[go: up one dir, main page]

WO2012065139A3 - Entpd5 inhibitors - Google Patents

Entpd5 inhibitors Download PDF

Info

Publication number
WO2012065139A3
WO2012065139A3 PCT/US2011/060487 US2011060487W WO2012065139A3 WO 2012065139 A3 WO2012065139 A3 WO 2012065139A3 US 2011060487 W US2011060487 W US 2011060487W WO 2012065139 A3 WO2012065139 A3 WO 2012065139A3
Authority
WO
WIPO (PCT)
Prior art keywords
entpd5
inhibitors
cancer cells
apoptosis
promoting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/060487
Other languages
French (fr)
Other versions
WO2012065139A8 (en
WO2012065139A2 (en
Inventor
Xiaodong Wang
John B. Macmillan
Song Huang
Min Fang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of WO2012065139A2 publication Critical patent/WO2012065139A2/en
Publication of WO2012065139A8 publication Critical patent/WO2012065139A8/en
Publication of WO2012065139A3 publication Critical patent/WO2012065139A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides methods and pharmaceutical compositions for treating cancer or promoting apoptosis of cancer cells, or reducing the resistance of cancer cells to chemotherapy or apoptosis-promoting therapies by contacting the cancer cells with an ENTPD5-specific inhibitor.
PCT/US2011/060487 2010-11-11 2011-11-11 Entpd5 inhibitors Ceased WO2012065139A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41270810P 2010-11-11 2010-11-11
US61/412,708 2010-11-11

Publications (3)

Publication Number Publication Date
WO2012065139A2 WO2012065139A2 (en) 2012-05-18
WO2012065139A8 WO2012065139A8 (en) 2012-12-27
WO2012065139A3 true WO2012065139A3 (en) 2013-02-21

Family

ID=46051598

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/060487 Ceased WO2012065139A2 (en) 2010-11-11 2011-11-11 Entpd5 inhibitors

Country Status (1)

Country Link
WO (1) WO2012065139A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9505768B2 (en) 2012-09-27 2016-11-29 The Regents Of The University Of California Compositions and methods for modulating TLR4

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013023300A1 (en) * 2011-08-15 2013-02-21 The University Of British Columbia Inhibitors of androgen receptor activation function-2 (af2) as therapeutics and methods for their use
CA2880487C (en) 2012-07-30 2018-07-24 Kyoto University Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor
WO2014028939A2 (en) * 2012-08-17 2014-02-20 California Institute Of Technology Targeting phosphofructokinase and its glycosylation form for cancer
EP2953939A1 (en) 2013-02-07 2015-12-16 Merck Patent GmbH Substituted quinoxaline derivatives and their use as positive allosteric modulators of mglur4
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics
ITMI20131410A1 (en) * 2013-08-26 2015-02-27 Univ Degli Studi Modena E Reggio Emilia COMPOUNDS AND COMPOSITIONS FOR USE IN THE INHIBITION OF LBC-RHOA INTERACTION
EP3148986A4 (en) * 2014-05-27 2018-01-10 Navigen, Inc. Arf6 inhibitors and methods of synthesis and use thereof
CN105541806A (en) * 2015-12-25 2016-05-04 中国药科大学 Barbiturate compound, preparing method and application thereof
WO2018200041A1 (en) * 2017-04-26 2018-11-01 University Of Cincinnati Methods, agents, and compositions for the treatment of acute myeloid leukemia
IL272571B2 (en) * 2017-08-10 2023-03-01 Texas A & M Univ Sys Nr4a1 ligands, pharmaceutical compositions, and related methods of use
WO2019099755A1 (en) * 2017-11-17 2019-05-23 Academia Sinica Bis(hydroxymethyl) pyrrolophthalazine hybrids, preparation methods and uses thereof
US11292776B2 (en) * 2019-12-12 2022-04-05 University Of Sharjah Small molecule inhibitors of fungal hyphae and biofilm formation
KR102635969B1 (en) * 2020-12-04 2024-02-13 한국기초과학지원연구원 Pyrazol-4-yl methylenepyrimidine compound and anticancer composition comprising the same
EP4433042A4 (en) * 2021-11-18 2025-10-15 Univ Nebraska NEW INHIBITORS OF CLAUDIN-1 FOR THERAPEUTIC INTERVENTIONS

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040043955A1 (en) * 2000-06-09 2004-03-04 Beaudoin Adrien R. C8-substituted purine nucleotide analogs and their use as inhibitors of nucleoside triphosphate diphosphohydrolases
US20070203236A1 (en) * 2006-01-11 2007-08-30 Smith Jeffrey W Novel antagonists of the human fatty acid synthase thioesterase
US20070292876A1 (en) * 2006-05-02 2007-12-20 Ordway Research Institute, Inc. Methods for identification of compounds that mimic the senescence-inducing activity of retinoic acid receptor ligands
US20080113993A1 (en) * 2000-06-05 2008-05-15 Via Ariosto, 23 Barbituric acid analogs as therapeutic agents
US20100204182A1 (en) * 2006-05-24 2010-08-12 Rheinische Friedrich-Wilhelms-Universitat Bonn Ectonucleotidase inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080113993A1 (en) * 2000-06-05 2008-05-15 Via Ariosto, 23 Barbituric acid analogs as therapeutic agents
US20040043955A1 (en) * 2000-06-09 2004-03-04 Beaudoin Adrien R. C8-substituted purine nucleotide analogs and their use as inhibitors of nucleoside triphosphate diphosphohydrolases
US20070203236A1 (en) * 2006-01-11 2007-08-30 Smith Jeffrey W Novel antagonists of the human fatty acid synthase thioesterase
US20070292876A1 (en) * 2006-05-02 2007-12-20 Ordway Research Institute, Inc. Methods for identification of compounds that mimic the senescence-inducing activity of retinoic acid receptor ligands
US20100204182A1 (en) * 2006-05-24 2010-08-12 Rheinische Friedrich-Wilhelms-Universitat Bonn Ectonucleotidase inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9505768B2 (en) 2012-09-27 2016-11-29 The Regents Of The University Of California Compositions and methods for modulating TLR4

Also Published As

Publication number Publication date
WO2012065139A8 (en) 2012-12-27
WO2012065139A2 (en) 2012-05-18

Similar Documents

Publication Publication Date Title
WO2012065139A8 (en) Entpd5 inhibitors
PH12019502810A1 (en) Bicyclic heterocycles as fgfr inhibitors
WO2012129084A3 (en) Glucosylceramide synthase inhibitors
MY188363A (en) Substituted tricyclic compounds as fgfr inhibitors
MX2013003594A (en) Dual inhibitors of met and vegf for the treatment of castration- resistant prostate cancer and osteoblastic bone metastases.
PH12015501660A1 (en) Erk inhibitors and uses thereof
EP2721033A4 (en) Compounds, their pharmaceutical compositions and their uses as idh1 mutants inhibitors for treating cancers
WO2012158843A3 (en) Kinase inhibitors
EA201300810A1 (en) ANTI-TRACT THERAPY USING DOUBLE INHIBITORS KINAZ AURORA / MEK
AR082340A1 (en) METHODS AND COMPOSITIONS FOR LIVER CANCER THERAPY
HK1213889A1 (en) Glutaminase inhibitors and method of use
PH12014501032A1 (en) 2-thiopyrimidinones
MX2014012477A (en) Pyrrolopyrazone inhibitors of tankyrase.
EP3087184A4 (en) Methods and compositions for the specific inhibition of glycolate oxidase (hao1) by double-stranded rna
WO2011129936A3 (en) Compositions and methods for the prevention and treatment of cancer
EP3079475A4 (en) Glucocorticoid inhibitors for treatment of prostate cancer
WO2014093988A3 (en) Methods and compositions for inhibiting cnksr1
WO2012162513A3 (en) Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors
WO2013052108A3 (en) Methods and compositions for the treatment and diagnosis of ovarian cancer
AU2016204389A1 (en) Kinase inhibitors for the treatment of cancer
WO2012106702A3 (en) Treatment of leukemia
WO2012125447A3 (en) Piperazinedione compounds
WO2013188824A3 (en) Hexim-1 as a target of leptin signaling to regulate obesity and diabetes
AP2011005893A0 (en) Thia-triaza-cyclopentazulenes as P13-kinases inhibitors for the treatment of cancer.
WO2013013238A3 (en) Compounds and related compositions and methods of use

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11839757

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11839757

Country of ref document: EP

Kind code of ref document: A2