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WO2011160845A3 - Phospholipides et lipoprotéines oxydés, et anticorps dirigés contre eux, à titre de biomarqueurs des états inflammatoires et méthodes de traitement - Google Patents

Phospholipides et lipoprotéines oxydés, et anticorps dirigés contre eux, à titre de biomarqueurs des états inflammatoires et méthodes de traitement Download PDF

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Publication number
WO2011160845A3
WO2011160845A3 PCT/EP2011/003110 EP2011003110W WO2011160845A3 WO 2011160845 A3 WO2011160845 A3 WO 2011160845A3 EP 2011003110 W EP2011003110 W EP 2011003110W WO 2011160845 A3 WO2011160845 A3 WO 2011160845A3
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Prior art keywords
lipoproteins
oxidized phospholipids
antibodies
well
inflammatory conditions
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Ceased
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PCT/EP2011/003110
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WO2011160845A2 (fr
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Johan FROSTEGÅRD
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MEDIRISTA BIOTECHNOLOGIES AB
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MEDIRISTA BIOTECHNOLOGIES AB
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Publication of WO2011160845A3 publication Critical patent/WO2011160845A3/fr
Anticipated expiration legal-status Critical
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0012—Lipids; Lipoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)

Abstract

Cette invention concerne un procédé permettant d'évaluer le risque de développer des états inflammatoires, et/ou le risque de mortalité associé à ceux-ci, comprenant la surveillance et/ou la détermination des taux d'un ou de plusieurs phospholipides et lipoprotéines oxydés, et des anticorps dirigés contre eux, et la comparaison desdits taux à des valeurs de seuil prédéterminées, ainsi qu'un kit pour la mise en œuvre de ladite méthode. Une méthode permettant de traiter ou de réduire le risque de développer des états inflammatoires, et/ou le risque de mortalité associé à ceux-ci, par administration de médicaments comprenant une annexine A5 et/ou des anticorps dirigés contre un ou plusieurs phospholipides et lipoprotéines oxydés, ainsi que des composants bioactifs et/ou des parties/fragments de ceux-ci est également décrite. Cette invention concerne également des compositions comprenant un ou plusieurs inhibiteurs de phospholipides et de lipoprotéines oxydés, ainsi que des composants bioactifs et/ou des parties/fragments de ceux-ci ; et des compositions comprenant un ou plusieurs conjugués de phospholipides et de lipoprotéines oxydés, ainsi que des composants bioactifs et/ou des parties/fragments de ceux-ci.
PCT/EP2011/003110 2010-06-24 2011-06-24 Phospholipides et lipoprotéines oxydés, et anticorps dirigés contre eux, à titre de biomarqueurs des états inflammatoires et méthodes de traitement Ceased WO2011160845A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US35810210P 2010-06-24 2010-06-24
US61/358,102 2010-06-24
US37344110P 2010-08-13 2010-08-13
US61/373,441 2010-08-13
US201161449276P 2011-03-04 2011-03-04
US61/449,276 2011-03-04

Publications (2)

Publication Number Publication Date
WO2011160845A2 WO2011160845A2 (fr) 2011-12-29
WO2011160845A3 true WO2011160845A3 (fr) 2012-03-15

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PCT/EP2011/003110 Ceased WO2011160845A2 (fr) 2010-06-24 2011-06-24 Phospholipides et lipoprotéines oxydés, et anticorps dirigés contre eux, à titre de biomarqueurs des états inflammatoires et méthodes de traitement

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2711705A1 (fr) 2008-12-19 2014-03-26 Medirista Biotechnologies AB Cardiolopide oxydée en tant que nouveau facteur pro-inflammatoire
GB201702144D0 (en) * 2017-02-09 2017-03-29 Annexin Pharmaceuticals Ab Therapeutic compositions
WO2018220224A1 (fr) * 2017-06-02 2018-12-06 Medirista Biotechnologies Ab Antigènes associés aux lipides et anticorps contre eux
US11530259B2 (en) 2018-01-29 2022-12-20 The Regents Of The University Of California Therapies and methods to treat TLR2-mediated diseases and disorders
US20210041448A1 (en) * 2018-04-19 2021-02-11 The University Of Tokyo Method and kit for assisting diagnosis of disease in subject
KR20220131222A (ko) * 2019-11-12 2022-09-27 앱센트라 엘엘시 암 치료 방법 및 조성물
WO2023057588A1 (fr) * 2021-10-06 2023-04-13 Iltoo Pharma Constructions chimériques d'interleukine 2 ont une spécificité de ciblage vis-à-vis des tissus enflammés
AU2024240129A1 (en) 2023-03-17 2025-10-09 Oxitope Pharma B.V. Anti-phosphocholine antibodies and methods of use thereof
CN118011012B (zh) * 2024-02-19 2025-01-21 中国科学院昆明动物研究所 LL-37-ApoB-100生物标志物及其应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2010069605A2 (fr) * 2008-12-19 2010-06-24 Medirista Biotechnologies Ab Cardiolopide oxydée en tant que nouveau facteur pro-inflammatoire

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US20050222030A1 (en) 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
DE602005018914D1 (de) 2004-04-15 2010-03-04 Athera Biotechnologies Ab Annexin zur prävention von der ruptur des plaques
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
EP2254589B1 (fr) 2008-02-22 2017-04-05 Annexin Pharmaceuticals AB Composés et procédés pour prévention ou le traitement de la resténose
EP2311109A2 (fr) 2008-07-06 2011-04-20 Lamos Inc. Structure thermoélectrique à deux éléments ainsi que dispositifs et systèmes utilisant ladite structure
WO2010043045A1 (fr) 2008-10-17 2010-04-22 London Health Sciences Centre Research Inc. Annexine et son utilisation pour le traitement de troubles inflammatoires

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2010069605A2 (fr) * 2008-12-19 2010-06-24 Medirista Biotechnologies Ab Cardiolopide oxydée en tant que nouveau facteur pro-inflammatoire

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