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WO2012076973A3 - Novel salts of dipeptidyl peptidase iv inhibitor - Google Patents

Novel salts of dipeptidyl peptidase iv inhibitor Download PDF

Info

Publication number
WO2012076973A3
WO2012076973A3 PCT/IB2011/002982 IB2011002982W WO2012076973A3 WO 2012076973 A3 WO2012076973 A3 WO 2012076973A3 IB 2011002982 W IB2011002982 W IB 2011002982W WO 2012076973 A3 WO2012076973 A3 WO 2012076973A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor
dipeptidyl peptidase
novel salts
novel
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/002982
Other languages
French (fr)
Other versions
WO2012076973A2 (en
Inventor
Mohammed Umar Khan
Ranjith Kumar Srinivasan
Vipin Kumar Kaushik
Koilpillai Joseph Prabahar
Meenakshisunderam Sivakumaran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aurobindo Pharma Ltd
Original Assignee
Aurobindo Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd filed Critical Aurobindo Pharma Ltd
Publication of WO2012076973A2 publication Critical patent/WO2012076973A2/en
Publication of WO2012076973A3 publication Critical patent/WO2012076973A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel pharmaceutically acceptable salts of 7-[(3R)-3- amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-[1,2,-4]-triazolo [4,3-a]pyrazine of Formula (I), or solvates or hydrates thereof.
PCT/IB2011/002982 2010-12-09 2011-12-07 Novel salts of dipeptidyl peptidase iv inhibitor Ceased WO2012076973A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3759CH2010 2010-12-09
IN3759/CHE/2010 2010-12-09

Publications (2)

Publication Number Publication Date
WO2012076973A2 WO2012076973A2 (en) 2012-06-14
WO2012076973A3 true WO2012076973A3 (en) 2012-08-02

Family

ID=45509547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/002982 Ceased WO2012076973A2 (en) 2010-12-09 2011-12-07 Novel salts of dipeptidyl peptidase iv inhibitor

Country Status (1)

Country Link
WO (1) WO2012076973A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012131005A1 (en) * 2011-03-29 2012-10-04 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical composition of sitagliptin
CN106905321A (en) 2011-10-14 2017-06-30 劳乐斯实验室私营有限公司 New sitagliptin salt, its preparation method and its pharmaceutical composition
WO2015114657A2 (en) 2014-01-21 2015-08-06 Cadila Healthcare Limited Amorphous form of sitagliptin free base
CN105503883B (en) * 2015-12-30 2018-03-02 西安交通大学 A kind of Xi Gelieting nitrates heterozygote and its preparation method and application
CA3164093A1 (en) * 2019-12-20 2021-06-24 Center For Intelligent Research In Crystal Engineering, S.L. Cocrystals of pterostilbene and compositions comprising them

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2218721A1 (en) * 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
WO2010117738A2 (en) * 2009-03-30 2010-10-14 Teva Pharmaceutical Industries Ltd. Solid state forms of sitagliptin salts
WO2011060213A2 (en) * 2009-11-12 2011-05-19 Dr. Reddy's Laboratories Ltd. Preparation of sitagliptin and salts thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
JO2625B1 (en) 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
AU2004268024B2 (en) 2003-09-02 2007-07-12 Merck Sharp & Dohme Llc Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
US20070021430A1 (en) 2003-09-23 2007-01-25 Chen Alex M Novel crystalline form of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
WO2005072530A1 (en) 2004-01-16 2005-08-11 Merck & Co., Inc. Novel crystalline salts of a dipeptidyl peptidase-iv inhibitor
US7612072B2 (en) 2004-09-15 2009-11-03 Merck & Co., Inc. Amorphous form of a phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
EP1909776A2 (en) 2005-07-25 2008-04-16 Merck & Co., Inc. Dodecylsulfate salt of a dipeptidyl peptidase-iv inhibitor
EP2599781A1 (en) 2007-12-20 2013-06-05 Dr. Reddy's Laboratories Ltd. Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
EP2318411A2 (en) 2008-07-03 2011-05-11 Ratiopharm GmbH Crystalline salts of sitagliptin
EP2324027B1 (en) 2008-07-29 2016-02-24 Medichem, S.A. New crystalline salt forms of a 5,6,7,8-tetrahydro-1,2,4- triazolo[4,3-a]pyrazine derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2218721A1 (en) * 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
WO2010117738A2 (en) * 2009-03-30 2010-10-14 Teva Pharmaceutical Industries Ltd. Solid state forms of sitagliptin salts
WO2011060213A2 (en) * 2009-11-12 2011-05-19 Dr. Reddy's Laboratories Ltd. Preparation of sitagliptin and salts thereof

Also Published As

Publication number Publication date
WO2012076973A2 (en) 2012-06-14

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