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WO2012000791A3 - Agent de diagnostic permettant de localiser un tissu malade - Google Patents

Agent de diagnostic permettant de localiser un tissu malade Download PDF

Info

Publication number
WO2012000791A3
WO2012000791A3 PCT/EP2011/059924 EP2011059924W WO2012000791A3 WO 2012000791 A3 WO2012000791 A3 WO 2012000791A3 EP 2011059924 W EP2011059924 W EP 2011059924W WO 2012000791 A3 WO2012000791 A3 WO 2012000791A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic
diseased tissue
localizing
biomolecule
aptamer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/059924
Other languages
German (de)
English (en)
Other versions
WO2012000791A2 (fr
Inventor
Hartmuth C. Kolb
Ursus KRÜGER
Oliver Lade
Arno Steckenborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Siemens Corp
Original Assignee
Siemens AG
Siemens Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens AG, Siemens Corp filed Critical Siemens AG
Publication of WO2012000791A2 publication Critical patent/WO2012000791A2/fr
Publication of WO2012000791A3 publication Critical patent/WO2012000791A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne un agent de diagnostic permettant de localiser un tissu malade (18) et comprenant un agent A avec un complexe (6) comportant un aptamère (4) et une molécule de liaison (5), et un agent B avec une biomolécule (1) qui se lie au complexe (6). L'aptamère (4) se lie au tissu malade (18) et la biomolécule (1) comprend un acide aminé (2) avec un atome de carbone 11 (11C). L'invention concerne également l'utilisation d'une biomolécule (1) pour produire un tel agent de diagnostic.
PCT/EP2011/059924 2010-06-30 2011-06-15 Agent de diagnostic permettant de localiser un tissu malade Ceased WO2012000791A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010026057.6 2010-06-30
DE201010026057 DE102010026057A1 (de) 2010-06-30 2010-06-30 Diagnostikum zur Lokalisation eines krankhaften Gewebes

Publications (2)

Publication Number Publication Date
WO2012000791A2 WO2012000791A2 (fr) 2012-01-05
WO2012000791A3 true WO2012000791A3 (fr) 2012-04-19

Family

ID=44343640

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/059924 Ceased WO2012000791A2 (fr) 2010-06-30 2011-06-15 Agent de diagnostic permettant de localiser un tissu malade

Country Status (2)

Country Link
DE (1) DE102010026057A1 (fr)
WO (1) WO2012000791A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007039858A2 (fr) * 2005-10-04 2007-04-12 Koninklijke Philips Electronics N.V. Imagerie et/ou therapie ciblees faisant intervenir la cycloaddition [3+2] azide-alcyne
WO2011012414A1 (fr) * 2009-07-29 2011-02-03 Siemens Aktiengesellschaft Procédé de fabrication d'un peptide radiomarqué

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100183504A1 (en) * 2007-06-14 2010-07-22 Fanqing Frank Chen Multimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics
DE102009035648B3 (de) 2009-07-29 2011-03-17 Siemens Aktiengesellschaft Verfahren zur Herstellung eines radioaktiv markierten Carboxylats sowie die Verwendung einer Mikroelektrode zur elektrochemischen Synthese eines radioaktiv markierten Carboxylats

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007039858A2 (fr) * 2005-10-04 2007-04-12 Koninklijke Philips Electronics N.V. Imagerie et/ou therapie ciblees faisant intervenir la cycloaddition [3+2] azide-alcyne
WO2011012414A1 (fr) * 2009-07-29 2011-02-03 Siemens Aktiengesellschaft Procédé de fabrication d'un peptide radiomarqué

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CARMEN S DENCE ET AL: "Radiochemical Synthesis, Rodent Biodistribution and Tumor Uptake, and Dosimetry Calculations of [C] Methylated LY2181308", MOLECULAR IMAGING AND BIOLOGY, SPRINGER-VERLAG, NE, vol. 12, no. 6, 8 April 2010 (2010-04-08), pages 608 - 615, XP019861633, ISSN: 1860-2002, DOI: 10.1007/S11307-010-0319-8 *
HENRIKSEN G ET AL: "Proof of principle for the use of 11C-labelled peptides in tumour diagnosis with PET", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER VERLAG, HEIDELBERG, DE, vol. 31, no. 12, 10 August 2004 (2004-08-10), pages 1653 - 1657, XP002383248, ISSN: 1619-7070, DOI: 10.1007/S00259-004-1582-1 *
JAMES D ET AL: "A 'click chemistry' approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 51, no. 8, 24 February 2010 (2010-02-24), pages 1230 - 1232, XP026861763, ISSN: 0040-4039, [retrieved on 20100119] *
KOBORI N ET AL: "VISUALIZATION OF MRNA EXPRESSION IN CNS USING 11C-LABELED PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE", NEUROREPORT, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 10, no. 14, 29 September 1999 (1999-09-29), pages 2971 - 2974, XP009014077, ISSN: 0959-4965, DOI: 10.1097/00001756-199909290-00018 *
SANDELL J ET AL: "Labelling of a cholecystokinin (CCK) peptide with 11C, and examination of its brain uptake in a cynomolgus monkey with PET", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 40, 1 December 1997 (1997-12-01), pages 771 - 773, XP002663002, ISSN: 0362-4803 *
SCHIRRMACHER R ET AL: "Rapid in situ synthesis of [<11>C]methyl azide and its application in <11>C click-chemistry", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 49, no. 33, 11 August 2008 (2008-08-11), pages 4824 - 4827, XP022819091, ISSN: 0040-4039, [retrieved on 20080610], DOI: 10.1016/J.TETLET.2008.06.020 *

Also Published As

Publication number Publication date
DE102010026057A1 (de) 2012-01-05
WO2012000791A2 (fr) 2012-01-05

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