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WO2012047993A3 - N-hydroxypyrimidine-2,4-diones as inhibitors of hiv and hcv - Google Patents

N-hydroxypyrimidine-2,4-diones as inhibitors of hiv and hcv Download PDF

Info

Publication number
WO2012047993A3
WO2012047993A3 PCT/US2011/054916 US2011054916W WO2012047993A3 WO 2012047993 A3 WO2012047993 A3 WO 2012047993A3 US 2011054916 W US2011054916 W US 2011054916W WO 2012047993 A3 WO2012047993 A3 WO 2012047993A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
hiv
hcv
methods
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/054916
Other languages
French (fr)
Other versions
WO2012047993A2 (en
Inventor
Zhengqiang Wang
Robert J. Geraghty
Robert Vince
Jinq Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota Twin Cities
University of Minnesota System
Original Assignee
University of Minnesota Twin Cities
University of Minnesota System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota Twin Cities, University of Minnesota System filed Critical University of Minnesota Twin Cities
Publication of WO2012047993A2 publication Critical patent/WO2012047993A2/en
Publication of WO2012047993A3 publication Critical patent/WO2012047993A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides antiviral compounds that can be used in therapy against human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Compounds of the invention can be dual targeted inhibitors of HIV, inhibiting both the reverse transcriptase and the integrase enzyme systems, thus increasing the barrier to development of viral resistance in patients. Prodrugs of the inventive antiviral compounds are also provided. Compounds of the invention can be used to treat HCV secondary infections in HIV-afflicted patients, reducing the need for administration of drug cocktails containing multiple, potentially conflicting, medicinal compounds. Methods of synthesis of the compounds and methods of treatment using the compounds are also provided.
PCT/US2011/054916 2010-10-05 2011-10-05 N-hydroxypyrimidine-2,4-diones as inhibitors of hiv and hcv Ceased WO2012047993A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38979510P 2010-10-05 2010-10-05
US61/389,795 2010-10-05

Publications (2)

Publication Number Publication Date
WO2012047993A2 WO2012047993A2 (en) 2012-04-12
WO2012047993A3 true WO2012047993A3 (en) 2012-05-31

Family

ID=45928401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/054916 Ceased WO2012047993A2 (en) 2010-10-05 2011-10-05 N-hydroxypyrimidine-2,4-diones as inhibitors of hiv and hcv

Country Status (1)

Country Link
WO (1) WO2012047993A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11253521B2 (en) 2015-09-25 2022-02-22 Ludwig Institute For Cancer Research Ltd 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016141220A1 (en) * 2015-03-03 2016-09-09 Regents Of The University Of Minnesota 3-hydroxypyrimidine-2,4-dione-5-carboxamides as potent inhibitors of hiv
JPWO2023017699A1 (en) * 2021-08-12 2023-02-16

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000021936A1 (en) * 1998-10-12 2000-04-20 Sumitomo Chemical Company, Limited Uracil herbicides
US20030119814A1 (en) * 2001-10-16 2003-06-26 The University Of Kansas Novel prodrugs of N-H bond-containing compounds and methods of making thereof
US20100074889A1 (en) * 2008-09-15 2010-03-25 Yao-Ling Qiu 4'-allene-substituted nucleoside derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000021936A1 (en) * 1998-10-12 2000-04-20 Sumitomo Chemical Company, Limited Uracil herbicides
US20030119814A1 (en) * 2001-10-16 2003-06-26 The University Of Kansas Novel prodrugs of N-H bond-containing compounds and methods of making thereof
US20100074889A1 (en) * 2008-09-15 2010-03-25 Yao-Ling Qiu 4'-allene-substituted nucleoside derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11253521B2 (en) 2015-09-25 2022-02-22 Ludwig Institute For Cancer Research Ltd 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators

Also Published As

Publication number Publication date
WO2012047993A2 (en) 2012-04-12

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