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WO2012011009A1 - Améliorations apportées à la photothérapie - Google Patents

Améliorations apportées à la photothérapie Download PDF

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Publication number
WO2012011009A1
WO2012011009A1 PCT/IB2011/053026 IB2011053026W WO2012011009A1 WO 2012011009 A1 WO2012011009 A1 WO 2012011009A1 IB 2011053026 W IB2011053026 W IB 2011053026W WO 2012011009 A1 WO2012011009 A1 WO 2012011009A1
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WO
WIPO (PCT)
Prior art keywords
skin
filter
light
phototherapy
body portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/053026
Other languages
English (en)
Inventor
Liesbeth Van Pieterson
Franck Anton Van Abeelen
Guofu Zhou
Gerrit Oversluizen
Martinus Petrus Creusen
Jorgen Meeusen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Publication of WO2012011009A1 publication Critical patent/WO2012011009A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00477—Coupling
    • A61B2017/00482—Coupling with a code
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes

Definitions

  • the present disclosure relates to phototherapy, in particular to apparatus and methods for dermatological phototherapy.
  • the apparatus and methods may be used both in professional and domestic use, and for curative, cosmetic and wellness purposes.
  • UV ultraviolet
  • IR infrared
  • Infrared (IR) phototherapy is often used in the context of hair removal (depilation), where a sufficient amount of heat energy is needed near the hair shaft and hair bulb to 'burn' the hair. Such treatment should be performed without damaging the skin through energy absorption. The correct amount of energy deposition is generally determined by trial and error.
  • UV treatment is often used in treatment of various dermatological diseases such as e.g. psoriasis.
  • the main problem of UV treatment is that the absorbed UV radiation can cause DNA damage and skin cancer when the irradiation dose is too high.
  • a MED value minimum erythemal dose
  • the MED is the smallest dose to produce visible reddening of the skin, which is indicative of a skin irritation.
  • the MED indicates an upper dose limit but provides no useful information for doses below the MED, reducing usefulness of the parameter.
  • EP 1 797 923 discloses a phototherapy apparatus using excimer radiation in which, by skillful use of the individual peak wavelength of 308 nm and of the emission range of shorter wavelengths than 308 nm, the therapy effect is enhanced, and in which, at the same time, harm can be reduced. This is achieved using a XeCl excimer lamp and diseased sites of skin disorders are irradiated with UV-B radiation with an optical filter being used for changing the spectral shape of the UV-B radiation with which the diseased sites are irradiated.
  • EP 1 797 923 teaches to determine the strength of the filter to be used by trial and error, oscillating between ineffective therapy due to too low dosage and hurting the patient by too high dosage.
  • Bio-stimulating skin phototherapy may be applied for treating jaundice and psoriasis and may comprise curative phototherapy like wound healing or cosmetic phototherapy like rejuvenation.
  • a particular branch of bio- stimulating phototherapy is known as Low Level Light Therapy (or: LLLT).
  • LLLT Low Level Light Therapy
  • any damage to the tissue must be prevented. This poses significantly stricter requirements on the applied dose, since doses which are considered acceptable for the earlier-referenced fields of phototherapy may in fact already exceed stimulatory effective thresholds.
  • reducing the applied illumination doses for safety reasons can easily lead to administration of a dose which is therapeutically ineffective.
  • the concept of bio-stimulating phototherapy be it for curative or cosmetic purposes, is generally incompatible with determination of a correct dosage through trial and error.
  • An apparatus for bio-stimulating phototherapy of a subjects body portion which comprises a light source for providing light with a phototherapeutic wavelength and an optical filter for modifying at least a portion of the light emitted by the light source.
  • the apparatus is arranged for illuminating a skin portion of the body portion with the modified light.
  • the apparatus is formed for conforming to at least part of the body portion, e.g. being a human wearable object such as a deformable or flexible patch or bandage, which may be pliable.
  • the filter has a modification function corresponding to the skin type of the subject's skin portion.
  • the apparatus being formed for conforming to at least part of the body portion to be treated improves user comfort and allows prolonged treatment.
  • Such apparatus in particular in the form of a patch or bandage, may be worn inconspicuously under clothing.
  • Such apparatus allows improved and predictable illumination of the body portion since shifted illumination portions and/or shadows caused by relative movement of the apparatus and the body portion are prevented. Further, illumination at an oblique angle may be prevented which may otherwise cause undesired reflection of the light and inaccurate dosing.
  • the skin type determines the response of the skin to known illumination factors, such as tanning or sunburn in daylight.
  • Providing a modification filter function corresponding to the skin type reduces chances of over- or underdosing the phototherapy light.
  • the modification function may be wavelength dependent.
  • the skin type may be defined according to the Fitzpatrick scale. For more accurately determining the skin type, the skin type may be determined by the melanin index M and/or the lightness L* of the skin portion.
  • the melanin index M indicates the melanin content in the skin considered and the lightness L* is defined in 1976 by the Commission International d'Eclairage (CIE) and is a measure of how the human eye perceives the lightness of the skin, see M.D. Shriver and E.J. Parra, "Comparison of Narrow-band reflectance spectroscopy and tristimulus colorimetry for measurements of skin and hair color in persons of different biological ancestry", Amer. J Phys Philosophy 112: 17-27 (2000). In humans, melanin is almost exclusively located in the epidermis.
  • CIE Commission International d'Eclairage
  • the irradiation losses in the epidermis may be correctly assessed, and that for deeper-lying tissue (e.g. dermis, hypodermic tissue) absorption losses due to melanin are of little to no influence. Hence, the actually administered phototherapeutic dose into these deeper-lying tissues can be reliably assessed.
  • Determining the melanin index or the lightness of the skin portion provides quantitative information on, and determination of, the effective filtering function of the skin due to the melanin.
  • the melanin index M may be measured by apparatus commonly used in cosmetic industry, e.g. the Skin Pigmentation Analyzer ⁇ SPA 99 of CK electronic GmbH, or the DSM II ColorMeter by Cortex Technology, which latter apparatus can measure both the melanin index M and the lightness L*.
  • Measurement of the melanin index is preferred over measuring the lightness since it has been found that the melanin index is a more reliable parameter for quantifying the melanin content of the skin, seeshriver and Parra cited above.
  • Bio-stimulating phototherapy may comprise inter alia pain reduction, growth promotion, tissue restoration, treatment of (infantile) jaundice, for curative and/or substantially cosmetic treatments.
  • the apparatus, and in particular the filter may be arranged in close contact with the subjects skin portion to minimize light leakage and reduce protruding portions. In such case the material should be substantially bio-compatible.
  • the modification function may be wavelength dependent, e.g. transmitting or blocking one or more predetermined wavelength ranges, to accommodate a phototherapeutic wavelength range and/or sensitivity of the skin portion to a particular wavelength range, in particular when the light source produces light with a relatively broad emitted spectrum and/or when the light source provides high-intensity light at one or more wavelengths, compared to desired values of wavelength range and/or spectral intensity.
  • the filter may comprise an optically active portion which may shift at least a portion of the wavelength range emitted by the light source and incident on the filter to another wavelength range, which may be within and/or outside of the wavelength range emitted by the light source, so as to illuminate the skin portion of the body portion with the modified and wavelength shifted light.
  • Suitable materials are phosphors and fluorescent materials.
  • the optically active portion may comprise the entire filter.
  • the optically active material may change one or more of its properties as a function of the incident light, which may be substantially irreversible, e.g. coloring, bleaching, opacification, and/or otherwise aging.
  • the change when at least partially reversible, it may be used to adapt the modification function to (the duration of) the administered treatment, e.g. to increase or decrease the transmitted modified light and/or modified shifted light .
  • the apparatus may comprise an optical redistribution portion, which may be comprised at least partially in the filter, for distributing and/or redistributing the light from the light source into a desired direction.
  • the redistribution portion may comprise a reflector and/or diffuser. Such apparatus may improve homogeneity of the illumination.
  • the apparatus may be formed for facilitating exchanging the filter to provide a modification function corresponding to the skin type of other subject's skin portion.
  • the melanin index of the subject's body portion may vary. Exchanging the filter allows adapting to such varying circumstances and thus improving treatment for the same subject.
  • the filter may be attachable to and detachable from other portions comprised in the apparatus by using one or more adhesive materials, one or more fasteners and/or clamps, one or more hook-and-loop type fasteners, etc.
  • the filter is disposable which improves hygiene.
  • the above-described optically active portion may be used to indicate (the end of) a characteristic lifetime of the filter.
  • the apparatus may comprise an input system for determining a skin type and/or a filter type associated with a particular modification function, and the apparatus may comprise a controller for controlling operation of the apparatus, in particular the light source, as a function of the input skin type and/or modification function.
  • At least one of the inputs may comprise a user interface, e.g. with a selector switch having one or more settings, a keypad, or any other user interface.
  • the apparatus may comprise a sensor for non-invasively determining the skin type of a subject's skin portion and/or a sensor for determining the modification function of the filter, to provide at least partly automated determination of these aspects.
  • the apparatus comprises a sensor for non- invasively determining the melanin index and/or the lightness of the subject's skin portion, to objectively determine and quantify the skin type.
  • the operation of the apparatus may comprise indicating information relating to the determined skin type and/or modification function, respectively, for which one or more indicators may be provided.
  • a signal may be provided when the combination of the detected skin type and modification function fulfils, or does not fulfill, one or more predetermined criteria, e.g. a warning signal if an attenuation of the filter for one or more wavelength ranges is too weak or too strong for the skin type, or an "OK" signal if the skin type and the filter function correspond to each other. This facilitates selection of a filter with a modification function correctly corresponding to the skin type of the subject's skin portion and it prevents inappropriate, possibly ineffective or rather harmful use of the apparatus.
  • a filter sensor may be configured to detect a marking or code contained in or on the filter and/or its packaging, e.g. a bar code or a matrix code; the sensor may also be configured to measure transmittance of the filter at one or more wavelengths, with respect to one or more reference values, e.g. comparing modified light reflected off an object with unmodified light reflected off that object.
  • the skin type indicator and/or filter indicator may be separate or combined and may have any suitable form, e.g. a display indicating one or more alfanumeric indications, a series of light emitting diodes wherein one or more number of the diodes lights up corresponding to a certain skin type or modification function, respectively, a sound system, etc. or combinations thereof.
  • the filter indicator may also indicate that a filter has been used and/or changed to a predetermined extent, e.g. due to exposure or aging, e.g. for suggesting replacement of the filter.
  • a filter for use in such apparatus comprising a filter sensor may suitably comprise at least one marking corresponding to the modification function of the filter, wherein the at least one marking is readable by the input system for determining the modification function of the filter.
  • One or more filter markings may comprise expiry time/date information and the apparatus may comprise a clock and a controller for comparing the filter marking(s) with the clock for determining age of the filter.
  • the clock and controller may also be used for timing and/or controlling a treatment or treatment protocol.
  • a method of bio-stimulating phototherapy of a subject's body portion comprising non-invasively determining the skin type of a skin portion of the subject's body portion, providing an optical filter with a modification function corresponding to the determined skin type and providing light in a phototherapeutic wavelength from a light source through the optical filter.
  • the skin type is determined and defined by the melanin index M and/or the lightness L* of the skin portion.
  • the method applied with the apparatus may comprise the steps of selecting a bio-stimulating wavelength range to be used; determining a first phototherapeutic dose to be administered to the subjects body portion; determining the melanin index or the lightness at least at or near a skin portion of the body portion; calculating a second phototherapeutic dose as a function of the first dose, the selected wavelength range and the determined melanin index or lightness, respectively, of the skin portion; providing a filter with a modification function for modifying an emitted dose provided by the light source to the second
  • phototherapeutic dose and providing the second phototherapeutic dose to the body portion by illuminating at least the skin portion with modified light in the selected wavelength range.
  • the first and second phototherapy doses may comprise a full treatment dose or a predetermined portion thereof.
  • the melanin index and lightness may, and generally will be, dependent on the body portion, the skin portion (e.g. outside or inside of an upper arm) and the tanning of the skin portion. Further, the absorption of melanin and therewith the modification function are dependent on the wavelength of the phototherapy light. Taking such features into account allows providing an accurate prediction of the attenuation of an applied dose so that a second dose of phototherapeutic radiation may reliably be determined for achieving a desired first dose phototherapeutic radiation.
  • the function for calculating a phototherapy dose to be administered to the skin e.g.
  • This function Icf corresponds to the inverse of the attenuation of the radiation by melanin absorption and it provides an approximation of the modification function of the skin under consideration.
  • the function is applicable to usefully provide correction factors over a large wavelength range, from UV to near IR wavelengths, and for substantially all skin types, ranging from light Caucasian type skin to dark negroid type skin.
  • the melanin index or the lightness, respectively is determined in a wavelength range between approx. 400 nm and approx. 2000 nm, in particular between approx. 500 nm and approx. 1500 nm, more in particular between approx. 600 nm and approx. 900 nm, and the body portion is illuminated with a phototherapy wavelength in that wavelength range.
  • Fig. 1 is a schematic representation of a skin portion
  • Fig. 2 indicates typical irradiance correction factors for different skin types
  • Fig. 3 is a block scheme of an embodiment of a method of bio-stimulating phototherapy of a subject's body portion
  • Fig. 4 is a schematic side view of a phototherapy apparatus
  • Figs. 5-7 are schematic side views of different phototherapy apparatus.
  • Fig. 1 illustrates illumination of a human body portion 1, showing a skin portion 3, and illumination light 5.
  • the skin 3 comprises an epidermis layer 7 of ca 0.1 mm thickness, a ca 1-4 mm thick dermis layer 9 covering hypodermic tissue 11.
  • a fraction of the illumination light 5 penetrates into the dermis 9, and another fraction may penetrate into the hypodermic tissue 11 indicated with the arrows 13 and 15, respectively.
  • the main optical absorbers are melanin and water.
  • the main optical absorbers are water and blood. These absorbers are the most important factors determining the skin type.
  • the skin type may be usefully classified in six skin types using the Fitzpatrick scale, which mainly relates to tanning and sunburn (erythema, or even blistering), and thus to the skins response to UV radiation. For some therapies, in particular using longer visible or (near) infrared wavelength ranges, it has been found that such classification is insufficient, since within one Fitzpatrick skin type, significant deviations in response to an optical stimulus may still occur.
  • the absorbing or filtering effect of melanin is concentrated in the epidermis 7, and that, once the reduction in optical energy by the epidermis 7 is known, the fraction of the energy available for deposition in the dermis 9 and hypodermic tissue 11 can be calculated. It has further been found that determining the melanin index of the skin portion 3 in fact substantially returns the melanin index of the epidermis 7 and thus provides a reliable quantification of the filtering effect of the epidermis 7 and determination of the dose available for deeper- lying tissue. Similarly, the absorption of the illumination light 5 by the melanin can be readily determined and therewith heating of the epidermis 5 can be predicted to prevent overheating or hurting.
  • the filtering effect of the melanin in the epidermis can be substantial.
  • the irradiance dose to be applied onto the skin may be a large multiple of the dose to be deposited in the dermis or hypodermic tissue, in particular for phototherapy with blue light for Asian or Negroid skin types.
  • blue phototherapy light at a wavelength near 450 nm e.g. for treating
  • the correction factor Icf for dose administration may differ by a factor of 20 between a light Caucasian skin type and a dark negroid skin type.
  • the correction factor Icf also indicates the relative energy absorption in the epidermis 3, and therewith the chances of overheating that skin part, risking pain and damage.
  • the dose is a combination of illumination irradiance and illumination time.
  • Phototherapy may therefore be made available for domestic use with little to no risk of damage or maltreatment.
  • FIG. 3 An operating scheme of an embodiment of the method is provided in Fig. 3.
  • a phototherapeutic wavelength (range) ⁇ is selected and a suitable dose Dl to be administered to the body portion 1 are determined in step 17, e.g. by a practitioner.
  • D. Barolet "Light-emitting diodes (LEDs) in dermatology", Semin Cutan Med Surg 27:227-238 (2008), elucidates on the existence of suitable wavelengths and optimal doses or fluences for different phototherapies, dependent on the tissue and condition to be treated.
  • An overview of conditions which may be treated with bio-stimulating phototherapy, the mechanism believed to underlie the treatment effect and the associated wavelengths is provided in the following table:
  • the skin type S or the melanin index M of the skin portion 3 of the body portion 1 is determined in step 19.
  • the melanin index M may be determined by measuring light reflectance of the skin portion 3 at one or more wavelengths and deducing the skins absorbance at the used wavelength(s). Using plural wavelengths facilitates removing contribution to the absorption by (oxy-) haemoglobin and/or water.
  • step 21 the absorption of light at the phototherapeutic wavelength (range) ⁇ to be used is determined and a correction factor Icf is calculated based on the skin type S to give Icf(S, ⁇ ) or based on the melanin index M, e.g. according to the above-reference formula to give Icf(M, ⁇ ).
  • a phototherapy dose D2 to be applied onto the skin portion 3 is calculated based on the dose Dl to be administered.
  • the phototherapy dose D2 may be applied by suitable selection of illumination intensity and duration, which may comprise illumination in one or more pulses of which the pulse intensity, duration and interval may be selected.
  • step 25 the thus calculated phototherapy dose D2 and an emitted dose D3 from the light source is used to determine a modification function F of the filter
  • step 26 the second phototherapy dose is applied to the body portion 1 by illuminating the skin portion 3 through the filter, resulting in administering the suitable dose Dl .
  • the effect of heating of the epidermis by the absorbed radiation may be included, so as to determine a maximum applied irradiance in order not to overheat the skin.
  • a skin temperature of below 42°C is considered suitable, higher temperatures, in particular during prolonged periods, are undesired and temperatures of ca 45°C and higher are painful.
  • the method may be employed in separate stages, wherein the skin type or melanin index is determined at one moment and later on used for determining the function for operation of the light source.
  • the melanin index may, and generally will, depend inter alia on the particular location of the skin portion and on its tanning, it is preferred to (re-)determine the melanin index shortly before applying a phototreatment.
  • a phototherapy apparatus 27 for use in the above described method comprises a light source 29 for providing light at a bio-stimulating phototherapeutic wavelength, here comprising a plurality of sub- light sources 31 mounted to a carrier 33, an optical filter 34, a sensor 35 for determining the melanin index of a subjects skin portion 3, and a sensor 36 for determining the modification function of the filter 34.
  • the sub- light sources 31 may provide light at different wavelengths.
  • the apparatus is arranged for illuminating the subject's skin portion 3 with light 30 emitted by the light source 29 and modified by the filter 34.
  • the apparatus further comprises a controller 37 for controlling operation of the light source 29 as a function of the determined melanin index.
  • the apparatus 27 may be powered from any suitable power source 39, for portability powering from a battery is preferred.
  • the controller 37 may comprise one or more user operable input systems e.g. with selectable settings.
  • the input system(s) may comprise one or more user interfaces and may be arranged for inputting skin type data and/or modification function data of a filter 34.
  • the controller may be configured to take additional input, e.g. for determining parameters of a therapy, user settings, timing, driving schemes for different skin colors etc.
  • Such additional input may be provided in machine readable format on a suitable data carrier, e.g. a disk, a memory card, a flash-drive, etc, as well as via transmission systems from a remote data storage medium, such as wired or wireless data transmission from a computer and/or via the internet.
  • the apparatus may suitably comprise a memory for storing one or more settings and/or programs, which may be user-selectable via a user interface.
  • the controller is arranged, programmable or programmed for controlling operation of the light source 29 with a function based on the Icf discussed above.
  • the controller 37 may be configured for controlling operation of the light source 29 during use, possibly automated, e.g. for adaptation to skin heating, tanning, increased or decreased blood perfusion etc.
  • the phototherapy apparatus 27 may be a human wearable patch or bandage, such as an apparatus conforming to human physique, preferably being deformable or even pliable, indicated in Fig. 5.
  • the patch may be maintained in position with any suitable means such as one or more adhesive portions, hook-and- loop-type fastener and/or a strap 41 closable around the body portion.
  • a phototherapy apparatus may be an assembly comprising the light source, the sensor and/or the controller as separate objects, which may be interconnected for communicating with each other, e.g. with cables or via wireless communication.
  • a phototherapy apparatus 27 may comprise plural sensors 35 for determining the melanin index of the subject's skin portion 3 to detect local variations of the skin portion.
  • the light source 29 may comprise plural sub-light sources 31.
  • the light source 29 comprises one or more Light Emitting Diodes or LEDs, which are available for numerous suitable wavelengths, provide significant optical output power per watt input power and generate little heat. Incoherent LEDs are considered particularly advantageous, since lasers require additional control, increasing complexity and cost of the apparatus 27 and relatively narrowband radiation poses a high risk of overheating skin. Laser radiation may also present a danger to users eyes.
  • the sensor 35 may comprise at least one light source and at least one detector for detecting light, the sensor being configured to illuminate a subject's skin portion 3 and detect light reflected off the subject's skin portion 3, wherein the sensor 35 is configured for determining a reflectivity of the subject's skin portion 3 at a plurality of wavelengths. This allows accurate determination of the reflectance of the skin portion 3 and thus of determining the melanin index M.
  • Fig. 6 shows a patch 27 comprising surface-emitting LEDs 29 for emitting light with a wavelength of approx. 450 nm.
  • the patch 27 further comprises a tapered optically active filter 34 having a first end 43 with a relatively small surface area and a second end 45 with a relatively large surface area.
  • the filter 34 comprises a material mixed with one or more photoluminescent materials which is (are) excitable by the light of the first light sources 29.
  • the first light sources 29 and the filter 34 are arranged such that the light sources 29 illuminate the first end 43 of the filter 34. A first portion of the light of the first light sources 29 received in the filter 34 is emitted redistributed over the surface area of the second end 45.
  • a second portion of the light of the first light sources 29 received in the filter 34 excites the photoluminescent material, which subsequently fluoresces at one or more longer wavelengths, e.g. in a range between approximately 550 and 1500 nm, e.g. between about 600 and 700 nm, and/or between about 800 and 1500 nm, depending on the chosen photoluminescent material(s).
  • the use of photoluminescent material(s) may provide a relatively broad useful spectrum which would otherwise require plural narrowband light sources, e.g. LEDs. This light is also emitted distributed over the surface area of the second end 45.
  • the filter 34 serves the plural purposes of filtering a portion of the light emitted by the first light sources 29, being a redistributing light guide and being a light source for a second wavelength, i.e. a second light source.
  • the first light (here: blue) and the second light (here: IR) may be substantially homogeneously mixed, depending on the distribution of the photoluminescent material in the filter 34.
  • the relative intensities of the light with different wavelengths (blue and IR) may be determined by selecting the (relative) amount of photoluminescent material in the filter 34 and possibly its location, during manufacturing of the filter.
  • the filter 34 is not optically active, but has an intensity redistributing shape, as illustrated in Fig. 6.
  • Fig. 7 illustrates a patch 27 comprising side-illumination of a flexible, optically active, filter 34 by blue or UV light sources 29 via opposite first ends 43A, 43B.
  • the filter 34 comprises a material mixed with a photoluminescent material which is excitable by the light of the light sources 29, emitting red, and near-IR light. The resultant light of different wavelengths is scattered within the filter 34, possibly being reflected by an optional reflector 47, to be emitted substantially homogeneously from the filter 34 via second end 45 (see the open white arrows).
  • a photoluminescent material may also be provided as a coating on a surface of the filter 34.
  • the filter may comprise ridges, bumps or lens portions. Also or alternatively, the filter may comprise one or more fiberoptic portions, e.g. one or more fiber bundles for redistributing the light, wherein at least part of the fiberoptic portion comprises a
  • the filter may comprise silicone incorporating absorption or reflection particles, fabrics or any other filter material.
  • redistributing filter may improve homogeneity of the illumination and/or assist illuminating a relatively large skin surface area from a relatively small light emitting surface.
  • Light emitting diode or LED includes “organic light emitting diode” or OLED.
  • the word “comprising” does not exclude other elements or steps, and the indefinite article “a” or “an” does not exclude a plurality. Options presented with the conjunction “or” may be provided in combination unless stated otherwise.
  • a single processor or other unit may fulfill the functions of several items recited in the claims.
  • a computer program may be stored and/or distributed on a suitable medium, such as an optical storage medium or a solid- state medium supplied together with or as part of other hardware, but may also be distributed in other forms, such as via the Internet or other wired or wireless telecommunication systems. Any reference signs in the claims should not be construed as limiting the scope.

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Abstract

L'invention porte sur un appareil de photothérapie bio-stimulante d'une partie corporelle d'un sujet, lequel appareil comprend une source de lumière pour la fourniture d'une lumière ayant une longueur d'ondes photothérapeutique et un filtre optique pour la modification d'au moins une partie de la lumière émise par la source de lumière. L'appareil est conçu pour éclairer une partie de peau de la partie corporelle avec la lumière modifiée. L'appareil est conçu pour être conforme à au moins une partie de la partie corporelle, par exemple un objet pouvant être porté par un humain, tel qu'un timbre ou un bandage déformable ou souple, qui peut être plié. Le filtre a une fonction de modification correspondant au type de peau de la partie de peau du sujet. L'invention porte également sur un procédé et sur un filtre.
PCT/IB2011/053026 2010-07-22 2011-07-07 Améliorations apportées à la photothérapie Ceased WO2012011009A1 (fr)

Applications Claiming Priority (2)

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EP10170398.1 2010-07-22
EP10170398 2010-07-22

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WO2012011009A1 true WO2012011009A1 (fr) 2012-01-26

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD760398S1 (en) 2015-06-12 2016-06-28 Verilux, Inc. Lamp for light therapy
USD760913S1 (en) 2015-06-12 2016-07-05 Verilux, Inc. Light therapy luminaire
CN113995962A (zh) * 2021-12-10 2022-02-01 固安翌光科技有限公司 利于调节式身体监测装置
US12478797B2 (en) * 2020-07-30 2025-11-25 Shenzhen Yangwo Electronic Co., Ltd. Portable hair-removal apparatus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050143793A1 (en) * 2001-12-06 2005-06-30 Avner Korman Phototherapy for psoriasis and other skin disordes
US20050177208A1 (en) * 2001-10-18 2005-08-11 Irwin Dean S. Device for oral UV photo-therapy
EP1797923A2 (fr) 2005-12-13 2007-06-20 Ushiodenki Kabushiki Kaisha Appareil de photothérapie par rayonnement excimère
US20090143773A1 (en) * 2007-12-03 2009-06-04 Ekkyo Device for assistance in the wound healing processes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050177208A1 (en) * 2001-10-18 2005-08-11 Irwin Dean S. Device for oral UV photo-therapy
US20050143793A1 (en) * 2001-12-06 2005-06-30 Avner Korman Phototherapy for psoriasis and other skin disordes
EP1797923A2 (fr) 2005-12-13 2007-06-20 Ushiodenki Kabushiki Kaisha Appareil de photothérapie par rayonnement excimère
US20090143773A1 (en) * 2007-12-03 2009-06-04 Ekkyo Device for assistance in the wound healing processes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
C.V. SUSCHEK, C. OPLANDER, E.E. VAN FAASSEN: "Non-enzymatic NO production in human skin; effect of UVA on cutaneous NO stores", NITRIC OXIDE, vol. 22, 2010, pages 120 - 135, XP026883857, DOI: doi:10.1016/j.niox.2009.10.006
D. BAROLET: "Light-emitting diodes (LEDs) in dermatology", SEMIN CUTAN MED SURG, vol. 27, 2008, pages 227 - 238, XP025767669, DOI: doi:10.1016/j.sder.2008.08.003
J. LIEBMANN, M. BUM, V. KOIB-BACHOFEN: "Blue-light irradiation regulates proliferation and differentiation in human skin cells", J. OF INVESTIGATIVE DERMATOLOGY, vol. 130, 2010, pages 259 - 269
M.D. SHRIVER, E.J. PARRA: "Comparison of Narrow-band reflectance spectroscopy and tristimulus colorimetry for measurements of skin and hair color in persons of different biological ancestry", AMER. J PHYS ANTHROPOLOGY, vol. 112, 2000, pages 17 - 27, XP055009902

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD760398S1 (en) 2015-06-12 2016-06-28 Verilux, Inc. Lamp for light therapy
USD760913S1 (en) 2015-06-12 2016-07-05 Verilux, Inc. Light therapy luminaire
US12478797B2 (en) * 2020-07-30 2025-11-25 Shenzhen Yangwo Electronic Co., Ltd. Portable hair-removal apparatus
CN113995962A (zh) * 2021-12-10 2022-02-01 固安翌光科技有限公司 利于调节式身体监测装置
CN113995962B (zh) * 2021-12-10 2024-01-26 固安翌光科技有限公司 利于调节式身体监测装置

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