[go: up one dir, main page]

WO2011156641A3 - Réseaux de micro-aiguilles pour la distribution d'un agent actif - Google Patents

Réseaux de micro-aiguilles pour la distribution d'un agent actif Download PDF

Info

Publication number
WO2011156641A3
WO2011156641A3 PCT/US2011/039858 US2011039858W WO2011156641A3 WO 2011156641 A3 WO2011156641 A3 WO 2011156641A3 US 2011039858 W US2011039858 W US 2011039858W WO 2011156641 A3 WO2011156641 A3 WO 2011156641A3
Authority
WO
WIPO (PCT)
Prior art keywords
microneedle arrays
active agent
agent delivery
methods
microneedle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/039858
Other languages
English (en)
Other versions
WO2011156641A2 (fr
Inventor
Roger L. Kaspar
Tycho Speaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2011156641A2 publication Critical patent/WO2011156641A2/fr
Publication of WO2011156641A3 publication Critical patent/WO2011156641A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Anesthesiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des réseaux de micro-aiguilles ainsi que des systèmes et des procédés apparentés. L'invention porte plus particulièrement sur des réseaux de micro-aiguilles qui sont conçus pour distribuer des agents actifs, y compris des acides nucléiques et des vaccins. La présente invention concerne également des méthodes de vaccination et de réduction de la quantité de vaccin nécessaire pour une inoculation efficace.
PCT/US2011/039858 2010-06-09 2011-06-09 Réseaux de micro-aiguilles pour la distribution d'un agent actif Ceased WO2011156641A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35310810P 2010-06-09 2010-06-09
US61/353,108 2010-06-09

Publications (2)

Publication Number Publication Date
WO2011156641A2 WO2011156641A2 (fr) 2011-12-15
WO2011156641A3 true WO2011156641A3 (fr) 2012-05-10

Family

ID=45098675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/039858 Ceased WO2011156641A2 (fr) 2010-06-09 2011-06-09 Réseaux de micro-aiguilles pour la distribution d'un agent actif

Country Status (1)

Country Link
WO (1) WO2011156641A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105579059B (zh) 2013-09-03 2020-07-31 佐治亚科技研究公司 热稳定的疫苗配制物、工艺和包含疫苗配制物的微针
EP3763383A1 (fr) 2013-12-16 2021-01-13 Massachusetts Institute Of Technology Formulations de vaccin à libération pulsatile imprimées en 3d ou micromoulées
US20180056053A1 (en) * 2016-08-26 2018-03-01 Juvic Inc. Protruding microstructure for transdermal delivery
CN111093629A (zh) * 2017-07-16 2020-05-01 麻省理工学院 微针纹身贴剂和其用途
CN110680908B (zh) * 2018-07-04 2024-02-20 辽宁成大生物股份有限公司 一种速崩型a群c群脑膜炎球菌多糖结合疫苗可溶性微针及其制备方法
CN115835856A (zh) 2020-05-13 2023-03-21 麻省理工学院 聚合物微装置的组合物以及其在癌症免疫疗法中的用途
CN113171930B (zh) * 2021-06-01 2025-07-22 苏州璟丰机电有限公司 微针提拉装置
US20240416097A1 (en) * 2021-11-03 2024-12-19 Merck Sharp & Dohme Llc Microneedle injector and methods of making and using same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050065463A1 (en) * 2003-09-18 2005-03-24 Nano Device And System Research Inc. Applicator for applying functional substances into human skin
US20060127465A1 (en) * 2003-06-10 2006-06-15 Shinya Maenosono Pad base for transdermal administration and needle
US20070060867A1 (en) * 2005-05-18 2007-03-15 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20090043279A1 (en) * 2007-08-06 2009-02-12 Kaspar Roger L Microneedle arrays formed from polymer films

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060127465A1 (en) * 2003-06-10 2006-06-15 Shinya Maenosono Pad base for transdermal administration and needle
US20050065463A1 (en) * 2003-09-18 2005-03-24 Nano Device And System Research Inc. Applicator for applying functional substances into human skin
US20070060867A1 (en) * 2005-05-18 2007-03-15 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20090043279A1 (en) * 2007-08-06 2009-02-12 Kaspar Roger L Microneedle arrays formed from polymer films

Also Published As

Publication number Publication date
WO2011156641A2 (fr) 2011-12-15

Similar Documents

Publication Publication Date Title
WO2011156641A3 (fr) Réseaux de micro-aiguilles pour la distribution d'un agent actif
WO2015023649A3 (fr) Peptides destinés à améliorer l'administration transdermique
MY169352A (en) Vaccine against rsv
WO2012125987A3 (fr) Système d'administration
ZA201404199B (en) Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same.
WO2013028942A8 (fr) Ciblage de microbulles
WO2013006569A3 (fr) Vaccin contre le virus de l'herpès et procédés d'utilisation
WO2013170170A3 (fr) Compositions et méthodes de thérapie génique
MX343048B (es) Oligodesoxinucleotidos inmunoestimulantes.
MX2013013801A (es) Oligodesoxinucleotidos inmunoestimuladores.
EA201790178A1 (ru) Пептиды, несущие маннозо-6-фосфат, слитые с лизосомальным ферментом
WO2012112489A3 (fr) Compositions et méthodes de thérapie et de diagnostic de la grippe
MX346596B (es) Oligodesoxinucleotidos inmunoestimuladores.
WO2012158437A3 (fr) Appareil à canule et systèmes d'assistance ventriculaire utilisant l'appareil à canule
IT1396017B1 (it) Dispositivo medico per l'applicazione di cateteri, particolarmente per procedure di toracentesi.
EP2574170A4 (fr) Compositions immunostimulatrices et vaccinales
WO2012067866A3 (fr) Vaccin multivalent pour la filariose
WO2013055418A3 (fr) Vaccins fournissant une protection croisée contre les arénavirus et leur procédé d'utilisation
PL2729008T3 (pl) Systemy, sposoby i formulacje do leczenia raka
IT1402945B1 (it) Sistema di comando controllo attivo e diagnostico per pantografo ferroviario.
WO2010053610A3 (fr) Formulations stables de vaccin contre l'anthrax
BR112014021497A2 (pt) sistema de entrega de fármaco baseado em jcv-vlp
MX2014005270A (es) Sistema de administracion vaginal con activiad osmotica.
EP4321218A3 (fr) Vaccins contre le cancer ciblant des cellules souches cancéreuses
WO2009100886A3 (fr) Formules à base de flibansérine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11793191

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205N DATED 15/02/2013)

122 Ep: pct application non-entry in european phase

Ref document number: 11793191

Country of ref document: EP

Kind code of ref document: A2