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WO2012075114A3 - Nucleic acid-polymer conjugates and uses thereof - Google Patents

Nucleic acid-polymer conjugates and uses thereof Download PDF

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Publication number
WO2012075114A3
WO2012075114A3 PCT/US2011/062588 US2011062588W WO2012075114A3 WO 2012075114 A3 WO2012075114 A3 WO 2012075114A3 US 2011062588 W US2011062588 W US 2011062588W WO 2012075114 A3 WO2012075114 A3 WO 2012075114A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
polymer conjugates
polymer
conjugates
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/062588
Other languages
French (fr)
Other versions
WO2012075114A2 (en
Inventor
Nicholas Lee Hammond
Tyler Weis Hodges
Lisa Kay Kemp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ABLITECH Inc
Original Assignee
ABLITECH Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ABLITECH Inc filed Critical ABLITECH Inc
Publication of WO2012075114A2 publication Critical patent/WO2012075114A2/en
Anticipated expiration legal-status Critical
Publication of WO2012075114A3 publication Critical patent/WO2012075114A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described herein are nucleic acid-polymer conjugates comprising a nucleic acid linked to a polymer described herein. Also described herein is the use of such nucleic acid-polymer conjugates for the treatment of disease.
PCT/US2011/062588 2010-12-01 2011-11-30 Nucleic acid-polymer conjugates and uses thereof Ceased WO2012075114A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41866310P 2010-12-01 2010-12-01
US61/418,663 2010-12-01

Publications (2)

Publication Number Publication Date
WO2012075114A2 WO2012075114A2 (en) 2012-06-07
WO2012075114A3 true WO2012075114A3 (en) 2014-04-10

Family

ID=46172528

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/062588 Ceased WO2012075114A2 (en) 2010-12-01 2011-11-30 Nucleic acid-polymer conjugates and uses thereof

Country Status (1)

Country Link
WO (1) WO2012075114A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2968599A4 (en) 2013-03-14 2016-11-09 Albany Molecular Res Inc Ligand-therapeutic agent conjugates and silicon-based linkers
US20160122760A1 (en) * 2013-06-07 2016-05-05 Rana Therapeutics, Inc. Compositions and methods for modulating foxp3 expression
KR20170029577A (en) * 2014-07-10 2017-03-15 레플리코르 인코포레이티드 Methods for the treatment of hepatitis b and hepatitis d virus infections
CN113304274B (en) * 2021-04-23 2025-03-04 天津全和诚生物技术有限公司 Conjugate and preparation method and use thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017196A1 (en) * 1998-07-02 2003-01-23 Stein Cy A. Oligonucleotide inhibitors of bcl-xL
US20040127694A1 (en) * 2000-09-28 2004-07-01 Komeluk Robert G. Antisense IAP oligonucleotides and uses thereof
US20050176667A1 (en) * 2001-01-09 2005-08-11 Alnylam Europe Ag Compositions and methods for inhibiting expression of anti-apoptotic genes
US20080058322A1 (en) * 2001-11-01 2008-03-06 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
WO2008043561A2 (en) * 2006-10-11 2008-04-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Influenza targets
US20090163702A1 (en) * 2002-11-14 2009-06-25 Dharmacon Inc. siRNA targeting Myeloid cell leukemia sequence 1
US20090186802A1 (en) * 2005-12-16 2009-07-23 Diatos Cell Penetrating Peptide Conjugates for Delivering of Nucleic Acids into a Cell

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017196A1 (en) * 1998-07-02 2003-01-23 Stein Cy A. Oligonucleotide inhibitors of bcl-xL
US20040127694A1 (en) * 2000-09-28 2004-07-01 Komeluk Robert G. Antisense IAP oligonucleotides and uses thereof
US20050176667A1 (en) * 2001-01-09 2005-08-11 Alnylam Europe Ag Compositions and methods for inhibiting expression of anti-apoptotic genes
US20080058322A1 (en) * 2001-11-01 2008-03-06 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
US20090163702A1 (en) * 2002-11-14 2009-06-25 Dharmacon Inc. siRNA targeting Myeloid cell leukemia sequence 1
US20090186802A1 (en) * 2005-12-16 2009-07-23 Diatos Cell Penetrating Peptide Conjugates for Delivering of Nucleic Acids into a Cell
WO2008043561A2 (en) * 2006-10-11 2008-04-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Influenza targets

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOGOI ET AL.: "A versatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water.", NUCLEIC ACIDS RES., vol. 35, no. 21, 2007, pages E139 *
RAJAGOPAL ET AL.: "Functions of the type 1 BMP receptor Acvr1 (AIk2) in lens development: cell proliferation, terminal differentiation, and survival.", INVEST. OPHTHAMOL. VIS. SCI., vol. 49, no. 11, 2008, pages 4953 - 4960 *
ROZEMA ET AL.: "Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.", PROC. NATL. ACAD. SCI. USA, vol. 104, no. 32, 2007, pages 12982 - 12987 *
XUE ET AL.: "Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats.", GENE THER., vol. 17, no. 3, 2009, pages 370 - 379 *

Also Published As

Publication number Publication date
WO2012075114A2 (en) 2012-06-07

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