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WO2011108001A3 - Process for the preparation of methyl-methyl-3, 4-dihydro-2h-pyran-5-carboxylate - Google Patents

Process for the preparation of methyl-methyl-3, 4-dihydro-2h-pyran-5-carboxylate Download PDF

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Publication number
WO2011108001A3
WO2011108001A3 PCT/IN2011/000111 IN2011000111W WO2011108001A3 WO 2011108001 A3 WO2011108001 A3 WO 2011108001A3 IN 2011000111 W IN2011000111 W IN 2011000111W WO 2011108001 A3 WO2011108001 A3 WO 2011108001A3
Authority
WO
WIPO (PCT)
Prior art keywords
methyl
formula
pyran
dihydro
carboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2011/000111
Other languages
French (fr)
Other versions
WO2011108001A2 (en
Inventor
Snehal R. Patel
P.N. Roshan Rakesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPC LIFESCIENCES PVT Ltd
Original Assignee
SPC LIFESCIENCES PVT Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SPC LIFESCIENCES PVT Ltd filed Critical SPC LIFESCIENCES PVT Ltd
Priority to CN201180011151.1A priority Critical patent/CN102781927B/en
Publication of WO2011108001A2 publication Critical patent/WO2011108001A2/en
Publication of WO2011108001A3 publication Critical patent/WO2011108001A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

The present invention provides an improved process for the preparation of methyl-methyl-3,4-dihydro-2H-pyran-5-carboxylate of formula (IV), comprising the steps of: (IV) (i) alkylating 1-Bromo-3-chloropropane of formula (I) with Methylacetoacetate of formula (II) to prepare haloketone of formula (VII) in presence of an alcoholic solvent; (I) (II) (VII) (ii) O-alkylating the compound of formula (VII) with sodium methoxide to obtain the desired molecule methyl-methyl-3,4-dihydro-2H-pyran-5-carboxylate of formula (IV) in its crude form; (VII) (IV) (iii) Purifying the content of step (ii) above by fractional distillation to obtain the purified molecule of formula (IV).
PCT/IN2011/000111 2010-03-02 2011-02-24 Process for the preparation of methyl-methyl-3, 4-dihydro-2h-pyran-5-carboxylate Ceased WO2011108001A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201180011151.1A CN102781927B (en) 2010-03-02 2011-02-24 Preparation process of methyl-methyl-3, 4-dihydro-2H-pyran-5-carboxylate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN544/MUM/2010 2010-03-02
IN544MU2010 2010-03-02

Publications (2)

Publication Number Publication Date
WO2011108001A2 WO2011108001A2 (en) 2011-09-09
WO2011108001A3 true WO2011108001A3 (en) 2011-11-10

Family

ID=44477761

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000111 Ceased WO2011108001A2 (en) 2010-03-02 2011-02-24 Process for the preparation of methyl-methyl-3, 4-dihydro-2h-pyran-5-carboxylate

Country Status (2)

Country Link
CN (1) CN102781927B (en)
WO (1) WO2011108001A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023228083A1 (en) * 2022-05-23 2023-11-30 Ami Organics Ltd. A process for the preparation of pentoxifylline intermediate
WO2024161377A1 (en) 2023-02-04 2024-08-08 Lavender Laboratories Private Limited Process for the preparation of halo alkyl ketone
CN116178136B (en) * 2023-04-28 2023-07-14 北京天弘天达科技股份有限公司 A kind of preparation method of 2-hexyldecanoic acid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422107A (en) * 1964-09-05 1969-01-14 Albert Ag Chem Werke Certain oxoalkyldimethylxanthines and a process for the preparation thereof
DD266709A3 (en) * 1984-09-05 1989-04-12 Dresden Arzneimittel PROCESS FOR PREPARING 2-METHYL-5,6-DIHYDRO-PYRAN-3-CARBOXYLIC ACID ESTERS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD226709A1 (en) * 1984-09-03 1985-08-28 Robotron Elektronik MULTIPLEXERS FOR LOW-CHANNEL DIGITAL TRANSMISSION SYSTEMS
DE10207410C1 (en) * 2002-02-21 2003-06-26 Bayer Ag Production of 3,6-dihydro-2H-pyran-2-carboxylic esters by thermal hetero-Diels-Alder reaction involves heating glyoxylic esters in absence of catalyst and stabilizer before addition, preferably dosed addition, of diene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422107A (en) * 1964-09-05 1969-01-14 Albert Ag Chem Werke Certain oxoalkyldimethylxanthines and a process for the preparation thereof
DD266709A3 (en) * 1984-09-05 1989-04-12 Dresden Arzneimittel PROCESS FOR PREPARING 2-METHYL-5,6-DIHYDRO-PYRAN-3-CARBOXYLIC ACID ESTERS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
E. P. ANDERSON ET. AL.: "Synthesis of 1-Diethylamino-5-aminohexane.", JOURNAL OF THE AMEIRICAN CHEMICAL SOCIETY, vol. 68, no. 7, 1 July 1946 (1946-07-01), pages 1294 - 1296, XP002657781 *

Also Published As

Publication number Publication date
CN102781927B (en) 2016-02-03
WO2011108001A2 (en) 2011-09-09
CN102781927A (en) 2012-11-14

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