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WO2011157873A1 - Système et procédé pour obtenir des données sur le cycle respiratoire d'un patient - Google Patents

Système et procédé pour obtenir des données sur le cycle respiratoire d'un patient Download PDF

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Publication number
WO2011157873A1
WO2011157873A1 PCT/ES2011/070242 ES2011070242W WO2011157873A1 WO 2011157873 A1 WO2011157873 A1 WO 2011157873A1 ES 2011070242 W ES2011070242 W ES 2011070242W WO 2011157873 A1 WO2011157873 A1 WO 2011157873A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient
respiratory
video sequence
abdomen
regions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2011/070242
Other languages
English (en)
Spanish (es)
Inventor
Luís GOLDMAN TARLOVKY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz
Original Assignee
Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz filed Critical Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz
Publication of WO2011157873A1 publication Critical patent/WO2011157873A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/113—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
    • A61B5/1135—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing by monitoring thoracic expansion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A61B5/0878—Measuring breath flow using temperature sensing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/1126—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb using a particular sensing technique
    • A61B5/1128—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb using a particular sensing technique using image analysis

Definitions

  • the object of the present invention is a non-invasive system and method for obtaining data about the respiratory cycle of a patient. Specifically, the procedure evaluates: 1) periodic changes related to breathing that occur in certain areas of a patient's body by processing a video sequence obtained by means of a thermal imager and 2) from the curves of the chest, abdomen and Nasal airflow resulting from the previous procedure, accurately measures respiratory synchrony without virtually no instrumental lag. BACKGROUND OF THE INVENTION
  • the Obstructive Sleep Apnea Syndrome is characterized by more or less prolonged respiratory pauses and an obstruction in the upper airways that decreases the air flow.
  • respiratory pauses can also occur due to neurological and muscular conditions or prolonged apnea of etiology not yet fully elucidated as Sudden Infant Death Syndrome. Therefore, it is necessary to know data about the patient's respiratory cycle to be able to make an accurate differential diagnosis and take the necessary life support measures if the event is prolonged putting the patient's life at risk.
  • the respiratory cycle of a patient originates primarily in the cyclic contraction of the diaphragm muscle and results in displacements of the chest and abdomen causing a bidirectional air flow detectable at the level of the nostrils and / or in the mouth.
  • the lack of relative synchrony between Displacements of the thorax and abdomen and air flow may be indicative of different respiratory pathologies.
  • Nasal air flow refers to the air entering and exiting through the nose during inspiration and expiration
  • thoracic and abdominal displacements refer respectively to the way in which the chest and abdomen swell and deflate during the breathing. Under physiological conditions these processes are synchronous, accepted as a normal angle thoraco abdominal desfazamiento between 0 and 54 ° or.
  • thermographic video sequence of a region of interest of a patient and of a duration that can range from a few seconds to a few minutes is taken, and then the thermal map variations (of size, of shape, position and / or magnitude) in said region of interest. That is, considering that the map of surface temperatures of, for example, a patient's chest is relatively constant, the periodic changes that occur in a thermographic image of the region of interest should be the consequence of movements related to breathing.
  • One aspect of the invention describes a method for obtaining data about a patient's respiratory cycle from a video sequence of the patient recorded with a thermal imager.
  • the thermal imager is capable of detecting thermal emissions whose wavelength corresponds to the range of surface temperatures of a person and their environment in a hospital ward, for example between 25 ° C and 40 ° C.
  • the data obtained about the respiratory cycle are represented as graphs that allow a user to identify the moments of beginning and end of the inspiration and expiration phases, as well as possible respiratory pauses, inspiration or forced expiration, or other respiratory abnormalities and provide the angle of lag between the respiratory movements of the thorax and abdomen.
  • the process of the invention comprises the following steps:
  • thermographic video sequence 1) Identify in the thermographic video sequence the regions of the thoracic, abdominal patient and at least one nasal vestibule.
  • this step in turn comprises the steps of:
  • the difference between areas 1 and 0 represents the value of the thermal variation in each region of interest. This value is updated 50 times per second (which is the number of frames recorded per second) giving rise to a series of time whose magnitude varies with the respiratory displacements of the thorax and abdomen and the change in temperature in the nostrils. Finally, a cross-correlation analysis allows to obtain the offset angle or delay time between the signals.
  • the respiratory rate may range between approximately 12 and 40 breaths per minute, while the heart rate may be between approximately 60 and 100 pulses per minute, both values being dependent on the subject's age. Accordingly, it is possible to filter frequencies greater than 0.8 Hz to prevent changes due to heart rate interfering with the identification of data about the respiratory cycle. That is, the filter will eliminate artifacts at more than 48 cycles per second. More preferably, a low-pass filter of Chebyshev type II and order 6 is used.
  • the described invention is directed to a procedure, it is understood that said procedure is capable of being encoded as a computer program.
  • the program may have the form of source code, object code, an intermediate source of code and object code (for example, in partially compiled form), or in any other form suitable for the implementation of the method according to the invention.
  • Said computer program may be located on or within a carrier, any entity or device capable of supporting the program being a carrier.
  • the carrier can be a storage medium such as a ROM, a CD ROM or a semiconductor ROM, or a magnetic recording medium, for example, a flexible disk or a hard disk.
  • the carrier can also be a transmissible carrier, for example, an electrical or optical signal that could be transported through electrical or optical cable, by radio or by any other means.
  • the carrier When the program is incorporated into a signal that can be directly transported by a cable or other device or medium, the carrier may be constituted by said cable or other device or means.
  • the carrier could also be an integrated circuit in which the program is included, the integrated circuit adapted to execute, or to be used in the execution of, the corresponding processes.
  • a second aspect of the present invention describes a system capable of carrying out the process described above comprising
  • thermographic video camera capable of obtaining a video sequence of at least one region of interest of a patient; and - a processing medium, preferably a PC, connected to the thermographic video camera and configured to carry out the procedure described above.
  • Fig. 1 shows an example in grayscale of a frame corresponding to a thermographic video sequence of the torso and face of a patient where thermal zones are displayed that move with the respiratory movements of the thorax and abdomen.
  • Fig. 2 shows a pair of thermographic frames corresponding to the nasal region highlighting the predominance of the gray areas (lower temperature) at the end of inspiration (Fig. 2A) and a decrease of these areas (higher temperature) at the end of the expiration (Fig. 2B).
  • the inhalation of air at room temperature is what causes the thermal decrease in the nostrils.
  • Fig. 3 shows the result of subtracting pixel by pixel consecutive frames.
  • the non-significant results (around 0) were eliminated since they represent undetermined noise while the positive and negative results were respectively assigned to 1 and 0.
  • the complementary pattern of areas 1 and 0 is observed during inspiration and expiration.
  • Figs. 4A-C show respectively the fluctuations corresponding to the respiratory movements of the regions of interest TX, AB and NS, the nasal pressures obtained by means of a nasal probe used to check results and the correlation between thoracic and abdominal movements.
  • Figs. 4A-C show respectively the fluctuations corresponding to the respiratory movements of the regions of interest TX, AB and NS, the nasal pressures obtained by means of a nasal probe used to check results and the correlation between thoracic and abdominal movements.
  • the thermal imager used in this example is a Flir Thermovision A40 M (Flir Systems, AB, Sweden) controlled by software from the same company (Therma Cam Researcher software, Flir Systems, AB, Sweden) that measures thermal emissivity in a range spectral between 7.5-13 ⁇ .
  • the camera was connected to a PC through a firewire connection.
  • thermographic video sequences acquired in AVI format 50 frames per second, 76000 pixels per frame), lasting at least 10 minutes, were transformed to Matlab format (Matlab 7.0, Mathworks, Inc., Natick, MA) for post processing
  • Matlab format Matlab 7.0, Mathworks, Inc., Natick, MA
  • the room temperature was maintained between 22 0 and 24 °.
  • Fig. 1 shows a frame corresponding to a patient during the inspiration process. The lighter areas correspond to warmer temperatures, while the dark ones correspond to colder temperatures, such as It is seen on the scale on the right.
  • the three regions of interest usually used for the diagnosis of respiratory problems are also represented: abdomen (AB), thorax (TX) and nose (NS).
  • Fig. 2 shows the frames of a nostril corresponding to the end of inspiration (Fig. 2A) and expiration (Fig.
  • Figs. 4A-C show the signals obtained non-invasively and without any instrumental delay corresponding to the respiratory pattern in the abdominal, thoracic and nasal regions of a healthy patient.
  • thermographic curves corresponding to the regions mentioned and represented in arbitrary units have a totally physiological synchrony.
  • Fig. 5 shows the same curves but obtained in a patient with respiratory involvement, asynchrony is evident between the thermographic signals obtained (Fig. 5A).
  • the curves of the thorax and abdomen do not coincide with the nasal pressure (Fig. 5B) considered as a reference and confirming its lack of synchrony.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physiology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention concerne un système et un procédé à effraction minimale pour l'obtention de données sur le cycle respiratoire d'un patient à partir d'une séquence vidéo du patient enregistrée au moyen d'une caméra thermographique. Le procédé comprend les étapes suivantes qui consistent : à identifier dans la séquence vidéo thermographique les zones thoracique (TX), abdominale (AB) et au moins un vestibule nasal (NS) du patient; et à traiter la séquence vidéo thermographique pour déduire, en fonction de changements périodiques dans lesdites zones, des données sur le cycle respiratoire du patient.
PCT/ES2011/070242 2010-06-16 2011-04-11 Système et procédé pour obtenir des données sur le cycle respiratoire d'un patient Ceased WO2011157873A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201030927A ES2387153B1 (es) 2010-06-16 2010-06-16 Sistema y procedimiento para obtener datos acerca del ciclo respiratorio de un paciente
ESP201030927 2010-06-16

Publications (1)

Publication Number Publication Date
WO2011157873A1 true WO2011157873A1 (fr) 2011-12-22

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PCT/ES2011/070242 Ceased WO2011157873A1 (fr) 2010-06-16 2011-04-11 Système et procédé pour obtenir des données sur le cycle respiratoire d'un patient

Country Status (2)

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ES (1) ES2387153B1 (fr)
WO (1) WO2011157873A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9218668B2 (en) 2013-02-28 2015-12-22 Koninklijke Philips N.V. Differentiating among a plurality of subjects in a field-of-view based on vital signs
WO2019239124A1 (fr) * 2018-06-13 2019-12-19 Braintrain2020 Limited Appareil de détection
US10602962B2 (en) 2013-11-01 2020-03-31 Koninklijke Philips N.V. System and method for determining vital sign information of a subject
EP3967215A1 (fr) * 2020-09-15 2022-03-16 Alunos AG Dispositif de mesure et procédé d'évaluation de données vitales d'un sujet humain ou animal

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10750980B2 (en) * 2014-12-02 2020-08-25 Brainlab Ag Human body measurement using thermographic images

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000015A2 (fr) * 2001-06-25 2003-01-03 Science Applications International Corporation Identification par l'analyse de variations biometriques
WO2007105951A1 (fr) * 2006-03-15 2007-09-20 Van Den Boom Ipo Paulus Willem Procédé et dispositif de codage et de décodage de données
JP2008086741A (ja) * 2005-12-26 2008-04-17 Akira Tomono 呼吸検出型化学物質提示装置、および、呼吸検出装置
WO2008130903A1 (fr) * 2007-04-17 2008-10-30 Mikos, Ltd. Système et procédé pour utilisation d'imagerie infrarouge tridimensionnelle pour des bibliothèques d'imagerie médicale normalisées
US20090226043A1 (en) * 2008-03-05 2009-09-10 International Business Machines Corporation Detecting Behavioral Deviations by Measuring Respiratory Patterns in Cohort Groups

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000015A2 (fr) * 2001-06-25 2003-01-03 Science Applications International Corporation Identification par l'analyse de variations biometriques
JP2008086741A (ja) * 2005-12-26 2008-04-17 Akira Tomono 呼吸検出型化学物質提示装置、および、呼吸検出装置
WO2007105951A1 (fr) * 2006-03-15 2007-09-20 Van Den Boom Ipo Paulus Willem Procédé et dispositif de codage et de décodage de données
WO2008130903A1 (fr) * 2007-04-17 2008-10-30 Mikos, Ltd. Système et procédé pour utilisation d'imagerie infrarouge tridimensionnelle pour des bibliothèques d'imagerie médicale normalisées
US20090226043A1 (en) * 2008-03-05 2009-09-10 International Business Machines Corporation Detecting Behavioral Deviations by Measuring Respiratory Patterns in Cohort Groups

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9218668B2 (en) 2013-02-28 2015-12-22 Koninklijke Philips N.V. Differentiating among a plurality of subjects in a field-of-view based on vital signs
US10602962B2 (en) 2013-11-01 2020-03-31 Koninklijke Philips N.V. System and method for determining vital sign information of a subject
WO2019239124A1 (fr) * 2018-06-13 2019-12-19 Braintrain2020 Limited Appareil de détection
US20210212595A1 (en) * 2018-06-13 2021-07-15 Braintrain2020 Limited Apparatus for sensing
EP3967215A1 (fr) * 2020-09-15 2022-03-16 Alunos AG Dispositif de mesure et procédé d'évaluation de données vitales d'un sujet humain ou animal

Also Published As

Publication number Publication date
ES2387153A1 (es) 2012-09-14
ES2387153B1 (es) 2013-08-08

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