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WO2011127056A3 - Biomarkers for assessing exposure to ionizing radiation and absorbed dose - Google Patents

Biomarkers for assessing exposure to ionizing radiation and absorbed dose Download PDF

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Publication number
WO2011127056A3
WO2011127056A3 PCT/US2011/031253 US2011031253W WO2011127056A3 WO 2011127056 A3 WO2011127056 A3 WO 2011127056A3 US 2011031253 W US2011031253 W US 2011031253W WO 2011127056 A3 WO2011127056 A3 WO 2011127056A3
Authority
WO
WIPO (PCT)
Prior art keywords
exposure
biomarkers
absorbed dose
radiation
ionizing radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/031253
Other languages
French (fr)
Other versions
WO2011127056A2 (en
Inventor
Martin R. Johnson
Ashley Nicole Upton Filiano
Hassan Fathallah-Shaykh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Original Assignee
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UAB Research Foundation filed Critical UAB Research Foundation
Publication of WO2011127056A2 publication Critical patent/WO2011127056A2/en
Publication of WO2011127056A3 publication Critical patent/WO2011127056A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/40—Disorders due to exposure to physical agents, e.g. heat disorders, motion sickness, radiation injuries, altitude sickness, decompression illness

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention concerns radiation-responsive biomarkers capable of determining qualitative exposure status (yes/no. i.e., irradiated/non-irradiated) and distinguishing levels of exposure (quantitative absorbed dose determination), and materials and methods to profile the radiation-responsive biomarkers in blood samples to detect radiation exposure and/or to determine the dose of radiation exposure.
PCT/US2011/031253 2010-04-05 2011-04-05 Biomarkers for assessing exposure to ionizing radiation and absorbed dose Ceased WO2011127056A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32106210P 2010-04-05 2010-04-05
US61/321,062 2010-04-05
US39154310P 2010-10-08 2010-10-08
US61/391,543 2010-10-08

Publications (2)

Publication Number Publication Date
WO2011127056A2 WO2011127056A2 (en) 2011-10-13
WO2011127056A3 true WO2011127056A3 (en) 2012-03-01

Family

ID=44763516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/031253 Ceased WO2011127056A2 (en) 2010-04-05 2011-04-05 Biomarkers for assessing exposure to ionizing radiation and absorbed dose

Country Status (1)

Country Link
WO (1) WO2011127056A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11564948B2 (en) 2015-12-22 2023-01-31 Sangui Bio Pty Ltd Therapeutic methods using erythrocytes

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6000253B2 (en) 2010-09-24 2016-09-28 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド Materials and methods for improving gastrointestinal function
WO2014105249A2 (en) * 2012-10-05 2014-07-03 University Of Florida Research Foundation Inc. Use of anoctamin as biomarker for radiation biodosimetry
CN103805682A (en) * 2012-11-09 2014-05-21 中国疾病预防控制中心辐射防护与核安全医学所 Method for detecting dose of ionizing radiation on human peripheral blood lymphocytes
CN110522744B (en) 2013-03-11 2023-04-07 佛罗里达大学研究基金会有限公司 Materials and methods for improving lung function and for preventing and/or treating radiation-induced pulmonary complications
EP3254115A4 (en) * 2015-02-05 2018-06-20 University of Florida Research Foundation, Inc. Use of nhe3 as biomarker for radiation biodosimetry
WO2017059477A1 (en) 2015-10-07 2017-04-13 Sangui Bio Pty. Ltd Blood preparation and profiling
AU2017379367B2 (en) 2016-12-20 2023-12-07 Sangui Bio Pty. Ltd Blood profiling with protease inhibitors
WO2019210195A1 (en) * 2018-04-27 2019-10-31 Arizona Board Of Regents On Behalf Of The University Of Arizona Integrated device for self-collecting and automated pre-processing of biological fluids
CN110672860B (en) * 2019-11-04 2023-07-14 中国科学院近代物理研究所 Combination of five cytokines as biomarkers of ionizing radiation damage
US20230273223A1 (en) * 2020-08-05 2023-08-31 The Trustees Of The University Of Pennsylvania Panel of inflammasome proteins as radiation biodosimeter
CN114966040B (en) * 2022-04-25 2023-10-13 中国人民解放军军事科学院军事医学研究院 Application of Hp protein in constructing post-irradiation lethality prediction model or preparing kits and reagents
CN115725587B (en) * 2022-09-14 2023-07-18 中国人民解放军军事科学院军事医学研究院 Oligonucleotide aptamer group for specifically recognizing radiation-sensitive protein TP53I3, kit and detection method
CN118910065B (en) * 2024-08-22 2025-07-25 中国人民解放军军事科学院军事医学研究院 Sequence and detection method of oligonucleotide aptamer for specifically recognizing radiation-sensitive protein CDKN1A

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070212718A1 (en) * 2006-03-09 2007-09-13 Tessarae Inc. Apparatus and methods for applications of genomic microarrays in screening, surveillance and diagnostics
WO2008082712A2 (en) * 2006-08-25 2008-07-10 The Trustees Of Columbia University In The City Of New York Systems and methods for biodosimetry with biochip using gene expression signatures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070212718A1 (en) * 2006-03-09 2007-09-13 Tessarae Inc. Apparatus and methods for applications of genomic microarrays in screening, surveillance and diagnostics
WO2008082712A2 (en) * 2006-08-25 2008-07-10 The Trustees Of Columbia University In The City Of New York Systems and methods for biodosimetry with biochip using gene expression signatures

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STRAUME, T.: "Meeting Report--NASA Radiation Biomarker Workshop", LAWRENCE BERKELEY NATIONAL LABORATORY, April 2008 (2008-04-01) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11564948B2 (en) 2015-12-22 2023-01-31 Sangui Bio Pty Ltd Therapeutic methods using erythrocytes

Also Published As

Publication number Publication date
WO2011127056A2 (en) 2011-10-13

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