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WO2012002777A2 - Composition contenant des extraits de plante permettant de freiner la sécrétion granulaire des mastocytes - Google Patents

Composition contenant des extraits de plante permettant de freiner la sécrétion granulaire des mastocytes Download PDF

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Publication number
WO2012002777A2
WO2012002777A2 PCT/KR2011/004866 KR2011004866W WO2012002777A2 WO 2012002777 A2 WO2012002777 A2 WO 2012002777A2 KR 2011004866 W KR2011004866 W KR 2011004866W WO 2012002777 A2 WO2012002777 A2 WO 2012002777A2
Authority
WO
WIPO (PCT)
Prior art keywords
extract
allergic
extracts
willow
mountain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2011/004866
Other languages
English (en)
Korean (ko)
Other versions
WO2012002777A3 (fr
Inventor
권대혁
오정미
양유수
최기두
황재성
이승규
이주형
오창규
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sungkyunkwan University Foundation for Corporate Collaboration
ForHuman Tech Co Ltd
Original Assignee
Sungkyunkwan University Foundation for Corporate Collaboration
ForHuman Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sungkyunkwan University Foundation for Corporate Collaboration, ForHuman Tech Co Ltd filed Critical Sungkyunkwan University Foundation for Corporate Collaboration
Publication of WO2012002777A2 publication Critical patent/WO2012002777A2/fr
Publication of WO2012002777A3 publication Critical patent/WO2012002777A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/50—Fumariaceae (Fumitory family), e.g. bleeding heart
    • A61K36/505—Corydalis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/76—Salicaceae (Willow family), e.g. poplar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Definitions

  • Antihistamines are relatively safe drugs and are most commonly used as a popular remedy for allergic diseases. Antihistamines have a similar effect of blocking histamine action, but the side effects are different from each other. The most common side effects are tremor and hypnosis, and other factors such as excitement, irritability, insomnia, anxiety, dizziness, nightmares and hallucinations Excitatory effects can also occur, and there have been reports of unusual excitatory effects, particularly in children.
  • Another object of the present invention is the Japanese leaf larch extract, elm extract, mountain fire bag extract, hay fever extract, ginseng extract, willow extract, mountain viburnum extract, oyster tree extract, weasel extract, nectarine extract, non-repair extract, It is to provide a pharmaceutical composition for the prevention or treatment of allergic diseases, including one or more extracts selected from the group consisting of water palm flower extract, and eyeball willow extract as an active ingredient.
  • Still another object of the present invention is to provide a cosmetic composition for improving or preventing allergic diseases including the extract as an active ingredient.
  • Another object of the present invention in the manufacture of a medicament for the prevention or treatment of allergic diseases, Japanese leaf larch extract, elm tree extract, fire bulge extract, hay fever extract, ginseng extract, willow extract, mountain viburnum extract, To provide the use of one or more extracts selected from the group consisting of oyster bark extract, weasel extract, nectarine extract, non-repair extract, water flower extract, and snow willow extract.
  • the present invention is Japanese leaf larch extract, elm tree extract, mountain bag fire extract, hay fever extract, dumplings extract, willow extract, mountain viburnum extract, oyster bark extract, weasel extract, stone extract, It provides a quasi-drug composition for improvement or prevention of allergic diseases, including as an active ingredient at least one extract selected from the group consisting of non-repair extract, birch flower extract, and snow willow extract.
  • the allergic diseases include allergic symptoms, and allergic symptoms include symptoms appearing due to allergic diseases or symptoms appearing before allergic diseases occur.
  • Japanese leaf larch, elm tree, mountain fire bag, straw shinnyum, ginseng, willow, mountain viburnum, gulpina Provided is a method for preparing at least one plant extract selected from the group consisting of radish, weasel, pear tree, non-prey, birch, and snow cover.
  • Figure 2 shows the beta-hexosaminidase inhibition rate analysis to determine the inhibitory effect of the granule secretion formation of the plant extract, showing the natural plant extracts showing an inhibitory effect of more than 50%.
  • the numbers at the bottom of Figure 2 show the serial numbers in Table 1.
  • Nc / Nga female mice were treated with DNCB solution to induce atopic dermatitis. It is shown.
  • 13 kinds of plant extracts according to the present invention can inhibit degranulation of mast cells, they can be used as a prophylactic or therapeutic agent for allergic diseases, and can be used as cosmetic preparations, quasi-drug preparations, and food preparations containing the extracts. .

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention se rapporte à un inhibiteur de la sécrétion granulaire des mastocytes qui comprend, comme ingrédients actifs, un ou plusieurs extraits sélectionnés dans le groupe constitué par les extraits de Larix leptolepis, les extraits de Maackia amurensis, les extraits de Corydalis speciosa, les extraits de Agrimonia pilosa, les extraits de Codonopsis pilosula, les extraits de Salix koreensis, les extraits de Viburnum wrightii, les extraits de Platycarya strobilacea, les extraits de Amorpha fruticosa, les extraits de Pyrus pyrifolia, les extraits de Lespedeza cuneata, les extraits de Potentilla cryptotaeniae et les extraits de Salix graciliglans. La présente invention se rapporte également à une composition qui comprend lesdits extraits comme ingrédients actifs afin d'empêcher ou de traiter des maladies allergiques, et à une composition alimentaire, à une composition quasi-médicamenteuse et à une composition cosmétique qui comprennent lesdits extraits comme ingrédients actifs afin de freiner ou d'empêcher des maladies allergiques. La présente invention se rapporte également à un procédé permettant d'empêcher ou de traiter des maladies allergiques, ainsi qu'aux utilisations desdits extraits.
PCT/KR2011/004866 2010-07-02 2011-07-01 Composition contenant des extraits de plante permettant de freiner la sécrétion granulaire des mastocytes Ceased WO2012002777A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100064099A KR20120003317A (ko) 2010-07-02 2010-07-02 식물 추출물을 포함하는 비만세포의 과립 분비 억제용 조성물
KR10-2010-0064099 2010-07-02

Publications (2)

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WO2012002777A2 true WO2012002777A2 (fr) 2012-01-05
WO2012002777A3 WO2012002777A3 (fr) 2012-05-03

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KR (1) KR20120003317A (fr)
WO (1) WO2012002777A2 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102908428A (zh) * 2012-09-27 2013-02-06 安徽金太阳生化药业有限公司 一种用于治疗感冒的中药
CN103989957A (zh) * 2014-05-14 2014-08-20 张华� 用于治疗胃阴亏虚型慢性胃炎的药物组合物及其制备方法
WO2016199976A1 (fr) * 2015-06-09 2016-12-15 한국콜마주식회사 Composition cosmétique pour améliorer des rides de peau contenant un extrait de maackia amurensis comme principe actif, et produit cosmétique l'utilisant
US11633636B2 (en) 2017-12-02 2023-04-25 Mighty Fire Breaker Llc Wireless neighborhood wildfire defense system network supporting proactive protection of life and property in a neighborhood through GPS-tracking and mapping of environmentally-clean anti-fire (AF) chemical liquid spray applied to the property before wild fires reach the neighborhood
US11826592B2 (en) 2018-01-09 2023-11-28 Mighty Fire Breaker Llc Process of forming strategic chemical-type wildfire breaks on ground surfaces to proactively prevent fire ignition and flame spread, and reduce the production of smoke in the presence of a wild fire
US11865390B2 (en) 2017-12-03 2024-01-09 Mighty Fire Breaker Llc Environmentally-clean water-based fire inhibiting biochemical compositions, and methods of and apparatus for applying the same to protect property against wildfire
US11865394B2 (en) 2017-12-03 2024-01-09 Mighty Fire Breaker Llc Environmentally-clean biodegradable water-based concentrates for producing fire inhibiting and fire extinguishing liquids for fighting class A and class B fires
US11911643B2 (en) 2021-02-04 2024-02-27 Mighty Fire Breaker Llc Environmentally-clean fire inhibiting and extinguishing compositions and products for sorbing flammable liquids while inhibiting ignition and extinguishing fire
US12168152B2 (en) 2021-02-04 2024-12-17 Mighty Fire Breaker Llc Remotely-triggered wildfire defense system for automatically spraying environmentally-clean water-based liquid fire inhibitor to proactively form thin fire-inhibiting alkali metal salt crystalline coatings on sprayed combustible surfaces prior to wildfire

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KR101373997B1 (ko) * 2012-08-13 2014-03-12 성균관대학교산학협력단 항알러지 물질을 스크리닝하는 방법
KR101866082B1 (ko) * 2016-10-31 2018-06-11 가천대학교 산학협력단 배나무속 식물 추출물을 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학 조성물
KR101865142B1 (ko) * 2016-11-11 2018-06-11 대한민국 조팝나무, 배나무, 뱀무의 혼합 추출물을 유효성분으로 함유하는 알러지성 질환의 예방 및 치료용 약학적 조성물
KR20200009450A (ko) 2018-07-19 2020-01-30 주식회사 실러캔스 어망 감시용 부표의 위치 확인 및 이 부표를 이용한 적조의 확산 예측 방법
KR102099559B1 (ko) * 2019-01-29 2020-04-10 김두성 당뇨의 예방 및 치료용 조성물, 및 그 제조방법
WO2022086020A1 (fr) * 2020-10-19 2022-04-28 Dongguk University Industry-Academic Cooperation Foundation Composition comprenant des composés isolés d'extrait d'agrimonia coreana nakai en tant qu'ingrédient actif pour la prévention ou le traitement d'une maladie d'origine immunitaire et son utilisation
KR20220149856A (ko) 2021-04-30 2022-11-09 주식회사 실러캔스 해상보안감시를 위한 선박 검출 방법
KR102876252B1 (ko) * 2025-03-04 2025-10-27 자이언트코리아 주식회사 병풀 엑소좀 및 병풀 pdrn을 포함하는 스킨케어 화장료 조성물

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JP2008174526A (ja) * 2007-01-22 2008-07-31 Naris Cosmetics Co Ltd アレルゲン不活化剤、及びそれを含有する皮膚外用剤、又はアレルゲン不活化用製品
KR100881754B1 (ko) * 2007-09-04 2009-02-06 영남대학교 산학협력단 굴피나무 추출물을 유효성분으로 함유하는 염증성 장질환치료 및 예방용 약학조성물
KR100999283B1 (ko) * 2008-08-19 2010-12-07 장문식 항염 및 피부자극완화 효과가 있는 울금, 시호 및 버드나무의 고체 발효 혼합 추출물을 함유한 화장료 조성물

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102908428A (zh) * 2012-09-27 2013-02-06 安徽金太阳生化药业有限公司 一种用于治疗感冒的中药
CN103989957A (zh) * 2014-05-14 2014-08-20 张华� 用于治疗胃阴亏虚型慢性胃炎的药物组合物及其制备方法
WO2016199976A1 (fr) * 2015-06-09 2016-12-15 한국콜마주식회사 Composition cosmétique pour améliorer des rides de peau contenant un extrait de maackia amurensis comme principe actif, et produit cosmétique l'utilisant
US11730987B2 (en) 2017-12-02 2023-08-22 Mighty Fire Breaker Llc GPS tracking and mapping wildfire defense system network for proactively defending homes and neighborhoods against threat of wild fire by spraying environmentally-safe anti-fire chemical liquid on property surfaces to inhibit fire ignition and flame spread in the presence of wild fire
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US11642555B2 (en) 2017-12-02 2023-05-09 Mighty Fire Breaker Llc Wireless wildfire defense system network for proactively defending homes and neighborhoods against wild fires by spraying environmentally-clean anti-fire chemical liquid on property and buildings and forming GPS-tracked and mapped chemical fire breaks about the property
US11654314B2 (en) 2017-12-02 2023-05-23 Mighty Fire Breaker Llc Method of managing the proactive spraying of environment ally-clean anti-fire chemical liquid on GPS-specified property surfaces so as to inhibit fire ignition and flame spread in the presence of wild fire
US11654313B2 (en) 2017-12-02 2023-05-23 Mighty Fire Breaker Llc Wireless communication network, GPS-tracked ground-based spraying tanker vehicles and command center configured for proactively spraying environmentally-safe anti-fire chemical liquid on property surfaces to inhibit fire ignition and flame spread in the presence of wild fire
US11697040B2 (en) 2017-12-02 2023-07-11 Mighty Fire Breaker Llc Wild fire defense system network using a command center, spraying systems and mobile computing systems configured to proactively defend homes and neighborhoods against threat of wild fire by spraying environmentally-safe anti-fire chemical liquid on property surfaces before presence of wild fire
US11697039B2 (en) 2017-12-02 2023-07-11 Mighty Fire Breaker Llc Wireless communication network, GPS-tracked back-pack spraying systems and command center configured for proactively spraying environmentally-safe anti-fire chemical liquid on property surfaces to inhibit fire ignition and flame spread in the presence of wild fire
US12364885B2 (en) 2017-12-02 2025-07-22 Mighty Fire Breaker Llc System for proactively forming and maintaining GPS-tracked and mapped environmentally-clean chemical fire protection zones over the property surfaces of a neighborhood of homes so as to inhibit fire ignition and flame spread in the presence of wild fire
US11707639B2 (en) 2017-12-02 2023-07-25 Mighty Fire Breaker Llc Wireless communication network, GPS-tracked mobile spraying systems, and a command system configured for proactively spraying environmentally-safe anti-fire chemical liquid on combustible property surfaces to protect property against fire ignition and flame spread in the presence of wild fire
US11633636B2 (en) 2017-12-02 2023-04-25 Mighty Fire Breaker Llc Wireless neighborhood wildfire defense system network supporting proactive protection of life and property in a neighborhood through GPS-tracking and mapping of environmentally-clean anti-fire (AF) chemical liquid spray applied to the property before wild fires reach the neighborhood
US11794044B2 (en) 2017-12-02 2023-10-24 Mighty Fire Breaker Llc Method of proactively forming and maintaining GPS-tracked and mapped environmentally-clean chemical firebreaks and fire protection zones that inhibit fire ignition and flame spread in the presence of wild fire
US11638844B2 (en) 2017-12-02 2023-05-02 Mighty Fire Breaker Llc Method of proactively protecting property from wild fire by spraying environmentally-clean anti-fire chemical liquid on property surfaces prior to wild fire arrival using remote sensing and GPS-tracking and mapping enabled spraying
US12364886B2 (en) 2017-12-02 2025-07-22 Mighty Fire Breaker Llc Neighborhood of homes provided with a system installed for proactively forming and maintaining environmentally-clean chemical fire protection zones over the property and ground surfaces of the neighborhood
US11865394B2 (en) 2017-12-03 2024-01-09 Mighty Fire Breaker Llc Environmentally-clean biodegradable water-based concentrates for producing fire inhibiting and fire extinguishing liquids for fighting class A and class B fires
US12458824B2 (en) 2017-12-03 2025-11-04 Mighty Fire Breaker Llc System for proactively protecting combustible property surfaces against fire ignition and flame spread by forming environmentally-clean thin potassium salt crystalline coatings on the combustible property surfaces
US11865390B2 (en) 2017-12-03 2024-01-09 Mighty Fire Breaker Llc Environmentally-clean water-based fire inhibiting biochemical compositions, and methods of and apparatus for applying the same to protect property against wildfire
US11826592B2 (en) 2018-01-09 2023-11-28 Mighty Fire Breaker Llc Process of forming strategic chemical-type wildfire breaks on ground surfaces to proactively prevent fire ignition and flame spread, and reduce the production of smoke in the presence of a wild fire
US12251587B2 (en) 2018-01-09 2025-03-18 Mighty Fire Breaker Llc Ground-based vehicle for making and applying a fire and smoke inhibiting slurry composition on ground surfaces before the arrival of wildfire
US12214233B2 (en) 2021-02-04 2025-02-04 Mighty Fire Breaker Llc Wildfire defense spraying system for spraying environmentally-clean water-based liquid fire inhibitor to proactively form thin fire-inhibiting potassium salt crystalline coatings on sprayed property surfaces prior to the presence of wildfire
US12226661B2 (en) 2021-02-04 2025-02-18 Might Fire Breaker Llc Wildfire defense spraying system for spraying environmentally-clean water-based liquid fire inhibitor to proactively form thin fire-inhibiting alkali metal salt crystalline coatings on sprayed property surfaces prior to the presence of wildfire
US12208296B2 (en) 2021-02-04 2025-01-28 Mighty Fire Breaker Llc Wildfire defense spraying process for automatically spraying environmentally-clean water-based liquid fire inhibitor over combustible property surfaces to form thin fire-inhibiting potassium salt crystalline coatings thereon before presence of wildfire
US12168152B2 (en) 2021-02-04 2024-12-17 Mighty Fire Breaker Llc Remotely-triggered wildfire defense system for automatically spraying environmentally-clean water-based liquid fire inhibitor to proactively form thin fire-inhibiting alkali metal salt crystalline coatings on sprayed combustible surfaces prior to wildfire
US11911643B2 (en) 2021-02-04 2024-02-27 Mighty Fire Breaker Llc Environmentally-clean fire inhibiting and extinguishing compositions and products for sorbing flammable liquids while inhibiting ignition and extinguishing fire

Also Published As

Publication number Publication date
KR20120003317A (ko) 2012-01-10
WO2012002777A3 (fr) 2012-05-03

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