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WO2011116112A3 - Fabrication of porous glass bioscaffolds by sol-gel and polymer sponge methods - Google Patents

Fabrication of porous glass bioscaffolds by sol-gel and polymer sponge methods Download PDF

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Publication number
WO2011116112A3
WO2011116112A3 PCT/US2011/028695 US2011028695W WO2011116112A3 WO 2011116112 A3 WO2011116112 A3 WO 2011116112A3 US 2011028695 W US2011028695 W US 2011028695W WO 2011116112 A3 WO2011116112 A3 WO 2011116112A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioscaffolds
methods
sol
interconnected
polymer sponge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/028695
Other languages
French (fr)
Other versions
WO2011116112A2 (en
Inventor
Himanshu Jain
Shaojie Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lehigh University
Original Assignee
Lehigh University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lehigh University filed Critical Lehigh University
Publication of WO2011116112A2 publication Critical patent/WO2011116112A2/en
Publication of WO2011116112A3 publication Critical patent/WO2011116112A3/en
Priority to US13/617,293 priority Critical patent/US9321675B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B19/00—Other methods of shaping glass
    • C03B19/12—Other methods of shaping glass by liquid-phase reaction processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/16—Preparation of silica xerogels
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/16—Preparation of silica xerogels
    • C01B33/166—Preparation of silica xerogels by acidification of silicate in the presence of an inert organic phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

Provided herein are biocompatible scaffolds and methods of preparing such bioscaffolds. The methods provide a superior high surface area, interconnected nanomacroporous bioactive glass scaffold, by combining a sol-gel process and polymer sponge replication methods. The formation of a uniformly nanoporous and interconnected macroporous bioscaffold is demonstrated using a starting material comprising a 70 mol% SiO2-30 mol% CaO glass composition as an example. The bioscaffold includes a series of open, interconnected macropores with size from 300 to 600 µm, as desired for tissue ingrowth and vascularization. At the same time, coexisting nanopores provide high-specific surface area (>150 m2/g), which is needed for enhancing the structure's degradation rate. These bioscaffolds hold promise for applications in hard tissue engineering.
PCT/US2011/028695 2010-03-16 2011-03-16 Fabrication of porous glass bioscaffolds by sol-gel and polymer sponge methods Ceased WO2011116112A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/617,293 US9321675B2 (en) 2010-03-16 2012-09-14 Fabrication of porous glass bioscaffolds by sol-gel and polymer sponge methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31437710P 2010-03-16 2010-03-16
US61/314,377 2010-03-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/617,293 Continuation US9321675B2 (en) 2010-03-16 2012-09-14 Fabrication of porous glass bioscaffolds by sol-gel and polymer sponge methods

Publications (2)

Publication Number Publication Date
WO2011116112A2 WO2011116112A2 (en) 2011-09-22
WO2011116112A3 true WO2011116112A3 (en) 2012-03-29

Family

ID=44649807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/028695 Ceased WO2011116112A2 (en) 2010-03-16 2011-03-16 Fabrication of porous glass bioscaffolds by sol-gel and polymer sponge methods

Country Status (1)

Country Link
WO (1) WO2011116112A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108892145A (en) * 2018-07-17 2018-11-27 佛山今兰生物科技有限公司 A kind of SiO2The quantization production method of based bioactive tissue renovation material

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101278099B1 (en) 2012-01-31 2013-06-24 고려대학교 산학협력단 Method for producing porous bioceramic granules and porous bioceramic granules manufactured thereby
CN105288725A (en) * 2015-11-23 2016-02-03 海安南京大学高新技术研究院 Nano-zirconia porous tissue engineering scaffold and preparation method thereof
CN107308499A (en) * 2017-04-19 2017-11-03 上海师范大学 Nanometer biological glass/polymer three-dimensional porous material and its preparation method and application
CN110227178A (en) * 2019-07-30 2019-09-13 广东工业大学 A kind of bioceramic scaffold and its application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6993406B1 (en) * 2003-04-24 2006-01-31 Sandia Corporation Method for making a bio-compatible scaffold
US20070162151A1 (en) * 2006-01-11 2007-07-12 Jiang Chang Resorbable macroporous bioactive glass scaffold and method of manufacture
KR20090108604A (en) * 2006-12-21 2009-10-15 누맷 에이에스 Metal oxide scaffold

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6993406B1 (en) * 2003-04-24 2006-01-31 Sandia Corporation Method for making a bio-compatible scaffold
US20070162151A1 (en) * 2006-01-11 2007-07-12 Jiang Chang Resorbable macroporous bioactive glass scaffold and method of manufacture
KR20090108604A (en) * 2006-12-21 2009-10-15 누맷 에이에스 Metal oxide scaffold

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HEO,S.J ET AL., WILEY INTERSCIENCE, 2008, pages 108 - 116 *
PARK,Y.S. ET AL., J MATER SCI, vol. 41, 2006, pages 4357 - 4364 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108892145A (en) * 2018-07-17 2018-11-27 佛山今兰生物科技有限公司 A kind of SiO2The quantization production method of based bioactive tissue renovation material

Also Published As

Publication number Publication date
WO2011116112A2 (en) 2011-09-22

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