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WO2012086878A1 - Appareil de fixation d'ancre dans un système d'électrode pour stimulation d'un nerf crânien - Google Patents

Appareil de fixation d'ancre dans un système d'électrode pour stimulation d'un nerf crânien Download PDF

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Publication number
WO2012086878A1
WO2012086878A1 PCT/KR2011/001715 KR2011001715W WO2012086878A1 WO 2012086878 A1 WO2012086878 A1 WO 2012086878A1 KR 2011001715 W KR2011001715 W KR 2011001715W WO 2012086878 A1 WO2012086878 A1 WO 2012086878A1
Authority
WO
WIPO (PCT)
Prior art keywords
anchor
cover
electrode
electrode system
nerve stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2011/001715
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English (en)
Korean (ko)
Inventor
황용섭
윤호
박세익
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MI Tech Co Ltd
Original Assignee
MI Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MI Tech Co Ltd filed Critical MI Tech Co Ltd
Publication of WO2012086878A1 publication Critical patent/WO2012086878A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0539—Anchoring of brain electrode systems, e.g. within burr hole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0534—Electrodes for deep brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Definitions

  • the present invention relates to an anchor anchoring device of a miniature cranial nerve stimulation electrode system, and more particularly, to easily anchor the anchor inserted with a stimulus electrode (stimulus electrode) used to stimulate a specific part of the brain of the test object to the skull.
  • the present invention relates to an anchor fixing device for an electrode system for minimizing nerve stimulation.
  • DBS deep brain stimulation
  • the advantages of the deep brain stimulation procedure is that the therapeutic effect is greater than the drug treatment or surgery, the risk of brain damage, and does not remove the brain tissue has the advantage of easy application of the new treatment.
  • the electrode system for brain stimulation which is currently being used in deep brain stimulation, has the disadvantages of overcoming frequent brain stimulator replacement due to limited battery life and complexity of surgery due to large size.
  • Next-generation cranial nerve stimulation electrode system is being actively developed to solve these shortcomings.
  • commonly used experimental rats Sprague
  • Duwley rat is used as the test subject.
  • the apparatus disclosed in Unexamined-Japanese-Patent No. 2005-319316 can be mentioned.
  • the stimulation electrode and the electrical stimulation In conducting the deep brain stimulation using such a test object, it should not affect the living body of the test object by the stimulation electrode and the electrical stimulation, there should be no destruction of brain cells, and the electrode material and the related device used for the stimulation electrode Should be safe for application to the living body. To this end, it is necessary to set the exact position of the target site in the deep structure such as the brain, and by using the image using magnetic resonance imaging (MRI) and the fine stimulation electrode can be significantly improved the accuracy of positioning and surgery.
  • MRI magnetic resonance imaging
  • Figure 1 shows a schematic cross-sectional view of the anchor used in the electrode system for brain nerve stimulation of the prior art used to stimulate the cranial nerve of the test subject while meeting the above safety standards.
  • a deep brain stimulation procedure using the conventional electrode system for stimulating the brain as shown in Figure 1 is as follows. First, the rat skull (1) of the test subject was punctured, and a target region of the brain was made by using a tungsten electrode (6) coated with 5 m parylene (parylene) using a stainless steel anchor (2) suitable for living body. It is inserted into the target site 3, embedded with a small amount of dental cement 4, and fixed stably. Subsequently, the anchor 2 into which the stimulation electrode 6 is inserted is wrapped in the fixing device 10 as shown in FIG.
  • the fixing device 10 is a tether band 14 made of a soft elastic material such that the test object does not feel pressure, and an upper part thereof is cut in order to prevent abnormal high heat from occurring at the cutting part of the test object.
  • the saddle 12 is provided with a brain stimulator (not shown) located at the top of the site, which serves to stably stabilize the brain stimulator when performing a behavioral experiment on the subject.
  • the conventional electrode for nerve stimulation electrode system is subject to the test subject rats are broken while moving from place to place within the breeding ground during the experiment. In this case, it becomes impossible to deliver the desired stimulus signal to the test object, which leads to a problem in deriving the test result.
  • a small cranial nerve stimulation electrode system is used to fix the anchor to the skull of the test subject and place the stimulation electrode at the correct target site of the deep brain through the anchor.
  • an anchor has a problem that it is difficult to fix it to the skull of the test object because it is small.
  • an object of the present invention is to provide an anchor fixing device that can easily fix the anchor of the small electrode nerve stimulation electrode system to the skull of the test subject.
  • the device for fixing the anchor to the target position of the skull of the test object is inserted into the anchor electrode of the electrode for nerve stimulation, the anchor portion is formed with a hollow portion is inserted
  • An anchor support portion including a holder and an insertion portion bent and extended from the anchor holder, and a slit formed at one end thereof so that the insertion portion of the anchor support portion is detachably inserted therein, and the anchor inserted into the anchor support portion includes the anchor It includes an anchor moving unit to move to the target position to set the position.
  • the anchor has screw grooves to which the pole electrode support member for supporting the pole electrode is fastened on both sides thereof, and the anchor holder guides the engagement of the electrode support member through the screw grooves of the anchor on both sides thereof. It includes a fastening groove formed to.
  • the insulation cover of the anchor is formed to be insertable, and further includes a cover gripping portion attachable to the other end of the anchor moving portion.
  • the cover gripping portion includes a cover socket having a hollow portion with an open bottom surface to allow the insulation cover of the anchor member to be inserted, and an insertion portion extending from the cover socket and attached to the other end of the anchor moving portion, wherein the anchor
  • the moving part has a slit in which the insertion part of the said cover holding part is detachably inserted in the other end part.
  • the guide projection is formed on the outer surface of the cover of the anchor, the cover socket of the cover holding portion is formed with a guide groove for engaging the guide projection so that the cover is slidably fastened.
  • FIG. 1 is a schematic cross-sectional view showing the configuration of an anchor used in the electrode system for nerve stimulation of the prior art
  • Figure 2 is a perspective view showing a fixing mechanism used in the electrode system for nerve stimulation of the prior art
  • Figure 3 is an exploded perspective view showing the anchor fixing device of the electrode system for small brain nerve stimulation according to an embodiment of the present invention
  • Figure 4 is a coupling state of the anchor fixing device of the electrode system for small brain nerve stimulation according to an embodiment of the present invention
  • FIG. 5 is a state diagram illustrating a state in which the anchor of the cranial nerve stimulation electrode system is gripped to the anchor gripping portion of FIG. 3;
  • FIG. 6 is a state diagram illustrating a state in which the anchor cover of the electrode system for cranial nerve stimulation is fastened to the anchor cover gripping portion of FIG. 3;
  • Figure 7 is a perspective view showing the configuration of the electrode system for brain nerve stimulation used in the present invention.
  • Figure 3 is an exploded perspective view showing an anchor fixing device of the miniature cranial nerve stimulation electrode system according to an embodiment of the present invention
  • Figure 4 is an anchor fixing device of the miniature cranial nerve stimulation electrode system according to an embodiment of the present invention Is a state of coupling.
  • Anchor fixing device 200 of the miniature cranial nerve stimulation electrode system is fixed to the target position of the skull surface by holding the anchor of the miniature cranial nerve stimulation electrode system shown in FIG. It is used to Prior to the description of the embodiment of the present invention will be described the configuration of the anchor of the miniature nerve stimulation electrode system.
  • the small electrode nerve stimulation electrode system has an anchor 20 whose bottom surface is fixed to the skull of the test object, and reaches a target site of the brain of the test object through the anchor 20. It includes a stimulation electrode 50 for applying an electrical stimulation to the target site.
  • the anchor 20 is composed of an electrode holder 40 of a hexahedron or cube that is supported by the magnetic pole electrode 50 and a flange portion 30 formed integrally with the lower portion of the electrode holder 40.
  • the flange portion 30 is made of a non-conductor such as Teflon, the bottom surface is configured to be fixed to the target position of the skull of the test object, and includes a through groove 36 through which the stimulation electrode 50 is inserted through the body. do.
  • the flange portion 30 is provided with inclined ends formed with thread grooves 32 on both front and rear sides thereof, and the screw 34 is screwed through the screw grooves 32 to fix the anchor 20 to the specimen. Fix it stably in the target position of the skull.
  • the screw groove 32 is formed to be inclined toward the electrode holder 40 in a direction perpendicular to the surface of the inclined end to securely anchor the anchor member 20 to the skull of the test object.
  • the electrode holder 40 is made of a non-conductor such as Teflon, and the insertion groove 42 into which the magnetic pole electrode 50 is inserted in communication with the through groove 36 of the flange portion 30 vertically. And two fastening grooves 44 penetrating to the left and right sides of the electrode holder 40 in the direction perpendicular to the insertion groove 42. As the insertion groove 42 and the through groove 36 are vertically communicated with each other, the stimulation electrode 50 may maintain verticality even if the surface of the skull of the test object is not horizontal.
  • the electrode system for brain nerve stimulation of the present invention is a pair of metal plate 70 and the electrode holder 40 is inserted into the insertion groove 42 of the electrode holder 40 with the stimulation electrode 50 therebetween.
  • the plate 70 serves to prevent deformation of the magnetic pole electrode 50, which may be caused by the electrode support member 60 fastened to the left and right fastening grooves 44 of the electrode holder 40.
  • Each of the pair of electrode support members 60 includes a screw part 62 fastened to the fastening groove 44 formed in the electrode holder 40, and a head 64 protruding from the screw part 62.
  • One side of the holder 40 is coupled to the metal connector 80 is interposed by the electrode support member 60, the other side of the electrode holder 40 is the pole electrode 50 by the electrode support member 60
  • a metal washer 90 is interposed and coupled to be positioned at the center.
  • the connector 80 is made of a conductive metal material, and is bent from the coupling portion 82 and the coupling portion 82 having a coupling groove coupled to the head 64 of the electrode support member 60, and the flange portion 30. It is composed of an extension portion 84 extending along the longitudinal direction of.
  • a current supplied through a brain stimulator (not shown) is provided to the stimulation electrode 50 through the connector 80 and the electrode support member 60.
  • the cover 22 of FIG. 6 may be fastened to the electrode holder 40 to insulate the current.
  • the anchor fixing device 200 of the cranial nerve stimulation electrode system of the present invention is formed such that the anchor mover 210 and the anchor 20 are insertable, and the anchor mover 210 Anchor support 230 attached to one end of the) and a cover 22 (see FIG. 6) fastened to the electrode holder 40 of the anchor 20 are formed to be insertable, and the other end of the anchor moving part 210.
  • Anchor cover grip portion 250 is attached to the.
  • the anchor moving part 210 has long slender slits 212 and 218 and a pair of through holes 214 and 216 formed at both ends thereof.
  • Anchor support 230 is an anchor member holder 226 having a hollow portion 222 formed so that a portion of the anchor 20 is inserted, and bent from the bottom of the anchor member holder 226 to extend the anchor of the moving portion 210 It includes an insertion unit 220 is inserted into the slit 212.
  • the hollow portion 222 of the anchor holder 226 corresponds to the side shape of the anchor 20, the fastening groove 225 for fastening the support member 60 is formed on both sides of the hollow portion 222.
  • the fastening groove 225 is formed larger than the fastening groove 44 of the electrode holder 40 so that the electrode support member 60 can pass therethrough.
  • the fastening groove 44 formed on both sides of the electrode holder 40 is the fastening groove 225 of the hollow part 222. Is exposed through).
  • the electrode support member 60 may be easily fastened to the fastening groove 44 of the electrode holder 40 while being guided through the fastening groove 225. Therefore, the small size electrode support member 60 can be easily assembled to the small anchor 20.
  • the anchor moving part 210 is moved to the target position of the skull of the test subject by the user and is inserted into the anchor support part 230.
  • the screw 34 is screwed into the target position of the skull of the test object through the screw groove 32 on one side of the flange portion 30 so that one side of the anchor 20 is fixed to the skull of the test object.
  • the anchor support 230 is retracted to separate the anchor 20 from the anchor support 230.
  • the screw 34 is screwed into the target position of the skull of the test object through the screw groove 32 on the other side of the flange portion 30 so that the other side of the anchor 20 is fixed to the skull. Therefore, when the small anchor 20 is fixed at the target position of the skull of the test object, it can be stably fixed.
  • the cover grip part 250 includes a cover socket 242 having an opening 245 having an open bottom surface 245 to allow the cover 22 of the anchor 20 to be inserted therein, and a cover socket ( The insertion part 240 is bent from the extension 242 and inserted into the slit 218 of the anchor moving part 210.
  • a pair of insertion holes 224 and 244 are inserted into the slits 212 and 218 on both sides of the anchor moving part 210 in the insertion part 220 of the anchor support part 230 and the insertion part 240 of the cover holding part 250, respectively.
  • the through holes 216 and 214 are formed to correspond respectively.
  • the insertion part 220 of the anchor support part 230 and the insertion part 240 of the anchor cover gripping part 250 are inserted into the slits 212 and 218 on both sides of the anchor moving part 210, respectively, and the insertion holes 224 and 244.
  • the through-holes 216 and 214 communicate with each other and are coupled to both sides of the anchor moving part 210 by being fastened using a rivet 24 or the like.
  • the insertion part 220 of the anchor support part 230 and the insertion part 240 of the anchor cover gripping part 250 may be fixed and attached by bolting or welding.
  • the anchor support portion 230 and the anchor cover gripping portion 250 are attached to the anchor movement portion 210 with the bending directions opposite to each other. This is because the anchor member and the cover attached to the anchor moving part 210 is maintained in the same direction as it is rotated 180 degrees even when the anchor moving part 210 is rotated to prevent collision with other structures during the procedure of the small-scale nerve stimulation electrode system, Ease of use is provided.
  • the cross-sectional shape of the cover socket 242 of the anchor member cover holding portion 250 corresponds to the shape of the anchor member cover 22 as a whole, the lower opening 245 is Since it is formed, attachment and detachment to the electrode holder 40 of the cover 22 can be facilitated.
  • the guide protrusion 26 is formed on the outer surface of the cover 22 which is fastened to the electrode holder 40 of the anchor member 20, and the cover (socket 242) of the cover holding part 250 is provided with a cover ( A guide groove 248 is formed to engage the guide protrusion 26 of 22. Accordingly, when the cover 22 is pushed into the cover socket 242 of the cover holding part 250 and the guide protrusion 26 of the cover 22 is engaged with the guide groove 248 of the cover socket 242, the cover ( 22 may be mounted on the cover grip part 250.
  • the cover holding part 250 attached to the anchor moving part 210 is moved to a target position where the anchor 20 is fixed by the user.
  • the cover 22 held by the cover holding part 250 is covered by the electrode holder 40 of the anchor 20 so that the cover 22 may be easily fastened to the electrode holder 40.
  • the anchor movement part 210 is pulled back while the cover 22 is fastened, the cover 20 fastened to the electrode holder 40 slides along the guide groove 248 to cover the electrode holder of the anchor 22. Is easily separated from the cover socket 242.
  • the anchor fixing device 200 of the miniature electrode system for cranial nerve stimulation uses the anchor support part 230 fixed to one side of the anchor moving part 210 to anchor the electrode support member 60 to the anchor 20. It is easy to assemble, the anchor 20, the electrode support member 60 is assembled can be easily fixed to the desired target position of the skull of the test object, the anchor moving part 210, the cover holding part 250 of the other side is used The cover 22 may be coupled to the electrode holder 40 of the anchor member 20.
  • the anchor 20 is easily separated from the anchor support 230, and similarly after the cover 22 is fastened to the anchor 20, from the cover holding portion 240 easily separated.
  • anchor support portion 230 and the cover holding portion 240 are fixed to the anchor movement portion 210 by reverse the bending direction to each other to prevent collision with other structures during the operation of the miniature nerve stimulation electrode system.

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  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Husbandry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Electrotherapy Devices (AREA)

Abstract

L'invention concerne un appareil servant à fixer une ancre, dans lequel est insérée une électrode de stimulation d'un système d'électrode destiné à stimuler un nerf crânien, sur un emplacement visé du crâne, l'appareil comportant : une partie de soutien de l'ancre comprenant un support d'ancre formé avec une partie creuse destinée à y insérer une partie de l'ancre, et une partie d'insertion qui fléchit et est déployée à partir du support d'ancre ; et une partie de déplacement de l'ancre dotée d'une fente formée sur une extrémité pour insérer la partie d'insertion de la partie de soutien de l'ancre de façon à pouvoir l'accrocher / la décrocher, afin de régler la position de l'ancre insérée dans la partie de soutien de l'ancre à la position souhaitée sur le crâne du sujet. L'appareil comporte en outre une partie de retenue de couvercle, qui est formée de manière à pouvoir insérer un couvercle d'isolement destiné à l'ancre et qui peut être fixée à l'autre extrémité de la partie de déplacement de l'ancre.
PCT/KR2011/001715 2010-12-23 2011-03-11 Appareil de fixation d'ancre dans un système d'électrode pour stimulation d'un nerf crânien Ceased WO2012086878A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100133635A KR101183559B1 (ko) 2010-12-23 2010-12-23 뇌신경 자극용 소형 전극 시스템의 전극 지지나사 체결구
KR10-2010-0133635 2010-12-23

Publications (1)

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WO2012086878A1 true WO2012086878A1 (fr) 2012-06-28

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PCT/KR2011/001715 Ceased WO2012086878A1 (fr) 2010-12-23 2011-03-11 Appareil de fixation d'ancre dans un système d'électrode pour stimulation d'un nerf crânien

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KR (1) KR101183559B1 (fr)
WO (1) WO2012086878A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5865842A (en) * 1996-08-29 1999-02-02 Medtronic, Inc. System and method for anchoring brain stimulation lead or catheter
JP2001231759A (ja) * 2000-02-24 2001-08-28 Tomy Ltd 脳電極固定装置
US6413263B1 (en) * 2000-04-24 2002-07-02 Axon Instruments, Inc. Stereotactic probe holder and method of use
US20100023100A1 (en) * 2008-07-24 2010-01-28 Boston Scientific Neoromodulation Corporation Cam lock burr hole plug for securing stimulation lead
US20100145357A1 (en) * 2007-10-26 2010-06-10 Boston Scientific Neuromodulation Corporation Burr hole plug having dual slidable clamping mechanisms

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5865842A (en) * 1996-08-29 1999-02-02 Medtronic, Inc. System and method for anchoring brain stimulation lead or catheter
JP2001231759A (ja) * 2000-02-24 2001-08-28 Tomy Ltd 脳電極固定装置
US6413263B1 (en) * 2000-04-24 2002-07-02 Axon Instruments, Inc. Stereotactic probe holder and method of use
US20100145357A1 (en) * 2007-10-26 2010-06-10 Boston Scientific Neuromodulation Corporation Burr hole plug having dual slidable clamping mechanisms
US20100023100A1 (en) * 2008-07-24 2010-01-28 Boston Scientific Neoromodulation Corporation Cam lock burr hole plug for securing stimulation lead

Also Published As

Publication number Publication date
KR20120071906A (ko) 2012-07-03
KR101183559B1 (ko) 2012-09-17

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