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WO2011102001A1 - Composition cosmétique - Google Patents

Composition cosmétique Download PDF

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Publication number
WO2011102001A1
WO2011102001A1 PCT/JP2010/053180 JP2010053180W WO2011102001A1 WO 2011102001 A1 WO2011102001 A1 WO 2011102001A1 JP 2010053180 W JP2010053180 W JP 2010053180W WO 2011102001 A1 WO2011102001 A1 WO 2011102001A1
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WO
WIPO (PCT)
Prior art keywords
ppg
cosmetic composition
weight
polyoxyethylenated
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2010/053180
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English (en)
Inventor
Kazuko Jimbo
Rena Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
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Filing date
Publication date
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Application filed by LOreal SA filed Critical LOreal SA
Priority to PCT/JP2010/053180 priority Critical patent/WO2011102001A1/fr
Priority to JP2012553447A priority patent/JP5774029B2/ja
Publication of WO2011102001A1 publication Critical patent/WO2011102001A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to a cosmetic composition with enhanced stability which is preferably used for whitening the skin.
  • compositions containing whitening agents are included in dermatological compositions containing whitening agents.
  • the substances most commonly used as whitening agents are
  • hydroquinone and derivatives thereof hydroquinone and derivatives thereof, kojic acid and derivatives thereof, azelaic acid, arbutin and derivatives thereof, alone or in combination with other active agents.
  • compositions comprising whitening agents are also used by individuals whose skin displays dyschromias. These dyschromias are of diverse origin: age (age marks), exposure to UV radiation, pregnancy marks, etc.
  • Kojic acid (2-hydroxymetyl-5-hydroxy-4H-pyran-4-one) is known to inhibit tyrosinase which is involved in the production of melanin in the skin, and therefore kojic acid is widely used for whitening the skin.
  • WO 00/7627 discloses a composition
  • the use of a surfactant or surfactants is difficult to be avoided, especially if the composition is used as a cosmetic composition, because the cosmetic composition typically contains several substances such as perfumes which need the aid of surfactant (s) to be dissolved in the cosmetic composition.
  • an objective of the present invention is to provide a cosmetic composition comprising kojic acid with good stability over time, even though the cosmetic composition includes a
  • surfactant or surfactants.
  • the above objective of the present invention can be achieved by combining, kojic acid with carefully selected surfactant (s) .
  • one aspect of the present invention is a cosmetic composition
  • a cosmetic composition comprising:
  • polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C 16 -C 24 ) ethers, polyoxyethylenated (30-50 EO) hydrogenated castor oils, and polyoxyethylenated (15-30 EO) mono- or tri-oleates; and
  • polyoxypropylenated (1-30 PO) alkyl (C 16 -C 24 ) ethers be selected from the group consisting of PPG-6 Decyltetradeceth-30, PPG-6 Decyltetradeceth-12, PPG-13 Decyltetradeceth-24 , PPG-6
  • polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C 16 -C 24 ) ethers are (15-40 EO) and polyoxypropylenated (5-30 PO) alkyl (C 16 -C 24 ) ethers, which could be selected from the group consisting of PPG-6
  • polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C 16 -C 24 ) ethers are (15-40 EO) and polyoxypropylenated (5-30 PO) alkyl (C 16 -C 24 ) ethers, which could be selected from the group consisting of PPG-6
  • the polyoxyethylenated (30-50 EO) hydrogenated castor oils be selected from the group consisting of PEG-30 Hydrogenated castor oil, PEG-40 Hydrogenated castor oil and PEG-50 Hydrogenated castor oil.
  • polyoxyethylenated (30-50 EO) hydrogenated castor oil be PEG-40 Hydrogenated castor oil.
  • polyoxyethylenated (15-30 EO) mono- or tri-oleates be selected from the group consisting of Polysorbate 80 and Polysorbate 85.
  • polyoxyethylenated (15-30 EO) mono- or tri-oleate is Polysorbate 80.
  • the non-ionic surfactant may be present in an amount of 0.01% to 10% by weight, preferably 0.01% to 5% by weight, and more
  • composition preferably 0.01% to 2.5% by weight, relative to the total weight of the composition.
  • the kojic acid may be present in an amount of 0.01% to 5% by weight, preferably 0.1% to 3.0% by weight, and more preferably 0.5% to 2.0% by weight, relative to the total weight of the composition .
  • the cosmetic composition according to the present invention may further comprise at least one perfume.
  • the perfume may be present in an amount of 0.01% to 1% by weight, preferably 0.01% to 0.5% by weight, and more preferably 0.01% to 0.3% by weight, relative to the total weight of the composition.
  • the cosmetic composition according to the present invention may further comprise at least one fatty compound in an amount of 0.01% to 10% by weight, preferably 0.01% to 5% by weight, and more preferably 0.01% to 1% by weight, relative to the total weight of the composition.
  • the cosmetic composition according to the present invention be intended for whitening the skin.
  • the cosmetic composition comprising kojic acid according to the present invention is stable over time.
  • Another aspect of the present invention is a cosmetic treatment process for the skin, comprising applying the cosmetic composition according to the present invention onto the skin.
  • the cosmetic composition according to the present invention is characterized by comprising:
  • non-ionic surfactant selected from the group consisting of polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C 15 -C 24 ) ethers, polyoxyethylenated (30-50 EO) hydrogenated castor oils, and polyoxyethylenated (15-30 EO) mono- or tri-oleates.
  • cosmetic composition according to the present invention further comprises
  • Kojic acid is a heterocyclic compound having the following chemical formula.
  • the cosmetic composition according to the present invention may comprise kojic acid in an amount of 0.01% to 5.0% by weight, preferably 0.1% to 3.0% by weight, and more preferably 0.5% to 2.0% by weight, relative to the total weight of the composition.
  • non-ionic surfactant selected from the group consisting of polyoxyethylenated (1-40 EO) and
  • polyoxyethylenated (15-30 EO) mono- or tri-oleates.
  • Two or more of the non-ionic surfactants may be used.
  • polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C 16 -C 24 ) ethers can preferably be selected from the group consisting of:
  • PPG-6 Decyltetradeceth-30 Polyoxyethlene (30) Polyoxypropylene (6) Tetradecyl Ether such as those sold as Nikkol PEN-4630 from Nikko Chemicals Co.,
  • PPG-6 Decyltetradeceth-12 Polyoxyethylene (12) Polyoxypropylene (6) Tetradecyl Ether such as those sold as Nikkol PEN-4612 from Nikko Chemicals Co.,
  • PPG-6 Decyltetradeceth-20 Polyoxyethylene (20) Polyoxypropylene (6) Decyltetradecyl Ether such as those sold as Nikkol PEN-4620 from Nikko Chemicals Co.,
  • PPG-4 Ceteth-1 Polyoxyethylene (1) Polyoxypropylene (4) Cetyl Ether such as those sold as Nikkol PBC-31 from Nikko Chemicals Co., PPG-8 Ceteth-1; Polyoxyethylene (1) Polyoxypropylene (8) Cetyl Ether such as those sold as Nikkol PBC-41 from Nikko Chemicals Co., PPG-4 Ceteth-10; Polyoxyethylene (10) Polyoxypropylene (4) Cetyl Ether such as those sold as Nikkol PBC-33 from Nikko Chemicals Co., PPG-4 Ceteth-20; Polyoxyethylene (20) Polyoxypropylene (4) Cetyl Ether such as those sold as Nikkol PBC-34 from Nikko Chemicals Co., PPG-5 Ceteth-20; Polyoxyethylene (20) Polyoxypropylene (5) Cetyl Ether such as those sold as Procetyl AWS from Croda Inc.,
  • PPG-23 Steareth-34 Polyoxyethylene Polyoxypropylene Stearyl Ether (34 E.O.) (23 P.O.) such as those sold as Unisafe 34S-23 from Pola Chemical Industries. They can provide a composition with stability for a long time, even though the temperature of the composition is increased and decreased in a relatively short period of time.
  • polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C 16 -C 24 ) ethers are (15-40 EO) and polyoxypropylenated (5-30 PO) alkyl (C 16 -C 24 ) ethers, which could be selected from the group consisting of PPG- ⁇
  • polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C 16 -C 24 ) ethers are (15-40 EO) and polyoxypropylenated (5-30 PO) alkyl (C 16 -C 24 ) ethers, which could be selected from the group consisting of PPG-6
  • Decyltetradeceth-30, PPG-13 Decyltetradeceth-24, PPG-5 Ceteth-20, and PPG-8 Ceteth-20 They can also provide a composition with transparency for a long time.
  • polyoxyethylenated (30-50 EO) hydrogenated castor oils can preferably be selected from the group consisting of:
  • PEG-30 Hydrogenated castor oil Polyoxyethylene (30) Hydrogenated Castor Oil such as those sold as Nikkol HCO-30 from Nikko
  • PEG-40 Hydrogenated castor oil Polyoxyethylene (40) Hydrogenated Castor Oil such as those sold as Nikkol HCO-40 from Nikko
  • PEG-50 Hydrogenated castor oil Polyoxyethylene (50) Hydrogenated Castor Oil such as those sold as Nikkol HCO-50 from Nikko
  • Chemicals Co They can provide a composition with stability for a long time, even though the temperature of the composition is increased and decreased in a relatively short period of time.
  • polyoxyethylenated (30-50 EO) hydrogenated castor oil be PEG-40 Hydrogenated castor oil. This can also provide a composition with transparency for a long time.
  • the HLB value of the polyoxyethylenated (30-50 EO) hydrogenated castor oils is preferably 14.5 or less, more preferably 14 or less, further more preferably 13.5 or less, and most preferably 13.0 or less .
  • the polyoxyethylenated (15-30 EO) mono- or tri-oleates can preferably be selected from the group consisting of:
  • Polysorbate 80 Polyoxyethylene Sorbitan Oleate (20 E.O.) such as those sold as Tween 80 from Croda, Inc.,
  • Polysorbate 85 Polyoxyethylene Sorbitan Trioleate (20 E.O.) such as those sold as Tween 85 from Croda, Inc. They can provide a composition with stability for a long time, even though the temperature of the composition is increased and decreased in a relatively short period of time.
  • polyoxyethylenated (15-30 EO) mono- or tri-oleate is Polysorbate 80. This can also provide a
  • composition with transparency for a long time
  • the cosmetic composition according to the present invention may comprise the non-ionic surfactant in an amount of 0.01% to 10% by weight, preferably 0.01% to 5% by weight, and more preferably 0.01% to 2.5% by weight, relative to the total weight of the composition .
  • the cosmetic composition according to the present invention comprises water in an amount of 50% or more relative to the total weight of the composition.
  • the water may be a floral water such as cornflower water, and/or a mineral water such as Vittel water, Lucas water, or La Roche Posay water, and/or a thermal water, and/or seawater such as deep seawater .
  • the amount of water may range from 50 to 99.5% by weight
  • the cosmetic composition according to the present invention may further comprise at least one perfume.
  • a natural or synthetic fragrance or aroma and a mixture thereof can be employed.
  • natural fragrances and aromas mention may be made of, for example, extracts of flowers (lily, lavender, rose, jasmine, or ylang-ylang) , extracts of stems and of leaves
  • fragrances and aromas mention may be made of, for example, esters, ethers, aldehydes, ketones, aromatic alcohols, and hydrocarbon-based compounds.
  • esters As specified examples of the aforementioned esters, mention may be made of benzyl acetate, benzyl benzoate, phenoxyethyl isobutyrate, p-t-butylcyclohexyl acetate, citronellyl acetate, citronellyl formate, geranyl acetate, linalyl acetate, dimethylbenzylcarbonyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethylmethylphenyl glycinate, alkylcyclohexyl propionate, styralyl propionate, benzyl salicylate, and the like.
  • aldehydes mention may be made of, for example, linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyl oxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial, bourgeonal, and the like.
  • ketones As examples of the aforementioned ketones, mention may be made of, for example, ionones such as -isomethylionone and methyl cedryl ketone .
  • terpene alcohols mention may be made of anethole, citronellol, eugenol, isoeugenol, geraniol, linalol, phenylethyl alcohol, terpineol, and the like.
  • hydrocarbon-based compounds mention may be made of, in particular, terpenes.
  • aforementioned compounds are often provided in the form of a blended product having two or more odorous substances in many cases .
  • An essential oil can also be employed as an aroma component.
  • sage oil chamomile oil, clove oil, balm oil, mint oil, cinnamon leave oil, lime blossom oil, juniper oil, vetiver oil, olibanum oil, galbanum oil, labolanum oil, lavandin oil, and the like are employed.
  • perfumes described below can be employed alone or in combination.
  • various perfumes can be employed by blending the same. Thereby, a scent which is pleasing to the user can be obtained.
  • the cosmetic composition according to the present invention may comprise the perfume in an amount of 0.01% to 1% by weight, preferably 0.01% to 0.5% by weight, and more preferably 0.01% to 0.3% by weight, relative to the total weight of the composition.
  • the cosmetic composition according to the present invention may further comprise at least one organic solvent which is miscible with water at ambient temperature (25°C) .
  • organic solvent which is miscible with water at ambient temperature (25°C)
  • polyols having 2 to 20 carbon atoms, preferably having 2 to 10 carbon atoms, and more preferably having 2 to 6 carbon atoms, such as glycerin, as well as alkylene glycols such as propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, and diethylene glycol;
  • glycol ethers in particular, having 3 to 16 carbon atoms
  • the cosmetic composition according to the present invention may comprise the aforementioned water-miscible organic solvent (s) in an amount ranging from 0.1 to 30% by weight, preferably ranging from 5 to 25% by weight, and more preferably ranging from 10 to 20% by weight, with respect to the total weight of the composition.
  • ethanol is contained in an amount of 0.1 to 15% by weight, if ethanol is present. in the composition.
  • alkylene glycol (s) is/are contained in an amount of 0.1 to 25% by weight, if alkylene
  • glycol (s) is/are present in the composition, with respect to the total weight of the composition.
  • the cosmetic composition according to the present invention may further comprise Vitamin E or a derivative thereof.
  • the Vitamin E derivative is not particularly limited, and examples thereof include, for example, tocopherol acetate and the like.
  • the blending amount of Vitamin E or the derivative thereof in the cosmetic composition according to the present invention is not particularly limited, and preferably ranges from 0.01 to 5% by weight on the basis of the total weight of the composition.
  • the cosmetic composition according to the present invention may further comprise at least one fatty compound.
  • the fatty compound may be in the form of a liquid or a solid.
  • liquid means that the fatty compound is in the form of a liquid or a paste (non-solid) at room temperature (25°C) under atmospheric pressure (760 ' mmHg) .
  • oils generally used in cosmetics can be used alone or in
  • the oil may be a non-polar oil such as a hydrocarbon oil, a
  • silicone oil or the like; a polar oil such as a vegetable oil and an ester oil; or a mixture thereof.
  • hydrocarbon oils mention may be made of, for example, linear or branched hydrocarbons such as mineral oil
  • silicone oils mention may be made of, for example, linear organopolysiloxanes such as dimethylpolysiloxane,
  • octamethylcyclotetrasiloxane decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and the like; and mixtures thereof.
  • vegetable oils mention may be made of, for example, linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflo er oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, and mixtures thereof.
  • ester oils mention may be made of, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl caprylate/caprate, methyl palmitate, ethyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isodecyl oleate,
  • the fatty compound may be a wax.
  • wax means that the fatty compound is substantially in the form of a solid at room
  • waxes generally used in cosmetics can be used alone or in combination thereof.
  • the wax may be chosen from carnauba wax,
  • microcrystalline waxes ozokerites, hydrogenated jojoba oil, polyethylene waxes such as the wax sold under the name
  • silicone waxes for instance poly(C 2 4- C 28 ) alkylmethyldimethylsiloxane, such as the product sold under the name "Abil Wax 9810" by the company Goldschmidt, palm butter, the C 20 -C 40 alkyl stearate sold under the name "Kester Wax K82H” by the company Kester Keunen, stearyl benzoate, shellac wax, and mixtures thereof.
  • a wax chosen from carnauba wax, candelilla wax, ozokerites, hydrogenated jojoba oil and polyethylene waxes is used.
  • the wax is preferably chosen from candelilla wax and ozokerite, and mixtures thereof.
  • the cosmetic composition according to the present invention may comprise the fatty compound in an amount of 0.01% to 10% by weight, preferably 0.01% to 5% by weight, and more preferably 0.01% to 1% by weight, relative to the total weight of the composition.
  • the fatty compound may be combined with a fatty acid such as stearic acid, myristic acid, or the like; a higher alcohol such as cetyl alcohol, stearyl alcohol, octyldodecanol, or the like; and the like.
  • a fatty acid such as stearic acid, myristic acid, or the like
  • a higher alcohol such as cetyl alcohol, stearyl alcohol, octyldodecanol, or the like; and the like.
  • the cosmetic composition according to the present invention is preferably intended for whitening the skin.
  • the whitening cosmetic composition of the present invention is a topical composition for applying on the surface of the body of human beings for the purpose of whitening, and is preferably a cosmetic composition for topical application on the skin.
  • whitening means all effects of inhibiting the production and/or deposition of melanin, and includes inhibiting the
  • the cosmetic composition according to the present invention may further comprise at least one additional whitening active ingredient.
  • additional whitening active ingredients mention may be made of, for example, ascorbic acid or derivatives thereof, tranexamic acid or derivatives thereof, resorcinol or derivatives thereof, alkoxysalicylic acid or salts thereof, adenosine phosphate or salts thereof, hydroquinone or glycosides thereof or derivatives thereof, glutathione, 4-(4- hydroxyphenyl) -2-butanol, magnolignan (5, 5' -dipropyl-biphenyl- 2,2'-diol), placenta extracts, chamomilla recutita, and the like.
  • ascorbic acid or derivatives thereof tranexamic acid or derivatives thereof, resorcinol or derivatives thereof, alkoxysalicylic acid or salts thereof, adenosine phosphate or salts thereof, hydroquinone or glycosides thereof or derivatives thereof, glutathione, 4-(4- hydroxyphenyl) -2-
  • Ascorbic acid has a D-configuration or L-configuration, and the L- configuration one is preferably employed. Ascorbic acid is also referred to as vitamin C, , and has effects of inhibiting the production of melanin due to the strong reduction effects of ascorbic acid.
  • the derivatives of ascorbic acid may be salts of ascorbic acid, and the salts of ascorbic acid are preferably selected from sodium ascorbate, magnesium ascorbyl phosphate, and sodium ascorbyl phosphate.
  • the derivatives of ascorbic acids may be glycosides of ascorbic acid or esters of ascorbic acid. As an example of glycosides of ascorbic acid, mention may be made of, for example, ascorbyl glucoside. As examples of esters of ascorbic acid, mention may be made of, for example, silyl
  • alkyl ascorbate methyl ascorbate or ethyl ascorbate is preferably used.
  • ascorbyl glucoside is preferable.
  • Ascorbic acid or derivatives thereof can be used alone or in combination with two or more types thereof.
  • derivatives of ascorbic acid mention may be made of, for example, 5, 6-di-O-dimethylsilyl ascorbate, which is commercially available as PRO-AA from Exsymol SAM; dl-alpha- tocopheryl-2-l-ascorbyl phosphate which is commercially available as SEPIVITAL EPC from Senju Pharmaceutical Co., Ltd.; sodium ascorbyl phosphate which is commercially available as Stay-C 50 from Roche; ascorbyl glucoside which is commercially available from Hayashibara Biochemical Labs., Inc.; 3-O-ethyl ascorbic acid; and the like.
  • Ascorbic acid or the derivative thereof is preferably used in combination with a copolymer of styrene and maleic anhydride.
  • a copolymer of styrene and maleic anhydride is preferably hydrolyzed.
  • aforementioned hydrolyzed maleic anhydride unit may be in the form of an alkaline salt such as a sodium salt, a potassium salt, a lithium salt, or the like.
  • the aforementioned maleic anhydride unit preferably occupies 0.4 to 0.9 mol per one mol of the entire copolymer, and the ratio of the maleic anhydride unit and the styrene unit is preferably 50:50.
  • the ratio of the maleic anhydride unit and the styrene unit be preferably 50:50, and an ammonium salt or sodium salt be used.
  • a copolymer of styrene and maleic anhydride (50/50) in the form of an ammonium salt in a concentration of 30% in water which is commercially available as product number SMA 1000 H (trademark) from Atofina Chemicals Inc.
  • a copolymer of styrene and maleic anhydride (50/50) in the form of a sodium salt in a concentration of 40% in water which is commercially available as product number SMA 1000 H Na (trademark) from Atofina Chemicals Inc., can be used.
  • the aforementioned copolymer is used in a concentration ranging from 0.1 to 20% by weight, and preferably ranging from 0.1 to 10% by weight, with respect to the total weight of the whitening agent for topical application.
  • derivatives of tranexamic acid mention may be made of dimmers of tranexamic acid (such as hydrochloric acid trans-4- (trans-aminomethylcyclohexanecarbonyl) aminomethylcyclohexane carboxylic acid) , esters of tranexamic acid and hydroquinone (such as 4 ' -hydroxyphenyl trans-4-aminomethylcyclohexane carboxylate) , esters of tranexamic acid and gentisic acid (such as 2-(trans-4- aminomethylcyclohexanecarbonyloxy) -5-hydroxybenzoic acid and salts thereof) , tranexamic amides (such as trans-4- aminomethylcyclohexanecarboxylic acid methylamide and salts
  • resorcinol As examples of derivatives of resorcinol, mention may be made of, for example, 4-n-butylresorcinol (Rucinol) and the like.
  • An alkoxysalicylic acid is a compound in which any one of hydrogen atoms in the 3-position, the 4-position, or the 5-position of salicylic acid is substituted by an alkoxy group.
  • aforementioned alkoxy group is preferably any one of a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, and isobutoxy group, and is more preferably a
  • methoxy group or an ethoxy group methoxy group or an ethoxy group.
  • alkali metal salts or alkaline earth metal salts such as sodium salts, potassium salts, calcium salts, and the like, ammonium salts, amino acid salts, and the like.
  • a potassium salt of 4-methoxysalicylic acid is preferable.
  • adenosine phosphate or salts thereof mention may be made of, for example, disodium adenosine phosphate, and the like .
  • glycosides of hydroquinone mention may be made of, for example, hexose glycosides such as hydroquinone alpha-D- glucose, hydroquinone beta-D-glucose, hydroquinone alpha-L-glucose, hydroquinone beta-L-glucose, hydroquinone alpha-D-galactose, hydroquinone beta-D-galactose, hydroquinone alpha-L-galactose, hydroquinone beta-L-galactose, and the like; pentose glycosides such as hydroquinone alpha-D-ribose, hydroquinone beta-D-ribose, hydroquinone alpha-L-ribose, hydroquinone beta-L-ribose,
  • hydroquinone alpha-D-arabinose hydroquinone beta-D-arabinose, hydroquinone alpha-L-arabinose, hydroquinone beta-L-arabinose, and the like; amino sugar glycosides such as hydroquinone alpha-D- glucosamine, hydroquinone beta-D-glucosamine, hydroquinone alpha- L-glucosamine, hydroquinone beta-L-glucosamine, hydroquinone alpha-D-galactosamine, hydroquinone beta-D-galactosamine,
  • hydroquinone alpha-L-galactosamine hydroquinone beta-L- galactosamine, and the like
  • urocanic acid glycosides such as hydroquinone alpha-D-glucuronic acid, hydroquinone beta-D- glucuronic acid, hydroquinone alpha-L-glucuronic acid,
  • hydroquinone beta-L-glucuronic acid hydroquinone alpha-D- galacturonic acid, hydroquinone beta-D-galacturonic acid,
  • hydroquinone alpha-L-galacturonic acid hydroquinone beta-L- galacturonic acid, and the like; and the like.
  • aromatic hydroquinone beta-D-glucose
  • hydroquinone or glycosides thereof mention may be made of, for example, salts of hydroquinone or glycosides thereof.
  • arbutin derivatives mention may be made of, for example, 6-O-caffeoylarbutin, and the like.
  • additional whitening active ingredients in particular, L- ascorbic acid or derivatives thereof, tranexamic acid or
  • ascorbic acid glycosides such as L-ascorbic acid glucoside are further preferable.
  • the blending amount of the additional whitening active ingredient in the whitening agent for topical application of the present invention is not particularly limited, and commonly ranges from 0.01 to 20% by weight, preferably ranges from 0.01 to 15% by weight, and more preferably ranges from 0.01 to 10% by weight, on the basis of the total weight of the whitening agent for topical application.
  • components typically employed in cosmetics specifically, water- soluble polymers, acids, bases, salts, pigments, antioxidants, UV absorbing agents, whitening agents, blood circulation accelerators, metal chelators, sebum controllers, powders, astringents, skin softeners, surfactants other than the aforementioned component (B) , oils, organic solvents, silicones, silicone derivatives, natural extracts derived from animals or vegetables, waxes, and the like can be appropriately selected and employed within a range which does not impair the effects of the present invention.
  • the form of the cosmetic composition is not particularly limited, and may take various forms such as a W/O emulsion, an O/ emulsion, an aqueous gel, an aqueous solution, or the like.
  • the cosmetic composition may be any of skin cosmetics, hair
  • the cosmetic composition according to the present invention is not in the form of an emulsion, but in the form of an aqueous solution such as a cosmetic water.
  • the aforementioned cosmetic water is preferably transparent or
  • the expression "transparent” means allowing light to pass through without causing any deviation due to refraction or reflection.
  • the transparency of a composition such as a cosmetic water can be measured by means of a turbidimeter.
  • a portable turbidimeter model 2100 P (trade mark) manufactured by Hach can be employed in order to measure the transparency ranges of a composition.
  • a composition has a measured turbidity value ranging from 0 to 250 NTU, the composition can be considered as being transparent.
  • the cosmetic composition according to the present invention can be used in a cosmetic treatment process containing the step of applying the cosmetic composition onto the skin.
  • the process is, in particular, suitable for removing brownish pigmentation
  • blemishes for example, caused by external factors such as UV rays, and/or blemishes caused by, for example, internal factors such as aging and the like, and/or is suitable for lightening brown skin.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne principalement une composition cosmétique comprenant : de l'acide kojique ; et au moins un tensioactif non ionique choisi dans le groupe constitué d'éthers d'alkyle (C16-C24) polyoxyéthylénés (1-40 EO) et polyoxypropylénés (1-30 PO), des huiles de ricin hydrogénées polyoxyéthylénées (30-50 EO), et des mono- ou tri-oléates de polyoxyéthylène (15-30 EO) ; et de l'eau en une quantité de 50 % ou plus par rapport au poids total de la composition. La présente invention est utile parce que la composition cosmétique reste stable dans le temps malgré le fait qu'elle comprend de l'acide kojique.
PCT/JP2010/053180 2010-02-22 2010-02-22 Composition cosmétique Ceased WO2011102001A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/JP2010/053180 WO2011102001A1 (fr) 2010-02-22 2010-02-22 Composition cosmétique
JP2012553447A JP5774029B2 (ja) 2010-02-22 2010-02-22 化粧品組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2010/053180 WO2011102001A1 (fr) 2010-02-22 2010-02-22 Composition cosmétique

Publications (1)

Publication Number Publication Date
WO2011102001A1 true WO2011102001A1 (fr) 2011-08-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/053180 Ceased WO2011102001A1 (fr) 2010-02-22 2010-02-22 Composition cosmétique

Country Status (2)

Country Link
JP (1) JP5774029B2 (fr)
WO (1) WO2011102001A1 (fr)

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GB2486951A (en) * 2010-12-30 2012-07-04 Lvmh Rech Cosmetic composition comprising a tocopherol phosphate and process for the preparation thereof

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Publication number Priority date Publication date Assignee Title
JP6716285B2 (ja) * 2016-02-24 2020-07-01 三省製薬株式会社 化粧品用組成物

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Publication number Priority date Publication date Assignee Title
GB2486951A (en) * 2010-12-30 2012-07-04 Lvmh Rech Cosmetic composition comprising a tocopherol phosphate and process for the preparation thereof
GB2486951B (en) * 2010-12-30 2013-10-23 Lvmh Rech Composition comprising a tocopherol phosphate and preparation process

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JP5774029B2 (ja) 2015-09-02

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