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WO2011159781A3 - Modulateurs de goût amer - Google Patents

Modulateurs de goût amer Download PDF

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Publication number
WO2011159781A3
WO2011159781A3 PCT/US2011/040491 US2011040491W WO2011159781A3 WO 2011159781 A3 WO2011159781 A3 WO 2011159781A3 US 2011040491 W US2011040491 W US 2011040491W WO 2011159781 A3 WO2011159781 A3 WO 2011159781A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
bitter taste
taste modulators
taste
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/040491
Other languages
English (en)
Other versions
WO2011159781A2 (fr
Inventor
Catherine Tachdjian
Xiaodong Li
Donald S. Karanewsky
Joseph R. Fotsing
Andrew Patron
Vincent Darmohusodo
Victor Selchau
Brett Ching
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich Inc
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of WO2011159781A2 publication Critical patent/WO2011159781A2/fr
Publication of WO2011159781A3 publication Critical patent/WO2011159781A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/86—Addition of bitterness inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention comprend des antagonistes de récepteurs de goût de type 2 humains (hT2R) ayant la formule structurale (I). La présente invention concerne en outre des compositions contenant ces antagonistes, l'utilisation de ces antagonistes pour moduler la perception du goût, en particulier un goût amer, et le procédé de préparation de ces antagonistes (I).
PCT/US2011/040491 2010-06-17 2011-06-15 Modulateurs de goût amer Ceased WO2011159781A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35580010P 2010-06-17 2010-06-17
US61/355,800 2010-06-17

Publications (2)

Publication Number Publication Date
WO2011159781A2 WO2011159781A2 (fr) 2011-12-22
WO2011159781A3 true WO2011159781A3 (fr) 2012-04-19

Family

ID=45348841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/040491 Ceased WO2011159781A2 (fr) 2010-06-17 2011-06-15 Modulateurs de goût amer

Country Status (1)

Country Link
WO (1) WO2011159781A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106458912B (zh) 2014-04-04 2020-10-27 辉瑞公司 双环稠合的杂芳基或芳基化合物以及它们作为irak4拟制剂的用途
WO2017156071A1 (fr) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Composés céto-amides cycliques utilisés en tant que modulateurs de la calpaïne, et leurs procédés de production et d'utilisation
US11292801B2 (en) 2016-07-05 2022-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
PE20191153A1 (es) 2016-09-28 2019-09-05 Blade Therapeutics Inc Moduladores de calpainas y usos terapeuticos de los mismos
CN112969687B (zh) 2018-10-30 2024-08-23 吉利德科学公司 作为α4β7整合素抑制剂的喹啉衍生物
ES3003232T3 (en) 2018-10-30 2025-03-10 Gilead Sciences Inc Compounds for inhibition of alpha4beta7 integrin
CA3115820A1 (fr) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Composes pour l'inhibition de l'integrine .alpha.4.beta.7
EP3873900B1 (fr) 2018-10-30 2025-01-08 Gilead Sciences, Inc. Dérivés de imidazo[1,2-a]pyridine en tant qu'inhibiteurs d'integrin alpha4beta7 pour le traitement de maladies inflammatoires
CA3148613A1 (fr) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Composes derives de la phenylalanine et utilisation comme inhibiteurs del'integrine alpha-4 beta-7

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006052722A1 (fr) * 2004-11-09 2006-05-18 Smithkline Beecham Corporation Composes inhibiteurs de la phosphorylase du glycogene et compositions pharmaceutiques les comprenant
WO2006055725A2 (fr) * 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Acides amino carboxyliques substitues
EP1873144A1 (fr) * 2005-04-20 2008-01-02 Takeda Pharmaceutical Company Limited Compose heterocyclique fusionne
US20080096877A1 (en) * 2006-10-19 2008-04-24 Tsuneo Yasuma Indole compound
US20090117547A1 (en) * 2006-09-05 2009-05-07 Senomyx, Inc. NOVEL HAPLOTYPE OF HUMAN T2R RECEPTOR hT2R50 AND ITS USE IN ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006052722A1 (fr) * 2004-11-09 2006-05-18 Smithkline Beecham Corporation Composes inhibiteurs de la phosphorylase du glycogene et compositions pharmaceutiques les comprenant
WO2006055725A2 (fr) * 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Acides amino carboxyliques substitues
EP1873144A1 (fr) * 2005-04-20 2008-01-02 Takeda Pharmaceutical Company Limited Compose heterocyclique fusionne
US20090117547A1 (en) * 2006-09-05 2009-05-07 Senomyx, Inc. NOVEL HAPLOTYPE OF HUMAN T2R RECEPTOR hT2R50 AND ITS USE IN ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS
US20080096877A1 (en) * 2006-10-19 2008-04-24 Tsuneo Yasuma Indole compound

Also Published As

Publication number Publication date
WO2011159781A2 (fr) 2011-12-22

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