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WO2011111687A1 - Contenant pour une administration dans une cavité nasale - Google Patents

Contenant pour une administration dans une cavité nasale Download PDF

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Publication number
WO2011111687A1
WO2011111687A1 PCT/JP2011/055325 JP2011055325W WO2011111687A1 WO 2011111687 A1 WO2011111687 A1 WO 2011111687A1 JP 2011055325 W JP2011055325 W JP 2011055325W WO 2011111687 A1 WO2011111687 A1 WO 2011111687A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
main body
protrusion
locking
pressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2011/055325
Other languages
English (en)
Japanese (ja)
Inventor
久保　朋彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nipro Corp
Original Assignee
Nipro Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nipro Corp filed Critical Nipro Corp
Priority to JP2012504464A priority Critical patent/JP5786852B2/ja
Publication of WO2011111687A1 publication Critical patent/WO2011111687A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod

Definitions

  • the present invention relates to a nasal cavity administration container for administering a drug solution into the nasal cavity.
  • nasal administration containers administer drug solutions to the left and right nasal cavities.
  • the nasal cavity administration container is inserted into one nasal cavity, and a predetermined amount of drug solution is administered to one nasal cavity.
  • the nasal cavity administration container is inserted into the other nasal cavity, and the remaining drug solution is administered to the other nasal cavity.
  • Patent Document 1 discloses a syringe that administers a drug solution in two portions using a plunger and a plunger rod.
  • Patent Document 1 Suppose that the technique disclosed in Patent Document 1 is applied to a nasal administration container.
  • the plunger rod is provided with a locking portion, and the plunger is provided with a locking receiving portion. Insert the plunger rod into the plunger. Prior to advancement of the locking portion of the plunger rod, the locking receiving portion of the plunger is arranged.
  • Execute the first dose by pushing the plunger rod into the plunger.
  • the first administration is completed.
  • the plunger rod is rotated to release the contact state between the locking portion and the locking receiving portion.
  • a second dose can be carried out by further pushing the plunger rod into the plunger.
  • Patent Document 1 When the technique disclosed in Japanese Patent Application Laid-Open No. 2004-49726 (Patent Document 1) is applied to a nasal cavity administration container to administer a drug solution to each nasal cavity, it is necessary to rotate the plunger rod as described above. In order to rotate the plunger rod, the plunger is grasped with one hand and the plunger rod is rotated with the other hand. It is not easy to rotate the plunger rod with only one hand, and it is necessary to use both hands.
  • An object of the present invention is to provide a nasal cavity administration container that can be easily administered with one hand when a drug solution is administered to each nasal cavity.
  • the nasal cavity administration container includes a barrel, a plunger, a gasket, a plunger rod, and an elastic member.
  • the barrel includes a first main body, a spray nozzle, a first opening, and a protrusion.
  • the first main body is formed in a cylindrical shape.
  • the first main body is filled with a predetermined chemical solution.
  • the spray nozzle is provided at one end of the first main body.
  • the first opening is provided at the other end of the first main body.
  • the protruding portion is provided on the inner peripheral surface of the first main body portion so as to protrude inward in the cylinder radial direction.
  • the plunger has a second main body portion, a second opening portion, a first elongated hole portion, and a second elongated hole portion.
  • the second main body is formed in a cylindrical shape.
  • the second opening is provided at the other end of the second main body.
  • the first elongated hole portion is provided in the second main body portion and extends in a direction parallel to the cylinder axis direction.
  • the second long hole portion is provided closer to the second opening than the first long hole portion, and extends in a direction parallel to the cylinder axis direction.
  • the plunger is inserted into the barrel from one end side and is slid in the cylinder axis direction with respect to the inner peripheral surface of the barrel.
  • the gasket is attached to one end of the second main body.
  • the gasket is inserted into the barrel together with the plunger, thereby enclosing the chemical solution in the interior together with the inner peripheral surface of the barrel.
  • the plunger rod has a third main body portion, a pressing portion, a first locking portion, and a second locking portion.
  • the pressing portion is provided at the other end of the third main body portion.
  • the first locking portion is provided on the third main body portion.
  • the first locking portion protrudes toward the outside in the cylinder radial direction, and can be elastically displaced toward the inside in the cylinder radial direction.
  • the second locking portion is provided on the third body portion closer to the pressing portion than the first locking portion.
  • the second locking portion protrudes toward the outer side in the cylindrical radial direction and can be displaced following the first locking portion toward the inner side in the cylindrical radial direction.
  • the plunger rod is inserted into the second main body portion from one end side and is slid in the cylindrical axis direction with respect to the inner peripheral surface of the second main body portion.
  • the elastic member urges the plunger rod inserted into the plunger in a direction of extracting from the plunger.
  • the second locking portion is locked to the first elongated hole portion.
  • the elastic member is compressed.
  • the first locking portion protrudes further outward in the cylindrical radial direction from the outer peripheral surface of the second main body portion through the first elongated hole portion.
  • the first locking portion advances toward the protruding portion.
  • the first locking portion is in contact with the protruding portion.
  • the first locking portion is elastically displaced toward the inner side in the cylinder radial direction.
  • the locked state of the second locking portion to the first elongated hole portion is released.
  • the nasal cavity administration container moves to the first administration completion state.
  • the pressing portion and the second locking portion are retracted by the restoring force of the elastic member.
  • the second locking portion is locked to the second long hole portion.
  • the nasal cavity administration container moves to the second administration start state.
  • the plunger is pressed against the plunger rod by the locking of the second locking portion to the second long hole portion.
  • the second main body portion further has a first protrusion.
  • the first protrusion is disposed so as to be positioned closer to the one end of the second main body than a position where the first locking portion protrudes through the first elongated hole in the first administration start state. Is done.
  • the first protrusion protrudes from the outer peripheral surface of the second main body portion toward the outside in the cylindrical radial direction and can be elastically displaced toward the inner side in the cylindrical radial direction.
  • the first protrusion advances toward the protrusion as the pressing portion is pressed.
  • the volume of the drug solution to be administered is set when the first protrusion comes into contact with the protrusion.
  • the nasal cavity administration container shifts to the first administration start state.
  • the second main body portion further has a second protrusion.
  • the second projecting portion protrudes from the outer peripheral surface toward the outer side in the cylindrical radial direction and can be elastically displaced toward the inner side in the cylindrical radial direction.
  • the pressing portion is pressed in the first administration start state, the second protrusion advances toward the protrusion.
  • the first locking portion is elastically displaced toward the inner side in the cylindrical radial direction.
  • a nasal cavity administration container that can be easily administered with one hand when a drug solution is administered to each nasal cavity.
  • FIG. 1 It is a perspective view which shows the barrel, plunger, plunger rod, gasket, and elastic member which comprise the nasal cavity administration container which concerns on embodiment of this invention. It is sectional drawing which shows the barrel, plunger, plunger rod, gasket, and elastic member which comprise the nasal cavity administration container which concerns on embodiment of this invention. It is a perspective view which shows the plunger which concerns on embodiment of this invention. It is sectional drawing which shows the preparation state of the nasal cavity administration container which concerns on embodiment of this invention. It is sectional drawing which shows the 1st administration start state of the nasal cavity administration container which concerns on embodiment of this invention. It is sectional drawing which shows the 1st administration completion state of the nasal cavity administration container which concerns on embodiment of this invention.
  • a nasal cavity administration container according to an embodiment of the present invention will be described below with reference to the drawings.
  • the scope of the present invention is not necessarily limited to the number, amount, and the like unless otherwise specified.
  • the same parts and corresponding parts are denoted by the same reference numerals, and redundant description may not be repeated.
  • the nasal cavity administration container 100 includes a barrel 1, a plunger 2, a plunger rod 3, a gasket 4, and an elastic member 5.
  • the barrel 1 has a first main body 10, a spray nozzle 12, a first opening 14, and a protrusion 16.
  • the 1st main-body part 10 is formed in the cylinder shape.
  • the 1st main-body part 10 is comprised from the large diameter part 10M and the small diameter part 10T whose cylinder diameter is smaller than the large diameter part 10M.
  • the protruding portion 16 is inclined and formed between the large diameter portion 10M and the small diameter portion 10T.
  • the protruding portion 16 is configured to gradually protrude from the inner peripheral surface 10c of the first main body portion 10 toward the inner side in the cylinder radial direction as it goes from the large diameter portion 10M side to the small diameter portion 10T side.
  • the first opening 14 is located at the other end 10 b of the first main body 10.
  • the spray nozzle 12 is provided at one end 10 a of the first main body 10.
  • the spray nozzle 12 is inserted into a nasal cavity (not shown).
  • the chemical solution is ejected in a mist form.
  • Screw processing 15 may be applied to the peripheral edge of the spray nozzle 12.
  • a predetermined device (not shown) is screwed into the peripheral portion of the spray nozzle 12 using the screw processing 15.
  • medical solution (adjuband) can be filled into the inside 10s of the 1st main-body part 10 from the spray nozzle 12 side using a predetermined
  • the barrel 1 may further have a finger clip portion 18.
  • the finger clip portion 18 is provided on the other end 10 b side of the first main body portion 10.
  • the finger clip portion 18 extends from the outer peripheral surface 10d on the other end 10b side of the first main body portion 10 toward the outer side in the cylinder radial direction.
  • the plunger 2 has a second main body portion 20, a second opening portion 24, a first long hole portion 26, and a second long hole portion 28.
  • the 2nd main-body part 20 is formed in the cylinder shape.
  • the second opening 24 is located at the other end 20 b of the second main body 20.
  • the length of the first long hole portion 26 is set to be longer than the distance from the front end portion 36a of the first locking portion 36 described later to the rear end portion 38b of the second locking portion 38 (see FIG. 2).
  • the first long hole portion 26 extends in a direction parallel to the cylinder axis of the second main body portion 20.
  • the length of the second long hole portion 28 is set longer than the distance from the front end portion 38a of the second locking portion 38 to be described later to the rear end portion 38b of the second locking portion 38.
  • the second elongated hole portion 28 also extends in a direction parallel to the cylinder axis of the second main body portion 20.
  • the 1st long hole part 26 and the 2nd long hole part 28 are arrange
  • the second long hole portion 28 is located closer to the second opening 24 than the first long hole portion 26.
  • the gasket 4 is attached to a screw portion 22 provided at one end 20a of the plunger 2.
  • the plunger 2 is inserted into the barrel 1 together with the gasket 4 from one end 20a.
  • the plunger 2 and the gasket 4 slide in the cylinder axis direction with respect to the inner peripheral surface 10 c of the barrel 1.
  • the plunger 2 may further have a groove 29.
  • the groove 29 is disposed on the inner peripheral surface 20c on the other end 20b side of the plunger 2 (second main body portion 20).
  • the groove 29 extends in a direction parallel to the cylinder axis.
  • a rib 39 (see FIG. 2) corresponding to the groove 29 is provided on the plunger rod 3 to be inserted into the plunger 2. With the rib 39 fitted in the groove 29, the plunger rod 3 is slid in the cylinder axis direction with respect to the inner peripheral surface 20 c of the plunger 2. The rotation operation of the plunger rod 3 around the cylinder axis is suppressed.
  • the plunger 2 may further include any or all of the first protrusion 25, the second protrusion 27, and the annular protrusion 23.
  • the plunger 2 further includes the first protrusion 25, the volume of the drug solution to be administered to the nasal cavity can be appropriately set.
  • the 1st projection part 25 is comprised including the projection part 25a and the leaf
  • the protrusion 25a is provided near the end (on the lower side in FIG. 2) of the leaf spring 25b.
  • the protruding portion 25a slightly protrudes from the leaf spring portion 25b toward the outside in the cylinder radial direction.
  • the leaf spring portion 25b extends in a direction parallel to the cylinder axis.
  • the leaf spring portion 25 b is formed by providing a substantially C-shaped cutout 25 c in the second main body portion 20.
  • the leaf spring part 25b is elastically bent toward the inner side in the cylinder radial direction (see FIG. 4 for other details regarding the first protrusion 25). Reference later).
  • the plunger 2 further includes the second projecting portion 27, it is possible to appropriately set the volume of the drug solution to be administered to the nasal cavity.
  • the 2nd projection part 27 is comprised including the projection part 27a and the leaf
  • the protrusion 27a is provided near the end (on the lower side in FIG. 2) of the leaf spring 27b.
  • the protruding portion 27a slightly protrudes from the leaf spring portion 27b toward the outside in the cylinder radial direction.
  • the leaf spring portion 27b extends in a direction parallel to the cylinder axis.
  • the leaf spring portion 27 b is formed by providing a substantially C-shaped cutout 27 c in the second main body portion 20.
  • the leaf spring part 27b is elastically bent toward the inner side in the cylinder radial direction (see FIG. 5 for other details regarding the second protrusion 27). Reference later).
  • the plunger 2 has the annular protrusion 23
  • the annular protrusion 23 is disposed on the outer peripheral surface 20 d of the second main body portion 20.
  • the annular protrusion 23 is formed in an annular shape so as to protrude outward from the outer peripheral surface 20d of the second main body portion 20 in the cylinder radial direction (see FIG. 9 for other details regarding the annular protrusion 23). Will be described later).
  • the plunger rod 3 includes a third main body portion 30, a pressing portion 34, a first locking portion 36, and a second locking portion 38.
  • the third main body 30 includes a support 30M and a leaf spring 30L.
  • the support portion 30M and the leaf spring portion 30L are continuous with the pressing portion 34 located on the other end 30b side.
  • a substantially L-shaped notch 37 extends (in the direction perpendicular to the plane of FIG. 2) between the support portion 30M and the leaf spring portion 30L.
  • the leaf spring portion 30L can be elastically bent in the direction indicated by the arrow AR6 with the other end 30b as the center.
  • the direction indicated by the arrow AR6 is a direction toward the inner side of the cylindrical diameter direction of the plunger 2 when the plunger rod 3 is inserted into the plunger 2.
  • the first locking portion 36 is provided on the leaf spring portion 30L.
  • the first locking portion 36 is located closer to the tip (upper side of FIG. 2) of the leaf spring portion 30L.
  • the first locking portion 36 protrudes from the leaf spring portion 30L in a direction toward the outer side in the cylinder radial direction.
  • the front end portion 36a of the first locking portion 36 is gradually inclined toward the inner side in the cylinder radial direction from the portion on the other end 30b side toward the portion on the one end 30a side.
  • locking part 38 is provided on the leaf
  • the leaf spring portion 30L When the first locking portion 36 is displaced toward the inside in the cylinder radial direction (in the direction indicated by the arrow AR6), the leaf spring portion 30L is also bent in the same direction. When the leaf spring portion 30L is bent, a restoring force is applied to the first locking portion 36 to displace the first locking portion 36 toward the outside in the cylinder radial direction. That is, the 1st latching
  • the second locking portion 38 is also displaced in the same direction.
  • a restoring force is also applied to the second locking portion 38 to displace the second locking portion 38 toward the outside in the cylinder radial direction. That is, the second locking portion 38 is also elastically displaced toward the inside in the cylinder radial direction.
  • the plunger rod 3 is inserted into the plunger 2 from one end 30a.
  • the elastic member 5 is disposed between a pedestal portion 32 provided at one end 30 a of the plunger rod 3 and a pedestal portion 21 provided on the inner peripheral surface 20 c on the one end 20 a side of the plunger 2.
  • the plunger rod 3 slides in the cylinder axis direction with respect to the inner peripheral surface 20c of the plunger 2 when the pressing portion 34 is pressed.
  • the elastic member 5 opposes the pressing force applied to the pressing part 34.
  • the elastic member 5 urges the plunger rod 3 inserted into the plunger 2 in the direction of extracting from the plunger 2.
  • the elastic member 5 may be disposed in another place as long as it can urge the plunger rod 3 in the direction of extracting the plunger rod 3 from the plunger 2.
  • the elastic member 5 may be arrange
  • the elastic member 5 is not limited to the coil spring, and may be a rubber-like member as long as the above biasing is possible.
  • the elastic member 5 may be configured to include a plate spring-like member as long as the above-described biasing is possible.
  • the plunger rod 3 may further include a rib 39.
  • the rib 39 is provided so as to protrude from the third main body 30 toward the outer side in the cylinder radial direction.
  • the rib 39 extends with a predetermined length in a direction parallel to the cylinder axis.
  • a groove 29 corresponding to the rib 39 is provided in the plunger 2 into which the plunger rod 3 is inserted. With the rib 39 fitted in the groove 29, the plunger rod 3 is slid in the cylinder axis direction with respect to the inner peripheral surface 20 c of the plunger 2. The rotation operation of the plunger rod 3 around the cylinder axis is suppressed.
  • FIG. The recess 33 is located on the one end 30 a side of the plunger rod 3.
  • the recess 33 is formed to be recessed from the back surface 35 of the plunger rod 3 toward the inside in the cylinder radial direction.
  • the recess 33 extends with a predetermined length in a direction parallel to the cylinder axis.
  • the back surface portion 35 slides with respect to the inner peripheral surface 20 c of the plunger 2. The operations of the recessed portion 33 and the back surface portion 35 will be described later.
  • nasal cavity administration container 100 The operation and effect of the nasal cavity administration container 100 will be described with reference to FIGS.
  • the nasal cavity administration container 100 is in the preparation state S1 (FIG. 4), the first administration start state S2 (FIG. 5), and the first administration completion state S3 (FIG. 6). Then, the state sequentially shifts to the respective states of the pressed release state S4 (FIG. 7), the second administration start state S5 (FIG. 8), and the second administration completion state S6 (FIG. 9).
  • the elastic member 5 is compressed.
  • the plunger rod 3 is inserted into the plunger 2 until the rear end portion 38 b of the second locking portion 38 reaches the first long hole portion 26.
  • the second locking portion 38 When the rear end portion 38b of the second locking portion 38 reaches the first elongated hole portion 26, the second locking portion 38 is displaced toward the outside in the cylinder radial direction by the restoring force of the leaf spring portion 30L. The second locking portion 38 is locked to the first long hole portion 26.
  • locking part 36 is also displaced toward the outer side of a cylinder radial direction. The first locking portion 36 protrudes further outward in the cylinder radial direction from the outer peripheral surface 20d of the second main body portion 20 through the first elongated hole portion 26.
  • the gasket 4 and the plunger 2 are sequentially inserted into the barrel 1 in a state where the second locking portion 38 is locked to the first long hole portion 26 by the urging force of the elastic member 5.
  • the front end portion 36a of the first locking portion 36 and the protruding portion 16 (16a) of the barrel 1 are opposed to each other.
  • a space (inside 10 s) surrounded by the gasket 4 and the barrel 1 is filled with a chemical solution (adjuband). In this way, the state shown in FIG. 4 is obtained as the preparation state S1.
  • the patient supports the barrel 1 so that the index finger and the middle finger touch the surface 18a and the thumb touches the back surface 34b of the pressing portion 34.
  • the patient can grasp the barrel 1 so that the little finger is positioned closer to the one end 10a and the thumb touches the back surface 34b of the pressing portion 34. Good.
  • the pressing part 34 is slowly pressed by the patient's thumb in the direction indicated by the arrow AR1.
  • the other end 20 b of the plunger 2 is pressed against the surface 34 a of the pressing portion 34.
  • the plunger 2, the plunger rod 3, the gasket 4 and the elastic member 5 are integrally moved forward with respect to the barrel 1 (upward in the drawing).
  • the chemical solution is gradually discharged from the spray nozzle 12 as the gasket 4 advances. As the gasket 4 advances, unnecessary air is also evacuated from the spray nozzle 12. Thus, the nasal cavity administration container 100 transitions from the preparation state S1 to the first administration start state S2 (state shown in FIG. 5).
  • the plunger 2 may further include the first protrusion 25.
  • the first protrusion 25 is disposed on the second body 20 at the next position.
  • the first locking portion 36 protrudes from the first long hole portion 26.
  • the first protrusion 25 is positioned on the second main body 20 so that the protrusion 25a of the first protrusion 25 is located on the front side (on the one end 20a side) of the first locking portion 36. Arranged.
  • the first protrusion 25 advances toward the protruding portion 16 (16b).
  • the first protrusion 25 advances by a distance L1.
  • the first protrusion 25 abuts on the protrusion 16b. This contact makes the patient's thumb feel resistance.
  • the patient stops pressing against the pressing unit 34.
  • the chemical liquid is not discharged from the spray nozzle 12.
  • the plunger 2 Since the plunger 2 has the first protrusion 25, it is possible to accurately set the volume of the drug solution to be administered. By changing the position of the 1st projection part 25, it becomes possible to obtain freely the volume of the chemical
  • First administration start state S2, first administration completion state S3 Referring to FIG. 5, in the first administration start state S ⁇ b> 2, the second locking portion 38 is locked to the first long hole portion 26 by the urging force of the elastic member 5. The elastic member 5 is compressed. The first locking portion 36 protrudes outward in the cylinder radial direction through the first long hole portion 26. The front end portion 36a of the first locking portion 36 and the protruding portion 16a face each other. In this state, the nasal cavity administration container 100 is inserted into one of the left and right nasal cavities.
  • the patient resumes pressing against the pressing unit 34.
  • the pressing portion 34 is pressed in the direction indicated by the arrow AR2 by the patient's thumb.
  • the other end 20 b of the plunger 2 is pressed against the surface 34 a of the pressing portion 34.
  • the plunger 2, the plunger rod 3, the gasket 4 and the elastic member 5 are integrally moved forward with respect to the barrel 1.
  • the press part 34 is pressed vigorously.
  • the 1st projection part 25 bends elastically when a patient provides the pressing force more than predetermined with respect to the press part 34.
  • FIG. The inner peripheral surface 10c of the barrel 1 displaces the protruding portion 25a toward the inside in the cylinder radial direction.
  • the leaf spring portion 25b is elastically bent toward the inside in the cylinder radial direction.
  • the leaf spring portion 25b (and the protrusion portion 25a) is configured to be able to bend toward the space formed in the recess portion 33 when the plunger rod 3 has the recess portion 33. Good.
  • the contact state between the first protrusion 25 and the protrusion 16b is released. Even if the plunger 2 has the first protrusion 25, the first protrusion 25 does not prevent the plunger 2, the plunger rod 3, the gasket 4, and the elastic member 5 from moving forward.
  • the patient can administer the medicinal solution into the nasal cavity at high pressure (desired pressure) from the start of spraying.
  • the plunger 2, the plunger rod 3, the gasket 4 and the elastic member 5 advance by a distance L2.
  • a surface 34 a of the pressing portion 34 abuts on the other end 10 b of the barrel 1. This contact makes the patient's thumb feel a strong resistance. The patient stops pressing against the pressing unit 34. By this contact, the volume of the drug solution to be administered to one nasal cavity is set.
  • the plunger 2 may further include the second protrusion 27.
  • the second protrusion 27 is disposed such that the distance between the protrusion 27a of the second protrusion 27 and the protrusion 16 is equal to the distance L2 in the first administration start state S2. Good.
  • the second protrusion 27 advances toward the protruding portion 16b.
  • the second protrusion 27 advances by a distance L2.
  • the contact of the second protrusion 27 with the protruding portion 16b and the contact of the surface 34a of the pressing portion 34 with the other end 10b of the barrel 1 may be simultaneous. By this contact, the patient stops pressing against the pressing portion 34.
  • the plunger 2 has the second protrusion 27, it is possible to more appropriately set the volume of the drug solution to be administered. By changing the position of the second protrusion 27, the volume of the drug solution to be administered can be freely obtained.
  • the first locking part 36 As the pressing part 34 is pressed, the first locking part 36 also advances.
  • the protruding portion 16a displaces the first locking portion 36 in the direction indicated by the arrow AR6.
  • the leaf spring portion 30L is elastically bent in the same direction with the other end 30b as a center.
  • the nasal cavity administration container 100 transitions from the first administration start state S2 to the first administration completion state S3 (state shown in FIG. 6).
  • Press release state S4 Referring to FIG. 6, the patient releases the pressure on pressing portion 34.
  • the nasal cavity administration container 100 transitions from the first administration completion state S3 to the press release state S4 (state shown in FIG. 7).
  • the leaf spring part 27 b (the inner peripheral surface side) of the second protrusion 27 and the back part 35 of the plunger rod 3 slide. It is good to be configured to do so.
  • the back surface portion 35 suppresses the leaf spring portion 27b from bending toward the inside in the cylinder radial direction.
  • the restoring force of the elastic member 5 may act in the direction in which the plunger 2 moves forward. Even in this case, since the leaf spring portion 27b does not bend inward in the cylinder radial direction, the contact state between the protruding portion 27a of the second protruding portion 27 and the protruding portion 16b is not released. Since the plunger 2 and the gasket 4 do not move forward, it is possible to prevent the chemical liquid from leaking unexpectedly.
  • Time T0 is a moment when the pressing portion 34 is retracted and the contact state between the first locking portion 36 and the protruding portion 16a is released.
  • the rear end portion 38b of the second locking portion 38 is displaced outward in the cylindrical radial direction, and this rear end portion 38b reaches above the paper surface of the rear end portion 26b of the first long hole portion 26.
  • the time required to do this is defined as time T1.
  • the surface portion 38c of the second locking portion 38 retreats downward in the drawing, and this surface portion 38c is located on the inner periphery located between the first long hole portion 26 and the second long hole portion 28.
  • the time required to reach the left side of the surface 10ca is defined as time T2.
  • the patient needs to release the pressure on the pressing portion 34 so that the time T2 is shorter than the time T1.
  • the plunger rod 3 moves backward by a distance L3 (see FIG. 6) until the front end portion 38a of the second locking portion 38 reaches the second long hole portion 28.
  • the second locking portion 38 is indicated by an arrow AR7 toward the outer side in the cylinder radial direction by the restoring force of the leaf spring portion 30L. It is displaced in the direction (see FIG. 8).
  • the second locking portion 38 is locked to the second long hole portion 28 by the urging force of the elastic member 5.
  • the first locking portion 36 may be configured to protrude toward the outside in the cylinder radial direction through the first long hole portion 26.
  • the pressing part 34 is pressed in the direction indicated by the arrow AR5.
  • the front end portion 28 a of the second elongated hole portion 28 is pressed against the front end portion 38 a of the second locking portion 38.
  • the plunger 2, the plunger rod 3, the gasket 4 and the elastic member 5 are integrally moved forward with respect to the barrel 1. As the gasket 4 advances, the chemical liquid is ejected from the spray nozzle 12.
  • the second protrusion 27 is elastic when the patient applies a pressing force more than a predetermined value to the pressing portion 34. Flex.
  • the inner peripheral surface 10c of the barrel 1 displaces the protrusion 27a toward the inner side in the cylinder radial direction.
  • the leaf spring portion 27b is elastically bent toward the inside in the cylinder radial direction.
  • the leaf spring portion 27b (and the projection portion 27a) is configured to be able to bend toward the space formed in the recess portion 33 when the plunger rod 3 has the recess portion 33. Good.
  • the contact state between the second protrusion 27 and the protrusion 16 (16b) is released. Even when the plunger 2 has the second protrusion 27, the second protrusion 27 does not prevent the plunger 2, the plunger rod 3, the gasket 4 and the elastic member 5 from moving forward.
  • the patient can administer the medicinal solution into the nasal cavity at high pressure (desired pressure) from the start of spraying.
  • the plunger 2, the plunger rod 3, the gasket 4 and the elastic member 5 advance by a distance L4 (see FIG. 8).
  • the front end of the gasket 4 abuts on the inner peripheral surface 10 c on the one end 10 a side of the barrel 1.
  • This contact makes the patient's thumb feel a strong resistance.
  • the patient stops pressing against the pressing unit 34.
  • the volume of the drug solution to be administered to the other nasal cavity is set.
  • the chemical liquid is no longer ejected from the spray nozzle 12.
  • the nasal cavity administration container 100 transitions from the second administration start state S5 to the second administration completion state S6 (state shown in FIG. 9). Administration of the drug to each nasal cavity is complete.
  • the plunger 2 may further include the annular protrusion 23.
  • the annular protrusion 23 is arranged so that the distance between the annular protrusion 23 and the protrusion 16 is equal to the distance L4 in the second administration start state S5 (see FIG. 8). Good.
  • the annular protrusion 23 advances toward the protruding portion 16.
  • the annular protrusion 23 advances by a distance L4.
  • the annular protrusion 23 abuts on the protrusion 16.
  • the contact of the annular protrusion 23 with the protrusion 16 and the contact of the front end of the gasket 4 with the inner peripheral surface 10c on the one end 10a side of the barrel 1 may be simultaneous. By this contact, the patient stops pressing against the pressing portion 34.
  • the chemical liquid is no longer ejected from the spray nozzle 12.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention porte sur un contenant (100) pour une administration dans une cavité nasale, lequel contenant comporte un corps (1), un piston (2), une tige de piston (3), un joint d'étanchéité (4) et un élément élastique (5). Une section de pression (34) est pressée dans un premier état de début d'administration (S2). La surface (34a) de la section de pression (34) est pressée sur l'autre extrémité (20b) du piston (2). Le piston (2) est pressé par la tige de piston (3). Lorsqu'une première section de prise (36) entre en contact avec une section de saillie (16), une seconde section de prise (38) et une première section de trou profond (26) sont désolidarisées l'une de l'autre. Lorsque que la force de pression sur la section de pression (34) est retirée, la force de rappel de l'élément élastique (5) amène la seconde section de prise (38) à se rétracter, et la seconde section de prise (38) entre en prise avec une seconde section de trou profond (28). Lorsque la section de pression (34) est à nouveau pressée, la prise entre la seconde section de prise (38) et la seconde section de trou profond (28) amène le piston (2) à être pressé par la tige de piston (3). Le dispositif (100) pour une administration dans une cavité nasale permet à l'utilisateur d'administrer un liquide médical à chacune des cavités nasales au moyen d'une seule main.
PCT/JP2011/055325 2010-03-09 2011-03-08 Contenant pour une administration dans une cavité nasale Ceased WO2011111687A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2012504464A JP5786852B2 (ja) 2010-03-09 2011-03-08 鼻腔投与容器

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Application Number Priority Date Filing Date Title
JP2010-051501 2010-03-09
JP2010051501 2010-03-09

Publications (1)

Publication Number Publication Date
WO2011111687A1 true WO2011111687A1 (fr) 2011-09-15

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PCT/JP2011/055325 Ceased WO2011111687A1 (fr) 2010-03-09 2011-03-08 Contenant pour une administration dans une cavité nasale

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JP (1) JP5786852B2 (fr)
WO (1) WO2011111687A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013230208A (ja) * 2012-04-27 2013-11-14 Yoshino Kogyosho Co Ltd 定量シリンジ型噴出器
JP2014217399A (ja) * 2013-04-30 2014-11-20 株式会社吉野工業所 シリンジ型噴出容器
JP2014233384A (ja) * 2013-05-31 2014-12-15 株式会社吉野工業所 シリンジ型噴出容器
JP2015173748A (ja) * 2014-03-13 2015-10-05 株式会社吉野工業所 定量シリンジ型噴出器
JP2016501126A (ja) * 2012-12-04 2016-01-18 スルザー ミックスパック アクチェンゲゼルシャフト 分配装置
JP2016537080A (ja) * 2013-11-13 2016-12-01 ジェネンテック， インコーポレイテッド 補助装置付き手動注射装置と方法
WO2016188428A1 (fr) * 2015-05-25 2016-12-01 美敦力公司 Appareil de perfusion de fluide utilisé pour administrer un médicament à un patient
JP2017159096A (ja) * 2017-05-17 2017-09-14 株式会社吉野工業所 定量シリンジ型噴出容器
CH714774B1 (de) * 2018-05-08 2019-09-13 Akroswiss Ag Bi-Dosis Nasenspray.
CN110559518A (zh) * 2014-08-21 2019-12-13 欧文蒙福德有限公司 安全注射器
WO2019215235A3 (fr) * 2018-05-08 2019-12-26 Akroswiss Ag Pulvérisation nasale bi-dose
WO2022153933A1 (fr) * 2021-01-14 2022-07-21 ニプロ株式会社 Pulvérisateur
WO2023013515A1 (fr) * 2021-08-02 2023-02-09 ニプロ株式会社 Pulvérisateur

Families Citing this family (1)

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US20240277940A1 (en) 2021-06-29 2024-08-22 Taisei Kako Co., Ltd. Syringe

Citations (1)

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WO2009057572A1 (fr) * 2007-10-30 2009-05-07 Daikyo Seiko, Ltd. Appareil nasal prérempli à gouttes

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JP2004049726A (ja) * 2002-07-23 2004-02-19 Shimizu Pharmaceutical Co Ltd 注射器

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009057572A1 (fr) * 2007-10-30 2009-05-07 Daikyo Seiko, Ltd. Appareil nasal prérempli à gouttes

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013230208A (ja) * 2012-04-27 2013-11-14 Yoshino Kogyosho Co Ltd 定量シリンジ型噴出器
JP2016501126A (ja) * 2012-12-04 2016-01-18 スルザー ミックスパック アクチェンゲゼルシャフト 分配装置
JP2014217399A (ja) * 2013-04-30 2014-11-20 株式会社吉野工業所 シリンジ型噴出容器
JP2014233384A (ja) * 2013-05-31 2014-12-15 株式会社吉野工業所 シリンジ型噴出容器
JP2016537080A (ja) * 2013-11-13 2016-12-01 ジェネンテック， インコーポレイテッド 補助装置付き手動注射装置と方法
JP2015173748A (ja) * 2014-03-13 2015-10-05 株式会社吉野工業所 定量シリンジ型噴出器
CN110559518B (zh) * 2014-08-21 2022-06-07 欧文蒙福德有限公司 安全注射器
CN110559518A (zh) * 2014-08-21 2019-12-13 欧文蒙福德有限公司 安全注射器
WO2016188428A1 (fr) * 2015-05-25 2016-12-01 美敦力公司 Appareil de perfusion de fluide utilisé pour administrer un médicament à un patient
JP2017159096A (ja) * 2017-05-17 2017-09-14 株式会社吉野工業所 定量シリンジ型噴出容器
CH714774B1 (de) * 2018-05-08 2019-09-13 Akroswiss Ag Bi-Dosis Nasenspray.
WO2019215235A3 (fr) * 2018-05-08 2019-12-26 Akroswiss Ag Pulvérisation nasale bi-dose
US12239780B2 (en) 2018-05-08 2025-03-04 Akroswiss Ag Bi-dose nasal spray
WO2022153933A1 (fr) * 2021-01-14 2022-07-21 ニプロ株式会社 Pulvérisateur
JP2022108870A (ja) * 2021-01-14 2022-07-27 ニプロ株式会社 噴霧器
JP7517160B2 (ja) 2021-01-14 2024-07-17 ニプロ株式会社 噴霧器
WO2023013515A1 (fr) * 2021-08-02 2023-02-09 ニプロ株式会社 Pulvérisateur

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