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WO2012004811A8 - Process for the preparation of 5-substsituted indole derivative - Google Patents

Process for the preparation of 5-substsituted indole derivative Download PDF

Info

Publication number
WO2012004811A8
WO2012004811A8 PCT/IN2011/000447 IN2011000447W WO2012004811A8 WO 2012004811 A8 WO2012004811 A8 WO 2012004811A8 IN 2011000447 W IN2011000447 W IN 2011000447W WO 2012004811 A8 WO2012004811 A8 WO 2012004811A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
formula
eletriptan
relates
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2011/000447
Other languages
French (fr)
Other versions
WO2012004811A1 (en
Inventor
Shekhar Bhaskar Bhirud
Perminder Singh Johar
Ekta Sharma
Ramkaran Prajapaty
Chandan Kumar Gupta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IND-SWIFT LABORATORIES Ltd
Ind Swift Laboratories Ltd
Original Assignee
IND-SWIFT LABORATORIES Ltd
Ind Swift Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IND-SWIFT LABORATORIES Ltd, Ind Swift Laboratories Ltd filed Critical IND-SWIFT LABORATORIES Ltd
Publication of WO2012004811A1 publication Critical patent/WO2012004811A1/en
Publication of WO2012004811A8 publication Critical patent/WO2012004811A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved and industrially advantageous process for preparation of eletriptan of formula I, or pharmaceutically acceptable salts thereof from bromo indole intermediate of formula II, through isolation of N-acetylated bromo indole intermediate of formula III, to elude carrying forward of impurities to next stage. The present invention relates to process for the preparation of 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indol of formula II, a key intermediate for the synthesis of eletriptan or pharmaceutically acceptable salts thereof, through novel keto carbamate intermediate. The present invention also relates to novel process for the preparation of α-form of eletriptan hydrobromide.
PCT/IN2011/000447 2010-07-06 2011-07-04 Process for the preparation of 5-substsituted indole derivative Ceased WO2012004811A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1580/DEL/2010 2010-07-06
IN1580DE2010 2010-07-06
IN1469/DEL/2011 2011-05-23
IN1469DE2011 2011-05-23

Publications (2)

Publication Number Publication Date
WO2012004811A1 WO2012004811A1 (en) 2012-01-12
WO2012004811A8 true WO2012004811A8 (en) 2012-08-09

Family

ID=45440827

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000447 Ceased WO2012004811A1 (en) 2010-07-06 2011-07-04 Process for the preparation of 5-substsituted indole derivative

Country Status (1)

Country Link
WO (1) WO2012004811A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
EP2953972B1 (en) 2013-02-05 2020-07-08 EngMab Sàrl Method for the selection of antibodies against bcma
CN104292217A (en) * 2013-04-08 2015-01-21 上海医药工业研究院 Preparation method and purification method of alpha crystal form eletriptan hydrobromide
CN104230895B (en) * 2013-06-08 2017-02-08 上海医药工业研究院 Preparation method for eletriptan intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
GB0317229D0 (en) * 2003-07-23 2003-08-27 Pfizer Ltd Improved process

Also Published As

Publication number Publication date
WO2012004811A1 (en) 2012-01-12

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