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WO2011161544A3 - 疲労のバイオマーカーおよびその利用 - Google Patents

疲労のバイオマーカーおよびその利用 Download PDF

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Publication number
WO2011161544A3
WO2011161544A3 PCT/IB2011/001917 IB2011001917W WO2011161544A3 WO 2011161544 A3 WO2011161544 A3 WO 2011161544A3 IB 2011001917 W IB2011001917 W IB 2011001917W WO 2011161544 A3 WO2011161544 A3 WO 2011161544A3
Authority
WO
WIPO (PCT)
Prior art keywords
ratio
fatigue
acid ratio
acid
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/001917
Other languages
English (en)
French (fr)
Other versions
WO2011161544A8 (ja
WO2011161544A2 (ja
Inventor
弘彦 倉恒
洋祐 片岡
光華 金
恭良 渡辺
世貴 田島
朋義 曽我
恵美 山野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osaka Metropolitan University
RIKEN
University of Osaka NUC
Original Assignee
Osaka University NUC
Osaka City University PUC
RIKEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka University NUC, Osaka City University PUC, RIKEN filed Critical Osaka University NUC
Priority to US13/805,449 priority Critical patent/US20130210045A1/en
Publication of WO2011161544A2 publication Critical patent/WO2011161544A2/ja
Publication of WO2011161544A3 publication Critical patent/WO2011161544A3/ja
Publication of WO2011161544A8 publication Critical patent/WO2011161544A8/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

生体サンプル中のグルコース、クエン酸、cis—アコニット酸の、健常者の測定値に対する被験者の測定値の比率を算出し、グルコースの比率、クエン酸の比率、cis—アコニット酸の比率を疲労の評価および／または判定に用いる。 同様に、イソクエン酸の比率、コハク酸の比率、リンゴ酸の比率、乳酸の比率を算出し、上記3つの比率と併せて疲労の評価および／または判定に用いる。これにより、客観的かつ簡便な疲労の診断および評価を可能にする。
PCT/IB2011/001917 2010-06-24 2011-08-22 疲労のバイオマーカーおよびその利用 Ceased WO2011161544A2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/805,449 US20130210045A1 (en) 2011-02-21 2011-08-22 Biomarker for fatigue, and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010144128 2010-06-24
JP2010-144128 2010-06-24
JP2011034875A JP5811545B2 (ja) 2010-06-24 2011-02-21 疲労のバイオマーカーおよびその利用
JP2011-034875 2011-02-21

Publications (3)

Publication Number Publication Date
WO2011161544A2 WO2011161544A2 (ja) 2011-12-29
WO2011161544A3 true WO2011161544A3 (ja) 2012-03-01
WO2011161544A8 WO2011161544A8 (ja) 2012-04-19

Family

ID=45371880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/001917 Ceased WO2011161544A2 (ja) 2010-06-24 2011-08-22 疲労のバイオマーカーおよびその利用

Country Status (2)

Country Link
JP (1) JP5811545B2 (ja)
WO (1) WO2011161544A2 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040082B2 (en) * 2011-06-24 2015-05-26 K-Pax Pharmaceuticals, Inc. Compositions and methods for treatment of chronic fatigue
WO2015030211A1 (ja) * 2013-08-30 2015-03-05 独立行政法人理化学研究所 疲労のバイオマーカーおよびその利用
ES2963859T3 (es) * 2016-06-17 2024-04-02 Predictive Safety Srp Inc Sistema y método de detección de incapacidad
WO2018147472A1 (ja) * 2017-02-09 2018-08-16 学校法人慶應義塾 血中バイオマーカー

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0977688A (ja) * 1995-09-14 1997-03-25 Taisho Pharmaceut Co Ltd 疲労度の測定方法
US6143784A (en) * 1997-11-25 2000-11-07 The University Of Nottingham Reducing muscle fatigue
JP2010085369A (ja) * 2008-10-02 2010-04-15 Ttc:Kk 疲労の評価方法及び評価用キット

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0977688A (ja) * 1995-09-14 1997-03-25 Taisho Pharmaceut Co Ltd 疲労度の測定方法
US6143784A (en) * 1997-11-25 2000-11-07 The University Of Nottingham Reducing muscle fatigue
JP2010085369A (ja) * 2008-10-02 2010-04-15 Ttc:Kk 疲労の評価方法及び評価用キット

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
GIBALA, MARTIN J. ET AL.: "Tricarboxylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 275, no. 2, 1998, pages E235 - E242 *
GIBALA, MARTIN J. ET AL.: "Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cycling", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 272, no. 2, 1997, pages E239 - E244 *
MOHAN P K ET AL.: "Modulation of muscle dehydrogenases by ascorbic acid in exhausted albino rats", INDIAN J BIOCHEM BIOPHYS, vol. 24, no. 2, 1987, pages 114 - 116 *
NOZAKI SATOSHI ET AL.: "Mental and physical fatigue-related biochemical alterations", NUTRITION, vol. 25, no. 1, 2009, pages 51 - 57 *
OSAMI KAJIMOTO: "Development of human fatigue biochemical biomarkers (Ketsueki, Nyo)", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 228, no. 6, 2009, pages 659 - 663 *
POERTNER, H. 0. ET AL.: "Metabolism and energetics in squid (Illex illecebrosus, Loligo pealei) during muscular fatigue and recovery", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 265, no. 1, 1993, pages R157 - R165 *
RENNIE M J ET AL.: "Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione", THE JOURNAL OF NUTRITION, vol. 131, no. 9, 2001, pages 2488S - 2490S *
SPENCER M K ET AL.: "EFFECT OF LOW GLYCOGEN ON CARBOHYDRATE AND ENERGY METABOLISM IN HUMAN MUSCLE DURING EXERCISE", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 262, no. 4, 1992, pages C975 - C979 *
TARNOPOLSKY, MARK A. ET AL.: "Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans", JOURNAL OF PHYSIOLOGY, vol. 533, no. 3, 2001, pages 881 - 889 *
WLODEK DANUTA ET AL.: "Decreased energy levels can cause and sustain obesity", JOURNAL OF THEORETICAL BIOLOGY, vol. 225, no. 1, 2003, pages 33 - 44 *

Also Published As

Publication number Publication date
WO2011161544A8 (ja) 2012-04-19
WO2011161544A2 (ja) 2011-12-29
JP2012024555A (ja) 2012-02-09
JP5811545B2 (ja) 2015-11-11

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