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WO2012066338A2 - Procédé et appareil pour l'écriture directe - Google Patents

Procédé et appareil pour l'écriture directe Download PDF

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Publication number
WO2012066338A2
WO2012066338A2 PCT/GB2011/052248 GB2011052248W WO2012066338A2 WO 2012066338 A2 WO2012066338 A2 WO 2012066338A2 GB 2011052248 W GB2011052248 W GB 2011052248W WO 2012066338 A2 WO2012066338 A2 WO 2012066338A2
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WO
WIPO (PCT)
Prior art keywords
layer
substrate
disc
acceptor
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2011/052248
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English (en)
Other versions
WO2012066338A3 (fr
Inventor
Richard Lione
Jitka Brynjolffssen
Paul Sheard
Neil Davies
Simon Pickhaver
Jonas Rundqvist
Andreal Larsson
Anders Hanning
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lingvitae Holding AS
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Lingvitae Holding AS
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Filing date
Publication date
Application filed by Lingvitae Holding AS filed Critical Lingvitae Holding AS
Publication of WO2012066338A2 publication Critical patent/WO2012066338A2/fr
Publication of WO2012066338A3 publication Critical patent/WO2012066338A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B7/00—Recording or reproducing by optical means, e.g. recording using a thermal beam of optical radiation by modifying optical properties or the physical structure, reproducing using an optical beam at lower power by sensing optical properties; Record carriers therefor
    • G11B7/24—Record carriers characterised by shape, structure or physical properties, or by the selection of the material
    • G11B7/241—Record carriers characterised by shape, structure or physical properties, or by the selection of the material characterised by the selection of the material
    • G11B7/242—Record carriers characterised by shape, structure or physical properties, or by the selection of the material characterised by the selection of the material of recording layers
    • G11B7/244—Record carriers characterised by shape, structure or physical properties, or by the selection of the material characterised by the selection of the material of recording layers comprising organic materials only
    • G11B7/246—Record carriers characterised by shape, structure or physical properties, or by the selection of the material characterised by the selection of the material of recording layers comprising organic materials only containing dyes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00441—Maskless processes using lasers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00536—Sheets in the shape of disks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays

Definitions

  • the present invention relates to the field of direct writing techniques. More specifically, the present invention relates to a method and apparatus for directly writing materials to controlled micron and sub-micron-sized features at defined addressable locations on solid substrates at high speed using an optical disc drive assembly.
  • the present invention provides an optical medium for performing direct writing, the medium comprises: an acceptor substrate including:
  • a reflective layer provided on the substrate layer; and a donor substrate including:
  • the optical medium comprises tracking and addressing means arranged to allow an optical drive to determine the position of a read/write laser on the medium;
  • the optical medium is arranged such that a portion of the transfer layer is transferred from the donor substrate to the acceptor substrate when the ablative layer is ablated by a beam of laser light, wherein the location of the beam of light can be determined using the tracking an addressing means.
  • the ablative layer and the transfer layer can be one and the same layer.
  • the donor portion further comprises:
  • an encapsulation layer positioned between the ablative layer and the transfer layer, and arranged to transfer the ablative energy of the ablative layer to the transfer layer, such that transfer to the acceptor substrate is achieved.
  • the reflective layer is a partially reflective layer.
  • the tracking and addressing means can form part of the acceptor substrate.
  • the tracking and addressing means forms part of the donor substrate.
  • the optical medium is an optical disc.
  • the present invention also provides a method of direct writing using the above-described optical medium, the method comprises the steps of:
  • the present invention further provides an acceptor substrate comprising one or more portions of a transfer layer transferred from a donor substrate in accordance with the method described above.
  • the acceptor substrate comprises an area configured in a data format for providing tracking and address information to an optical reader, wherein the one or more portions of the transfer layer are disposed at addressable locations in the data format.
  • the portions of transfer layer are reagents configured to selectively cause a change in an optical property when contacted with an analyte.
  • the present invention further provides an optical medium comprising: a substrate comprising an area configured in a data format for providing tracking and address information to an optical reader, and
  • reagents disposed at addressable locations in the data format, wherein the reagents are configured to selectively cause a change in an optical property of the medium when contacted with an analyte.
  • the present invention also provides an acceptor substrate for performing direct writing, the acceptor substrate comprises:
  • tracking and addressing means arranged to allow an optical drive to determine the position of a read/write laser on the acceptor substrate.
  • the reflective layer is a partially reflective layer.
  • the acceptor substrate is transparent.
  • the acceptor substrate is an optical disc.
  • the present invention also provides a donor substrate for performing direct writing, the donor substrate comprises:
  • the donor substrate is arranged such that when the ablative layer is ablated by a beam of laser light, a portion of the transfer layer is transferred from the donor substrate.
  • the donor substrate can further comprise tracking and addressing means arranged to allow an optical drive to determine the position of a read/write laser on the donor substrate.
  • the donor substrate is an optical disc.
  • the present invention provides several advantages over the prior art. For example, because the present invention uses ubiquitous low cost optical drive technology, it provides a very low cost Direct Writing alternative to known methods. Moreover, because the present invention uses the high focusing power of semiconductor laser diodes and optics to achieve focused spot sizes of approximately 600nm on a target sample, the present invention provides an apparatus and method which achieve smaller feature sizes than prior art systems. Furthermore, through optimization of the design of the donor and acceptor substrates, the present invention shows that it is possible to focus and track on the acceptor (target) substrate while Direct Writing the material from the donor substrate. This allows the writing material to be targeted to precise locations (for subsequent accurate readback) on an addressable acceptor disc. Also, the present invention provides a method and apparatus which is capable of Direct Writing at speeds equivalent to recordable Digital Versatile Discs (DVDR).
  • DVDR Digital Versatile Discs
  • Figure 1 is a diagram of one example of the prior art
  • Figure 2 is a diagram of a first embodiment of the present invention
  • Figure 3 is a further diagram of the first embodiment of the present invention, after use with a second donor disc;
  • Figure 4 is a diagram of the final acceptor disc of the first embodiment of the present invention.
  • Figure 5 is another diagram of the final acceptor disc of the first embodiment of the present invention.
  • Figure 6 is a diagram of a second embodiment of the present invention.
  • FIG. 7 is a block diagram of a system in accordance with the present invention.
  • FIG. 1 shows one version of a DVDR disc in accordance with the prior art.
  • the disc comprises a bottom substrate 13 comprising grooves 16 which are suitable for allowing a beam of laser light 14 to track across the disc.
  • a dye layer 12 which is formed of a material suitable to be ablated by a beam of laser light 14 of a particular frequency.
  • a reflective layer 1 1 which is arranged to reflect the beam of laser light 14 back towards a receiver (not shown) in order to allow binary information to be read from the disc.
  • a portion of the dye material is ablated, leaving an ablated portion 15 of the dye layer, which ablated portion comprises different reflective/refractive properties to the rest of the dye layer.
  • FIG. 2 is a diagram of an optical medium in accordance with the present invention.
  • the optical medium comprises a donor disc 22, 23 and an acceptor disc 20, 21 , the donor and acceptor discs being fixed together by process of, for example, glue-less vacuum lamination.
  • Vacuum lamination is particularly advantageous in that it allows the discs to be cleanly separated once material from the donor disc has been transferred to the acceptor disc.
  • the donor disc 22, 23 comprises a bottom substrate 23 which is preferably made of polycarbonate with a thickness of 0.6mm.
  • the donor disc also comprises a transfer layer 22, the transfer layer 22 being formed of any suitable material which absorbs laser light and ablates upon irradiation (e.g. dye films).
  • the transfer layer 22 is typically between 10 and 200 nm in thickness.
  • the donor disc 22, 23 can also comprise a metal reflector layer (not shown) made of, for example, gold, silver or alloys thereof, above bottom substrate 23 and a dielectric layer (not shown) between the metal reflector layer and the transfer layer 22, the dielectric layer being suitable to improve reflectivity.
  • the acceptor disc 20, 21 comprises a reflector layer 21 , preferably comprising a layer of a precious metal, such as gold or silver, or alloys therefore, or another inert material of high reflectivity.
  • the acceptor disc 20, 21 also comprises a grooved disc 20 (for example, a DVDR formatted polycarbonate disc about 0.6mm thick, which would allow the disc to be read using a standard DVD drive).
  • the grooves 26, or tracking means allow the laser to track across the acceptor disc 20, 21.
  • a gap between the donor disc 22, 23 and the acceptor disc 20, 21 can provide further advantages to the present invention.
  • such a gap will prevent a situation where the lands of the acceptor disc layer are in direct contact with the transfer layer.
  • Direct touch contact between the transfer layer and the acceptor disc lands can often result in unwanted touch transfer of the transfer layer to the acceptor disc land regions when the discs are separated. This extra material on the lands of the acceptor disc could act as unwanted noise over the signal given from the materials 25, 25' which have been transferred into the grooves.
  • the incorporation of a small gap between the donor and acceptor discs may confer an additional benefit.
  • the act of pulsed laser writing produces significant heat in the absorber (eg dye) material. This heat is dissipated mainly through conduction over a period of nanoseconds. Physically separating the donor and acceptor surfaces with an air gap may reduce heat transfer to the acceptor surface so that microprinting can take place at a cooler temperature, which is preferred for temperature sensitive materials.
  • a beam of laser light of a particular intensity and frequency is directed to the reflector surface 21 on which the laser is tracking. Because the transfer layer 22 lies within the focal depth of the laser beam, a portion 25 of that layer is ablated, by the beam which is tracking on 21 , and projected towards the reflector surface 21 , by a technique known as Laser Induced Forward Transfer (LIFT).
  • LIFT Laser Induced Forward Transfer
  • the transfer layer 22 can be any suitable material which absorbs and ablates when exposed to incident laser light of suitable frequency and intensity.
  • the transfer layer 22 is composed of, or mixed with, a material which is subsequently to be used to react with, or otherwise detect, other compounds.
  • microdots of the projected transfer layer 22 can be arranged into addressable arrays on the acceptor disc, which is then spliced from the donor disc.
  • microdots upon exposure to a suitable second sample (or samples) can undergo chemical, or other, change which can induce an optical change detectable by a scanning laser beam tracking the acceptor substrate surface.
  • the microdots therefore act as reagents on the acceptor substrate surface. Since the reagents are transferred to the acceptor substrate surface using a direct writing technique which is controlled using the address and tracking information on the acceptor substrate, they can be placed at addressable locations on that substrate. Accordingly, the optical changes that occur when the reagents are used to carry out chemical assays can be efficiently read by an optical reader.
  • Figure 3 shows the same acceptor disc 20, 21 being vacuum laminated to a second donor disc 22', 23'.
  • the second donor disc 22', 23' comprises a bottom substrate 23' which is preferably be made of polycarbonate with a thickness of 0.6mm.
  • the donor disc also comprises a transfer layer 22', the transfer layer 22' being formed of a second transfer material which absorbs laser light and ablates upon irradiation. This transfer layer 22' is also typically between 10 and 200 nm in thickness.
  • the second donor disc 22', 23' can also comprise a metal reflector layer, such as gold or silver, or alloys thereof, or another inert material of high reflectivity (not shown) above bottom substrate 23' and a dielectric layer (not shown) between the metal reflector layer and the transfer layer 22', the dielectric layer being suitable to improve reflectivity.
  • the second donor disc can be used to direct print a second material 25' onto the acceptor disc.
  • the acceptor disc is not bonded to the donor disc, it is possible to direct print any number of materials onto an acceptor disk by using the same number of donor discs.
  • the required chemical materials are printed onto the acceptor disc, it is possible, as described above, to bring those materials into contact with one or more organic or inorganic agents.
  • the transferred chemical materials then act as reagents which can alter the optical properties of the medium according to the nature of the organic or inorganic agents.
  • Figure 4 shows an acceptor disc 20, 21 being read by a beam of laser light 24.
  • substrate X can either be a donor disc or another suitable disc. In the case of current DVD technology, any transparent polycarbonate substrate of 0.6mm in thickness would be suitable to allow the beam of laser light 24 from the optical drive to read the acceptor disc.
  • substrate X can also be a donor disk, as described above.
  • the acceptor is designed in such a way that is can be tracked in either orientation by laser beam 24, such that it is possible to track through the original donor disc 22, 23 (or a suitable replacement disc), or track through the reverse side of substrate 20, as shown in Figure 5, after said microdot exposure to detect the optical changes without needing to re-laminate a donor replacement disc to track though.
  • the grooved disc 20 must be a DVDR substrate of material transparent to the incident laser frequency and which exhibits the appropriate combination of refractive index and thickness such that the incident laser 24 will be brought to focus on the reflector layer 21.
  • the thickness requirement will be approximately 0.6mm.
  • the grooved disc 20 is transparent to the incident laser frequency, it is possible to implement the present invention without a transparent grooved disc 20.
  • Appropriate non-transparent materials for the grooved disc 20 may be selected according to physical requirements (they could be silicon, or metal-coated plastics for example). The choice of material may additionally/alternatively take into account desired surface chemistry for attaching particular molecules. For example, it may be relevant to consider the interaction between silane chemistry and the native oxide surface of a silicon substrate.
  • the reflector layer 21 be thin enough (preferably between 9 and 20 nm) so that at least some light can pass through it in order to reach the materials 25, 25' printed onto the disc.
  • the reflector layer 21 it is possible to produce, by way of known techniques such as, for example, a silver enhancement reaction, a thin reflective layer S on the top of the materials 25, 25' which will reflect the laser light back toward the drive optics.
  • the optical reader can both track along the disc (i.e. follow each groove) and infer address information from the disk. Address information is inferred from the disc in the same way as such information is inferred from typical DVDR discs (i.e. from slight sinusoidal deviations known as "wobbles").
  • each portion of material (i.e. each reagent) 25' and 25 can be determined with a very high degree of precision. Moreover, the large amount of individual portions of material which can be printed to an acceptor disc will result in a very high density disc.
  • LIFT Laser Induced Forward Transfer
  • the tracking means need not be provided on the acceptor disc 20, 21.
  • the donor disc 22, 23 could be provided with grooves (similar to grooves 26) and the acceptor disc could be substantially flat.
  • the acceptor disc could be read using a micro-scope.
  • the transfer layers 22, 22' were ablated and printed onto the acceptor disc 20, 21.
  • One disadvantage with the first embodiment of the present invention is that for it to be useful in the context of chemical assays, that transfer material must be suitable for ablation (i.e. it must absorb laser light and ablates upon irradiation), and it also must be useful for use as a reagent.
  • the second embodiment of the present invention which will now be described with reference to Figure 6 solves this problem by providing an ablation layer and a separate non-absorbing layer of material which is to be printed, these layers being separated by a flexible encapsulation layer.
  • FIG. 6 is a diagram of an optical medium in accordance with a second embodiment of the present invention.
  • the optical medium comprises a donor disc 33, 32, 38, 39 and an acceptor disc 30, 31 , the donor and acceptor discs being fixed together by process of, for example, glue-less vacuum lamination.
  • the acceptor disc 30, 31 comprises a reflector layer 31 , preferably comprising a precious metal, such as gold or silver, or other alloys, or another inert material of high reflectivity.
  • the acceptor disc 30, 31 also comprises a grooved disc 30 (for example, a DVDR formatted polycarbonate disc about 0.6mm thick, which would allow the disc to be read using a standard DVD drive).
  • the grooves 36, or tracking means, allow the laser 34 to track across the acceptor disc 30, 31.
  • the acceptor disc 30, 31 of the second embodiment of the present invention is similar to the acceptor disc of the first embodiment described above.
  • a gap which is necessarily smaller than the focal depth of the incident laser; preferably ⁇ 1 micron distance, most preferably ⁇ 200nm distance.
  • the donor disc 33, 32, 38, 39 of the second embodiment of the present invention comprises a bottom substrate 33 which is preferably made of polycarbonate and has a thickness of 0.6mm.
  • the donor disc 33, 32, 38, 39 also comprises a laser-absorbing layer 32, the layer 32 being formed of any suitable material which absorbs laser light and ablates upon irradiation (e.g. dye films).
  • the layer is typically between 10 and 200 nm in thickness.
  • the donor disc 33, 32, 38, 39 can also comprise a metal reflector layer made of, for example, gold or silver or other alloys thereof (not shown) above bottom substrate 33 and a dielectric layer (not shown) between the metal reflector layer and the laser absorbing layer 32, the dielectric layer being suitable to improve reflectivity.
  • the second embodiment of the present invention also comprises an encapsulation layer 38.
  • the encapsulation layer 38 is a protective layer (e.g. dielectric such as ZnS-Si02) which exhibits high transmission at the incident laser frequency and which will deform under pressure from the ablation of the laser absorbing layer 32.
  • the encapsulation layer 38 is preferably between 5 and 50 nm thick.
  • the transfer layer 39 can be comprised of any material for transfer which does not appreciably absorb at the incident laser wavelength.
  • the transfer layer 39 is preferably between 1 and 100nm thick.
  • the deformation of the encapsulation layer is what causes the transfer layer to be printed to the acceptor disc 30, 31.
  • a beam of laser light 34 of a particular intensity and frequency is directed to the laser absorbing layer 32, a portion of the laser absorbing layer 32 is ablated and creates an area of increased pressure.
  • This increase in pressure causes the encapsulation layer to deform towards the acceptor disc 30, 31 , thereby printing a portion of the transfer layer onto the acceptor disc 30, 31.
  • the transfer layer is composed of a chemical material which can then react to a second chemical material which is placed on the disc at a later stage, as described above.
  • the acceptor disc of the second embodiment of the present invention can be read in exactly the same manner as the acceptor disc of the first embodiment, and as described above.
  • the medium in accordance with the abovementioned embodiments is a disc
  • other shapes and configurations of optical medium can be contemplated within the scope of the invention.
  • this invention could equally be applied to a rectangular substrate where tracking was made along grooves arranged to Cartesian coordinates.
  • a donor disc in accordance with the present invention can be manufactured is as follows.
  • a 0.6mm polycarbonate mirror substrate (no grooves) is created through injection moulding.
  • An absorbing dye layer e.g. CibaTM IRGAPHORTM Ultragreen
  • a DVD drive laser diode e.g. 40-60nm.
  • a transmissive encapsulation layer of, for example, ZnS-SiO2 is sputter coated onto the dye layer in thickness range of between 10nm and 50nm, and typically 10nm.
  • a transfer layer is then deposited onto the encapsulation layer surface.
  • the transfer layer can be any compound (e.g. thin dye film, DNA or other bio-material) and is typically deposited by spin coating, evaporation or sputter coating.
  • an acceptor disc in accordance with the present invention can be manufactured is as follows. A 0.6mm polycarbonate substrate with DVD+R format and groove geometry of 40nm depth and 360nm width is injection moulded. The groove side of the disc is then sputtered with a thin semi- reflecting layer of gold (e.g. 9nm).
  • One example of how a microprinting operation can be accomplished is as follows.
  • the donor disc and acceptor disc surfaces are brought together in parallel fashion in an evacuated chamber. This action closes off the tops of all the grooves and creates an evacuated spiral channel on the disc.
  • the discs Upon venting of the chamber, the discs remain gluelessly laminated together - touching at the acceptor land / donor mirror interface. It is now possible to place the disc into a suitable DVDR drive (donor disc closest to laser) and focus and track on the DVDR as if it were a standard DVDR disc.
  • the laser focuses through the donor and tracks on the groove of the acceptor disc.
  • the transfer layer on the donor disc can be printed to the acceptor groove through the bump forming action of the encapsulation layer as described in Figure 6.
  • a PulstecTM ODU1000 DVD tester to record equi-spaced 3T (400nm length) pulses into the groove of the acceptor disc.
  • a gap is provided between the donor disc 22, 23 and the acceptor disc 20, 21.
  • the printed data can be accessed, by simply breaking the vacuum seal between the donor and acceptor substrates. This may be achieved with use of a DVD splicer, or more simply by gently pulling the discs apart at their interface.
  • spots of printed transfer material in the grooves of the acceptor disc may then be analysed under a suitable microscope.
  • suitable chemical tests can be made on the spots such that positive reaction yields an optical change and results of the tests can be analysed using, for example, a microscope, or by turning the disc over, as shown in Figure 5, and reading back the optically changed data in a modified optical drive.
  • the present invention uses discs operating with similar tracking and reflectivity values as a standard DVDR disc. Consequently, it is possible to achieve such a printing process on discs as described above, using discs drives based on commercial DVD recorders with only slight modifications.
  • FIG. 7 shows a functional block diagram of a disc drive in accordance with the present invention.
  • the drive comprises all of the functional blocks of known DVD drives, plus additional hardware.
  • This additional hardware intercepts the read signal from the output of the amplifier and sends it to both the drive, which decodes the Address In Pregroove (ADIP) "groove wobble" addresses, and to the added circuitry alongside the drive, which will then decode the data.
  • ADIP Address In Pregroove
  • the drive modification includes a new laser driver which sends signals to the laser at intervals determined by the FPGA. The original laser driver in the drive is bypassed by the new circuitry, such that it is never triggered to write itself.
  • the ablative layer 22 is ablated by laser light which travels through the donor substrate 23.
  • the laser light may reach the ablative layer 22 via the acceptor substrate 20, and this will still cause the transfer of material to the acceptor 20, 21.
  • the donor substrate 23 need not be transparent to the laser light and the material used for the substrate may be chosen for other qualities, such as mechanical strength or chemical properties.
  • the abovementioned advantages allow the present invention to be advantageously used in a wide range of applications.
  • One particularly advantageous application is the use of the present invention to produce chemical/biological assays for use in biotechnology, which assay would be created quickly, would be of a very high density and would be readable by using a DVD drive with low cost modification.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optical Recording Or Reproduction (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

L'invention concerne un procédé permettant de réaliser une écriture directe et un support optique permettant de réaliser une écriture directe. Ledit support comprend un substrat accepteur comportant une couche de substrat et une couche réfléchissante qui se trouve sur cette couche de substrat. Ledit support possède également un substrat donneur doté d'une couche de substrat, d'une couche ablative située sur ladite couche de substrat et d'une couche de transfert. Le support optique est conçu de façon à ce que, lorsqu'une ablation est effectuée sur la couche ablative par un faisceau de lumière laser, une partie de la couche de transfert soit transférée du substrat donneur au substrat accepteur. Le support optique comprend en outre un moyen de poursuite et d'adressage destiné à permettre à un lecteur optique de déterminer la position d'un laser de lecture-écriture sur le support.
PCT/GB2011/052248 2010-11-19 2011-11-17 Procédé et appareil pour l'écriture directe Ceased WO2012066338A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201019579A GB201019579D0 (en) 2010-11-19 2010-11-19 Method and apparatus for direct writing
GB1019579.0 2010-11-19

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WO2012066338A2 true WO2012066338A2 (fr) 2012-05-24
WO2012066338A3 WO2012066338A3 (fr) 2012-08-09

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GB (1) GB201019579D0 (fr)
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WO2015056253A1 (fr) 2013-10-14 2015-04-23 Orbotech Ltd. Impression lift de structures en matériaux à compositions multiples
WO2017103007A1 (fr) * 2015-12-16 2017-06-22 Institute Of Communication And Computer Systems (Iccs)- National Technical University Of Athens (Ntua) Procédé d'activation de réactions click par transfert de molécules induit par laser
US10193004B2 (en) 2014-10-19 2019-01-29 Orbotech Ltd. LIFT printing of conductive traces onto a semiconductor substrate
US10633758B2 (en) 2015-01-19 2020-04-28 Orbotech Ltd. Printing of three-dimensional metal structures with a sacrificial support
US10688692B2 (en) 2015-11-22 2020-06-23 Orbotech Ltd. Control of surface properties of printed three-dimensional structures
LU102294B1 (en) 2020-12-17 2022-06-21 Fyzikalni Ustav Av Cr V V I A method and a device for assembly of a nanomaterial structure
US11881466B2 (en) 2017-05-24 2024-01-23 Orbotech Ltd. Electrical interconnection of circuit elements on a substrate without prior patterning

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DE10249095A1 (de) * 2002-10-21 2004-04-29 Fuji Magnetics Gmbh Speichermedium
WO2008152119A1 (fr) * 2007-06-12 2008-12-18 Lingvitae Holding As Disques optiques pour analyse de biomolécules
TW200945339A (en) * 2007-12-19 2009-11-01 Koninkl Philips Electronics Nv Optical disk format for direct writing materials on a substrate

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015056253A1 (fr) 2013-10-14 2015-04-23 Orbotech Ltd. Impression lift de structures en matériaux à compositions multiples
JP2016535817A (ja) * 2013-10-14 2016-11-17 オルボテック リミテッド 複数組成材料構造体のｌｉｆｔ印刷
EP3058113A4 (fr) * 2013-10-14 2017-08-09 Orbotech Ltd. Impression lift de structures en matériaux à compositions multiples
US10629442B2 (en) 2013-10-14 2020-04-21 Orbotech Ltd. Lift printing of multi-composition material structures
US10193004B2 (en) 2014-10-19 2019-01-29 Orbotech Ltd. LIFT printing of conductive traces onto a semiconductor substrate
US10633758B2 (en) 2015-01-19 2020-04-28 Orbotech Ltd. Printing of three-dimensional metal structures with a sacrificial support
US10688692B2 (en) 2015-11-22 2020-06-23 Orbotech Ltd. Control of surface properties of printed three-dimensional structures
WO2017103007A1 (fr) * 2015-12-16 2017-06-22 Institute Of Communication And Computer Systems (Iccs)- National Technical University Of Athens (Ntua) Procédé d'activation de réactions click par transfert de molécules induit par laser
US11881466B2 (en) 2017-05-24 2024-01-23 Orbotech Ltd. Electrical interconnection of circuit elements on a substrate without prior patterning
LU102294B1 (en) 2020-12-17 2022-06-21 Fyzikalni Ustav Av Cr V V I A method and a device for assembly of a nanomaterial structure
EP4015135A1 (fr) 2020-12-17 2022-06-22 Fyzikální ústav AV CR, v.v.i. Procédé et dispositif d'assemblage d'une structure de nanomatériau

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