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WO2012075501A3 - Diagnosing and grading acute lymphocytic leukemia - Google Patents

Diagnosing and grading acute lymphocytic leukemia Download PDF

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Publication number
WO2012075501A3
WO2012075501A3 PCT/US2011/063320 US2011063320W WO2012075501A3 WO 2012075501 A3 WO2012075501 A3 WO 2012075501A3 US 2011063320 W US2011063320 W US 2011063320W WO 2012075501 A3 WO2012075501 A3 WO 2012075501A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosing
lymphocytic leukemia
acute lymphocytic
well
grading acute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/063320
Other languages
French (fr)
Other versions
WO2012075501A2 (en
Inventor
Steven Kornblau
Nianxiang Zhang
Yi Hua Qiu
Kevin Coombes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of WO2012075501A2 publication Critical patent/WO2012075501A2/en
Publication of WO2012075501A3 publication Critical patent/WO2012075501A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides for a proteomic approach to diagnosing, classifying and grading acute lymphocytic leukemia (ALL), as well as for predicting patient survival. This approach employs global protein expression patterns to identify gene groups whose expression is altered in various ALLs and can thus be used to classify the type of ALL, the stage of ALL, as well as indicate whether a given patient will be a short- or long-term survivor.
PCT/US2011/063320 2010-12-03 2011-12-05 Diagnosing and grading acute lymphocytic leukemia Ceased WO2012075501A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41971410P 2010-12-03 2010-12-03
US61/419,714 2010-12-03

Publications (2)

Publication Number Publication Date
WO2012075501A2 WO2012075501A2 (en) 2012-06-07
WO2012075501A3 true WO2012075501A3 (en) 2012-09-27

Family

ID=46172614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/063320 Ceased WO2012075501A2 (en) 2010-12-03 2011-12-05 Diagnosing and grading acute lymphocytic leukemia

Country Status (1)

Country Link
WO (1) WO2012075501A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009064481A1 (en) * 2007-11-14 2009-05-22 Stc.Unm Identification of novel subgroups of high-risk pediatric precursor b acute lymphoblastic leukemia, outcome correlations and diagnostic and therapeutic methods related to same
WO2010056351A2 (en) * 2008-11-14 2010-05-20 Stc.Unm Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and out come prediction in pedeatric b-precursor acute lymphoblastic leukemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009064481A1 (en) * 2007-11-14 2009-05-22 Stc.Unm Identification of novel subgroups of high-risk pediatric precursor b acute lymphoblastic leukemia, outcome correlations and diagnostic and therapeutic methods related to same
WO2010056351A2 (en) * 2008-11-14 2010-05-20 Stc.Unm Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and out come prediction in pedeatric b-precursor acute lymphoblastic leukemia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KORNBLAU, S. M. ET AL.: "Functional proteomic profiling of AML predicts response and survival", BLOOD., vol. 113, no. 1, 7 October 2008 (2008-10-07), pages 154 - 164 *
YEOH, E. ET AL.: "Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling", CANCER CELL., vol. 1, no. 2, March 2002 (2002-03-01), pages 133 - 143 *

Also Published As

Publication number Publication date
WO2012075501A2 (en) 2012-06-07

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