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WO2012009448A3 - Nanoparticules de silice mésoporeuses revêtues d'un polymère cationique et leurs utilisations - Google Patents

Nanoparticules de silice mésoporeuses revêtues d'un polymère cationique et leurs utilisations Download PDF

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Publication number
WO2012009448A3
WO2012009448A3 PCT/US2011/043874 US2011043874W WO2012009448A3 WO 2012009448 A3 WO2012009448 A3 WO 2012009448A3 US 2011043874 W US2011043874 W US 2011043874W WO 2012009448 A3 WO2012009448 A3 WO 2012009448A3
Authority
WO
WIPO (PCT)
Prior art keywords
cationic polymer
mesoporous silica
silica nanoparticles
oligonucleotide
polymer coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/043874
Other languages
English (en)
Other versions
WO2012009448A2 (fr
Inventor
Jeffrey I. Zink
Andre E. Nel
Tian Xia
Zhaoxia Ji
Huan MENG
Zongxi Li
Monty Liong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of WO2012009448A2 publication Critical patent/WO2012009448A2/fr
Priority to US13/428,830 priority Critical patent/US20120207795A1/en
Publication of WO2012009448A3 publication Critical patent/WO2012009448A3/fr
Anticipated expiration legal-status Critical
Priority to US15/698,486 priority patent/US10343903B2/en
Priority to US16/427,253 priority patent/US20190382265A1/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne une structure sous-micronique ayant un corps en silice définissant une pluralité de pores et un polymère cationique à la surface dudit corps en silice. La structure sous-micronique peut, en outre, comprendre un oligonucléotide et servir à administrer ledit oligonucléotide à une cellule. La structure sous-micronique peut, en outre, comprendre un agent thérapeutique et servir à administrer ledit agent thérapeutique à une cellule. Un oligonucléotide et un agent thérapeutique peuvent être utilisés ensemble. Par exemple, quand l'oligonucléotide est un ARNsi, la composition peut être utilisée pour réduire la résistance cellulaire à l'agent thérapeutique par réduction de la traduction d'un gène de résistance.
PCT/US2011/043874 2010-07-13 2011-07-13 Nanoparticules de silice mésoporeuses revêtues d'un polymère cationique et leurs utilisations Ceased WO2012009448A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/428,830 US20120207795A1 (en) 2010-07-13 2012-03-23 Cationic polymer coated mesoporous silica nanoparticles and uses thereof
US15/698,486 US10343903B2 (en) 2010-07-13 2017-09-07 Cationic polymer coated mesoporous silica nanoparticles and uses thereof
US16/427,253 US20190382265A1 (en) 2010-07-13 2019-05-30 Cationic polymer coated mesoporous silica nanoparticles and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36394510P 2010-07-13 2010-07-13
US61/363,945 2010-07-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/428,830 Continuation-In-Part US20120207795A1 (en) 2010-07-13 2012-03-23 Cationic polymer coated mesoporous silica nanoparticles and uses thereof

Publications (2)

Publication Number Publication Date
WO2012009448A2 WO2012009448A2 (fr) 2012-01-19
WO2012009448A3 true WO2012009448A3 (fr) 2012-07-05

Family

ID=45470059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/043874 Ceased WO2012009448A2 (fr) 2010-07-13 2011-07-13 Nanoparticules de silice mésoporeuses revêtues d'un polymère cationique et leurs utilisations

Country Status (1)

Country Link
WO (1) WO2012009448A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104027821A (zh) * 2014-06-06 2014-09-10 上海交通大学 一种装载siRNA的纳米颗粒及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993437B2 (en) 2007-12-06 2018-06-12 The Regents Of The University Of California Mesoporous silica nanoparticles for biomedical applications
US20120207795A1 (en) 2010-07-13 2012-08-16 The Regents Of The University Of California Cationic polymer coated mesoporous silica nanoparticles and uses thereof
US10220004B2 (en) 2011-07-14 2019-03-05 The Regents Of The University Of California Method of controlled delivery using sub-micron-scale machines
EP2900598A4 (fr) * 2012-09-28 2016-06-15 Univ California Nanocoquilles de silice dégradables pour imagerie/thérapie à ultrasons
WO2014138278A1 (fr) 2013-03-05 2014-09-12 The Regents Of The University Of California Nanoparticules de silice mésoporeuse revêtues par une bi-couche lipidique ayant une capacité élevée de charge pour un ou plusieurs agents anticancer
EP3119203A4 (fr) * 2014-03-18 2017-12-27 The Trustees Of The University Of Pennsylvania Système de distribution de polyphosphazène pour des nanocristaux métalliques
KR102408525B1 (ko) 2016-01-08 2022-06-13 더 리전트 오브 더 유니버시티 오브 캘리포니아 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자
WO2018222648A1 (fr) * 2017-06-02 2018-12-06 Saudi Arabian Oil Company Particules de silice enrobées
CN109200294A (zh) * 2017-07-06 2019-01-15 天津大学 类病毒基因—药物共传递纳米载体及其制备方法和应用
US20210093654A1 (en) * 2017-07-28 2021-04-01 Lemonex Inc. Pharmaceutical composition for preventing or treating liver cancer
US12383499B2 (en) 2018-01-01 2025-08-12 The Regents Of The University Of California Scale up synthesis of silicasome nanocarriers
JP7486505B2 (ja) 2018-10-16 2024-05-17 ファーマ イン シリカ ラボラトリーズ インコーポレイティド シリカカプセル／スフェアの調製のためのチューニング可能な方法及びそれらの使用
SG11202108224VA (en) 2019-01-31 2021-08-30 Agency Science Tech & Res A composite material and a method of preparing the same
US11230661B2 (en) 2019-09-05 2022-01-25 Saudi Arabian Oil Company Propping open hydraulic fractures
CN111574723B (zh) * 2020-04-08 2020-12-29 南京医科大学 广谱抗微生物的介孔氧化硅席夫碱银配合物纳米材料及其制备方法
CN112535739B (zh) * 2020-12-08 2023-05-05 中山大学 一种基于肿瘤自身微环境提高基因转染效率的纳米颗粒及其制备方法和应用
CN114522238B (zh) * 2022-02-25 2023-07-07 陕西万佳态元生物科技有限公司 一种基于镧系氧氟纳米晶体的miRNA载体及其应用
CN115845084A (zh) * 2022-12-22 2023-03-28 河北工业大学 一种聚乙烯亚胺修饰的介孔二氧化硅纳米球的制备方法和应用

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KR100924786B1 (ko) * 2007-06-28 2009-11-03 연세대학교 산학협력단 진단 및 치료용 자성 메탈 나노 복합체

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100924786B1 (ko) * 2007-06-28 2009-11-03 연세대학교 산학협력단 진단 및 치료용 자성 메탈 나노 복합체

Non-Patent Citations (4)

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HUGHES GARETH A ET AL.: "Nanostructure-mediated drug delivery, Nanomedicine", NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, vol. 1, March 2005 (2005-03-01), pages 22 - 30 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104027821A (zh) * 2014-06-06 2014-09-10 上海交通大学 一种装载siRNA的纳米颗粒及其应用

Also Published As

Publication number Publication date
WO2012009448A2 (fr) 2012-01-19

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