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WO2012018635A3 - Dérivés d'arylsulfonamide, compositions en contenant et leurs méthodes d'utilisation - Google Patents

Dérivés d'arylsulfonamide, compositions en contenant et leurs méthodes d'utilisation Download PDF

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Publication number
WO2012018635A3
WO2012018635A3 PCT/US2011/045390 US2011045390W WO2012018635A3 WO 2012018635 A3 WO2012018635 A3 WO 2012018635A3 US 2011045390 W US2011045390 W US 2011045390W WO 2012018635 A3 WO2012018635 A3 WO 2012018635A3
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disorders
pain
migraine
disease
aura
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WO2012018635A2 (fr
Inventor
Stephen Wanaski
Stephen Collins
John Kincaid
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NeuroTherapeutics Pharma Inc
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NeuroTherapeutics Pharma Inc
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Priority to EP11815079.6A priority Critical patent/EP2598478A2/fr
Priority to CA2806664A priority patent/CA2806664A1/fr
Priority to JP2013521910A priority patent/JP2013536178A/ja
Publication of WO2012018635A2 publication Critical patent/WO2012018635A2/fr
Publication of WO2012018635A3 publication Critical patent/WO2012018635A3/fr
Anticipated expiration legal-status Critical
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    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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Abstract

La présente invention concerne des acylsulfonamides comprenant des dérivés de bumétanide, ainsi que des compositions contenant lesdits analogues. La présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que leurs méthodes d'utilisation. Tous ces analogues peuvent, en particulier, être utilisés en vue du traitement et/ou de la prophylaxie d'affections impliquant le cotransporteur Na+K+Cl- ou le récepteur GABAA, parmi lesquelles on peut notamment citer, mais la liste n'est pas limitative, les troubles addictifs, la maladie d'Alzheimer, les troubles de l'anxiété, l'ascite, le trouble déficitaire de l'attention avec hyperactivité, les troubles du spectre autistique (autisme), le trouble bipolaire, le cancer, l'amélioration de la fonction cognitive, la déficience cognitive, le dysfonctionnement cognitif, la dépression, la dystrophie de l'endothélium cornéen, l'œdème, l'épilepsie, le glaucome, la chorée de Huntington, la douleur inflammatoire, l'insomnie, l'ischémie, la migraine, la migraine avec aura, la migraine sans aura, la douleur neuropathique, la névralgie nociceptive, la douleur nociceptive, les maladies oculaires, la douleur, la maladie de Parkinson, le mouvement involontaire des membres, les troubles de la personnalité, la névralgie post-herpétique, la psychose, le syndrome des jambes sans repos, la schizophrénie, les troubles épileptiques, l'hypertonie spastique, les acouphènes et les syndromes de manque.
PCT/US2011/045390 2010-07-26 2011-07-26 Dérivés d'arylsulfonamide, compositions en contenant et leurs méthodes d'utilisation Ceased WO2012018635A2 (fr)

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EP11815079.6A EP2598478A2 (fr) 2010-07-26 2011-07-26 Dérivés d'arylsulfonamide, compositions en contenant et leurs méthodes d'utilisation
CA2806664A CA2806664A1 (fr) 2010-07-26 2011-07-26 Derives d'arylsulfonamide, compositions en contenant et leurs methodes d'utilisation
JP2013521910A JP2013536178A (ja) 2010-07-26 2011-07-26 アリールスルホンアミド誘導体、組成物、および使用方法

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