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WO2012018594A3 - Plant-derived polysaccharides for delivery of rna-based therapies - Google Patents

Plant-derived polysaccharides for delivery of rna-based therapies Download PDF

Info

Publication number
WO2012018594A3
WO2012018594A3 PCT/US2011/045239 US2011045239W WO2012018594A3 WO 2012018594 A3 WO2012018594 A3 WO 2012018594A3 US 2011045239 W US2011045239 W US 2011045239W WO 2012018594 A3 WO2012018594 A3 WO 2012018594A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna
delivery
plant
based therapies
derived polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/045239
Other languages
French (fr)
Other versions
WO2012018594A2 (en
Inventor
Alexzander A.A. Asea
Rajani Srinivasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor Scott and White Health
Original Assignee
Scott and White Healthcare
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scott and White Healthcare filed Critical Scott and White Healthcare
Publication of WO2012018594A2 publication Critical patent/WO2012018594A2/en
Publication of WO2012018594A3 publication Critical patent/WO2012018594A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compositions and methods are provided involving polysaccharides and nucleic acids. In particular embodiments, the nucleic acid is an siRNA directed to a mammalian heat shock protein coding sequence. In additional embodiments, the polysaccharide comprises galactomannan or galacturonic acid.
PCT/US2011/045239 2010-07-26 2011-07-25 Plant-derived polysaccharides for delivery of rna-based therapies Ceased WO2012018594A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36750710P 2010-07-26 2010-07-26
US61/367,507 2010-07-26
US201061424434P 2010-12-17 2010-12-17
US61/424,434 2010-12-17

Publications (2)

Publication Number Publication Date
WO2012018594A2 WO2012018594A2 (en) 2012-02-09
WO2012018594A3 true WO2012018594A3 (en) 2012-05-18

Family

ID=45559981

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/045239 Ceased WO2012018594A2 (en) 2010-07-26 2011-07-25 Plant-derived polysaccharides for delivery of rna-based therapies

Country Status (1)

Country Link
WO (1) WO2012018594A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040063654A1 (en) * 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
US20060240092A1 (en) * 2005-04-01 2006-10-26 Kurt Breitenkamp Polymeric micelles for drug delivery
US20070213287A1 (en) * 2000-03-03 2007-09-13 Genetronics, Inc. Nucleic Acid Formulations for Gene Delivery and Methods of Use
US20090142391A1 (en) * 2007-08-14 2009-06-04 Mutz Mitchell W Conjugated RNAi Therapeutics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070213287A1 (en) * 2000-03-03 2007-09-13 Genetronics, Inc. Nucleic Acid Formulations for Gene Delivery and Methods of Use
US20040063654A1 (en) * 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
US20060240092A1 (en) * 2005-04-01 2006-10-26 Kurt Breitenkamp Polymeric micelles for drug delivery
US20090142391A1 (en) * 2007-08-14 2009-06-04 Mutz Mitchell W Conjugated RNAi Therapeutics

Also Published As

Publication number Publication date
WO2012018594A2 (en) 2012-02-09

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