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WO2012002760A3 - 세균유래 마이크로베시클을 이용한 암치료 및 암진단 방법 - Google Patents

세균유래 마이크로베시클을 이용한 암치료 및 암진단 방법 Download PDF

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Publication number
WO2012002760A3
WO2012002760A3 PCT/KR2011/004821 KR2011004821W WO2012002760A3 WO 2012002760 A3 WO2012002760 A3 WO 2012002760A3 KR 2011004821 W KR2011004821 W KR 2011004821W WO 2012002760 A3 WO2012002760 A3 WO 2012002760A3
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WIPO (PCT)
Prior art keywords
cell
treating
derived microvesicles
diagnosing cancer
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2011/004821
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English (en)
French (fr)
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WO2012002760A2 (ko
Inventor
고용송
김오연
장수철
윤창민
김윤근
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POSTECH Academy Industry Foundation
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POSTECH Academy Industry Foundation
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Application filed by POSTECH Academy Industry Foundation filed Critical POSTECH Academy Industry Foundation
Priority to CN201180041981.9A priority Critical patent/CN103079592B/zh
Priority to US13/807,843 priority patent/US9066971B2/en
Priority to EP11801165.9A priority patent/EP2589391B1/en
Priority to JP2013518259A priority patent/JP5635690B2/ja
Publication of WO2012002760A2 publication Critical patent/WO2012002760A2/ko
Publication of WO2012002760A3 publication Critical patent/WO2012002760A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
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  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

본 발명은 세균유래 마이크로베시클을 이용하여 암을 치료 및/또는 진단하는 방법에 관한 것이다. 또한 본 발명은 세균유래 마이크로베시클을 이용하여 암을 치료함에 있어 항암치료효능을 증가시키고, 치료약물의 부작용을 감소시키는 방법을 제공한다. 이에 더하여, 본 발명은 세균유래 마이크로베시클에 질병 치료용 또는 진단용 약물을 로딩하여 표적 세포 또는 조직에 전달하는 방법 등을 제공한다.
PCT/KR2011/004821 2010-07-01 2011-06-30 세균유래 마이크로베시클을 이용한 암치료 및 암진단 방법 Ceased WO2012002760A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201180041981.9A CN103079592B (zh) 2010-07-01 2011-06-30 使用来自细胞的微泡治疗和诊断癌症的方法
US13/807,843 US9066971B2 (en) 2010-07-01 2011-06-30 Method for treating and diagnosing cancer by using cell-derived microvesicles
EP11801165.9A EP2589391B1 (en) 2010-07-01 2011-06-30 Bacterial cell-derived microvesicles for use in a method of treating cancer
JP2013518259A JP5635690B2 (ja) 2010-07-01 2011-06-30 細菌由来マイクロベシクルを用いた癌治療及び癌診断方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20100063637 2010-07-01
KR10-2010-0063637 2010-07-01
KR1020110065151A KR101752506B1 (ko) 2010-07-01 2011-06-30 세균유래 마이크로베시클을 이용한 암치료 및 암진단 방법
KR10-2011-0065151 2011-06-30

Publications (2)

Publication Number Publication Date
WO2012002760A2 WO2012002760A2 (ko) 2012-01-05
WO2012002760A3 true WO2012002760A3 (ko) 2012-05-03

Family

ID=45402592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/004821 Ceased WO2012002760A2 (ko) 2010-07-01 2011-06-30 세균유래 마이크로베시클을 이용한 암치료 및 암진단 방법

Country Status (6)

Country Link
US (1) US9066971B2 (ko)
EP (1) EP2589391B1 (ko)
JP (1) JP5635690B2 (ko)
KR (1) KR101752506B1 (ko)
CN (1) CN103079592B (ko)
WO (1) WO2012002760A2 (ko)

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US20130195765A1 (en) 2013-08-01
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