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WO2012019000A3 - Biomarkers for the identification monitoring and treatment of ovarian cancer - Google Patents

Biomarkers for the identification monitoring and treatment of ovarian cancer Download PDF

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Publication number
WO2012019000A3
WO2012019000A3 PCT/US2011/046581 US2011046581W WO2012019000A3 WO 2012019000 A3 WO2012019000 A3 WO 2012019000A3 US 2011046581 W US2011046581 W US 2011046581W WO 2012019000 A3 WO2012019000 A3 WO 2012019000A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
treatment
ovarian cancer
identification monitoring
monitoring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/046581
Other languages
French (fr)
Other versions
WO2012019000A2 (en
Inventor
William E. Pierceall
Kam Marie Sprott
David T. Weaver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
On-Q-ity
On Q ity
Original Assignee
On-Q-ity
On Q ity
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by On-Q-ity, On Q ity filed Critical On-Q-ity
Publication of WO2012019000A2 publication Critical patent/WO2012019000A2/en
Publication of WO2012019000A3 publication Critical patent/WO2012019000A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/54—Determining the risk of relapse

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This present provides methods of treating cancer and methods of assessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.
PCT/US2011/046581 2010-08-04 2011-08-04 Biomarkers for the identification monitoring and treatment of ovarian cancer Ceased WO2012019000A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37054610P 2010-08-04 2010-08-04
US61/370,546 2010-08-04

Publications (2)

Publication Number Publication Date
WO2012019000A2 WO2012019000A2 (en) 2012-02-09
WO2012019000A3 true WO2012019000A3 (en) 2012-05-24

Family

ID=45560069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/046581 Ceased WO2012019000A2 (en) 2010-08-04 2011-08-04 Biomarkers for the identification monitoring and treatment of ovarian cancer

Country Status (1)

Country Link
WO (1) WO2012019000A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807823C (en) 2010-08-24 2023-02-07 The Brigham And Women's Hospital, Inc. Methods for predicting anti-cancer response
WO2012174378A2 (en) 2011-06-17 2012-12-20 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
AU2012358244A1 (en) 2011-12-21 2014-06-12 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
EP4462120A3 (en) 2012-02-23 2025-01-08 Children's Medical Center Corporation Methods for predicting response to parp inhibitors
US11091808B2 (en) 2012-06-07 2021-08-17 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors
WO2014160080A1 (en) * 2013-03-14 2014-10-02 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
CN105531590A (en) * 2013-09-17 2016-04-27 利兰斯坦福初级大学董事会 Ovarian Cancer Biomarkers
US11149316B2 (en) 2013-12-09 2021-10-19 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors
ES3039109T3 (en) 2014-08-15 2025-10-17 Myriad Genetics Inc Methods and materials for assessing homologous recombination deficiency
US11594311B1 (en) 2016-03-31 2023-02-28 OM1, Inc. Health care information system providing standardized outcome scores across patients
US11967428B1 (en) 2018-04-17 2024-04-23 OM1, Inc. Applying predictive models to data representing a history of events
US11862346B1 (en) 2018-12-22 2024-01-02 OM1, Inc. Identification of patient sub-cohorts and corresponding quantitative definitions of subtypes as a classification system for medical conditions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059013A1 (en) * 2002-08-06 2005-03-17 The Johns Hopkins University Use of biomarkers for detecting ovarian cancer
US20070141582A1 (en) * 2005-12-15 2007-06-21 Weiwei Li Method and kit for detection of early cancer or pre-cancer using blood and body fluids
US20070292883A1 (en) * 2006-06-12 2007-12-20 Ossovskaya Valeria S Method of treating diseases with PARP inhibitors
US20080038723A1 (en) * 2004-06-07 2008-02-14 Bitter Grant A Functional assessment of DNA mismatch repair gene variants
US20100068818A1 (en) * 2006-10-04 2010-03-18 The Johns Hopkins University Algorithms for multivariant models to combine a panel of biomarkers for assessing the risk of developing ovarian cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059013A1 (en) * 2002-08-06 2005-03-17 The Johns Hopkins University Use of biomarkers for detecting ovarian cancer
US20080038723A1 (en) * 2004-06-07 2008-02-14 Bitter Grant A Functional assessment of DNA mismatch repair gene variants
US20070141582A1 (en) * 2005-12-15 2007-06-21 Weiwei Li Method and kit for detection of early cancer or pre-cancer using blood and body fluids
US20070292883A1 (en) * 2006-06-12 2007-12-20 Ossovskaya Valeria S Method of treating diseases with PARP inhibitors
US20100068818A1 (en) * 2006-10-04 2010-03-18 The Johns Hopkins University Algorithms for multivariant models to combine a panel of biomarkers for assessing the risk of developing ovarian cancer

Also Published As

Publication number Publication date
WO2012019000A2 (en) 2012-02-09

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