WO2011111962A2 - Iontophoresis patch - Google Patents

Abstract

Provided is an iontophoresis patch. The present invention comprises: a patch body having a connection region that connects a first region and a second region, each first and second regions having equal or different sizes from one another; a first electrode layer that coats one surface of the first region; a second electrode layer that coats one surface of the second region; an adhesive layer that coats in such a manner that the first electrode layer and the second electrode layer are covered thereby; and a power supply unit that is electrically connected to first and second terminal parts, which are connected to a first electrode exposing portion and a second electrode exposing portion respectively, the first and second electrode exposing portions extend from the first electrode layer and the second electrode layer and are externally exposed through the connection region, and mounted such that at least one battery is included, so that the replacement thereof in the connection region is enabled.

Description

Iontophoresis patch

The present invention relates to an iontophoresis patch, and more particularly, a power supply including a battery is provided in a detachable structure so as to be freely replaceable from the patch body according to the use environment, regardless of the capacity of the battery or the fermentation time of the drug. The present invention relates to an iontophoresis patch that can use a patch.

In general, iontophoresis refers to a technology that allows a microcurrent to flow through the skin to penetrate a substance of interest with charge into the skin by electrical repulsion. When a patch containing a substance of interest is attached to the skin, a circuit is formed to generate a current and the substance of interest penetrates into the skin by electrical repulsion. The rate of penetration of the substance of interest is known to be influenced by the amount of current flowing and the voltage.

The iontophoresis patch is generally composed of a power supply including a battery and a patch body forming an electrode, and generally divided into two types, a separate type and a single type integrated with each other.

In the case of the separate iontophoresis patch, the electrode is composed of a consumable material, and once used and disposed, the power supply unit can be used continuously by replacing only the battery, which is economical and has the advantage of using various electrode patch electrodes.

On the other hand, the integrated iontophoresis patch has a merit that the power supply unit consisting of a one-time battery is fixed to the electrode, which is suitable for simple disposable use and the volume is reduced in appearance.

As an integrated iontophoresis patch, Korean Patent Publication No. 10-2009-0106926 discloses a substrate having a variable shape, a first electrode layer in contact with the substrate, and a part of the first electrode layer. A first electrode layer, a second electrode layer in contact with the substrate and positioned on the same plane as the first electrode layer, a current collector in contact with the second electrode layer, and an electrical conductivity in contact with the second electrode layer and a current collector. An ion conductive polymer electrolyte in contact with an adhesive, the second electrode layer having a polarity opposite to the first electrode layer, and positioned between the first electrode layer and the second electrode layer; And it discloses a battery-integrated iontophoresis patch comprising an adhesive for sealing the ion conductive polymer electrolyte.

The integrated iontophoresis patch is provided with an integrated battery for providing current to the first and second electrode layers, thereby reducing the apparent volume and convenience of use without a complex peripheral power supply configured to supply current as described above. There is an advantage to provide a thin film iontophoresis patch.

However, if the use time of the battery integrally provided in the patch is longer or shorter than the fermentation time of the drug, there is a problem in use that the battery with the remaining capacity must be discarded with the patch or the patch with the remaining fermentation time of the drug must be discarded with the battery. Even if the adhesion of the hydrophilic conduction gel that adheres the electrode to the skin is weakened, it cannot be used regardless of the remaining battery capacity.

Accordingly, the present invention is to solve the above problems, the object of the present invention is to provide a simple and quick replacement of the power supply unit including a removable detachable iontophoresis patch is a simple thin film structure and ease of use By maintaining and replacing the batteries or patches separately as needed, the present invention aims to provide iontophoresis patches that are easy to manufacture and increase economic efficiency.

As a specific means for achieving the above object, the present invention, the patch body having a connecting area for connecting between the first region and the second region having the same size or different sizes; A first electrode layer applied to one surface of the first region: a second electrode layer applied to one surface of the second region: an adhesive layer applied to cover the first electrode layer and the second electrode layer; And at least one battery extending from the first electrode layer and the second electrode layer and electrically connected to the first and second terminal portions respectively connected to the first and second electrode exposure portions that are externally exposed through the connection region. The present invention provides an iontophoresis patch including a power supply unit disposed to be replaceable in the connection area.

Preferably, the adhesive layer may include a first adhesive layer applied to the first region to cover the first electrode layer coated on one surface of the first region, and a second electrode layer to cover the second electrode layer coated on one surface of the second region. It consists of a 2nd adhesive layer applied to an area | region.

Preferably, the connection region includes a connection adhesive layer which extends from the first adhesive layer or the second adhesive layer and is applied to externally expose the first and second electrode exposed portions.

Preferably, the power supply unit is provided with the first and second terminal parts, the lower cover in contact with one surface of the connection region, and is assembled to one end of the lower cover, the other end of the lower end is provided on the other end of the lower cover It includes an upper cover in contact with the other surface of the connection region having an elastic coupling portion elastically coupled to the elastic elastic coupling portion.

More preferably, the lower cover extends from the first and second terminal portions to expose the first and second lead lines respectively contacting one surface and the other surface of the battery, and has a battery arrangement groove into which the battery is inserted and disposed.

More preferably, the upper cover has an assembly protrusion which is inserted into the assembly hole formed in the lower cover and assembled to cover the upper part of the battery, and connected to the battery cover via the folding groove, the upper and lower pivots around the folding groove. And it includes a terminal cover for covering or exposing the first and second terminals.

Preferably, the power supply unit includes the first cover and the second terminal part to cover and fix the lower cover that is in contact with the lower surface, which is one surface of the connection area, and the battery inserted into the battery placement groove recessed in the upper surface of the lower cover. And a first cover protruding from the first and second terminal parts and correspondingly fixed to the first and second terminal protrusions externally exposed through the first and second terminal holes formed through the first and second electrode exposure parts. And a coupling fixing piece having 1,2 fixing holes.

More preferably, the coupling fixing piece is made of an insulating material.

Preferably, the power supply unit is provided with a light emitting means that is electrically connected to the battery.

According to the present invention, by providing a power supply unit electrically connected to the first and second electrode layers in the connection region connecting between the first region having the first electrode layer and the second region having the second electrode, The battery can be selectively removed and replaced according to the usage of the battery and the use of the patch body, which improves the convenience of using the patch. The effect which can prevent the lowering of the film is obtained.

1 is a rear view showing an iontophoresis patch according to a first embodiment of the present invention.

2 is an exploded perspective view showing an iontophoresis patch according to a first embodiment of the present invention.

3 is a detailed view showing an iontophoresis patch according to a first embodiment of the present invention.

4 (a) and 4 (b) are state diagrams showing the iontophoresis patch according to the first embodiment of the present invention.

5 is an exploded perspective view illustrating an iontophoresis patch according to a second embodiment of the present invention.

6 is an exploded perspective view illustrating an iontophoresis patch according to a third embodiment of the present invention.

100a: patch body 101: the first area

102: second area 103: connection area

110: first electrode layer 111: first electrode exposed portion

120: second electrode layer 122: second electrode exposed portion

130: adhesive layer 131, 132: first, second adhesive layer

140: power supply 140a, 140b: upper, lower cover

141,142: first and second terminal portion 143: battery

144: battery placement groove 147: battery cover

148: terminal cover 148a: elastic coupling portion

148b: elastic elastic coupling portion 149: folding groove

150: fixed coupling pieces 151,152: first and second terminal projections

Preferred embodiments of the present invention will be described in more detail with reference to the accompanying drawings.

As shown in FIGS. 1 to 3, the iontophoresis patch 100 according to the first embodiment of the present invention includes a patch body 100a, first and second electrode layers 110 and 120, an adhesive layer 130, and a power source. Supply unit 140 is included.

The patch body 100a may include a first region 101 and a second region 102, which may be shaped to have the same size or have different sizes, and the first region 101 and the first region 101. The two regions 102 are provided with a connecting region 103 which connects them integrally while separating them.

The patch body 100a is preferably a polyethylene terephthalate (polyethylene terephthalate) or polyacrylonitrile (polyacrylonitrile) film having a thickness of 5 ~ 200㎛, may be attached to a nonwoven fabric to produce a patch body.

Here, the first region 101 may be larger than the second region 102 and may be provided in different shapes, but the first region 101 is limited to the first region 101 and the second region 102 according to the use of the patch. Silver may be provided in the same shape with the same size.

The first electrode layer 110 and the second electrode layer 120 are conductive layers coated with a conductive material on the first region 101 and the second region 102 of the patch body 100a, respectively.

The first and second electrode layers 110 and 120 are conductive materials containing any one of carbon ink of carbon powder, silver ink of silver powder, and nickel ink of nickel powder on the first and second regions 101 and 102. It can be made by thickness coating.

The first and second electrode layers 110 and 120 may extend from the first and second electrode layers 110 and 120 to protrude in the direction facing each other to form the connection region 103, and may be electrically connected to the anode and the cathode of the power supply unit. 111 and a second electrode exposing portion 112.

The first electrode exposing unit 111 and the second electrode exposing unit 112 may be made of the same conductive material as the first electrode layer 110 and the second electrode layer 120, but is not limited thereto. A slurry made of a material, a conductive agent, and a binder may be applied to extend from the first and second electrode layers 110 and 120 to the connection region 103 to face each other.

In this case, manganese dioxide powder and carbon powder are preferable as materials generating electricity applied to form the first and second electrode exposed portions 111 and 112. The binder may be made of any one of polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, polymethyl methacrylate, or a combination thereof.

The adhesive layer 130 is a first adhesive layer 131 is applied in accordance with the shape of the first region 101 to cover the entire first electrode layer 110 coated on one surface of the first region 101 and the first A second adhesive layer 132 is applied to the shape of the second region so as to cover the entire second electrode layer 120 coated on one surface of the second region 101.

Here, the first and second adhesive layers 131 and 132 constituting the adhesive layer 130 may be made of a gel conductive adhesive containing a conductive material.

Accordingly, the adhesive layer 130 is not applied to the connection region 103 connecting the first region 101 and the second region 102 to extend from the first and second electrode layers 110 and 120. An exposure area for externally exposing the two electrode exposure parts 111 and 122 is formed.

Here, the connection region 103 is further provided with a connection adhesive layer which extends from the first adhesive layer 131 or the second adhesive layer 132 and is applied to externally expose the first and second electrode exposure parts 111 and 122. As a result, the adhesive force of the patch body 100a may be further increased by increasing the adhesive region of the adhesive layer 130.

The power supply unit 140 includes power supply means for supplying current to the first and second electrode layers 110 and 120, through a connection area connecting the first and second regions 101 and 102. First and second terminal portions 141 and 142 respectively connected to the first and second electrode exposure portions 111 and 122 exposed to the outside, and electrically connected to the first and second terminal portions 141 and 142. At least one battery 143 is provided to be replaceable in the connection region 103.

The power supply unit 140 includes first and second terminal portions 141 and 142 that correspond to the first electrode exposure portion 111 and the second electrode exposure portion 122, respectively, and is a surface of the connection region 103. An elastic that is elastically coupled to the lower cover 140b in contact with the lower surface, one end of the lower cover, the elastic coupling portion 148b provided on the other end of the lower cover 140b on the other end that is a free end The upper cover 140a includes a coupling part 148a and contacts the upper surface of the other side of the connection region 103.

Accordingly, the power supply 140 is the elastic coupling between the elastic coupling portion 148a formed at the end of the upper cover 140a and the elastic elastic coupling portion 148b formed at the end of the lower cover 140b. The connection area 103 is bitten and fixed between the upper cover 140a and the lower cover 140b so that the connection area 103 can be easily replaced with the connection area 103.

Here, the elastic coupling portion 148a is provided as an elastic projection jaw, and the elastic elastic coupling portion 148b is shown and described as being provided with an elastic groove that is elastically inserted into the elastic projection jaw is forcibly separated by an external force. The present invention is not limited thereto and may be provided opposite to each other, and may be provided in various forms of elastic coupling structures.

In addition, the lower cover 140b extends from the first and second terminal parts 141 and 142 to expose the first and second lead lines 141a and 142a in contact with one surface and the other surface of the battery 143, respectively, and the battery 143 is provided with a battery placement groove 144 is inserted.

In addition, the upper cover 140a is provided with an assembly protrusion 146 inserted into the assembly hole 145 formed in the lower cover 140b to assemble the battery cover 147 covering the upper portion of the battery 143 and the folding groove. And a terminal cover 148 connected to the battery cover 147 through the 149 to cover or expose the first and second terminal parts 141 and 142 while pivoting up and down with respect to the folding groove 149.

Accordingly, the battery cover 147 is assembled to the assembly hole 145 of the lower cover 140b so that the upper cover 140a and the lower cover 140b are separated from the battery 143 by the upper and lower laminated structures. And the terminal cover 148 connects the power supply 140 to the connection area 103 of the patch body 100a by elastic coupling and separation between the elastic coupling part 148a and the elastic elastic coupling part 148b. It can be separated and detached from the connection area 103 to provide a fixing force to secure to or replaceable.

In addition, any one of the first and second lead lines 141a and 142a provided in the battery placement groove 144 of the lower cover 140b is shown in FIG. 5, and the first and second terminal parts 141 and 142 are respectively shown in FIG. Extends from any one of the battery 143 to contact the bottom surface of the battery 143 or extends from the other one of the first and second terminal portions so as to be connected to the top surface of the battery 143. Is bent.

Accordingly, when the upper cover 140a and the lower cover 140b are assembled in the state where the battery 143 is disposed in the battery placement groove 144, the first and second lead lines 141a and 142a may be formed. End portions are electrically connected to the first and second terminal portions 141a and 142a in contact with the top and bottom surfaces of the battery 143, respectively.

6, the power supply unit 140 includes first and second terminal portions 141 and 142 that correspond to the first and second electrode exposure portions 111 and 122, respectively. To cover and fix the lower cover 140a in contact with the lower surface of the connection area 103 and the battery 143 inserted into the battery placement groove 144 recessed in the upper surface of the lower cover 140b. External through the upper cover 140a and the first and second terminal holes 103 and 104 formed to protrude through the first and second terminal portions 141 and 142, respectively, to penetrate the first and second electrode exposed portions 111 and 122. The coupling fixing piece 150 having the first and second fixing holes 153 and 154 fixedly coupled to the exposed first and second terminal protrusions 151 and 152 may be provided.

Accordingly, the coupling fixing piece 150 has the first and second terminal protrusions 151 and 152 exposed upward from the first and second terminal holes 103 and 104 formed through the connection region 103. The power supply unit 140 is connected to the patch body 100a by the coupling and separation between the first and second terminal protrusions 151 and 152 and the coupling fixing piece 150 by inserting and fixing them in the interference fit type (153 and 154). It can be separated from the connection area 103 to provide a fixing force to secure the 103 or replaceable.

Here, the coupling fixing piece 150 is preferably made of an insulating material such as plastic, rubber material so that electrical connection between the first terminal protrusion and the second terminal protrusion is difficult.

In addition, the power supply unit 140 is provided with light emitting means such as a light emitting LED that is electrically connected to the battery so as to visually check the operating capacity of the battery 143 while visually checking the operating state of the battery 143. It is preferable to provide.

On the other hand, the electrode material to be applied to a portion of the first electrode layer 110 is determined according to the charge of the material of interest to be mounted on the first electrode layer 110, when the material of interest to be administered to the human body is applied to the negative electrode material If it is a positively charged material, it is designed to apply the positive electrode material to generate electric repulsive force.

In the exemplary embodiment of the present invention, the first electrode layer 110 operates as the anode and the second electrode layer 120 operates as the cathode. The operating principle of the present invention is based on the electron flow resulting from the battery reaction ( Electrical repulsive force using current) penetrates the polar substance of interest into the skin.

That is, the power supply unit 140 having a battery 143 provided as a battery or a rechargeable battery is elastic between the elastic coupling part 148a and the elastic elastic coupling part 148b by the upper and lower couplings of the upper and lower covers with the connection area. First and second terminal parts 141 and 142 which are assembled to be replaced in the connection area 103 by being coupled or elastically coupled between the first and second terminal protrusions 151 and 152 and the coupling fixing piece 150 and connected to the battery. Is electrically connected to the first and second electrode exposure parts 111 and 122 to supply the positive and negative currents of the battery 143 to the first and second electrode layers 110 and 120, respectively.

In such a state, when the material of interest is mounted on the first electrode layer 110 and the iontophoresis patch 100, in which the power supply is replaceably assembled, is attached to the skin via an adhesive layer containing a conductive material, the battery 143 ) And the first and second electrode layers 110 and 120 to form a circuit so that the material of interest penetrates into the skin.

When a series of circuits are formed, the electrons from the cathode are charged on the surface of the second electrode layer 120 via the battery 143, the second terminal portion 142, and the second electrode exposure portion 122. After passing through, it moves in the skin toward the first electrode layer 110 in the form of negative ions. Negative ions moving in the skin move to the anode in the form of electrons through the charge transfer step at the interface between the skin and the first electrode layer 110, and participate in the reduction reaction. This moves the substance of interest with the same polarity into the skin.

On the other hand, since the usage time of the battery 143 reaches the limit, the iontophoresis effect is weak or the battery 143 is completely discharged, so that the iontophoresis effect cannot be obtained at all, and thus, the power supply unit 140 is separated. And then dispose of the new power supply unit 140 again to the patch body or to separate the power supply unit from the patch body that has reached the end of its service life due to the remaining capacity of the battery 143, and then separated into a new patch body 100a. When the power supply unit 140 is to be remounted, the elastic coupling between the coupling portion and the coupling portion formed at each end of the upper and lower covers 140a and 140b is released or the interference between the first and second terminal protrusions and the coupling fixing piece is prevented. By releasing the fitting it is possible to easily perform the operation of separating the power supply unit 140 from the patch body.

While the invention has been shown and described with respect to particular embodiments, it will be understood that various changes and modifications can be made in the art without departing from the spirit or scope of the invention as set forth in the claims below. It will be appreciated that those skilled in the art can easily know.

Claims (9)

A patch body having a connection area connecting between the first area and the second area having the same size or different sizes; A first electrode layer applied to one surface of the first region: a second electrode layer applied to one surface of the second region: An adhesive layer applied to cover the first electrode layer and the second electrode layer; And At least one battery extending from the first electrode layer and the second electrode layer and electrically connected to the first and second terminal portions respectively connected to the first and second electrode exposure portions exposed to the outside through the connection region; An iontophoresis patch comprising a power supply disposed to be replaceable in the connection area. The method of claim 1, The adhesive layer is applied to the first region to cover the first electrode layer coated on one surface of the first region, and to the second region to cover the second electrode layer coated on one surface of the second region. An iontophoresis patch, comprising a second adhesive layer. The method of claim 1, And the connection adhesive layer extending from the first adhesive layer or the second adhesive layer so as to externally expose the first and second electrode exposed portions in the connection region. The method of claim 1, The power supply unit includes the first cover and the second terminal part, a lower cover in contact with one surface of the connection region, and an elastic coupling part provided at the other end of the lower cover at one end of the lower cover and assembled at one end of the lower cover. And an upper cover in contact with the other surface of the connection region, having an elastic coupling portion elastically coupled with the iontophoresis patch. The method of claim 4, wherein The lower cover extends from the first and second terminal portions to expose the first and second lead lines respectively in contact with one surface and the other surface of the battery, and has a battery arrangement groove into which the battery is inserted and disposed. Foresis Patch. The method of claim 4, wherein The upper cover is provided with an assembly protrusion which is inserted into the assembly hole formed in the lower cover and assembled with the battery cover covering the upper part of the battery, and connected with the battery cover via the folding grooves, while turning up and down at the boundary of the folding grooves. An iontophoresis patch comprising a terminal cover for covering or exposing a two-terminal portion. The method of claim 1, The power supply unit includes the first cover and the second terminal part to cover the lower cover which is in contact with the lower surface which is one surface of the connection area, and the upper cover which covers and fixes the battery inserted into the battery placement groove recessed in the upper surface of the lower cover. And first and second protrusions protruding from the first and second terminal portions, respectively, and correspondingly fixed to the first and second terminal protrusions externally exposed through the first and second terminal holes formed through the first and second electrode exposure portions. Iontophoresis patch, characterized in that it comprises a coupling fixing piece having a fixing hole. The method of claim 7, wherein The coupling fixing piece is an iontophoresis patch, characterized in that made of an insulating material. The method of claim 1, The power supply unit is iontophoresis patch, characterized in that it comprises a light emitting means which is electrically connected to the battery is turned on.

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