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WO2012013191A3 - Recombinant proteins as vaccines for protection against disease induced by infection with mink astrovirus - Google Patents

Recombinant proteins as vaccines for protection against disease induced by infection with mink astrovirus Download PDF

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Publication number
WO2012013191A3
WO2012013191A3 PCT/DK2011/050269 DK2011050269W WO2012013191A3 WO 2012013191 A3 WO2012013191 A3 WO 2012013191A3 DK 2011050269 W DK2011050269 W DK 2011050269W WO 2012013191 A3 WO2012013191 A3 WO 2012013191A3
Authority
WO
WIPO (PCT)
Prior art keywords
mink
vaccines
infection
protection against
astrovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2011/050269
Other languages
French (fr)
Other versions
WO2012013191A2 (en
Inventor
Claudia Baule
Mehdi Bidokhti
Karin Ullman
Anne Sofie Hammer
György CZIFRA
Mariann CHRIÉL
Hans Henrik Dietz
Peter SANDBØL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pelsdyrserhvervets Forsogs Og Forskningscenter/kopenhagen fur
Danmarks Tekniske Universitet
Statens Veterinarmedicinska Anstalt(sva)
Original Assignee
Pelsdyrserhvervets Forsogs Og Forskningscenter/kopenhagen fur
Danmarks Tekniske Universitet
Statens Veterinarmedicinska Anstalt(sva)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pelsdyrserhvervets Forsogs Og Forskningscenter/kopenhagen fur, Danmarks Tekniske Universitet, Statens Veterinarmedicinska Anstalt(sva) filed Critical Pelsdyrserhvervets Forsogs Og Forskningscenter/kopenhagen fur
Priority to EP11732353.5A priority Critical patent/EP2598520A2/en
Publication of WO2012013191A2 publication Critical patent/WO2012013191A2/en
Publication of WO2012013191A3 publication Critical patent/WO2012013191A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/12011—Astroviridae
    • C12N2770/12022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/12011—Astroviridae
    • C12N2770/12034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Pre-weaning diarrhoea, has been a problem in mink farms for many years. The "greasy kits" syndrome is a condition of newborn mink characterised by diarrhoea accompanied by skin swelling and redness, skin exudates and blackness of the nails. The present invention relates to polynucleotides and polypeptides of the capsid protein of a novel mink astrovirus strain denoted DK7627. Such polynucleotides and polypeptides may be used for the production of vaccines against mink astrovirus which may induce pre-weaning diarrhoea in minks. The invention furthermore relates to vectors, host cells, compositions and detection methods.
PCT/DK2011/050269 2010-07-30 2011-07-08 Recombinant proteins as vaccines for protection against disease induced by infection with mink astrovirus Ceased WO2012013191A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11732353.5A EP2598520A2 (en) 2010-07-30 2011-07-08 Recombinant proteins as vaccines for protection against disease induced by infection with mink astrovirus

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36928410P 2010-07-30 2010-07-30
EP10171394 2010-07-30
EP10171394.9 2010-07-30
US61/369,284 2010-07-30

Publications (2)

Publication Number Publication Date
WO2012013191A2 WO2012013191A2 (en) 2012-02-02
WO2012013191A3 true WO2012013191A3 (en) 2012-06-21

Family

ID=43500271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2011/050269 Ceased WO2012013191A2 (en) 2010-07-30 2011-07-08 Recombinant proteins as vaccines for protection against disease induced by infection with mink astrovirus

Country Status (2)

Country Link
EP (1) EP2598520A2 (en)
WO (1) WO2012013191A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149089A1 (en) * 2015-03-13 2016-09-22 The Regents Of The University Of California Subunit vaccine for prevention of astrovirus disease

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BASS DORSEY M ET AL: "Characterization of human serotype 1 astrovirus-neutralizing epitopes", JOURNAL OF VIROLOGY, vol. 71, no. 11, 1997, pages 8666 - 8671, XP002674748, ISSN: 0022-538X *
DATABASE EMBL [Online] 3 March 2003 (2003-03-03), "Mink astrovirus, complete genome.", XP002619615, retrieved from EBI accession no. EMBL:AY179509 Database accession no. AY179509 *
MITTELHOLZER CHRISTIAN ET AL: "Detection and sequence analysis of Danish and Swedish strains of mink astrovirus.", JOURNAL OF CLINICAL MICROBIOLOGY NOV 2003 LNKD- PUBMED:14605160, vol. 41, no. 11, November 2003 (2003-11-01), pages 5192 - 5194, XP002619617, ISSN: 0095-1137 *
MITTELHOLZER CHRISTIAN ET AL: "Molecular characterization of a novel astrovirus associated with disease in mink.", JOURNAL OF GENERAL VIROLOGY, vol. 84, no. 11, November 2003 (2003-11-01), pages 3087 - 3094, XP002619616, ISSN: 0022-1317 *
WANG QIU-HONG ET AL: "Genetic analysis of the capsid region of astroviruses", JOURNAL OF MEDICAL VIROLOGY, vol. 64, no. 3, July 2001 (2001-07-01), pages 245 - 255, XP002674749, ISSN: 0146-6615 *

Also Published As

Publication number Publication date
EP2598520A2 (en) 2013-06-05
WO2012013191A2 (en) 2012-02-02

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WO2012013191A3 (en) Recombinant proteins as vaccines for protection against disease induced by infection with mink astrovirus

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