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WO2012062648A1 - Emballage à blister pour liquide et utilisation de celui-ci ainsi que procédé d'acheminement de liquide à un arrangement fluidique - Google Patents

Emballage à blister pour liquide et utilisation de celui-ci ainsi que procédé d'acheminement de liquide à un arrangement fluidique Download PDF

Info

Publication number
WO2012062648A1
WO2012062648A1 PCT/EP2011/069327 EP2011069327W WO2012062648A1 WO 2012062648 A1 WO2012062648 A1 WO 2012062648A1 EP 2011069327 W EP2011069327 W EP 2011069327W WO 2012062648 A1 WO2012062648 A1 WO 2012062648A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
packaging
cavity
opening
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/069327
Other languages
German (de)
English (en)
Inventor
Dirk Kurowski
Oliver Paul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Boehringer Ingelheim Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Microparts GmbH filed Critical Boehringer Ingelheim Microparts GmbH
Priority to EP11778602.0A priority Critical patent/EP2637948B1/fr
Priority to US13/883,896 priority patent/US20130327672A1/en
Priority to JP2013538133A priority patent/JP2014502236A/ja
Publication of WO2012062648A1 publication Critical patent/WO2012062648A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B65D75/367—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments
    • B65D75/368—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments the compartments being interconnected, e.g. by small channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2205/00—Venting means
    • B65D2205/02—Venting holes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2221/00—Small packaging specially adapted for product samples, single-use packages or échantillons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/36—One sheet or blank being recessed and the other formed or relatively stiff flat sheet material, e.g. blister packages
    • B65D2575/361—Details
    • B65D2575/362—Details with special means for gaining access to the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/36—One sheet or blank being recessed and the other formed or relatively stiff flat sheet material, e.g. blister packages
    • B65D2575/361—Details
    • B65D2575/362—Details with special means for gaining access to the contents
    • B65D2575/367—Details with special means for gaining access to the contents through a preformed opening in the flat sheet, e.g. the opening being defined by weakened lines

Definitions

  • the present invention relates to a package, in particular blister pack, having at least one cavity for receiving a liquid according to the preamble of claim 1. Further, the present invention relates to a use of a cavity of a blister pack as a reservoir for a liquid and a method for supplying liquid from a Packaging for a fluidic arrangement.
  • the present invention relates to the inclusion of a liquid in a package, in particular in a blister pack.
  • the liquid is taken up in a cavity of the package.
  • the following description is therefore directed in particular to a blister pack or to a blister for receiving a liquid, even if the present invention is not limited thereto, but preferably also in other liquid packaging can be used.
  • Blister packs are used in various industries and industries and are equipped with at least one cavity into which the content to be filled is received. As a rule, the content in the cavity is visible from the outside.
  • the blister packs can also cover or envelop the contents or the liquid picked up in a light-tight or opaque manner.
  • a typical blister pack usually has two foils, which in turn may be constructed of several layers of different or the same materials.
  • the films are usually made of plastic and / or metal, for example aluminum, wherein other materials such as paper or the like, in principle or additionally can be used.
  • the two films are, in particular, a bottom layer or base film (carrier) and a cover layer or cover film (cover).
  • cover film or the cover is then placed on the base film or the carrier and fixed thereto or connected thereto, for example at the edge locations or in a connection region, in particular flat surface areas, preferably by gluing, heat sealing, welding or like that takes place.
  • DE 103 43 668 AI discloses a particularly dense blister packaging for pharmaceuticals, which is not discussed in more detail on the opening of the blister pack.
  • the present invention is particularly concerned with a blister pack which is applied to a fluidic arrangement, preferably a medical cartridge (for example a so-called biosensor), wherein the liquid filled into the cavity of the blister pack, in particular provided with one or more reagents, has a certain amount Trigger or enable detection reaction in the arrangement.
  • a fluidic arrangement preferably a medical cartridge (for example a so-called biosensor)
  • the liquid filled into the cavity of the blister pack in particular provided with one or more reagents, has a certain amount Trigger or enable detection reaction in the arrangement.
  • the opening of the cavity should be easy and / or defined if necessary.
  • the present invention has for its object to provide a package, in particular a blister pack, with a cavity for receiving a liquid, a use of such a package and a method for supplying liquid to a fluidic arrangement, wherein a simple and / or defined opening of the Packaging or cavity allows or facilitates.
  • a package according to claim 1 a use according to claim 12 or a method according to claim 13.
  • Advantageous developments are the subject of the dependent claims.
  • the packaging has an opening device integrated into the packaging for opening the cavity or, in particular, a lid of the packaging.
  • the opening device is in particular formed in or by a carrier of the packaging. This allows a simple and / or cost-effective implementation as well as a simple and / or defined opening of the packaging or the cavity filled with the liquid.
  • the packaging or a blister pack with an integrated opening device in the aforementioned sense as a reservoir for a liquid, in particular for a test liquid, a washing liquid, a reaction liquid, a solvent or the like, is used, wherein the package or cavity to a fluidic arrangement is connected to receive the liquid after opening the package or cavity.
  • the fluidic arrangement is a microfluidic examination device, for example for determining at least one analyte in a biological sample, such as blood or blood components.
  • the supply of liquid from the packaging to a fluidic arrangement formed in particular in the aforementioned sense is effected in that the package is deformed - at least partially - in order to actuate the opening seal and thereby open the package or cavity.
  • the packaging or cavity (additionally and / or in a second step) can be deformed in order to displace liquid from the packaging and / or to supply it to the fluidic arrangement, in particular under pressure.
  • the opening can in particular also be automated and / or by means of a stamp or other tool which deforms the packaging for opening.
  • Fig. 1 is a schematic section of a proposed packaging
  • FIG. 2 shows a schematic section of the packaging with an associated fluidic arrangement.
  • FIG. 1 shows, in a schematic section, a proposed package 1 with at least one cavity 2 for receiving a liquid 3.
  • the packaging 1 preferably closes the liquid 3 at least substantially liquid-tight and / or gas-tight.
  • the packaging 1 is designed in particular as a blister pack.
  • the cavity 2 is formed in particular by a blister of the packaging 1 or blister pack.
  • the liquid 3 is, in particular, an examination liquid, a washing liquid, a reaction liquid, a solvent or the like, particularly preferably for use in a microfluidic system for determining an analyte or value and / or for examination, in particular a preferably biological sample or the like ,
  • the packaging 1 has a carrier 4 and an associated lid 5.
  • the support 4 is an at least substantially flat or planar or planar element and / or surface material and / or a bottom layer or bottom foil or the like.
  • the carrier 4 may be formed relatively rigid or flexible and / or at least partially deformable.
  • the carrier 4 has a relatively high rigidity or strength in its main extension direction or plane.
  • the carrier 4 is preferably stiffer or more rigid than the lid 5 and / or sufficiently rigid to at least significantly or primarily determine the shape of the package 1.
  • the cover 5 is preferably an at least substantially flat or planar and / or smooth element or surface material and / or a cover layer or covering film, particularly preferably for the planar covering of the associated support 4.
  • the carrier 4 and / or the lid 5 is formed as a film and / or made of film, plastic, metal and / or a particular plastic and / or metal-containing composite material.
  • the carrier 4 and the cover 5 can in principle be made of the same material. However, in the illustrated example, the carrier 4 and the lid 5 are preferably made of different materials.
  • the cover 5 is preferably designed to be flexible and / or deformable and in particular evidently, for example by tearing, pushing in, piercing or the like, particularly preferably for removal or delivery of the liquid 3.
  • the support 4 may be correspondingly apparent.
  • At least one cavity 2 for receiving the liquid 3 is formed between the carrier 4 and the cover 5. Particularly preferably, a plurality of cavities 2 are formed.
  • the packaging 1 or the carrier 4 and / or lid 5 may be particularly preferably strip-like endless material or the like.
  • the endless material can then in individual packages 1 with each at least one cavity 2 for receiving the liquid 3 before or preferably after the filling of the liquid 3, divided or separated, as needed.
  • only the preferred structure of a cavity 2 will be discussed in more detail, even if the endless material or the packaging 1 may have a plurality of such cavities 2, possibly also in different sizes and / or with different liquids 3.
  • the recess or bulge is formed in particular trough-like.
  • the depression or cavity 2 is produced in particular by thermoforming and / or deep-drawing, in this case the carrier 4.
  • the package 1 or cavity 2 is closed or closed.
  • the cover 5 is placed and at least partially connected to the carrier 4 in a connecting region 6.
  • the connecting region 6 is formed in particular in the region of flat surface areas of the carrier 4 and cover 5.
  • the connecting region 6 adjoins the cavity 2 in particular laterally and / or circumferentially.
  • the connection region may surround the cavity 2 in an annular manner.
  • the connecting region 6 or, in the case of a plurality of cavities 2, a plurality of connecting regions 6 preferably lies in a plane E and / or main extension plane E and / or on a flat side of the packaging 1, the carrier 4 and / or lid 5.
  • the connecting region 6 surrounds the connecting region 6 respective cavity 2 circumferential and / or ring-like.
  • the bonding of carrier 4 and lid 5 is preferably carried out by heat sealing, welding, gluing and / or in any other suitable manner.
  • the carrier 4 and the cover 5 are at least substantially liquid-tight in the connection region 6, in particular at least as far as possible gas-tight, full-surface, ring-like and / or circumferentially connected or connectable.
  • Fig. 1 shows the proposed package 1 in the filled state.
  • the cavity 2 (the blister) is filled with liquid 3 and sealed.
  • the packaging 1 has an opening device 7 integrated therein for opening the packaging 1 or cavity 2 or the lid 5.
  • the opening device 7 is preferably formed integrally with the package 1 or the carrier 4 and / or formed in or from the carrier 4, as indicated in Fig. 1 by way of example.
  • the opening device 7 preferably has a section 8 projecting into the cavity 2 or the cover 5 or is formed therefrom.
  • the opening device 7 or the section 8 is particularly preferably produced by thermoforming or deep drawing of the carrier 4 or of the material forming the carrier 4.
  • the opening device 7 or the projection 8 may also be formed by an additional, in particular fixedly connected to the carrier 4 element, piece of material or the like and / or by a thickening.
  • the opening seimichtung 7 and the section 8 can be reinforced with respect to other sections or areas of the support 4, for example, by a reinforcement, not shown, structure, such as ribs or the like, and / or by a material thickening, by a material reinforcement, by a Insert, by an additional layer and / or by additional or different or modified material or the like.
  • the section 8 or its end or free end is particularly preferably conical and / or pointed and / or directed towards the cover 4 and the main extension plane E out.
  • the opening segregation 7 is preferably arranged or formed somewhat spaced from the actual cavity 2, in particular in a channel 9, which is particularly preferably laterally adjoining the cavity 2, or the like.
  • Channel 9 is particularly Pack 1 also formed, particularly preferably by a corresponding recess or bulge of the carrier 4.
  • the channel 9 is preferably fluidly connected directly to the cavity 2 even with the package 1 or closed lid 5 in fluid communication.
  • the opening device 7 is formed in the representation example in the region of one end of the channel 9.
  • the channel wall spaced from the lid 5 or any other wall portion of the carrier 4 or channel 9 spaced from the lid 5 is provided with the opening device 7 or the projecting section 8.
  • the opening device 7 or the projecting section 8 is provided with the opening device 7 or the projecting section 8.
  • the packaging 1 or opening device 7 is preferably designed such that by at least regional deformation or depression, in particular of the carrier 4 or lid 5, here the carrier 4 or the wall of the channel 9 and the projecting portion 8, in particular in a predetermined Area or adjacent to the opening device 7, the package 1 is opened.
  • a depression causes the opening device 7 or the protruding section 8 to open the cover 5, in particular by tearing open, cutting open, piercing or the like.
  • the lid 5 is opened in particular in a region which is immediately adjacent or opposite the opening device 7 or the projecting section 8.
  • the cover 5 may be provided in the opening region with at least one "predetermined breaking point", for example by corresponding weakening of the material or the like.
  • the package 1 or the opening device 8 on a deformation region, which is here formed in particular by a wave-like structure 10, which allows a particularly easy deformation of the package 1 and here the support 4 for easy deformation or actuation of the opening device 7 in particular in order to be able to press the projecting portion 8 for opening the packaging 1 relatively easily against the lid 5.
  • the packaging 1 is permanently or non-detachably connected to the fluidic arrangement 11.
  • the packaging 1 is connected or connectable to the fluidic arrangement 11 in a liquid-tight and / or gastight manner, so that liquid 3 from the cavity 2 of the fluidic arrangement
  • the packaging 1 is attached or fastened, in particular with its flat side or the cover 5, to the fluidic arrangement 10, for example by gluing, heat-sealing, welding or the like.
  • the fluidic arrangement 10 for example by gluing, heat-sealing, welding or the like.
  • FIG. 2 it is schematically indicated that the closed package 1 or cavity 2 is supported on a carrier part
  • the packaging 1 or cavity 2 is preferably arranged such that it covers at least partially with its opening region, ie the region which can be opened by the opening device 7, an outflow 14 of the fluidic device 11, in particular above it.
  • the drain 14 is formed for example by a depression, a channel or the like, in particular in the support part 12.
  • At the outlet 14 may be a channel 15 or another, in particular microfluidic structure of the fluidic arrangement 1 1 connect.
  • the outflow 14 and / or channel 15 form part of a micro-fluidic structure of the fluidic arrangement 11.
  • "Microfluidic" is to be understood here as meaning volumes of preferably less than 1 ml.
  • the fluidic device 11 or microfluidic structure may further comprise an examination region or the like (not shown), for example for a biological sample such as blood, constituents of blood or the like.
  • the cavity 2 or the blister of the packaging 1 or blister pack formed therefrom is preferably used as a reservoir for the liquid 3, wherein the packaging 1 or cavity 2 to the fluidic assembly 11 for receiving the liquid 3 after opening the package. 1 or cavity 2 is connected.
  • the proposed packaging 1 can also be used for other purposes.
  • the packaging 1 is opened by means of the opening device 7, in particular by actuation of the opening device 7.
  • the packaging 1 or the carrier 4 in the representation example particularly preferably in the region of the channel 9 or the opening device 7, deformed, so that the opening device or the projecting portion 8 in particular opens the lid 5, in particular tears, pricks, cuts or the like.
  • This - preferably only partial - deformation of the package 1 and the carrier 4 is preferably carried out by means of a tool, such as a in Fig. 2 indicated punch 16, or the like.
  • the opening device 7 or 8 of the section for example, in a depression arranged below, such as the drain 14 and thereby locally deformed and overstressed until the lid 5 and the cover sheet in this area ruptures and thereby the cavity 2 - here via the channel 9 - opens to the fluidic assembly 11 out.
  • the liquid 3 can flow out of the cavity 2 into the fluidic arrangement 11 or the outflow 14 or the microfluidic system of the arrangement 11.
  • This leakage of the liquid 3 can be effected or promoted by gravitational force, capillary forces, suction force, pressing force, negative pressure, overpressure or the like.
  • the cavity 2 is preferably additionally deformed after opening the package 1 or the lid 5, in particular in a second step, in order to pressurize the liquid 3 and / or to force it out of the package 1 or cavity 2 and the fluidic assembly 11 zuzu meetings.
  • This deformation of the cavity 2 can be done, for example, by a tool, such as the indicated punch 17, or in any other suitable manner, if appropriate also by manual deformation with a finger or the like.
  • the punches 16 and 17 it is also possible, for example, for the punches 16 and 17 to be formed or moved by a common tool or the like and / or to be correspondingly correlated.
  • the opening of the package 1 or cavity 2 by means of the opening device 7 can, if necessary, also be effected by the fluidic arrangement 11, for example by means of a drive for the punch 16 assigned to the arrangement 11.
  • the packaging 1 may also be provided with a ventilation device (not shown), which is opened, for example, by corresponding deformation of the device 1 or of the carrier 4 or actuation of the opening segregation 7 and / or during deformation of the cavity 2 Ambient air can flow through a corresponding opening in the carrier 4 or cover 5 in the cavity 2.
  • the ventilation can also take place through the fluidic arrangement 11, possibly even via the opening produced by the opening device 7.
  • a particular advantage of the combination of the proposed packaging 1 with the fluidic arrangement 11 is that very simple such a connection, for example by the flat-side fastening, is made possible, so that a liquid-tight and preferably also gas-tight or closed to the ambient air connection between the Cavity 2 on the one hand and the fluidic device 11 or the microfluidic system formed or contained therein or the drain 14 or the like on the other hand can be produced.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un emballage (1), notamment un emballage à blister, comprenant au moins une cavité (2) pour recevoir un liquide (3) et comprenant un dispositif d'ouverture intégré (7). L'emballage peut être utilisé comme un réservoir pour un liquide à raccorder à un arrangement fluidique (11). L'ouverture de l'emballage s'effectue par une déformation partielle de l'emballage.
PCT/EP2011/069327 2010-11-10 2011-11-03 Emballage à blister pour liquide et utilisation de celui-ci ainsi que procédé d'acheminement de liquide à un arrangement fluidique Ceased WO2012062648A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP11778602.0A EP2637948B1 (fr) 2010-11-10 2011-11-03 Procédé d'acheminement de liquide à un arrangement fluidique
US13/883,896 US20130327672A1 (en) 2010-11-10 2011-11-03 Blister packaging for liquid and use thereof and method for supplying a liquid to a fluidic assembly
JP2013538133A JP2014502236A (ja) 2010-11-10 2011-11-03 液体用包装材並びにその使用及び液体をフルイディック組立体に供給する方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10014438.5 2010-11-10
EP10014438 2010-11-10

Publications (1)

Publication Number Publication Date
WO2012062648A1 true WO2012062648A1 (fr) 2012-05-18

Family

ID=43836563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/069327 Ceased WO2012062648A1 (fr) 2010-11-10 2011-11-03 Emballage à blister pour liquide et utilisation de celui-ci ainsi que procédé d'acheminement de liquide à un arrangement fluidique

Country Status (4)

Country Link
US (1) US20130327672A1 (fr)
EP (1) EP2637948B1 (fr)
JP (1) JP2014502236A (fr)
WO (1) WO2012062648A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014138563A1 (fr) * 2013-03-07 2014-09-12 Quidel Corporation Système de conditionnement de liquide à deux chambres
US20160158743A1 (en) * 2013-03-15 2016-06-09 Genmark Diagnostics, Inc. Devices and methods for manipulating deformable fluid vessels
US10495656B2 (en) 2012-10-24 2019-12-03 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US10864522B2 (en) 2014-11-11 2020-12-15 Genmark Diagnostics, Inc. Processing cartridge and method for detecting a pathogen in a sample
WO2021094593A1 (fr) 2019-11-15 2021-05-20 Centre National De La Recherche Scientifique Dispositif de production et/ou stockage d'energie comprenant un reservoir
US11952618B2 (en) 2012-10-24 2024-04-09 Roche Molecular Systems, Inc. Integrated multiplex target analysis

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012078696A2 (fr) 2010-12-06 2012-06-14 Aktivpak, Inc. Cartouche aseptique et dispositif distributeur
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
DE102013018722B4 (de) 2013-11-08 2017-07-13 Trw Automotive Gmbh Gurtstraffer für ein Sicherheitsgurtsystem
CN105980058A (zh) 2014-01-07 2016-09-28 达克雷诊断器材有限公司 流体输送装置、系统和方法
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
DE102015205906B4 (de) * 2015-04-01 2024-05-23 Robert Bosch Gmbh Bevorratungseinheit, Verfahren zum Herstellen einer Bevorratungseinheit und Verfahren zum Freisetzen eines in einer Bevorratungseinheit gelagerten Fluids
JP6966242B2 (ja) * 2017-07-04 2021-11-10 アークレイ株式会社 液体の収容容器
WO2019182167A1 (fr) * 2018-03-19 2019-09-26 (주)에스엠허스 Support de tube médical
KR20220128623A (ko) * 2020-01-16 2022-09-21 피코디야 테크놀로지스 엘티디. 블리스터 팩 및 블리스터 팩 홀더
US20220331802A1 (en) * 2021-04-16 2022-10-20 The Regents Of The University Of California Burstable liquid storage package for biological materials and valve substitution

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2290366A1 (fr) * 1974-11-08 1976-06-04 Contrapac Flacon pour le conditionnement de deux produits a melanger a l'interieur ulterieurement
DE29907740U1 (de) * 1999-05-03 1999-09-30 Klocke Verpackungs-Service GmbH, 76356 Weingarten Mehrkammerbehälter
DE10343668A1 (de) 2003-09-18 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittelblister
EP1710169A1 (fr) * 2005-04-08 2006-10-11 Campina Nederland Holding B.V. Récipient pour un produit et un additif
DE202007003050U1 (de) 2007-02-28 2007-05-10 Swif Gmbh South West International Fragrance Wirkstoffbehälter
US20070246395A1 (en) * 2006-02-28 2007-10-25 Arnold William S Child-resistant packaging for pharmaceutical products
WO2009008715A1 (fr) * 2007-07-06 2009-01-15 Friesland Brands B.V. Conteneur pour contenir un liquide pour la consommation, tel qu'un produit laitier, sous une forme non en mousse et pour distribuer le liquide pour obtenir le liquide sous une forme en mousse
EP2138233A1 (fr) * 2008-06-02 2009-12-30 Boehringer Ingelheim microParts GmbH Structure de feuille microliquide destinée au dosage de liquides

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184121A (en) * 1963-08-01 1965-05-18 Ivers Lee Co Package with self sealing closure
DE6946391U (de) * 1969-11-29 1970-05-14 Koellner Sigrune Mehrkammeriger behaelter zur getrennten aufnahme von miteinander reagierende subs anzen fuer die herstellung gebrauchsfertiger dentalpraeparate.
US3635376A (en) * 1970-06-05 1972-01-18 Hellstrom Harold R Quick-open flexible package
US4592493A (en) * 1984-10-15 1986-06-03 Unette Corporation Reclosable dispenser
US4574954A (en) * 1984-12-07 1986-03-11 Medication Services Inc. Pill dispenser
US4785931A (en) * 1987-09-24 1988-11-22 Letica Corporation Molded plastic closure having integral stacking support ribs and rupturable mix compartments
US5111932A (en) * 1989-08-03 1992-05-12 Land O'lakes, Inc. Spreadable material package with spreader
US5131760A (en) * 1990-07-03 1992-07-21 Farmer Bert E Packaging device
ES2125489T3 (es) * 1993-11-01 1999-03-01 Procter & Gamble Envase autocerrable de distribucion de liquido.
US5529224A (en) * 1993-11-01 1996-06-25 The Procter & Gamble Company Self-closing liquid dispensing package
EA000552B1 (ru) * 1996-02-02 1999-10-28 Сэнфорд Редмонд Упаковка для добавляемых в кофе сливок и другие упаковки в виде чашек и термоформованных коробочек
US5839609A (en) * 1997-08-27 1998-11-24 Colgate-Palmolive Company Thermoformed pack with ridge valve
WO2001076972A1 (fr) * 2000-04-05 2001-10-18 Sanford Redmond Inc. Sachet a liquide a ouverture facile pourvu d'un applicateur
US6976578B1 (en) * 2002-05-07 2005-12-20 Antony Austin Kenihan Dispensing lid closure for beverage container and method of making and using the closure
DE10243401B4 (de) * 2002-09-18 2004-07-29 Voco Gmbh Verpackung zum Lagern von Substanzen und Verfahren zum Herstellen eines direkt applizierbaren Gemisches zweier Substanzen aus dieser Verpackung
JP2005082195A (ja) * 2003-09-09 2005-03-31 Sumika Life Tech Co Ltd 家庭園芸用薬剤含有使い切り容器
US7073692B2 (en) * 2004-02-19 2006-07-11 Pieter Weyts Conical reinforced re-sealable dispenser
JP4582644B2 (ja) * 2004-06-08 2010-11-17 憲司 中村 注液含浸包装体
US7243798B2 (en) * 2004-08-04 2007-07-17 Fisher Clinical Services System and a method for a V-indent blister opening cavity
US20070228073A1 (en) * 2006-03-31 2007-10-04 Wyeth Tear and spill resistant package for dispensing liquids in a controlled manner
US7644821B2 (en) * 2006-04-10 2010-01-12 Poppack, Llc Sealed product delivery unit with rupturing pump
WO2008144439A1 (fr) * 2007-05-16 2008-11-27 Mystic Pharmaceuticals, Inc. Conteneurs de distribution de doses à unité de combinaison
US8795607B2 (en) * 2008-06-19 2014-08-05 Boehringer Ingelheim Microparts Gmbh Fluid metering container
EP2379422A1 (fr) * 2008-12-19 2011-10-26 Intervet International BV Emballage adapté pour recevoir des liquides
US9061796B2 (en) * 2009-04-23 2015-06-23 H.J. Heinz Company Multi-function condiment container
PL2499060T3 (pl) * 2009-11-12 2014-04-30 Mds Global Holding Ltd Pojemnik do dozowania substancji

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2290366A1 (fr) * 1974-11-08 1976-06-04 Contrapac Flacon pour le conditionnement de deux produits a melanger a l'interieur ulterieurement
DE29907740U1 (de) * 1999-05-03 1999-09-30 Klocke Verpackungs-Service GmbH, 76356 Weingarten Mehrkammerbehälter
DE10343668A1 (de) 2003-09-18 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittelblister
EP1710169A1 (fr) * 2005-04-08 2006-10-11 Campina Nederland Holding B.V. Récipient pour un produit et un additif
US20070246395A1 (en) * 2006-02-28 2007-10-25 Arnold William S Child-resistant packaging for pharmaceutical products
DE202007003050U1 (de) 2007-02-28 2007-05-10 Swif Gmbh South West International Fragrance Wirkstoffbehälter
WO2009008715A1 (fr) * 2007-07-06 2009-01-15 Friesland Brands B.V. Conteneur pour contenir un liquide pour la consommation, tel qu'un produit laitier, sous une forme non en mousse et pour distribuer le liquide pour obtenir le liquide sous une forme en mousse
EP2138233A1 (fr) * 2008-06-02 2009-12-30 Boehringer Ingelheim microParts GmbH Structure de feuille microliquide destinée au dosage de liquides

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10495656B2 (en) 2012-10-24 2019-12-03 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US11952618B2 (en) 2012-10-24 2024-04-09 Roche Molecular Systems, Inc. Integrated multiplex target analysis
WO2014138563A1 (fr) * 2013-03-07 2014-09-12 Quidel Corporation Système de conditionnement de liquide à deux chambres
US20160158743A1 (en) * 2013-03-15 2016-06-09 Genmark Diagnostics, Inc. Devices and methods for manipulating deformable fluid vessels
JP2017121970A (ja) * 2013-03-15 2017-07-13 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
JP2018184218A (ja) * 2013-03-15 2018-11-22 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
US10391489B2 (en) 2013-03-15 2019-08-27 Genmark Diagnostics, Inc. Apparatus and methods for manipulating deformable fluid vessels
US10807090B2 (en) 2013-03-15 2020-10-20 Genmark Diagnostics, Inc. Apparatus, devices, and methods for manipulating deformable fluid vessels
US10864522B2 (en) 2014-11-11 2020-12-15 Genmark Diagnostics, Inc. Processing cartridge and method for detecting a pathogen in a sample
WO2021094593A1 (fr) 2019-11-15 2021-05-20 Centre National De La Recherche Scientifique Dispositif de production et/ou stockage d'energie comprenant un reservoir
FR3103325A1 (fr) 2019-11-15 2021-05-21 Centre National De La Recherche Scientifique Dispositif de production d’énergie comprenant un réservoir

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US20130327672A1 (en) 2013-12-12
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EP2637948B1 (fr) 2015-09-16

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