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WO2011100325A3 - Polymorphes de sels de sunitinib - Google Patents

Polymorphes de sels de sunitinib Download PDF

Info

Publication number
WO2011100325A3
WO2011100325A3 PCT/US2011/024194 US2011024194W WO2011100325A3 WO 2011100325 A3 WO2011100325 A3 WO 2011100325A3 US 2011024194 W US2011024194 W US 2011024194W WO 2011100325 A3 WO2011100325 A3 WO 2011100325A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymorphs
sunitinib
salts
compositions
sunitinib salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/024194
Other languages
English (en)
Other versions
WO2011100325A2 (fr
Inventor
Pavel Vraspir
Maurizio Paiocchi
Alexandr Jegorov
Francesca Scarpitta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sicor Inc
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of WO2011100325A2 publication Critical patent/WO2011100325A2/fr
Publication of WO2011100325A3 publication Critical patent/WO2011100325A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des polymorphes de malate de sunitinib et d'autres sels. L'invention porte également sur des compositions qui comportent du sunitinib base, de l'acide L-malique et un autre acide carboxylique. De tels polymorphes et de telles compositions sont utiles, par exemple, dans la préparation de compositions pharmaceutiques.
PCT/US2011/024194 2010-02-09 2011-02-09 Polymorphes de sels de sunitinib Ceased WO2011100325A2 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US30261910P 2010-02-09 2010-02-09
US61/302,619 2010-02-09
US30564710P 2010-02-18 2010-02-18
US61/305,647 2010-02-18
US30660110P 2010-02-22 2010-02-22
US61/306,601 2010-02-22
US34801510P 2010-05-25 2010-05-25
US61/348,015 2010-05-25
US35209010P 2010-06-07 2010-06-07
US61/352,090 2010-06-07
US36071110P 2010-07-01 2010-07-01
US61/360,711 2010-07-01

Publications (2)

Publication Number Publication Date
WO2011100325A2 WO2011100325A2 (fr) 2011-08-18
WO2011100325A3 true WO2011100325A3 (fr) 2011-12-15

Family

ID=43899612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/024194 Ceased WO2011100325A2 (fr) 2010-02-09 2011-02-09 Polymorphes de sels de sunitinib

Country Status (1)

Country Link
WO (1) WO2011100325A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104114550A (zh) 2012-03-23 2014-10-22 劳拉斯实验室私人有限公司 制备舒尼替尼及其酸加成盐的改进的方法
EP3039424B1 (fr) 2013-08-28 2020-07-29 Crown Bioscience, Inc. (Taicang) Signatures d'expression génique permettant de prédire la réponse d'un sujet à un inhibiteur multikinase et leurs procédés d'utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156292A1 (en) * 2000-02-15 2002-10-24 Tang Peng Cho Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2009067674A2 (fr) * 2007-11-21 2009-05-28 Teva Pharmaceutical Industries Ltd. Polymorphes de base de sunitinib et procédés pour les préparer
WO2010023474A1 (fr) * 2008-08-25 2010-03-04 Generics [Uk] Limited Nouveaux polymorphes de sunitinib et leurs procédés de préparation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2623094T3 (es) 2001-08-15 2017-07-10 Pharmacia & Upjohn Company Llc Procedimientos de preparación de cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida
US8389562B2 (en) 2007-12-12 2013-03-05 Medichem, S.A. Polymorphic forms of a 3-pyrrole substituted 2-indolinone
EP2252607A2 (fr) 2008-02-21 2010-11-24 Generics [UK] Limited Nouveaux polymorphes et procédés de préparation
EP2098521A1 (fr) 2008-03-06 2009-09-09 Ratiopharm GmbH Formules cristallines de N-[2-(diéthylamino)éthyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidène)méthyl]-2,4-diméthyl-1H-pyrrole-3-carboxamide
CA2720943A1 (fr) 2008-04-16 2009-10-22 Natco Pharma Limited Nouvelles formes polymorphes du sunitinib base
WO2009156837A2 (fr) 2008-06-26 2009-12-30 Medichem, S.A. Forme amorphe d'un sel de malate de 2-indolinone à substitution 3-pyrrole
CN102164913A (zh) 2008-07-24 2011-08-24 麦迪凯姆股份公司 一种3-吡咯替代的2-吲哚酮苹果酸盐的结晶体形式
EP2373642A2 (fr) 2008-07-24 2011-10-12 Teva Pharmaceutical Industries Ltd Sunitinib et ses sels et leurs polymorphes
EP2181991A1 (fr) 2008-10-28 2010-05-05 LEK Pharmaceuticals D.D. Nouveaux sels de sunitinib

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156292A1 (en) * 2000-02-15 2002-10-24 Tang Peng Cho Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2009067674A2 (fr) * 2007-11-21 2009-05-28 Teva Pharmaceutical Industries Ltd. Polymorphes de base de sunitinib et procédés pour les préparer
WO2010023474A1 (fr) * 2008-08-25 2010-03-04 Generics [Uk] Limited Nouveaux polymorphes de sunitinib et leurs procédés de préparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954, ISSN: 0340-1022, ISBN: 978-3-540-36760-4, DOI: DOI:10.1007/3-540-69178-2_5 *

Also Published As

Publication number Publication date
WO2011100325A2 (fr) 2011-08-18

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