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WO2012016050A3 - Chemoradiotherapy for kras-mutant colorectal cancer - Google Patents

Chemoradiotherapy for kras-mutant colorectal cancer Download PDF

Info

Publication number
WO2012016050A3
WO2012016050A3 PCT/US2011/045735 US2011045735W WO2012016050A3 WO 2012016050 A3 WO2012016050 A3 WO 2012016050A3 US 2011045735 W US2011045735 W US 2011045735W WO 2012016050 A3 WO2012016050 A3 WO 2012016050A3
Authority
WO
WIPO (PCT)
Prior art keywords
kras
chemoradiotherapy
colorectal cancer
mutant colorectal
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/045735
Other languages
French (fr)
Other versions
WO2012016050A2 (en
Inventor
Kevin Haigis
Theodore Hong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of WO2012016050A2 publication Critical patent/WO2012016050A2/en
Publication of WO2012016050A3 publication Critical patent/WO2012016050A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to methods of treating KRAS-mutant cancers by administering a composition comprising Midostaurin (PKC-412), and methods for increasing the sensitivity of colorectal cancers to radiation, e.g., using Midostaurin (PKC-412) to radiosensitize colorectal cancers or cancer cells.
PCT/US2011/045735 2010-07-28 2011-07-28 Chemoradiotherapy for kras-mutant colorectal cancer Ceased WO2012016050A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36848210P 2010-07-28 2010-07-28
US61/368,482 2010-07-28

Publications (2)

Publication Number Publication Date
WO2012016050A2 WO2012016050A2 (en) 2012-02-02
WO2012016050A3 true WO2012016050A3 (en) 2012-05-24

Family

ID=45530722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/045735 Ceased WO2012016050A2 (en) 2010-07-28 2011-07-28 Chemoradiotherapy for kras-mutant colorectal cancer

Country Status (1)

Country Link
WO (1) WO2012016050A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015041837A1 (en) 2013-09-19 2015-03-26 The Research Foundation For The State University Of New York Methods and materials for treating diabetes or liver steatosis
JP2015096049A (en) * 2013-11-15 2015-05-21 凸版印刷株式会社 Method for predicting long-term efficacy of VEGF inhibitor
WO2016160590A1 (en) * 2015-03-27 2016-10-06 The Research Foundation For The State University Of New York Methods and materials for treating cancer
CA2981138A1 (en) 2015-03-27 2016-10-06 The Research Foundation For The State University Of New York Methods and materials for reducing amyloid beta levels within a mammal

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3325104A (en) * 1963-07-15 1967-06-13 Hartford Machine Screw Fuel injection nozzle
US6543421B2 (en) * 2000-03-21 2003-04-08 Siemens Automotive Corporation Fuel injector assembly for mounting a fuel injector to a fuel rail and permitting alignment of the fuel injector

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3325104A (en) * 1963-07-15 1967-06-13 Hartford Machine Screw Fuel injection nozzle
US6543421B2 (en) * 2000-03-21 2003-04-08 Siemens Automotive Corporation Fuel injector assembly for mounting a fuel injector to a fuel rail and permitting alignment of the fuel injector

Also Published As

Publication number Publication date
WO2012016050A2 (en) 2012-02-02

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