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WO2012079595A1 - Herbal composition to treat the hepatic diseases and fibrosis - Google Patents

Herbal composition to treat the hepatic diseases and fibrosis Download PDF

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Publication number
WO2012079595A1
WO2012079595A1 PCT/EG2011/000028 EG2011000028W WO2012079595A1 WO 2012079595 A1 WO2012079595 A1 WO 2012079595A1 EG 2011000028 W EG2011000028 W EG 2011000028W WO 2012079595 A1 WO2012079595 A1 WO 2012079595A1
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WIPO (PCT)
Prior art keywords
liver
fibrosis
drug
patient
tumors
Prior art date
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Ceased
Application number
PCT/EG2011/000028
Other languages
French (fr)
Inventor
Mahmoud Abou Elyazed Kotp Abo Talep
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Individual
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Individual
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Filing date
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Publication of WO2012079595A1 publication Critical patent/WO2012079595A1/en
Anticipated expiration legal-status Critical
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/886Aloeaceae (Aloe family), e.g. aloe vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Definitions

  • This drug aims that the man will recover the health, as this disease is too dangerous, it destroys the patient and makes him unable to perform his vital functions. It is one of the most dangerous diseases and the patients are millions all over the world.
  • the gallbladder is a small sac containing the biliary juice to be more concentrated and can digest the food easily.
  • Ligalon Cilimariene it is a vegetarian- origin plant aiming to support the functions of the cellular wall, protect the liver tissues against the harmful factors and improve the digestion process.
  • This drug is not too useful for the patient with hepatic diseases, especially the patient with enlarged liver suffering from fibrosis and tumors. It does not remove the fibrosis or the tumors, and does not improve the hepatic enzymes. Hence, the patient does not feel better, when he takes that drug.
  • the Chinese therapy (the yellow tablet): it is a herbal compound aiming to improve the liver functions and enzymes and decrease the blood contamination rate, but this improvement is limited and non- perman
  • This drug depends on the formation of the juice in the liver to react with the fibrosis and tumors located in the liver to get them out with the feces.
  • the pharmaceutical compound it is driven from a plant called "Al Sabr”. It is a medical plant used from long time in treating several diseases. This plant is squeezed, and the juice is boiled, dried and grinded into powder.
  • the percentage of the powder is about 67% of the drug.
  • This drug is able to secrete a juice in the patient's liver, which reacts with the fibrosis and tumors located in the liver to get them out of the body gradually, hence, the health of the patient improved gradually and the patient recovered his health.
  • the patient takes the drug he feels little spasms in the liver upon getting rid of the fibrosis and the tumors, and the patient can completely afford it.
  • X-ray is usually used, this ray demonstrated that, the liver was enlarged and suffering from the fibrosis pre the treatment, and it restores its normal position during 8 years after taking the drug.
  • the subject of the research is that, when the liver is infected with diseases, all other organs of the body are also infected, as it affects them.
  • the liver is a very crucial organ. It is located in the upper part of the abdominal cavity, under the diaphragm. The stomach, spleen, pancreas, bowels and colon are too substantial and located next to the diaphragm. The liver is divided into 3 parts: l)the right lobe, 2)the left lobe and 3) the gallbladder.
  • the liver is the largest organ, and it weighs about 1.5 kg.
  • the liver and the circulatory system are the liver and the circulatory system
  • the liver is connected with the portal vein and the hepatic artery. It filtrates the blood circulation.
  • the liver and the digestive system are the liver and the digestive system.
  • the liver cells secrete the biliary juice in the gallbladder canals that carry this juice to the gallbladder. It is a network of paths reaching the gallbladder, then the stomach through the gallbladder canal, so that, this juice could digest the food.
  • Functions of the kidney are a network of paths reaching the gallbladder, then the stomach through the gallbladder canal, so that, this juice could digest the food.
  • the liver is too significant, its functions are too vital as they regulate the activities of the body as a whole. If the liver is infected, all vital functions of the body will be badly affected.
  • the hepatic virus "c” it is recently discovered by the hemanalysis, however, this virus has prevailed all over the world, especially in Egypt for a long time.
  • the hepatic fibrosis it happens due to the existence of the virus in the blood in large quantities, so, the liver cells secrete it with the biliary juice in the gallbladder canal, causing the fibrosis in these canals.
  • the liver becomes enlarged, and the bigger the liver is, the health of the man will be gradually deteriorated. It leads to: 1) the formation of tumors in the colon and bowels, 2) the stomach and esophageal varicose, 3) ascites, and 4) the hepatic coma.
  • Cilimarin it is a vegetarian- origin drug. It aims to support the functions of the cellular wall, protect the liver tissues against the harmful factors, and improve the digestion process. But, it is not useful for the patient with the hepatic fibrosis at all.
  • the Chinese therapy The yellow tablet: it is derived from the herbs and used in Egypt. It aims to improve the liver functions and enzymes, and decrease the blood contamination rate.
  • This drug is able to activate and increase the secretion of the juice in the liver.
  • This juice reacts with the fibrosis and the tumors located in the liver to get them out of the body gradually, hence, the health of the patient improved gradually, until the patient recovered his health.
  • this drug it is very important, as it is the first one treating the fibrosis and virus C finally, as the number of the patients with liver diseases is millions all over the world, especially in Egypt.
  • This drug is able to form the juice in the liver, which reacts with fibrosis and tumors located in the liver to get them out gradually to be totally recovered.
  • the financial cost compared with any other drugs such as interferon, the cost of this drug is less than other drugs.
  • the drug must be tested. It is a suggested that it can be tested on 10 patients. If the tumor starts to get out of the patients' liver, then, it will be the only drug that can get the fibrosis and tumors out of the liver all over the world.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention is related to a plant mixture, comprising "El Sabr" and "Habet Al Baraka" (Nigella Sativa) able to activate and increase the secretion of the juice in the liver. This material reacts with the fibrosis and tumors located in the liver, and get them out of the body. Hence, the liver restores its normal position gradually, and the patient's health improves gradually. The drug was tested, there are pre- and post- treatment rays of liver and the enzymes. They demonstrate that, the patient's liver and health have improved.

Description

HERBAL COMPOSITION TO TREAT THE HEPATIC DISEASES AND FIBROSIS
Technical Field:
It is related to the drug for the hepatic fibrosis and tumors resulted from Virus C located in the liver.
This drug aims that the man will recover the health, as this disease is too dangerous, it destroys the patient and makes him unable to perform his vital functions. It is one of the most dangerous diseases and the patients are millions all over the world.
Background Art :
There are several types of the drugs to help the liver do its critical functions, such as:
1- The long- run Interfereon: it is given to the patient for 6 months. It is given with Ribarien. It stops any increase in the tumor, improves the enzymes in the blood of the patient to be better than the patient who does not take that drug. But, the drug has side effects including:
1 -the hair loss
2- the feeling of depression
3 - the patience's bad- temper
4- the patient's health will be deteriorated after a period of time
The problem and the deficiency of the previous Art
The gallbladder is a small sac containing the biliary juice to be more concentrated and can digest the food easily. Ligalon Cilimariene: it is a vegetarian- origin plant aiming to support the functions of the cellular wall, protect the liver tissues against the harmful factors and improve the digestion process. This drug is not too useful for the patient with hepatic diseases, especially the patient with enlarged liver suffering from fibrosis and tumors. It does not remove the fibrosis or the tumors, and does not improve the hepatic enzymes. Hence, the patient does not feel better, when he takes that drug.
The Chinese therapy (the yellow tablet): it is a herbal compound aiming to improve the liver functions and enzymes and decrease the blood contamination rate, but this improvement is limited and non- perman
Disclosure of Invention :
This drug depends on the formation of the juice in the liver to react with the fibrosis and tumors located in the liver to get them out with the feces.
1- The pharmaceutical compound: it is driven from a plant called "Al Sabr". It is a medical plant used from long time in treating several diseases. This plant is squeezed, and the juice is boiled, dried and grinded into powder.
The percentage of the powder is about 67% of the drug.
2- Plant of "Habet El Baraka": it is a medical plant known from long time. It belongs to the fragrant group. The seeds of this plant are taken, grinded and added to the drug. Its percentage in the drug is about 33%. It is packed into pharmaceutical capsules and given to the patient on daily basis.
This drug is able to secrete a juice in the patient's liver, which reacts with the fibrosis and tumors located in the liver to get them out of the body gradually, hence, the health of the patient improved gradually and the patient recovered his health. When the patient takes the drug, he feels little spasms in the liver upon getting rid of the fibrosis and the tumors, and the patient can completely afford it. X-ray is usually used, this ray demonstrated that, the liver was enlarged and suffering from the fibrosis pre the treatment, and it restores its normal position during 8 years after taking the drug.
This is the first drug treating this disease finally, and the patient's health improved completely.
How to take the drug: the patient takes a dose daily, which is accompanied by a small glass of milk sweetened by two spoons of honey.
The complete description of the invention
It contains:
(The previous literature- the problem or the deficiency in the previous literature- the new aspects of the invention- the detailed description, how to use it). (4/1) The previous literature: since the beginning of the human existence, he has suffered from several diseases and looked for a remedy for them. The most ancient civilizations, that left papyrus including the diseases, its diagnosis and remedy, are the pharaonic civilization, the Babylonian civilization in Iraq, the Greek and Romanian civilization and the old Arabic medicine. The Arab scientist Ibn Sina wrote the book "the law" In the medicine, which was translated into the Greek language and was the key reason for the progress of Europe in the medicine later. There is a honorable hadith urges us to search for the medicine.
The subject of the research is that, when the liver is infected with diseases, all other organs of the body are also infected, as it affects them.
What is the kidney? Where is it? The liver is a very crucial organ. It is located in the upper part of the abdominal cavity, under the diaphragm. The stomach, spleen, pancreas, bowels and colon are too substantial and located next to the diaphragm. The liver is divided into 3 parts: l)the right lobe, 2)the left lobe and 3) the gallbladder.
The liver is the largest organ, and it weighs about 1.5 kg.
The liver and the circulatory system
The liver is connected with the portal vein and the hepatic artery. It filtrates the blood circulation.
The liver and the digestive system
The liver cells secrete the biliary juice in the gallbladder canals that carry this juice to the gallbladder. It is a network of paths reaching the gallbladder, then the stomach through the gallbladder canal, so that, this juice could digest the food. Functions of the kidney:
1- the formation and secretion of the biliary juice
2- the formation of the protein in the blood
3- getting rid of the poisons of the food and filtrating the blood circulation
4- the formation of the complicated enzymes in the blood
5- regulating the glucose level in the bloodO
Hence, the liver is too significant, its functions are too vital as they regulate the activities of the body as a whole. If the liver is infected, all vital functions of the body will be badly affected.
The hepatic virus "c": it is recently discovered by the hemanalysis, however, this virus has prevailed all over the world, especially in Egypt for a long time. The hepatic fibrosis: it happens due to the existence of the virus in the blood in large quantities, so, the liver cells secrete it with the biliary juice in the gallbladder canal, causing the fibrosis in these canals.
Initially, it is white like fats; it is called the fatty liver, as there is no fibrosis. But it is wrong, as this is the fibrosis in its first stage, where the liver is not enlarged; its position is normal and the enzymes are natural.
Then, the liver becomes enlarged, and the bigger the liver is, the health of the man will be gradually deteriorated. It leads to: 1) the formation of tumors in the colon and bowels, 2) the stomach and esophageal varicose, 3) ascites, and 4) the hepatic coma.
There are several drugs to help the patient's liver do its vital functions:
1- Legalon, Cilimarin: it is a vegetarian- origin drug. It aims to support the functions of the cellular wall, protect the liver tissues against the harmful factors, and improve the digestion process. But, it is not useful for the patient with the hepatic fibrosis at all.
2- The Chinese therapy. The yellow tablet: it is derived from the herbs and used in Egypt. It aims to improve the liver functions and enzymes, and decrease the blood contamination rate.
The new aspects of the invention
(al Safaa)
This drug is able to activate and increase the secretion of the juice in the liver. This juice reacts with the fibrosis and the tumors located in the liver to get them out of the body gradually, hence, the health of the patient improved gradually, until the patient recovered his health.
The side effects: there are not any side effects at all How does the liver get rid of the fibrosis and tumors? When the patient takes the drug, he feels little spasms in the liver upon getting rid of the fibrosis and the tumors. They get out of the liver to the biliary vesicles, then to the bowel and out of the body.
Who will take the drug? The patient with the fibrosis must take this drug. The patient with no fibrosis must take this drug once every 6 months for a week or 2 weeks to avoid the infection of this diseaseO
The importance of this drug: it is very important, as it is the first one treating the fibrosis and virus C finally, as the number of the patients with liver diseases is millions all over the world, especially in Egypt.
The detailed Description :
It includes how to use it in terms of the appliances and equipments, or the chemical preparation in terms of the chemical and agricultural materials, the lab experiments and the side effects. It is supplemented with tables and illustrations- if it were- in separated pages following the new elements that must be protected. These illustrations must be vertically numerated without any data. The parts of the drawing are labeled with numbers to be explained in the detailed description.
(Al Safaa)
To treat and remove the fibrosis and the tumors resulted from Virus C.
The capacity of the drug: This drug is able to form the juice in the liver, which reacts with fibrosis and tumors located in the liver to get them out gradually to be totally recovered.
How to get rid of the fibrosis and tumors: when the patient takes the drug, he feels little spasms in the liver upon getting rid of the fibrosis and the tumors gradually. But, he must take the drug continuously. The side effects: there are not any side effects at all, although the patient feels some spasms when the tumor starts to get out of the liver. When the patient takes the drug, the dark liquid- which is collected in the tumor- sometimes gets down from the liver.
How to use it?
The importance of the drug: it is too crucial due to the non- existence of a drug for this disease all over the world.
Is the drug tested: it is totally tested. There are pre and post- treatment rays and hemanalysis (enzymes). There is also photography of the fibrosis and tumors that get out of the liver. The rays demonstrate that the liver was too enlarged pre the treatment , but upon taking the drug and getting rid of the fibrosis and tumors , the liver started to restore its normal position gradually.
The financial cost: compared with any other drugs such as interferon, the cost of this drug is less than other drugs.
The tests conducted on the drug: the drug must be tested. It is a suggested that it can be tested on 10 patients. If the tumor starts to get out of the patients' liver, then, it will be the only drug that can get the fibrosis and tumors out of the liver all over the world.

Claims

Claims
The elements of the protection:
1- The pharmaceutical compound: it is a powder derived from the plant called "El Sabr" at around 67%. It is a powder derived from the plant of "Habet Al Baraka" at percentage of 33%
2- The capsules lg, 500 mg derived from this material resulted from the mixture of these both elements.
3- This material is packed in the form of tablets, which are a mixture of these both materials
PCT/EG2011/000028 2010-12-15 2011-12-11 Herbal composition to treat the hepatic diseases and fibrosis Ceased WO2012079595A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EG2010122129 2010-12-15
EG2010122129 2010-12-15

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Publication Number Publication Date
WO2012079595A1 true WO2012079595A1 (en) 2012-06-21

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648089A (en) * 1995-07-03 1997-07-15 Shawkat; Tarek Extract solution and herbal mixture for treatment of hepatitis
US20020160065A1 (en) * 2000-09-20 2002-10-31 Shalaby Said I.A. Herbal compositions and treatment methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648089A (en) * 1995-07-03 1997-07-15 Shawkat; Tarek Extract solution and herbal mixture for treatment of hepatitis
US20020160065A1 (en) * 2000-09-20 2002-10-31 Shalaby Said I.A. Herbal compositions and treatment methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRENT SORENSON ET AL: "Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepatic metastasis", ONCOTARGETS AND THERAPY, 1 May 2011 (2011-05-01), pages 59, XP055018724, DOI: 10.2147/OTT.S17081 *
SAYED MOHAMED M ET AL: "Hypoglycemic effect of two mixtures of plant extracts on diabetic rats", JOURNAL OF THE MEDICAL RESEARCH INSTITUTE, vol. 23, no. 1, 2002, pages 35 - 43, XP002627262, ISSN: 1110-0133 *
SOLIMAN M ET AL: "SHORT TERM EFFECT OF NIGELLA SATIVA ON CHRONIC HEPATITIS C INFECTION IN HEMODIALYSIS PATIENTS (A PRELIMINARY REPORT)", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 11, no. 6, 1 June 1996 (1996-06-01), pages A223, XP000964617, ISSN: 0931-0509 *
TURKDOGAN M K ET AL: "The role of antioxidant vitamins (C and E), selenium and Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits: New hopes", DTW (DEUTSCHE TIERAERZTLICHE WOCHENSCHRIFT), vol. 108, no. 2, February 2001 (2001-02-01), pages 71 - 73, XP009156369, ISSN: 0341-6593 *

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