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WO2011104555A3 - Nouveau procédé - Google Patents

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Publication number
WO2011104555A3
WO2011104555A3 PCT/GB2011/050369 GB2011050369W WO2011104555A3 WO 2011104555 A3 WO2011104555 A3 WO 2011104555A3 GB 2011050369 W GB2011050369 W GB 2011050369W WO 2011104555 A3 WO2011104555 A3 WO 2011104555A3
Authority
WO
WIPO (PCT)
Prior art keywords
sunitinib
preparation
sunitinib malate
malate form
hydroxybutanedioate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2011/050369
Other languages
English (en)
Other versions
WO2011104555A2 (fr
Inventor
Vinayak Govind Gore
Laxmikant Narahari Patkar
Kiran Shivaji Pokharkar
Mahesh Gorakhnath Hublikar
Prakash Vishnu Bansode
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Mylan Pharmaceuticals Pvt Ltd
Original Assignee
Generics UK Ltd
Mylan India Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics UK Ltd, Mylan India Pvt Ltd filed Critical Generics UK Ltd
Publication of WO2011104555A2 publication Critical patent/WO2011104555A2/fr
Publication of WO2011104555A3 publication Critical patent/WO2011104555A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un procédé amélioré de préparation des sels d'addition acide du sunitinib, en particulier du (2S)-2-hydroxybutanedioate de sunitinib (I). La présente invention concerne également des compositions comprenant des sels d'addition acide du sunitinib comme le (2S)-2-hydroxybutanedioate (I) de sunitinib et l'emploi desdites compositions dans le traitement de pathologies.
PCT/GB2011/050369 2010-02-25 2011-02-24 Nouveau procédé Ceased WO2011104555A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN184KO2010 2010-02-25
IN184/KOL/2010 2010-02-25

Publications (2)

Publication Number Publication Date
WO2011104555A2 WO2011104555A2 (fr) 2011-09-01
WO2011104555A3 true WO2011104555A3 (fr) 2012-02-02

Family

ID=43748595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/050369 Ceased WO2011104555A2 (fr) 2010-02-25 2011-02-24 Nouveau procédé

Country Status (1)

Country Link
WO (1) WO2011104555A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013045878A1 (fr) 2011-09-30 2013-04-04 British Telecommunications Plc Attribution de contributions à un encombrement
WO2013190569A2 (fr) * 2012-06-22 2013-12-27 Shilpa Medicare Limited Nouveaux sels de sunitinib et leur préparation
US11136625B2 (en) 2013-08-28 2021-10-05 Crown Bioscience, Inc. (Taicang) Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060814A2 (fr) * 2000-02-15 2001-08-23 Sugen, Inc. Inhibiteurs de la proteine kinase 2-indolinone a substitution pyrrole
WO2009150523A1 (fr) * 2008-06-13 2009-12-17 Medichem, S.A. Procédé de préparation d’un sel 2-indolinone malate à substitution 3‑pyrrole
WO2009157011A1 (fr) * 2008-06-23 2009-12-30 Natco Pharma Limited Procédé de préparation de sunitinib de haute pureté et de ses sels pharmaceutiquement acceptables

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2004196A3 (cs) 2001-08-15 2005-01-12 Pharmacia & Upjohn Company Krystaly obsahující sůl N-[2-(diethylamino)ethyl]-5-[(5-fluor-2-oxo-3H-indol-3-yliden) methyl]-2,4-dimethyl-1H-pyrrol 3-karboxamidu s kyselinou jablečnou, způsob jejich výroby a kompozice na jejich bázi
AU2003216282A1 (en) 2002-02-15 2003-09-09 Pharmacia And Upjohn Company Llc Process for preparing indolinone derivatives
US20060009510A1 (en) 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
JP2011526615A (ja) 2008-07-02 2011-10-13 ジェネリクス・（ユーケー）・リミテッド ３−ピロール置換２−インドリノン誘導体の調製

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060814A2 (fr) * 2000-02-15 2001-08-23 Sugen, Inc. Inhibiteurs de la proteine kinase 2-indolinone a substitution pyrrole
WO2009150523A1 (fr) * 2008-06-13 2009-12-17 Medichem, S.A. Procédé de préparation d’un sel 2-indolinone malate à substitution 3‑pyrrole
WO2009157011A1 (fr) * 2008-06-23 2009-12-30 Natco Pharma Limited Procédé de préparation de sunitinib de haute pureté et de ses sels pharmaceutiquement acceptables

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. H. VAN 'T HOFF, H. M. DAWSON: "Die racemische Umwandlung des Ammoniumbimalats", CHEMISCHE BERICHTE, vol. 31, no. 1, 1898, pages 528 - 534, XP002630290 *
KAY SCHWARZKOPF ET AL: "Synthesis of Novel Optically Active Tin Hydrides Containing Chiral Ligands", CHEMISCHE BERICHTE, vol. 130, 1997, pages 1539 - 1546, XP002630291 *
TADASHI SHIRAIWA ET AL: "Racemic Structure and Optical Resolution by Preferential Crystalization of (+/-)-Organic Ammonium Hydrogen Malates", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 61, 1988, pages 899 - 903, XP002630292 *

Also Published As

Publication number Publication date
WO2011104555A2 (fr) 2011-09-01

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