[go: up one dir, main page]

WO2012006038A3 - Agents et composés pour l'imagerie et autres applications, leurs procédés d'utilisation et de synthèse - Google Patents

Agents et composés pour l'imagerie et autres applications, leurs procédés d'utilisation et de synthèse Download PDF

Info

Publication number
WO2012006038A3
WO2012006038A3 PCT/US2011/042061 US2011042061W WO2012006038A3 WO 2012006038 A3 WO2012006038 A3 WO 2012006038A3 US 2011042061 W US2011042061 W US 2011042061W WO 2012006038 A3 WO2012006038 A3 WO 2012006038A3
Authority
WO
WIPO (PCT)
Prior art keywords
agents
compounds
synthesis
applications
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/042061
Other languages
English (en)
Other versions
WO2012006038A2 (fr
Inventor
Dean A. Sherry
Yunkou Wu
Garry E. Kiefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of WO2012006038A2 publication Critical patent/WO2012006038A2/fr
Publication of WO2012006038A3 publication Critical patent/WO2012006038A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Selon un mode de réalisation illustratif, cette invention concerne des agents de contraste paramagnétiques pour IRM utilisant une technique de transfert de saturation dépendant des échanges chimiques contenant un ligand tétraazacyclododécane et un ion paramagnétique qui fournit une mesure d'imagerie ratiométrique qui peut être utilisée pour mesurer des paramètres biologiques comprenant le pH, la température, les espèces réactives de l'oxygène, et des enzymes spécifiques, entre autres. Les agents et les composés selon l'invention peuvent également être utilisés dans d'autres applications. Des procédés d'utilisation et de synthèse des agents et des composés de la présente sont également décrits.
PCT/US2011/042061 2010-06-28 2011-06-27 Agents et composés pour l'imagerie et autres applications, leurs procédés d'utilisation et de synthèse Ceased WO2012006038A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35933310P 2010-06-28 2010-06-28
US61/359,333 2010-06-28

Publications (2)

Publication Number Publication Date
WO2012006038A2 WO2012006038A2 (fr) 2012-01-12
WO2012006038A3 true WO2012006038A3 (fr) 2012-03-29

Family

ID=45441721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/042061 Ceased WO2012006038A2 (fr) 2010-06-28 2011-06-27 Agents et composés pour l'imagerie et autres applications, leurs procédés d'utilisation et de synthèse

Country Status (1)

Country Link
WO (1) WO2012006038A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106908170B (zh) * 2017-03-14 2019-04-19 吉首大学 一种拉曼频移测温方法及系统

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746662B1 (en) * 1999-02-09 2004-06-08 Board Of Regents The University Of Texas System pH sensitive MRI contrast agents
US20040146463A1 (en) * 2000-05-04 2004-07-29 Meade Thomas J. Functional MRI agents for cancer imaging
US20050191243A1 (en) * 2002-01-29 2005-09-01 Silvio Aime Responsive paramagnetic mri contrast agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20060057071A1 (en) * 2004-09-14 2006-03-16 Wing-Tak Wong Paramagnetic complexes with pendant crown compounds showing improved targeting-specificity as MRI contrast agents
US20060140869A1 (en) * 2004-12-23 2006-06-29 Egidijus Uzgiris Polymeric contrast agents for use in medical imaging
US20070218010A1 (en) * 2004-03-31 2007-09-20 Jens Hasserodt Contrast Agents for Magnetic Resonance Imaging

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746662B1 (en) * 1999-02-09 2004-06-08 Board Of Regents The University Of Texas System pH sensitive MRI contrast agents
US20040146463A1 (en) * 2000-05-04 2004-07-29 Meade Thomas J. Functional MRI agents for cancer imaging
US20050191243A1 (en) * 2002-01-29 2005-09-01 Silvio Aime Responsive paramagnetic mri contrast agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20070218010A1 (en) * 2004-03-31 2007-09-20 Jens Hasserodt Contrast Agents for Magnetic Resonance Imaging
US20060057071A1 (en) * 2004-09-14 2006-03-16 Wing-Tak Wong Paramagnetic complexes with pendant crown compounds showing improved targeting-specificity as MRI contrast agents
US20060140869A1 (en) * 2004-12-23 2006-06-29 Egidijus Uzgiris Polymeric contrast agents for use in medical imaging

Also Published As

Publication number Publication date
WO2012006038A2 (fr) 2012-01-12

Similar Documents

Publication Publication Date Title
IL285655B (en) A system for identifying bacteria in biological samples
GB2440628B (en) Nuclear magnetic resonance measurement techinques in non-uniform fields
IL261338A (en) Preparations and methods for treating broad-spectrum, undiagnosed or mixed clinical applications
WO2012054648A3 (fr) Détecteurs d'analyte, méthodes de préparation et d'utilisation de ces détecteurs, et méthodes de détection de l'activité d'un analyte
WO2011100708A3 (fr) Carte d'essai pour l'acquisition d'échantillon, traitement et réaction
GB2433602B (en) Combined titration and pH electrode for the preparation of liquid samples in particular for NMR spectroscopy
EP1972269B8 (fr) Système destiné à la mesure in vivo d'une concentration en analytes
SI2006680T1 (sl) Indikator biološke obremenitve in postopek merjenja biološke obremenitve
EP2545373A4 (fr) Dispositifs de mesure et procédés de mesure de la concentration d'analytes intégrant une correction du ph et de la température
EP2382462A4 (fr) Couche de membrane pour biocapteur électrochimique et procédé d'adaptation aux champs électromagnétiques et radiofréquences
EP2545367A4 (fr) Analyse quantitative de cinétique de liaison basee sur un capteur magnétique
WO2007129275A3 (fr) Biocapteur magnétique rapide
WO2011116006A3 (fr) Procédé rapide pour mesurer le cyanure dans des échantillons biologiques
IL185501A0 (en) Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
EP2118649A4 (fr) Système de mesure à biocapteur électrochimique
EP2179278A4 (fr) Système de mesure de biocapteur électrochimique
EP2116837A4 (fr) Instrument servant à mesurer une concentration de particules dans un fluide, procédé de mesure, et programme de mesure
PL2315655T3 (pl) Wytwarzanie worka na próbki biologiczne
EP1911398A3 (fr) Appareil de mesure de champs biomagnétique
WO2006114739A3 (fr) Utilisation d'agents de contraste cest en irm
EP2062178A4 (fr) Procédé non destructif en ligne de mesure de transformations d'états physiques, électrochimiques, chimiques et/ou biologiques prédéterminés d'une substance et système associé
SI2544582T1 (sl) Postopek za elektrokemijsko merjenje koncentracije analita in vivo in gorivna celica zanj
EP2755029A4 (fr) Procédé d'inhibition de liaison non spécifique lors d'une étape de détection de substance dans un échantillon biologique, et agent destiné à être utilisé dans le procédé
EP2615178A4 (fr) Procédé de préparation de cellules algales, et trousse pour l'évaluation de la toxicité d'une substance chimique
EP2684881A4 (fr) Composé ayant un chromophore fluorescent, capteur de concentration d'ion comprenant le composé, réactif comprenant le composé, coffret de réactif comportant le réactif, précurseur du composé, et procédé de synthèse du composé

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11804100

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11804100

Country of ref document: EP

Kind code of ref document: A2