weight and/or improving endurance during and regeneration after a physical activity is performed - Google Patents

Abstract

The invention relates to a composition, which contains a) a mixture of extracts from blood oranges, oranges, bitter oranges, and grapefruits and b) L-carnitine or a salt thereof. The invention further relates to the use of the composition according to the invention for reducing body weight and/or improving endurance during and regeneration after a physical activity is performed, and kit of parts, said kit containing the composition according to the invention.

Description

 Composition and its use for reducing body weight and / or improving endurance and recovery after

Exercise of a physical activity

The present invention relates to a composition and its

Use to reduce body weight and / or to improve endurance and regeneration after exercising a physical activity.

Means for reducing body weight are known. For example, Dallas, C. et al. : Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP phosphodiesterase (PDE). Phytomedicine 15: 783-792, 2008, an extract of blood oranges, grapefruit, oranges, bitter oranges and guarana, which can help lower body weight and prevent obesity.

Furthermore, Nardon et al. Green coffee extract Svetol ^® can manage weight: a review. AgroFood industry hi-tech 18, No.5: 37-39, 2007, a green coffee extract suitable for weight loss.

A composition that includes orange, pomelo, blood orange and

Bitter orange extract and a green coffee extract is, for example, under the name Thermo forehead from the manufacturer Olimp

Laboratories Sp. Z oo. (Debica, Poland).

WO 2009/066303 A2 describes a composition containing at least two extracts obtained from Curcuma longa, Moringa oleifera and Murraya koenigii. Optionally, the composition may contain other agents such as, among others, bitter orange extract, green coffee extract, carnitine, chromium picolinate, and green tea extract. US 2009/02 14 680 A1 describes a composition containing L-carnitine as a lipolytic agent.

A capsule with a variety of ingredients for a fast

Fat reduction is commercially available under the name Hellburner from the manufacturer Peak Performance Products S.A (Luxembourg). It contains, among many other plant extracts, bitter orange extract and L-carnitine tartrate.

A composition for aiding muscle building is available under the name Universal Nutrition Animal M-Stak 21 Paks from the manufacturer Universal Nutrition (New Brunswick, USA). It contains a flavon-sterone complex, growth hormone release agents, carnitine, anti-aromatase inhibitors, DHT blockers, carbohydrate metabolizers, a metabolic energy complex such as bitter orange extract, a liver detoxification complex and others Ingredients.

The above compositions have a variety of ingredients to which a variety of effects are attributed.

By Saper, R.B. et al. : Common Dietary Supplements for Weight Loss. In Am. Fern. Physican, Vol. 70, 2004, No. 9, pp. 1731-1738 describes the suitability of a variety of weight loss agents such as bitter orange extract, guarana, green tea extract and L-carnitine for weight loss. The effectiveness of the investigated funds is therefore not yet proven.

Reducing body weight through dieting and / or taking weight loss supplements can be positively supported by exercising. Overweight people fall physical

However, exercises are often difficult because, in addition to a lack of endurance, the body requires a long period of regeneration, which is often associated with fatigue and dullness, and therefore the exercise of a sporting activity severely limits. But even normal-weight people often come in particular in endurance sports at their physical limits, which require a long recovery time after exercise. A long period of regeneration of the body means an inevitable break and severely restricts exercise.

It is therefore an object of the present invention to provide a composition capable of reducing body weight and / or improving endurance and regeneration after a physical activity.

According to the invention the object is achieved by a composition according to claim 1.

The composition of the invention contains

a) a mixture of extracts of blood oranges, oranges, bitter oranges and grapefruit, and

b) L-carnitine or a salt thereof.

Component a) supports the release of fatty acids in an organism. Component b) acts as a carrier that transports fatty acids into the mitochondria. The fatty acids are burned. In combination with component b) component a) increases the burning of fat so that more energy is made available to the body. The combination of components a) and b) is therefore suitable for the reduction of body weight and / or for the improvement of endurance during and regeneration after the exercise of a physical activity.

Objects of the present invention are also the use of the composition according to the invention for reducing body weight and / or for improving endurance during and after regeneration

Performing a physical activity as well as a kit of parts that the

composition according to the invention. For the purposes of the present invention, an "extract" in accordance with component a) is understood to mean extracts from plants, in particular the fruits, more particularly the fruit juice, the shells and seeds The extract is preferably in solid, more preferably pulverulent, form.

Blood oranges correspond to Citrus sinensis L. Osbeck, oranges Citrus aurantium L. var. Sinensis / _. , Bitter oranges Citrus aurantium L. var. Amara and grapefruit Citrus paradisi. Blood oranges, oranges, bitter oranges and grapefruits belong to the genus of the citrus family of the family Rautengewächse. Ingredients of an extract of citrus trees are in particular polyphenols, in particular flavonoids.

An extract of fruits based on citrus fruits such as blood oranges, oranges, bitter oranges and grapefruit has a polyphenolic mixture of flavonoids such as anthocyanins such as delphinidin-3-glucoside, cyanidin-3-glucoside, pelargonidin-3-glycoside, peonidin-3-glucoside and Malvidin-3-glucoside and flavanones such as narirutin, naringin, hesperidin and neohesperidin.

Component a) preferably has the following ingredients: a total content of polyphenols of more than 60%, preferably less than 90% and a content of flavanones of more than 10%, preferably less than 20%. Preferably, component a) is present as a powder. The powder may be used as such or may be converted to another desired galenic form prior to use.

Component a) represents in particular an extract from the fruits of the plants, wherein all parts of the fruits such as juice, peel and seeds and all kinds of fruits such as fresh, dried and frozen fruits can be used for extraction. The choice of raw material, extraction conditions and extractant allow to extract with the desired

Produce ingredients. The skilled worker is familiar with processes for the preparation of an extract according to component a). Usually, the Preparation of an extract from fruits First, liquid fruit components such as the juice separated from the solid fruit components such as peels and seeds by cold pressing the fruits and filtering. While shells and seeds are extracted to obtain an extract with an extraction liquid, which is optionally subjected to a column separation, the

Centrifuged fruit juice to remove fine solid fruit components, decanted and then subjected to column separation.

Steps for the preparation of component a) can therefore one or more of the steps of crushing, pressing, extracting, centrifuging,

Filter and column separation of fruits include. For example, the desired choice of crops is pressed individually or mixed cold. Seeds and peel of the fruits are separated from the fruit juice by filtration, which is optionally brought to a pH of 1, 5 to 2 with hydrochloric acid or formic acid and centrifuged. For further separation of desired or

unwanted substances, the liquid phase can continue to one

Be subjected to column separation and then optionally concentrated under vacuum. For example, the seeds and skins are subjected to hydroalcoholic extraction, after centrifuging the hydroalcoholic extract, the liquid phase is subjected to column separation to separate desired extract ingredients, and

then optionally concentrated under vacuum. The fruit juice, seed and shell concentrates obtained can be mixed and dried. If necessary, they are filtered before drying. In order to obtain a uniform powder, the extract obtained is preferably sieved.

The advantage of using an extract in the invention

Composition is in the natural composition of the ingredients, in particular the flavonoids and flavonones obtained. It is particularly advantageous that the nutritive activity of the resulting flavonoids and flavanones can be higher than when using isolated components. By selecting the fruit raw material, the extraction conditions, the

Extractant, the separation column material and the separation column solvent The content of the extract can be adjusted to desired ingredients such as certain flavonoids. The same can be done by selecting the

Fruit raw material, the extraction conditions, the extractant, the separation column material and the separation column solvent, the content of the

Extract of unwanted ingredients are excluded.

Another advantage of using an extract over a mixture of isolated components is that, on the one hand, plants represent steadily renewable raw materials and, on the other hand, complicated chemical synthesis steps for producing individual natural substances and the associated waste products are avoided.

As component a) a mixture of extracts of blood oranges, oranges, bitter oranges and grapefruit is used. The citrus fruits may be in front

Preparation of the extract are mixed. Alternatively or additionally, the extracts obtained from the individual citrus fruits are mixed. For the preparation of the extract, the fruit juice of blood oranges and are advantageous

Oranges and the shells and seeds used by blood oranges, oranges, bitter oranges and grapefruits.

Component b) preferably represents a salt of L-carnitine. More preferred component b) is L-carnitine tartrate.

In a preferred embodiment, the composition further contains c) an extract of guarana and / or

d) an extract of green tea.

 Both guarana extract and green tea extract have a high level of native caffeine that promotes drive and concentration.

Component c) represents an extract from guarana. Guarana belongs to the plant genus Paullinia of the family of soap tree plants. Guarana is Paullinia cupana. Component c) is an extract of the guarana fruits, especially the seeds of Fruits is obtained. One ingredient of an extract of guarana is caffeine. Component c) therefore has caffeine. Component c) can by a

A method can be obtained which is carried out analogously to the method for producing an extract, as described for component a). Preferably, the extract is prepared from peeled and dried seeds subjected to hydroalcoholic extraction, and the resulting extract is optionally subjected to column separation, concentration and drying. Again, by choosing raw material and

Extraction conditions of the content of desired ingredients such as caffeine can be adjusted. Component c) is preferably present as a powder.

Component d) is an extract obtained from the leaves of green tea. The leaves are extracted. If necessary, the extract is concentrated, columned and / or dried. Preferably, component d) is in powder form.

In a further preferred embodiment, the composition further contains

e) at least one antioxidant selected from the group consisting of vitamin C, vitamin E and mixtures thereof.

 The above antioxidants act as scavengers and protect against oxidation of sensitive molecules. Component e) can be vitamin C. Alternatively, component e) may represent vitamin E. Preferably, component e) is a mixture of vitamin C and vitamin E. The ratio of vitamin C to vitamin E is preferably in the range of 5: 1 to 1: 1, more preferably 2.5: 1.

In a further preferred embodiment, the composition further contains alternatively or additionally

f) selenium.

 Selenium is the central atom of peroxidase, a repair enzyme. Selenium acts as a radical scavenger and plays an important role in the protection of

Cell membranes from oxidative destruction. By the component selenium the composition of the invention ensures adequate supply of this trace element and prevents deficiency symptoms, which may be associated in particular with a body weight reduction.

In a further preferred embodiment, the composition further contains alternatively or additionally

g) chromium picolinate.

 Component g) has an effect on the sugar balance. It influences the utilization of insulin in the body.

Alternatively or additionally, the composition according to the invention also contains

h) a Synephrine-containing extract of Citrus aurantium.

Component h) is an extract of bitter orange containing synephrine. Component h) stimulates thermogenesis, i. The dissipation of energy by generating heat and thus supports an effect of reducing body weight by the release of heat of the body.

Component h) is advantageously present in powder form. If component a) comprises an extract of bitter oranges, component h) corresponds to component a) at least partially. However, the extract according to component a) may be synephrine-free even if it contains an extract of bitter oranges.

Furthermore, the composition according to the invention preferably further contains i) an extract of green coffee.

 Component i) causes a reduced uptake of sugar in the intestine and a reduced release of sugar from the liver. At the same time is the

Fatty acid release increased, i. Fat burning is increased while lowering insulin levels. Overall, this is the

Fatty acid replacement process is supported.

Component i) is an extract obtained from the coffee beans of green coffee, the term "green" meaning that the coffee beans are raw and unroasted, and the extract may be of the same type obtained as described in relation to component a). In particular, the coffee beans are subjected to a hydroalcoholic extraction and the extract optionally to a column separation, to concentration and drying. Component i) is preferably an extract of green

Coffee beans. Robusta coffee is used as green coffee. Alternatively or additionally, green coffee is used for the era bica coffee. Component i) is particularly preferably an extract from beans of Coffea canephora robusta Pierre. Both Robusta coffee (Coffea canephora robusta Pierre) and Arabica coffee (Coffea arabica) belongs to the

Plant genus Coffee of the family of the redness family. The extract preferably has a caffeine content of <2%, more preferably 0%. This extract is preferably in powder form. He preferably has one

Total content of polyphenols from 50 to 55%, a total content

Chlorogenic acids (t-CGA) of 45 to 50%, a content of 5-caffeoylquinic acid (5-CQA) of 10 to 15%, caffeine 0 to 2% and a ratio of 5-CQA / t-CGA of 0.2 to 0.3 on. In addition to 5-caffeoylquinic acid, the extract also contains 3-caffeoylquinic acid and 4-caffeoylquinic acid. In addition, the extract contains dicaffeoylquinic acids. The extract preferably contains neither Cafestol nor Kahweol. The choice of raw material, extraction conditions and

Extractants allow to prepare an extract with the desired ingredients.

The composition of the invention may be in solid, semi-liquid and liquid dosage form. It may be present, for example, as a powder, tablet, effervescent tablet, chewable tablet, pill, hard or soft capsule such as gelatin capsule, dragee, granules, emulsion, suspension, paste, gel, liquid or bar. In particular, pills, tablets, dragées or bars may continue to be coated. The composition according to the invention may therefore contain at least one carrier, processing, auxiliary or additive or mixtures thereof. The person skilled in the art is aware of carriers, processing aids, auxiliaries or additives for the preparation of the abovementioned galenic forms. Preferably, the composition of the invention is in powder or capsule form. By way of example, carriers, processing agents, auxiliaries or additives may be mentioned which may be present in the composition according to the invention, without, however, restricting it to them.

Examples of a carrier include water, dairy product such as

for example, milk or yoghurt, dextrose, starch, gelatin or maltodextrin.

For the purposes of the present invention, a processing substance is, for example, a filler or free-flowing substance such as calcium carbonate or magnesium stearate

Mold release agent or a disintegrant.

For the purposes of the present invention, an adjuvant is, for example, an agent for improving the bioavailability, for improving the texture, for

Improving solubility, improving dissolution rate, improving durability, a disintegrant, a viscosity increasing or decreasing agent, a stabilizer such as gum arabic

Humectants such as glycerine or an emulsifier such as soy lecithin.

Examples of an additive include acidulants such as apple or

Citric acid, flavoring, taste-masking substances, taste-improving substances, colorants, sweeteners such as acesulfame K, fiber or

Coating materials such as sugar, shellac or celluloses.

The composition according to the invention can be used as a food,

Dietary supplements, dietary supplements, OTC medicines or medicines. The skilled artisan may suitably select a carrier, processing, auxiliary, additive or mixtures thereof to provide the desired formulation.

For example, the composition according to the present invention may be a food in the form of a solid such as a bar, a liquid as a drink or an emulsion or suspension such as a yogurt.

Furthermore, the composition may be a dietary supplement in the form of a granule, a tablet, for example effervescent tablet or a gel. Again, the shape of a powder is also conceivable.

Furthermore, it is possible that the composition of the invention, a dietary agent, for example in the form of a capsule, a tablet, a

Dragees, a chewable tablet, a paste or a powder.

Further, the composition of the present invention may be an OTC drug or a drug, for example, in the form of a powder, a tablet, a pill, a capsule, a granule or a liquid. Preferably, the composition according to the invention is in powder tablet, capsule or granule form or liquid. More preferably, the composition is in the form of a capsule and granules. Most preferably, the composition is in the form of a capsule.

 The composition of the invention is particularly suitable for

Reducing body weight and / or improving endurance during and after physical exercise. For the purposes of the present invention, "exercise of a physical activity" in particular a physically strenuous activity such as the exercise of sports such as running, swimming, cycling or strength training

Understood. Preferably, the composition of the present invention is used to reduce body weight and / or to improve endurance during and after sports exercise.

The composition according to the invention may be a mixture of

Component a), component b) and optionally the components c), d), e), f), g), h) and / or i). In a preferred embodiment, the composition is in capsule form. The composition may be divided into one or more capsules. The at least one capsule contains in addition to the component a) and the

Component b) preferably component c) and component d). The at least one capsule preferably contains 300 to 1300 mg, component a) and 100 to 1300 mg of component b). Preferably, the at least one capsule contains 300 to 1300 mg of component a), 100 to 1300 mg of component b), 40 to 500 mg

Component c) and 40 to 300 mg of component d). The composition may be divided into several capsules taken at the same time or throughout the day. In this case, a capsule preferably contains 150 to 650 mg of component a) and 50 to 650 mg of component b). In this case, a capsule preferably contains 150 to 650 mg of component a), 50 to 650 mg

Component b), 20 to 250 mg of component c) and 20 to 150 mg of component d). More preferably, in this case, one capsule contains 200 to 500 mg

Component a), 100 to 500 mg of component b), 20 to 200 mg of component c) and 20 to 150 mg of component d). Such a composition is particularly suitable for use before exercising a sporting activity.

The present invention further relates to a kit-of-parts comprising the

Composition according to the invention comprises separated from each other. The kit-of-parts or the composition comprises separately

 A) a composition containing component a),

 B) a composition containing component b).

 For the purposes of the present invention, compositions A) and

Composition B) administered at the same time or with a time offset or

be taken. Composition A) may consist of component a). Alternatively, composition A) contains further components in addition to component a)

Ingredients. Likewise, composition B) may consist of component b). Alternatively, composition B) contains further components in addition to component b)

Ingredients. The compositions A) and B) may be in the same galenical form or in different galenic forms.

Preferably, compositions A) and B) are in powder and / or gelatin capsule form. The kit of parts comprises in a preferred embodiment

A) a composition according to the invention comprising component a), component b) and component c),

 B) a further composition according to the invention, component a),

 Component b), component c) and component i),

 C) a composition containing component i).

In a preferred embodiment, the inventive

Composition Component of a kit-of-parts that is separate from each other

 A) a composition according to the invention comprising component a), component b), component c), component d), component e) and component f),

 B) a further composition according to the invention, component a),

 Component b), component c), component d), component g),

 Component h) and component i),

 C) a composition comprising component e), component f), component g), component h) and component i).

The compositions A), B) and C) can all be in the same galenic form or in different galenic forms. Preferably, the compositions A), B) and C) are in powder and / or

Gelatin capsule form before.

The composition of the invention may be administered alone or as part of a kit-of-parts. When the composition of the present invention is used as a means of improving endurance and regeneration after exercising sports or other physical activities, a single dose before exercise is usually sufficient. When the composition according to the invention is used as an agent for

Bodyweight reduction, administration is advantageous as part of a kit-of-parts whose components are distributed throughout the day, for example, in the morning, at noon and in the evening, in order to achieve a permanent supply and / or effect throughout the day.

The composition according to the invention is preferably administered in such a way that it mixes as active ingredients per day

 300 to 1300 mg, preferably 300 to 950 mg, more preferably 400 to 920 mg, component a) and

 - 100 to 1300 mg, preferably 150 to 950 mg, more preferably 150 to 650 mg, component b).

The amount of component b) refers to the amount of carnitine. When using a carnitine salt, the stated amounts of component b) refer to the amount of carnitine contained in the carnitine salt, not on the amount of carnitine salt.

Another composition of the present invention is administered so as to mix each day as effective ingredients

 From 300 to 1300 mg, preferably from 300 to 950 mg, component a),

 100 to 1300 mg, preferably 150 to 950 mg, component b) and

 40 to 500 mg, preferably 70 to 450 mg, component c) and / or

- 40 to 300 mg, preferably 50 to 250 mg, component d).

 The above compositions may be used in addition to components a) and b) and optionally c) and / or d)

 20 to 100 mg, preferably 30 to 80 mg, component e) and / or

- 10 to 80 μξ, preferably 20 to 70 μξ, component f).

Alternatively or additionally, the above compositions may be used in addition to components a) and b) and optionally c), d), e) and f)

 0, 1 to 2.5 mg, preferably 0, 5 to 2.0 mg, component g) and / or

10 to 200 mg, preferably 25 to 150 mg, component h) and / or

- 100 to 600 mg, preferably 150 to 400 mg, component i). When the composition of the present invention is used as a means of improving endurance in and regeneration after exercising sports or other physical activities, a single ingestion before performing the activity is sufficient.

When the composition according to the invention is used as an agent for

Body weight reduction is used as part of a kit-of-parts, the administration is preferably dosed per day so that the inventive kit-of-parts comprises separately

 A) a composition containing 300 to 1300 mg of component a), and

B) a composition containing 100 to 1300 mg of component b).

For example, the compositions A) and B) are present separately in powder form, wherein the daily rations are identified. Before ingestion, the compositions A) and / B) can optionally be mixed or taken separately.

However, the components a) and b) of the kit-of-parts need not be completely separate, but may be present at least partially mixed. More preferably, the kit includes parts

 A) the composition according to the invention, which contains 150 to 650 mg of component a) and 50 to 650 mg of component b), and

 B) the composition according to the invention which contains 150 to 650 mg of component a), 50 to 650 mg of component b) and 50 to 300 mg of component i).

 Optionally, the kit-of-parts can continue

 C) a composition containing 50 to 300 mg of component i). The compositions A), B) and C) are preferably in the morning (composition A)), at noon (composition B)) and in the evening

(Composition C)) taken. Composition A) activates the lipid metabolism in the morning. Composition B) keeps the fat metabolism active at noon. The additional component i) with regard to composition A) reduces the uptake of sugar from the intestine and the liberation of glucose from the liver. Overall, the fat burning is promoted.

Composition C) keeps fat burning active in the evening. Preferably, the administration is dosed per day such that the

inventive kit-of-parts separated from each other

 A) the composition of the invention, the 150 to 650 mg component a), 50 to 650 mg component b), 20 to 250 mg component c), 20 to 150 mg component d), 10 to 50 mg component e) and 5 to 40 μξ contains component f),

 B) the composition according to the invention comprising 150 to 650 mg of component a), 50 to 650 mg of component b), 20 to 250 mg of component c), 20 to 150 mg of component d), 0.05 to 1, 25 mg of component g) , 5 to 100 mg of component h) and 50 to 300 mg of component i),

 C) a composition containing 10 to 50 mg component e), 5 to 40 μξ

 Component f), 0.05 to 1, 25 mg of component g), 5 to 100 mg of component h) and 50 to 300 mg of component i).

More preferably, the administration is dosed per day such that the

inventive kit-of-parts separated from each other

 A) the composition according to the invention, the 400 to 600 mg component a), 150 to 450 mg component b), 50 to 200 mg component c), 50 to 150 mg component d), 15 to 40 mg component e) and 10 to 30 μξ contains component f),

 B) the composition according to the invention comprising 400 to 600 mg of component a), 150 to 450 mg of component b), 50 to 200 mg of component c), 50 to 150 mg of component d), 0.5 to 1, 5 mg of component g) Containing 40 to 60 mg of component h) and 150 to 250 mg of component i),

 C) a composition containing 15 to 40 mg component e), 10 to 30 μξ

 Component f), 0, 5 to 1, 5 mg component g), 40 to 60 mg component h) and 150 to 250 mg component i).

The present invention will now be described in more detail with reference to examples. However, the examples do not limit the present invention. In all examples, extracts are used which are in powder form. It is understood that the dosage forms of the invention

Composition comprising powder, tablet, effervescent tablet, chewable tablet, pill, hard or soft capsule such as gelatin capsule, dragee, granules, emulsion, suspension, paste, gel, liquid or bar, the usual carrier, processing, formulation used for the formulation , Auxiliaries and / or additives. In the examples, only the active substances contained are listed. The compositions listed in the examples can be used as such in powder form or converted into another galenic form with the addition of further substances.

In the examples, L-carnitine tartrate is used. 220 mg L-carnitine tartrate corresponds to about 150 mg L-carnitine.

example 1

Example 1 shows a composition according to the invention:

Component quantity

 Extract of a mixture of blood orange, orange, 400 mg

Bitter orange and grapefruit

 Guarana extract 150 mg

 L-carnitine tartrate 220 mg

 Green tea extract 100 mg

 Vitamin C 25 mg

 Vitamin E 10 mg

 Selenium 25 μξ

Example 2

Example 2 shows a further composition according to the invention: component

 Extract of a mixture of blood orange, orange

 Bitter orange and grapefruit

 Guarana extract

 L-carnitine tartrate

 Green tea extract

 Chromium picolinate

 Synephrine-containing extract of Citrus aurantium

Extract of green coffee

Example 3

Example 3 shows a kit of parts according to the invention.

In Example 1, a composition (referred to herein as Composition A3) and in Example 2 is a composition (referred to herein as

Composition B3) of a kit-of-parts according to the invention.

Composition A3 is formulated as two hard gelatin capsules. That is, the composition of Example 1 is divided among the two capsules such that both capsules taken together contain the amounts of active ingredients indicated in Example 1. Two capsules are taken in the morning.

Composition B3 is formulated as two hard gelatin capsules. That is, the composition of Example 2 is divided among the two capsules such that both capsules taken together contain the amounts of active ingredients given in Example 1. Two capsules are taken at noon.

The following composition (referred to herein as Composition C3) forms part of the kit-of-parts of the invention and is formulated as a hard gelatin capsule containing an amount of active ingredients as indicated below. One capsule is taken in the evening.

Composition C3: Component quantity

 Extract of green coffee 200 mg

 Vitamin C 25 mg

 Vitamin E 10 mg

 Selenium 25 μξ

 Chromium picolinate 1 mg

 Synephrine-containing extract of Citrus aurantium 50 mg

The combination of the three above compositions A3, B3 and C3 is particularly suitable for the reduction of body weight.

Example 4

Example 4 shows a further composition according to the invention:

Component quantity

 Extract of a mixture of blood orange, orange, 400 mg

Bitter orange and grapefruit

 Guarana extract 100 mg

 L-carnitine tartrate 450 mg

 Green tea extract 50 mg

The composition of Example 4 is formulated such that two hard gelatin capsules contain the indicated amount of active ingredients. The composition shown in Example 4 is particularly useful for improving endurance during exercise and regeneration after exercise has ceased, and is suitable for athletes as well as for people starting to exercise. Two capsules are preferably taken 1 to 2 hours before exercising.

Claims

claims: 1 . Composition containing  a) a mixture of extracts of blood oranges, oranges, bitter oranges and grapefruit,  b) L-carnitine or a salt thereof. 2. Composition according to claim 1, characterized in that  Component b) represents L-carnitine tartrate. 3. Composition according to claim 1 or claim 2, characterized  that they continue  c) an extract of guarana and / or  d) contains a green tea extract. 4. Composition according to one of the preceding claims 1 to 3,  characterized in that it continues  e) at least one antioxidant selected from the group consisting of vitamin C, vitamin E and mixtures thereof and / or  f) contains selenium. 5. Composition according to one of the preceding claims 1 to 4,  characterized in that it continues  g) chromium picolinate and / or  h) contains a synephrine-containing extract of Citrus aurantium. 6. Composition according to one of the preceding claims 1 to 5,  characterized in that it continues  i) contains a green coffee extract. 7. Composition according to one of the preceding claims 1 to 6, characterized in that as food, Dietary supplements, dietary supplements, OTC medicines or as  Drug is formulated. 8. Composition according to one of claims 1 to 7, characterized  characterized in that it is in powder or capsule form. 9. Composition according to one of the preceding claims 1 to 8,  characterized in that they per day  300 to 1300 mg, preferably 350 to 950 mg, component a) and  - 100 to 1300, preferably 150 to 950 mg, component b). 10. The composition according to any one of claims 1 to 9, characterized  characterized in that it is in capsule form and 150 to 650 mg,  Component a), 50 to 650 mg of component b), preferably, the composition contains 150 to 650 mg of component a), 50 to 650 mg  Component b), 20 to 250 mg of component c) and 20 to 150 mg  Component d). 1 1. A kit of parts comprising a composition according to any one of claims 1 to 10 separately from one another  A) a composition containing component a), and  B) a composition containing component b). 12. Kit-of-parts according to claim 1 1, comprising separated from each other  A) a composition containing component a) and component b), and  B) a composition, component a), component b) and  Component i) contains. 13. Kit-of-parts according to claim 1 1 or 12, comprising separated from each other A) a composition containing 150 to 650 mg component a) and 50 to 650 mg component b), B) a composition containing 150 to 650 mg component a), 50 to 650 mg component b) and 50 to 300 mg component i),  C) a composition containing 50 to 300 mg component i). 14. Kit-of-parts according to one of claims 1 1 to 13, comprising separated  from one another  A) the composition comprising 150 to 650 mg component a), 50 to 650 mg component b), 20 to 250 mg component c), 20 to 150 mg component d), 10 to 50 mg component e) and 5 to 40 μξ Contains component f)  B) the composition comprising 150 to 650 mg component a), 50 to 650 mg component b), 20 to 250 mg component c), 20 to 150 mg component d), 0.05 to 1, 25 mg component g), Contains 5 to 100 mg of component h) and 50 to 300 mg of component i),  C) a composition containing 10 to 50 mg component e), 5 to 40 μξ  Component f), 0.05 to 1, 25 mg of component g), 5 to 100 mg of component h) and 50 to 300 mg of component i). 15. Use of a composition according to any one of claims 1 to 10 or kit-of-parts according to any one of claims 1 1 to 14 for reducing body weight and / or for improving endurance in and  Regeneration after exercising a physical activity.